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River reflects human foibles

Hanu Yadav’s “Karmanasha Ki Haar” is a severe indictment of superstition and feudal values, says Diwan Singh Bajeli




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For the child in you




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Playing to the masses

As Saif Hyder Hasan brings "Mr. and Mrs. Murarilal" to the city, SWATI DAFTUAR takes stock of commercial theatre in the Capital




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Memories of a love lost

Anupam Kher speaks about the emotional core of Mera Woh Matlab Nahi Tha, to be staged this weekend in the city




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The lovable everyman

In a conversation that veers from nostalgia to cultural politics, Rajit Kapur reflects on his craft and concerns




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Bonds that last

An unabridged version of ‘Kuchelavritham’ was staged in Palakkad, to the delight of rasikas.




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The price of arrogance

A performance of ‘Dakshayagam’ in the capital city pointed out how inflated egos can rend asunder familial ties.




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Of dramatic possibilities

Ninasam Tirugata staged two plays -- Kalandugeya Kathe and Atta Dari Itta Puli. One reads the contemporary into classical, and the other bares the present itself




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It is a ‘golden’ milestone

Fifty years of Stage Creations’ existence will be marked with the play ‘Dowri Kalyana Vaibogamey’. Malathi Rangarajan attends a rehearsal.




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When stalwarts take stage

Ramchandra Singh and Himani Shivpuri, recipients of this year’s Sangeet Natak Akademi Award for theatre, moved the Delhi audience with their talent at the National Festival of Performing Arts, says Diwan Singh Bajeli




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Shakespeare all the way

Shakespeare’s A Midsummer Night’s Dream staged by E.M.G.Yadava Women’s College students brought to fore Elizabethan society, sense and sensibilities




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Stickler for tradition

Music is not a separate identity in Kathakali, says ace Kathakali musician Kalanilayam Rajeevan.




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When Palavakkam was an outback

Laugh non-stop, that’s what the audience did watching ‘Crazy Thieves...’




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Reflection on society

Visu’s play, enacted by Stage Creations, underlined greed and hypocrisy.




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Call of the stage

'Kimartham Draupathy', Aswathy Vijayan’s Sanskrit play, is about predicaments that women face even in the present day. The drama will be staged today




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Dream does the trick for this play

Y Gee Mahendran’s ‘Soppana Vazhvil’ is a witty commentary on the unruly ways of society, writes Srivathsan Nadadhur.




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Take one: scene one

Unarvu, the senior citizen’s forum, makes its debut in theatre




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Parking space

Manav Kaul’s Park, at one level, explores what constitutes home in the Bengaluru of today




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Art of acting

Swiss film maker and theatre director Heinz Gubler talks about his love for theatrical innovations




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When dreams are shattered...

Rani Balbir Kaur’s production of Balwant Gargi celebrated play “Kanak Di Balli” touched the hearts of the audience.




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Multiple themes, diverse genres

Theatre aspirants in Visakhapatnam were exposed to technical and histrionic trends from across the country.




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What the mirror says

Written by Girish Karnad in 2004 and directed by Alyque Padamsee, the play has seen Shabana make the character her own.




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Touch of parody, tinge of nostalgia

The 28th Urdu Drama Festival charmed the audience with the variety of themes and presentational styles.




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Gauhar, the fall of a star

Lillete Dubey’s ‘Gauhar’ is a terrific ode to one of the first singing sensations in the country




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With a touch of refinement

The Soorpanaka episode staged by Yakshagana artists at Niram Thiram stood out for its unusual treatment, writes Rupa Srikanth




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Amaravati Poetic Prism 2016 : Poetry sans barriers

Amaravati Poetic Prism 2016 makes its entry into Indian Book of Records as the largest poetic anthology comprising 527 poems.




