science and technology

Perseid Update

It isn't a great year to view these meteors.




science and technology

Scare-olina Skies returns!

Celebrate the Halloween season in traditional Morehead style, with shows for kids and adults.




science and technology

Teen Science Cafe on Oct. 10

"Why Not Nuclear Energy?" Dr. David McNelis shares some ideas about our options for sustainable energy.




science and technology

November's Star Families: Native American Skies

Curious about the Milky Way? Here's your chance to learn more.




science and technology

Opening Pandora's Box

At November's Carolina Science Cafe, Jonathan Berg discusses genomic sequencing in newborns.




science and technology

Astronomy in our national parks

Meet astronomer and artist Tyler Nordgren at "Stars Above, Earth Below" on Oct. 26.




science and technology

You're invited to preview Morehead's new website

Take a look at the beta version of our website redesign -- we want your feedback!




science and technology

Carolina Science Cafe on Dec. 3

Join us at Back Bar on Dec. 3 for a behind-the-scenes look into nuclear power and energy innovation with David McNelis.




science and technology

Skywatching in December

Join us for Skywatching on Dec. 12 at Little River Regional Park and Dec. 13 at Jordan Lake




science and technology

Jupiter Ball, Nov. 21 -- tickets are limited

Don't delay! Get your Jupiter Ball tickets today, while they're still available.




science and technology

"Grossology and You" premieres Nov. 22-23

Take advantage of everything during premiere weekend -- show, exhibit, free hands-on activities plus a gift!




science and technology

Pakistan expels senior Indian diplomat

Kaul, visa counsellor at the Indian High Commission in Islamabad, was expelled after being detained and was ordered to leave the country within 48 hours.




science and technology

Correct hardware design and verification methods [electronic resource] : 13th IFIP WG 10.5 advanced research working conference, CHARME 2005, Saarbrücken, Germany, October 3-6, 2005 : proceedings / Dominique Borrione, Wolfgang Paul (eds.)

Berlin ; New York : Springer, [2005]




science and technology

Continuous-time systems [electronic resource] / by Yuriy Shmaliy

Dordrecht, the Netherlands : Springer, [2007]




science and technology

Continuous system simulation [electronic resource] / François E. Cellier, Ernesto Kofman

New York : Springer Science+Business Media, [2006]




science and technology

Construction and analysis of safe, secure, and interoperable smart devices [electronic resource] : second international workshop, CASSIS 2005, Nice, France, March 8-11, 2005 : revised selected papers / Gilles Barthe [and others] (eds.)

Berlin ; New York : Springer, [2006]




science and technology

Construction and analysis of safe, secure, and interoperable smart devices [electronic resource] : international workshop, CASSIS 2004, Marseille, France, March 10-14, 2004 : revised selected papers / Gilles Barthe [and others] (eds.)

Berlin ; New York : Springer, [2005]




science and technology

New Videos from the Library of Congress, Feb. 14

The American Folklife Center at the Library of Congress challenged musical artists to interpret material from its unparalleled archive of ethnographic recordings of traditional folk music. Artists were asked to put their own spin on these archival treasures, and to perform them at a special showcase during the Folk Alliance International conference in Kansas City in 2018.

 




science and technology

New Videos from the Library of Congress, Feb. 15

The American Folklife Center at the Library of Congress challenged musical artists to interpret material from its unparalleled archive of ethnographic recordings of traditional folk music. Artists were asked to put their own spin on these archival treasures, and to perform them at a special showcase during the Folk Alliance International conference in Montreal, Canada in 2019.

 




science and technology

TONIGHT: Garth Brooks & Trisha Yearwood with Librarian Carla Hayden

TONIGHT, Monday, March 2 beginning at 7pm ET

Librarian of Congress Carla Hayden will host a conversation with Grammy Award-winning country music singer and songwriter Garth Brooks. Brooks and Hayden will be joined by country music artist, actress, author, celebrity chef and wife of Brooks, Trisha Yearwood. They will discuss their success as a country music power couple, their careers as music industry changemakers and the humanitarian projects they devote their efforts to each year.

Brooks will receive the Library of Congress Gershwin Prize for Popular Song later that week on Wednesday, March 4. The country music titan and multiple hall of famer is the youngest recipient of the prestigious prize.

