science and technology

On the State: Lectures at the Collège de France, 1989 - 1992


What is the nature of the modern state? How did it come into being and what are the characteristics of this distinctive field of power that has come to play such a central role in the shaping of all spheres of social, political and economic life?

In this major work the great sociologist Pierre Bourdieu addresses these fundamental questions. Modifying Max Weber’s famous definition, Bourdieu defines the state in terms of the monopoly of legitimate physical

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science and technology

Social Movements: An Introduction, 3rd Edition


 

A new, fully-revised and updated edition of the leading introduction to social movements and collective action –covers a broad range of approaches in the social sciences.

Now in its third edition, Social Movements is the market-leading introductory text on collective action in contemporary society. The text draws from theory-driven, systematic empirical research from across the social sciences to address central questions and concepts in the field.



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science and technology

The Wiley Handbook of Healthcare Treatment Engagement: Theory, Research, and Clinical Practice


 

Against a global backdrop of problematic adherence to medical treatment, this volume addresses and provides practical solutions to the simple question: “Why don’t patients take treatments that could save their lives?”

The Wiley handbook of Healthcare Treatment Engagementoffers a guide to the theory, research and clinical practice of promoting patient engagement in healthcare treatment at individual, organizational and systems levels. The concept of



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science and technology

A Companion to Adorno


 

A definitive contribution to scholarship on Adorno, bringing together the foremost experts in the field

As one of the leading continental philosophers of the last century, and one of the pioneering members of the Frankfurt School, Theodor W. Adorno is the author of numerous influential—and at times quite radical—works on diverse topics in aesthetics, social theory, moral philosophy, and the history of modern philosophy, all of which concern the contradictions



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science and technology

Political Geography: A Critical Introduction


 

Brings political geography to life—explores key concepts, critical debates, and contemporary research in the field. 

Political geography is the study of how power struggles both shape and are shaped by the places in which they occur—the spatial nature of political power. PoliticalGeography: A Critical Introduction helps students understand how power is related to space, place, and territory, illustrating how everyday life and the world of global conflict



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science and technology

Can Science Resolve the Nature / Nurture Debate?


 
Following centuries of debate about "nature and nurture" the discovery of DNA established the idea that nature (genes) determines who we are, relegating nurture (environment) to icing on the cake.

Since the 1950s, the new science of epigenetics has demonstrated how cellular environments and certain experiences and behaviors influence gene expression at the molecular level, with significant implications for health and wellbeing. To the amazement of

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science and technology

The World's Construction Mechanism: Trajectories, Imbalances, and the Future of Societies


 

The interdisciplinarity between the biological and human sciences is here to serve a daring objective: to decipher, by means of a logical chain, the explanatory factors of human trajectories and imbalances between societies and nations. To do this, The World’s Construction Mechanism is based on an unprecedented analysis of the dynamics of the human species, combining the contributions of anthropology, archeology, biology, climatology, economics, geography



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science and technology

Image Beyond the Screen: Projection Mapping


 

Videomapping with its use of digital images is an audiovisual format that has gained traction with the creative industries. It consists of projecting images onto diverse surfaces, according to their geometric characteristics. It is also synonymous with spatial augmented reality, projection mapping and spatial correspondence.

Image Beyond the Screen lays the foundations for a field of interdisciplinary study, encompassing the audiovisual, humanities



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science and technology

Companion to Women's and Gender Studies


 

A comprehensive overview of the interdisciplinary field of Women's and Gender Studies, featuring original contributions from leading experts from around the world

The Companion to Women's and Gender Studies is a comprehensive resource for students and scholars alike, exploring the central concepts, theories, themes, debates, and events in this dynamic field. Contributions from leading scholars and researchers cover a wide range of topics while providing



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09/21:11 EST Bush Walkers Weather Alert for Western and Central Plateau forecast districts




science and technology

Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors

RSC Med. Chem., 2020, Advance Article
DOI: 10.1039/D0MD00011F, Research Article
J. Muller, B. Cardey, A. Zedet, C. Desingle, M. Grzybowski, P. Pomper, S. Foley, D. Harakat, C. Ramseyer, C. Girard, M. Pudlo
A quantum chemistry guided optimisation (leading to piceatannol analogue 3t) with a good understanding of the catechol binding mode to the bimanganese cluster of arginase.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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science and technology

Recent progress on phenotype-based discovery of dengue inhibitors

RSC Med. Chem., 2020, Advance Article
DOI: 10.1039/D0MD00052C, Review Article
Fumiaki Yokokawa
The review presents the discovery of new dengue inhibitors by a phenotype-based approach.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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science and technology

Synthesis and 18F-radiolabeling of thymidine AMBF3 conjugates

RSC Med. Chem., 2020, Advance Article
DOI: 10.1039/D0MD00054J, Research Article
Antonio A. W. L. Wong, Jerome Lozada, Mathieu L. Lepage, Chengcheng Zhang, Helen Merkens, Jutta Zeisler, Kuo-Shyan Lin, François Bénard, David M. Perrin
One step radiofluorination of two thymidine bioconjugates for positron emission tomography (PET) imaging; proof concept with clinical-grade 18F-labeling and preliminary mouse images.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1H-pyrazole-5-carboxylate as an HIV-1 replication inhibitor