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The colour of nightmare

Sreemoyee Dasgupta’s “7 Raison d'etre” is an experimental dramatic piece which projects a dark and bitter vision of contemporary society




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Meet this year’s Shankar Nag awardees - Nimmy Raphel and Sharanya Ramprakash

Nimmy Raphel and Sharanya Ramprakash discuss the challenges theatre faces after the pandemic




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RSC - Toxicol. Res. latest articles




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Ultra-efficient delivery of CRISPR/Cas9 using ionic liquid conjugated polymers for genome editing-based tumor therapy

Biomater. Sci., 2024, 12,1716-1725
DOI: 10.1039/D3BM01981K, Paper
Zhongming Huang, Tongren Yang, Jie Yu, Yijian Gao, Yuhua Weng, Yuanyu Huang, Shengliang Li
Through molecular screening, ionic liquid-conjugated polymers (IL-CPs) are developed for highly efficient delivery of CRISPR/Cas9 system, which demonstrated high-performance genome editing-based tumor therapy.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A highly tuneable inverse emulsion polymerization for the synthesis of stimuli-responsive nanoparticles for biomedical applications

Biomater. Sci., 2024, 12,1707-1715
DOI: 10.1039/D3BM01765F, Paper
Andrew C. Murphy, Heidi F. Oldenkamp, Nicholas A. Peppas
This article demonstrates an inverse emulsion scheme to polymerize a variety of ionizable and non-ionizable monomers to form stimuli-responsive nanoparticles with potential applications in biomaterials science.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Applications of peptide-based nanomaterials in targeting cancer therapy

Biomater. Sci., 2024, 12,1630-1642
DOI: 10.1039/D3BM02026F, Review Article
Beilei Sun, Limin Zhang, Mengzhen Li, Xin Wang, Weizhi Wang
To meet the precise diagnosis and treatment as well as reduce systemic toxicity and side effects, self-assembled peptides are applied to the targeting therapy, including targeting theranostics, nanocarrier delivery, immunotherapy, and combination therapy.
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A microneedle patch realizes weight loss through photothermal induction of fat browning

Biomater. Sci., 2024, 12,1726-1737
DOI: 10.1039/D3BM01767B, Paper
Zichun Gao, Yixuan Liu, Wenjiao Lin, He Lian, Zhaoxu Meng
Hyaluronic acid microneedles loaded with polydopamine nanoparticles induce fat browning, offering innovative localized obesity treatment.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Optimization of hair follicle spheroids for hair-on-a-chip

Biomater. Sci., 2024, 12,1693-1706
DOI: 10.1039/D3BM02012F, Paper
Subin Jeong, Hyeon-Min Nam, Gun Yong Sung
We report spheroids prepared by injecting LEF1 and Wnt1 into DPCs via transfection and then adding KCs and HUVECs. Through SEM, we observed a part extending outward from the TK and TKH surfaces, as indicated by white arrows.
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One-pot reaction for the preparation of diatom hemostatic particles with effective hemostasis and economic benefits

Biomater. Sci., 2024, 12,1883-1897
DOI: 10.1039/D3BM01793A, Paper
Yunji Sun, Chang Su, Jinfeng Liu, Zheng He, Shengting Che, Qinglan Wan, Jingyu Cai, Hao Zhan, Chao Feng, Xiaojie Cheng, Feng Lin, Junqiang Wei, Xiguang Chen
Diatom hemostatic particles prepared by one-pot reaction have streamlined process and mass production potential, can significantly stop bleeding and reduce accidental deaths.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Efficient healing of diabetic wounds by MSC-EV-7A composite hydrogel via suppression of inflammation and enhancement of angiogenesis

Biomater. Sci., 2024, 12,1750-1760
DOI: 10.1039/D3BM01904G, Paper
Xinyi Long, Qian Yuan, Rui Tian, Wanting Zhang, Lang Liu, Minghui Yang, Xin Yuan, Zhujie Deng, Quanjiang Li, Ronghui Sun, Yuyi Kang, Yingying Peng, Xiubin Kuang, Lingfang Zeng, Zhengqiang Yuan
An alginate hydrogel loaded with mesenchymal stem-cell-derived extracellular vesicles (EVs) and a 7-amino-acid peptide (7A) constitutes a novel dressing for efficient healing of diabetic wounds with anti-inflammation and pro-angiogenesis mechanisms.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Comparative analysis of supercritical fluid-based and chemical-based decellularization techniques for nerve tissue regeneration