You can follow and join in on the #GershwinPrize conversation via Twitter.

Watch here on the Library's YouTube page.

Watch here on the Library's Facebook page.
Tune in to Facebook at 6:30 pm ET for a special edition of Garth Brooks' "Inside Studio G" Facebook program LIVE from the Library of Congress!

 

 




science and technology

TONIGHT: Author John Barry on 1918 Pandemic

Tonight, April 7 at 8 p.m. (ET): John M. Barry, author of “The Great Influenza: The Story of the Deadliest Pandemic in History," talks with David Rubenstein about the 1918 influenza pandemic, how the world responded and what it can teach us about COVID-19. The program will repeat this Saturday, April 11, at 3 p.m. (ET) and will be available on the Facebook, YouTube and the Library of Congress website.




science and technology

TUNE IN: Understanding the Pandemic

To help with understanding of the current global pandemic, the Library of Congress National Book Festival Presents program is offering a virtual multipart series with authors who have written books about widespread diseases and the worldwide response to them. The talks will be available on social media channels such as Facebook and YouTube, on the Library's website, and in some cases on C-SPAN.

Two talks in this series "Understanding the Pandemic," are already available, and the third, "Spillover: Animal Infections and the Next Human Pandemic" premieres tonight, Thursday, April 30, at 7 pm ET. The full schedule:

“The Great Influenza: The Story of the Deadliest Pandemic in History." This 2004 bestseller has become a bestseller once again. John M. Barry talked with David Rubenstein, co-chair of the National Book Festival, on the 1918 influenza pandemic that ravaged the world even as World War I was being fought on the ground in Europe. Now available for viewing.

"No One Was Immune: Mapping the Great Pandemics from Columbus to COVID-19." The Library of Congress's John Hessler and Marie Arana discuss the sweep of history from the 1500s small pox pandemic that decimated the indigenous population of the Americas to the meticulous work that is being done now to map COVID-19. Now available for viewing.

"Spillover": Animal Infections and the Next Human Pandemic." Prize-winning science writer David Quammen discusses “Spillover,” in which he tracks the animal origins of human diseases through the centuries, with David Rubenstein. Premieres Thursday, April 30, 7 p.m. ET

"Once Upon a Time I Lived on Mars: Space, Exploration and Life on Earth." NASA astronaut and scientist Kate Greene went into the mouth of a volcano in a space capsule called Mars and spent several months in isolation, in the dark, doing research. She has a lot to say about the stress, loneliness and other challenges of sequestration -- and all from a very novel and unique perspective. Interview by the Library's Marie Arana. Premieres Thursday, May 14, 7 p.m. ET

"Why It's Hard to Know Things, Lately, and How COVID-19 Will Go Down in History." Bestselling historian and Harvard professor Jill Lepore discusses how the current pandemic, its effects and our reaction to them say something very real about America in this moment and in the historical record that will emerge from it. Interview by the Library's John Haskell. Premieres Thursday, May 21, 7 p.m. ET

All talks will be available on Library of Congress Facebook and YouTube channels, on the Library's website, and in some cases on C-SPAN.

Click here for more information.




science and technology

New Videos from the Library of Congress, May 7

Watch these videos just added to the Library of Congress website.

How One Pandemic, SARS, Predicted Another, COVID-19
Author and journalist Karl Taro Greenfeld discusses his prescient book on the SARS epidemic, which foreshadowed the more devastating COVID-19 pandemic, with the chief of communications of the Library of Congress, Roswell Encina.

Dav Pilkey at Home
Take a break and watch author and illustrator Dav Pilkey in his ongoing video series for the Library, "Dav Pilkey at Home," where he draws and reads from his book series.

Write. Right. Rite. With Jason Reynolds
A new video from Jason Reynolds, seventh National Ambassador for Young People's Literature in his new series "Write. Right. Rite." as part of his "Grab the Mic: Tell Your Story" platform.