Biomater. Sci., 2024, 12,1847-1863
DOI: 10.1039/D3BM02072J, Paper
Open Access
Beom-Seok Kim, Jeong-Uk Kim, Jae Woo Lee, Kyung Min Ryu, Rachel H. Koh, Kyoung-Ha So, Nathaniel S. Hwang
The supercritical (SC) fluid-based method were utilized for nerve tissue decellualrization. In vitrovivo assessments underscore its potential for advanced tissue engineering and regenerative applications.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine

Biomater. Sci., 2024, 12,1662-1692
DOI: 10.1039/D3BM01451G, Review Article
Qiao Li, Yuan Lianghao, Gao Shijie, Wang Zhiyi, Tang Yuanting, Chen Cong, Zhao Chun-Qin, Fu Xianjun
In this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, the potential applications for cancer treatment and future development prospects are also prospected.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Gelatine–collagen photo-crosslinkable 3D matrixes for skin regeneration

Biomater. Sci., 2024, 12,1738-1749
DOI: 10.1039/D3BM01849K, Paper
Open Access
Gauthier Menassol, Boudewijn van der Sanden, Laetitia Gredy, Capucine Arnol, Thibaut Divoux, Donald K. Martin, Olivier Stephan
Immediate care of skin wounds and burns is essential to repair this mechanical and chemical barrier to infections.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Bi-functional quercetin/copper nanoparticles integrating bactericidal and anti-quorum sensing properties for preventing the formation of biofilms

Biomater. Sci., 2024, 12,1788-1800
DOI: 10.1039/D4BM00034J, Paper
Jingjing Cheng, Haixin Zhang, Kunyan Lu, Yi Zou, Dongxu Jia, Hong Yang, Hong Chen, Yanxia Zhang, Qian Yu
A bi-functional antibiofilm nanoplatform was developed based on a complex of quercetin and copper integrating bactericidal and anti-quorum sensing properties.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Copper(II)-based metal–organic framework delivery of calcium ascorbate for enhanced chemodynamic therapy via H2O2 self-supply and glutathione depletion

Biomater. Sci., 2024, 12,1871-1882
DOI: 10.1039/D3BM01922E, Paper
Meng Zhang, Hongjin Xue, Jiaxin Yang, Xin Zhao, Mei Xue, Wei Sun, Jianfeng Qiu, Zhihong Zhu
A Cu/ZIF-8/Vc-Ca/HA nanosystem synchronously releases Fenton catalytic Cu2+ and Vc-Ca to achieve improved chemodynamic therapy via H2O2 self-supply and GSH depletion.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Free drug and ROS-responsive nanoparticle delivery of synergistic doxorubicin and olaparib combinations to triple negative breast cancer models

Biomater. Sci., 2024, 12,1822-1840
DOI: 10.1039/D3BM01931D, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Robert J. Cavanagh, Patrícia F. Monteiro, Cara Moloney, Alessandra Travanut, Fatemeh Mehradnia, Vincenzo Taresco, Ruman Rahman, Stewart G. Martin, Anna M. Grabowska, Marianne B. Ashford, Cameron Alexander
Combinations of the topoisomerase II inhibitor doxorubicin and the poly (ADP-ribose) polymerase inhibitor olaparib offer potential drug–drug synergy for treatment of triple negative breast cancers (TNBC) both in free drug form and when delivered by oxidation-responsive nanoparticles.
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Ferroptosis and ferroptosis-inducing nanomedicine as a promising weapon in combination therapy of prostate cancer

Biomater. Sci., 2024, 12,1617-1629
DOI: 10.1039/D3BM01894F, Review Article
Mengjun Huang, Qiliang Teng, Fei Cao, Jinsheng Huang, Jun Pang
Existing treatments could be sensitized by targeting the ferroptosis pathway in prostate cancer.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Trap & kill: a neutrophil-extracellular-trap mimic nanoparticle for anti-bacterial therapy

Biomater. Sci., 2024, 12,1841-1846
DOI: 10.1039/D4BM00145A, Paper
Jingtao Zheng, Lei Rong, Yao Lu, Jing Chen, Kai Hua, Yongzhong Du, Qiang Zhang, Weishuo Li
A neutrophil-extracellular-trap mimic nanoparticle effectively eliminates bacteria in a trap & kill manner.
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Sorafenib and tetrakis (4-carboxyphenyl) porphyrin assembled nanoparticles for synergistic targeted chemotherapy and sonodynamic therapy of hepatocellular carcinoma

Biomater. Sci., 2024, 12,1864-1870
DOI: 10.1039/D3BM01994B, Paper
Yongzhi Chen, Qiuxia Tan, Yuanyu Tang, E. Pang, Rui Peng, Minhuan Lan, Dousheng Bai
Hepatocellular carcinoma (HCC) is characterized by a high degree of malignancy and mortality.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Extracellular vesicles produced by 3D cultured MSCs promote wound healing by regulating macrophage activation through ANXA1

Biomater. Sci., 2024, 12,1761-1770
DOI: 10.1039/D3BM02035E, Paper
Hao Deng, Yuheng Jiang, Junhao Deng, Feifan Chang, Junyu Chen, Xinyu Sun, Dongliang Cheng, Zhongqi Wang, Ran Li, Jiang Liu, Yi Li, Licheng Zhang, Pengbin Yin
Extracellular vesicles (EVs) produced by 3D-cultured MSCs can modulate macrophage activation through ANXA1, thereby promoting wound healing.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Advanced postoperative tissue antiadhesive membranes enabled with electrospun nanofibers

Biomater. Sci., 2024, 12,1643-1661
DOI: 10.1039/D3BM02038J, Review Article
Yanting Zhu, Chenwei Zhang, Ying Liang, Jianyuan Shi, Qiuhao Yu, Shen Liu, Dengguang Yu, Hui Liu
Electrospun nanofibers with fascinating properties provide a versatile platform for postoperative tissue anti-adhesion.
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Dynamic monitoring of the fibrosis disease by a collagen targeting near infrared probe

Biomater. Sci., 2024, 12,1924-1931
DOI: 10.1039/D3BM01926H, Paper
Xiaoke Zhang, Qianwen Yang, Sensen Zhou, Cheng Li, Xiqun Jiang
A H2O2-sensitive macromolecular optical probe which can effectively bind to collagen was developed for real time noninvasive visualization of fibrotic tissues.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Self-adjuvanted L-arginine-modified dextran-based nanogels for sustained local antigenic protein delivery to antigen-presenting cells and enhanced cellular and humoral immune responses

Biomater. Sci., 2024, 12,1771-1787
DOI: 10.1039/D3BM01150J, Paper
Jin Teng Chung, Mehrnoosh Rafiei, Ying Chau
Antigens are delivered in self-adjuvanted arginine-modified dextran-based nanogels to the dendritic cells in promoting antigen specific cellular immunity.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Futuristic Alzheimer's therapy: acoustic-stimulated piezoelectric nanospheres for amyloid reduction

Biomater. Sci., 2024, 12,1801-1821
DOI: 10.1039/D3BM01688A, Paper
Manju Sharma, Samraggi Choudhury, Anand Babu, Varun Gupta, Dipanjan Sengupta, Syed Afroz Ali, Mrunali D. Dhokne, Ashok Kumar Datusalia, Dipankar Mandal, Jiban Jyoti Panda
The graphical abstract portraying the utility of peizoactive polydopamine-coated PVDF nanospheres as potential therapeutic modalities for Alzheimer's disease. The nanospheres induced fibril disaggregation and neuroprotection upon acoustic activation in neural cells and animal model.
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