 




science and technology

Microfabricated electrochemical sensing devices

Lab Chip, 2020, 20,1358-1389
DOI: 10.1039/C9LC01112A, Critical Review
Fumihiro Sassa, Gokul Chandra Biswas, Hiroaki Suzuki
Electrochemistry provides possibilities to realize smart microdevices of the next generation with high functionalities.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Optically-controlled closable microvalves for polymeric centrifugal microfluidic devices

Lab Chip, 2020, 20,1426-1440
DOI: 10.1039/C9LC01187K, Paper
M. Shane Woolf, Leah M. Dignan, Hannah M. Lewis, Christopher J. Tomley, Aeren Q. Nauman, James P. Landers
Microvalving is a pivotal component in many microfluidic lab-on-a-chip platforms and micro-total analysis systems (μTAS).
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

A liquid biopsy-guided drug release system for cancer theranostics: integrating rapid circulating tumor cell detection and precision tumor therapy

Lab Chip, 2020, 20,1418-1425
DOI: 10.1039/D0LC00149J, Paper
Chun-Miao Xu, Man Tang, Jiao Feng, Hou-Fu Xia, Ling-Ling Wu, Dai-Wen Pang, Gang Chen, Zhi-Ling Zhang
A system integrating diagnostic and therapeutic functions for cancer is presented using magnetically controlled microfluidics.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Colorimetric absorbance mapping and quantitation on paper-based analytical devices

Lab Chip, 2020, 20,1441-1448
DOI: 10.1039/D0LC00028K, Paper
Open Access
Yoshiki Soda, Kye J. Robinson, Thomas J. Cherubini, Eric Bakker
A pixel-level colorimetric absorbance analysis can measure the total quantity of dye on paper, irrespective of shape and size.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Multi-corneal barrier-on-a-chip to recapitulate eye blinking shear stress forces

Lab Chip, 2020, 20,1410-1417
DOI: 10.1039/C9LC01256G, Paper
Rodi Abdalkader, Ken-ichiro Kamei
Human corneal epithelium coexists with tear fluids and shows its barrier functionality under the dynamic conditions of eye blinking. We developed a microfluidic platform enabling the dynamic culture of the human corneal barrier with recapitulation of eye blinking.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Advanced 96-microtiter plate based bioelectrochemical platform reveals molecular short cut of electron flow in cytochrome P450 enzyme

Lab Chip, 2020, 20,1449-1460
DOI: 10.1039/C9LC01220F, Paper
Ronny Frank, Christoph Prönnecke, Ronny Azendorf, Heinz-Georg Jahnke, Annette G. Beck-Sickinger, Andrea A. Robitzki
We developed a novel 96-well microtiter plate based bioelectrochemical platform with a vertical divided cell three-electrode architecture and a 96-multipotentiostat to perform fully parallelised bioelectrocatalytic screenings on redox enzymes.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

An implantable multifunctional neural microprobe for simultaneous multi-analyte sensing and chemical delivery

Lab Chip, 2020, 20,1390-1397
DOI: 10.1039/D0LC00021C, Communication
Bo Wang, Ximiao Wen, Yan Cao, Shan Huang, Hoa A. Lam, Tingyi “Leo” Liu, Pei-Shan Chung, Harold G. Monbouquette, Pei-Yu Chiou, Nigel T. Maidment
PDMS thin-film transfer and enzyme microstamping enabled 3-in-1 Si/PDMS hybrid chemtrode for multi-analyte sensing and chemical delivery in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Droplet encapsulation improves accuracy of immune cell cytokine capture assays

Lab Chip, 2020, 20,1513-1520
DOI: 10.1039/C9LC01261C, Paper
Yuan Yuan, Julie Brouchon, J. Mauricio Calvo-Calle, Jing Xia, Li Sun, Xu Zhang, Kiera L. Clayton, Fangfu Ye, David A. Weitz, John A. Heyman
In-droplet cytokine capture assays combined with FACS to accurately identify and isolate activated immune cells.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Monitoring tissue-level remodelling during inflammatory arthritis using a three-dimensional synovium-on-a-chip with non-invasive light scattering biosensing

Lab Chip, 2020, 20,1461-1471
DOI: 10.1039/C9LC01097A, Paper
Open Access
Mario Rothbauer, Gregor Höll, Christoph Eilenberger, Sebastian R. A. Kratz, Bilal Farooq, Patrick Schuller, Isabel Olmos Calvo, Ruth A. Byrne, Brigitte Meyer, Birgit Niederreiter, Seta Küpcü, Florian Sevelda, Johannes Holinka, Oliver Hayden, Sandro F. Tedde, Hans P. Kiener, Peter Ertl
We demonstrate that the integration of complex human synovial organ cultures in a lab-on-a-chip provides reproducible and reliable information on how systemic stress factors affect synovial tissue architectures using light scatter biosensing.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Scalable microfluidic droplet on-demand generator for non-steady operation of droplet-based assays

Lab Chip, 2020, 20,1398-1409
DOI: 10.1039/C9LC01103J, Paper
Open Access
Kartik Totlani, Jan-Willem Hurkmans, Walter M. van Gulik, Michiel T. Kreutzer, Volkert van Steijn
We developed a microfluidic droplet on-demand (DoD) generator that enables the production of droplets with a volume solely governed by the geometry of the generator for a range of operating conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Rapid lipolytic oscillations in ex vivo adipose tissue explants revealed through microfluidic droplet sampling at high temporal resolution

Lab Chip, 2020, 20,1503-1512
DOI: 10.1039/D0LC00103A, Paper
Juan Hu, Xiangpeng Li, Robert L. Judd, Christopher J. Easley
High temporal resolution sampling and quantitative detection of glycerol secretion dynamics from adipose tissue using our automated, droplet-based microfluidic system.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Contact lens-based lysozyme detection in tear using a mobile sensor

Lab Chip, 2020, 20,1493-1502
DOI: 10.1039/C9LC01039D, Paper
Zachary Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi, Aydogan Ozcan
A rapid and cost-effective method for monitoring proteins in tear-fluid is reported, which enables biomarker monitoring using contact lenses toward personalized mobile-health applications.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Applications of the microphysiology systems database for experimental ADME-Tox and disease models

Lab Chip, 2020, 20,1472-1492
DOI: 10.1039/C9LC01047E, Paper
Open Access
Mark Schurdak, Lawrence Vernetti, Luke Bergenthal, Quinn K. Wolter, Tong Ying Shun, Sandra Karcher, D. Lansing Taylor, Albert Gough
The Microphysiology Systems Database (MPS) is a critical tool for the design, management, analysis, and sharing of MPS study data.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Mathematical modeling and computational analysis of centrifugal microfluidic platforms: a review

Lab Chip, 2020, 20,1318-1357
DOI: 10.1039/C9LC00775J, Critical Review
Open Access
Masoud Madadelahi, Luis F. Acosta-Soto, Samira Hosseini, Sergio O. Martinez-Chapa, Marc J. Madou
This paper focuses on theory and computational modelling of lab-on-a-disc devices of relevance for novel applications discovery and optimal designs.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00051E, Paper
Jinxin Zhang, Jessica H. Hartman, Chuyi Chen, Shujie Yang, Qi Li, Zhenhua Tian, Po-Hsun Huang, Lin Wang, Joel N. Meyer, Tony Jun Huang
Acoustofluidic sorting of Caenorhabditis elegans in a high throughput manner.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Nanoplasmon-enhanced drop-screen for high throughput single-cell nucleocytoplasmic miRNA profiling

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01226E, Paper
Jia Liu, Guoyun Sun, Shih-Chung Wei, Song Guo, Weikang Nicholas Lin, Chia-Hung Chen
Nanoplasmon-enhanced drop screen is developed to measure single-cell multiple miRNAs with high sensitivity of 0.1 nM, addressing cell nucleocytoplasmic profile in a throughput ∼100 cells per minute.
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The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Stretching DNA to twice the normal length with single-molecule hydrodynamic trapping

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01028A, Paper
Open Access
Yan Jiang, Theodore Feldman, Julia A. M. Bakx, Darren Yang, Wesley P. Wong
High-speed hydrodynamic trapping enables combined surface-free force spectroscopy and fluorescence imaging of single DNA molecules at extreme forces.
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The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

ECM-based microchannel for culturing in vitro vascular tissues with simultaneous perfusion and stretch

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00254B, Paper
Azusa Shimizu, Wei Huang Goh, Shun Itai, Michinao Hashimoto, Shigenori Miura, Hiroaki Onoe
A perfusable and stretchable gelatin-based microfluidic system that can apply both simultaneous fluidic shear stress and stretch stress to in vitro endothelial 3D tissues is presented.
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The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Development of two-photon polymerised scaffolds for optical interrogation and neurite guidance of human iPSC-derived cortical neuronal networks

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01209E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
J. A. Crowe, A. El-Tamer, D. Nagel, A. V. Koroleva, J. Madrid-Wolff, O. E. Olarte, S. Sokolovsky, E. Estevez-Priego, A.-A. Ludl, J. Soriano, P. Loza-Alvarez, B. N. Chichkov, E. J. Hill, H. R. Parri, E. U. Rafailov
We identified photopolymers for 2-photon polymerisation with biocompatibility for human iPSC-derived neural network development. Generation of microscale scaffold topologies enabled neurite guidance, demonstrating use in reproducing aligned networks.
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The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01192G, Paper
Roman Mikhaylov, Fangda Wu, Hanlin Wang, Aled Clayton, Chao Sun, Zhihua Xie, Dongfang Liang, Yinhua Dong, Fan Yuan, Despina Moschou, Zhenlin Wu, Ming Hong Shen, Jian Yang, Yongqing Fu, Zhiyong Yang, Christian Burton, Rachel J. Errington, Marie Wiltshire, Xin Yang
We demonstrate a novel SAW device fabrication technique by mechanically clamping interdigital electrodes (IDEs) on the printed circuit board (PCB) to a LiNbO3 wafer. The novel PCB-SAW device is capable of performing all the functions of standard SAW devices.
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The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

A bespoke microfluidic pharmacokinetic compartment model for drug absorption using artificial cell membranes

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00263A, Paper
Jaime L. Korner, Elanna B. Stephenson, Katherine S. Elvira
A new type of pharmacokinetic compartment model using artificial cell membranes that predicts intestinal absorption three times more accurately than the current state of the art.
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The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Seeded droplet microfluidic system for small molecule crystallization

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00122H, Paper
N. Garg, R. Tona, P. Martin, P. M. Martin-Soladana, G. Ward, N. Douillet, D. Lai
A microfluidic approach to seeded crystallization has been demonstrated using abacavir hemisulfate, a nucleoside analog reverse transcriptase inhibitor, in droplet reactors to control polymorphism and produce particles with a low particle size distribution.
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The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

SLOCK (sensor for circadian clock): passive sweat-based chronobiology tracker

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00134A, Paper
Sayali Upasham, Shalini Prasad
SLOCK is a sweat based platform for monitoring circadian relevant biomarkers-cortisol and DHEA, using electrochemical detection modality.
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The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00059K, Paper
Open Access
Christian G. M. van Dijk, Maarten M. Brandt, Nikolaos Poulis, Jonas Anten, Matthijs van der Moolen, Liana Kramer, Erik F. G. A. Homburg, Laura Louzao-Martinez, Jiayi Pei, Merle M. Krebber, Bas W. M. van Balkom, Petra de Graaf, Dirk J. Duncker, Marianne C. Verhaar, Regina Luttge, Caroline Cheng
We present a microfluidic vascular device. Vascular cells in a 3D-ECM environment support hemodynamic flow and enable monocyte interaction.
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science and technology

Current commercialization status of electrowetting-on-dielectric (EWOD) digital microfluidics

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00144A, Critical Review
Jia Li, Chang-Jin “CJ” Kim
Electrowetting on EWOD surface: a droplet beading or spreading (left) or translating (right) by electric signals. The EWOD technology made the once-obscure electrowetting phenomenon practical, leading to the host of commercial products today.
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science and technology

Microfluidic device for high-throughput affinity-based isolation of extracellular vesicles

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01190K, Paper
Ting-Wen Lo, Ziwen Zhu, Emma Purcell, Daniel Watza, Joyful Wang, Yoon-Tae Kang, Shruti Jolly, Deepak Nagrath, Sunitha Nagrath
Immunoaffinity based EV isolation technologies use antibodies targeting surface markers on EVs to provide higher isolation specificity and purity compared to existing approaches.
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science and technology

Direct loading of blood for plasma separation and diagnostic assays on a digital microfluidic device

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00302F, Paper
Christopher Dixon, Julian Lamanna, Aaron R. Wheeler
The integration of 3D porous membranes in a digital microfluidic device enables the generation of cell-free plasma from finger-stick volumes of blood with in-line, on-chip analysis.
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The content of this RSS Feed (c) The Royal Society of Chemistry