RSC Med. Chem., 2020, Advance Article
DOI: 10.1039/D0MD00025F, Research Article
Jeanne Fichez, Cathia Soulie, Laurent Le Corre, Sophie Sayon, Stéphane Priet, Karine Alvarez, Olivier Delelis, Patrick Gizzi, Guillaume Prestat, Christine Gravier-Pelletier, Anne-Geneviève Marcelin, Vincent Calvez, Patricia Busca
Identified as an HIV-1 inhibitor in cellulo, this pyrazole does not belong to the three main classes of anti HIV-drugs, a feature of prime interest in the context of viral resistance.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Protein—fragment complex structures derived by NMR Molecular Replacement

RSC Med. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0MD00068J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Felix Torres, Dhiman Ghosh, Dean Strotz, Celestine Chi, Ben Davis, Julien Orts
Recently we have established an NMR Molecular Replacement method, which is capable of solving the structure of the interaction site of protein-ligand complexes in a fully automated manner. While the...
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Cyclic boronates as versatile scaffolds for KPC-2 β-lactamase inhibition

RSC Med. Chem., 2020, 11,491-496
DOI: 10.1039/C9MD00557A, Research Article
Catherine L. Tooke, Philip Hinchliffe, Alen Krajnc, Adrian J. Mulholland, Jürgen Brem, Christopher J. Schofield, James Spencer
Mono- (vaborbactam) and bi-cyclic (taniborbactam) boronate inhibitors bind KPC-2 similarly, but the latter is essentially irreversible.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

A promising anticancer drug: a photosensitizer based on the porphyrin skeleton

RSC Med. Chem., 2020, 11,427-437
DOI: 10.1039/C9MD00558G, Review Article
Qizhi Zhang, Jun He, Wenmei Yu, Yanchun Li, Zhenhua Liu, Binning Zhou, Yunmei Liu
This article reviews the research status of porphyrin photosensitizers; future perspectives and current challenges are discussed.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Vascular tone and angiogenesis modulation by catecholamine coordinated to ruthenium

RSC Med. Chem., 2020, 11,497-510
DOI: 10.1039/C9MD00573K, Research Article
Jacqueline Querino Alves, Laena Pernomian, Cássia Dias Silva, Mayara Santos Gomes, Ana Maria de Oliveira, Roberto Santana da Silva
The interaction of catecholamine site to receptors drives the proangiogenic to antiangiogenic character.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Recent progress in selective estrogen receptor downregulators (SERDs) for the treatment of breast cancer

RSC Med. Chem., 2020, 11,438-454
DOI: 10.1039/C9MD00570F, Review Article
Shagufta, Irshad Ahmad, Shimy Mathew, Sofia Rahman
This article reviews the current progress in the development of SERDs as anti-breast cancer agents.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Reversing binding sensitivity to A147T translocator protein

RSC Med. Chem., 2020, 11,511-517
DOI: 10.1039/C9MD00580C, Research Article
Sophie V. Vo, Samuel D. Banister, Isaac Freelander, Eryn L. Werry, Tristan A. Reekie, Lars M. Ittner, Michael Kassiou
A loss in binding affinity at A147T relative to WT TSPO is seen with most TSPO ligands. Provision of hydrogen-bonding opportunities on indole carboxamides rescues this loss in affinity.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Arylsulfonyl histamine derivatives as powerful and selective α-glucosidase inhibitors

RSC Med. Chem., 2020, 11,518-527
DOI: 10.1039/C9MD00559E, Research Article
M. I. Osella, M. O. Salazar, M. D. Gamarra, D. M. Moreno, F. Lambertucci, D. E. Frances, R. L. E. Furlan
N α,Nτ-Di-4-trifluorobenzenesulfonyl histamine inhibits α-glucosidase in vitro reversibly and selectively with a Ki value of 11.6 μM, and shows an in vivo hypoglycemic effect in mice.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Unveiling the active isomer of cycloalanopine, a cyclic opine from Lactobacillus rhamnosus LS8, through synthesis and analog production

RSC Med. Chem., 2020, 11,528-531
DOI: 10.1039/D0MD00033G, Research Article
Isaac Antwi, Sorina Chiorean, Marco J. van Belkum, John C. Vederas
Stereochemistry of the antimicrobial isomer of a cyclic opine was determined by synthesis using oxidative cyclisation of a bis-hydrazide.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?

RSC Med. Chem., 2020, 11,455-490
DOI: 10.1039/D0MD00062K, Review Article
Godwin Akpeko Dziwornu, Henrietta Dede Attram, Samuel Gachuhi, Kelly Chibale
After a century since the first antimonial-based drugs were introduced to treat the disease, anti-schistosomiasis drug development is again at a bottleneck with only one drug, praziquantel, available for treatment purposes.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Computer-aided discovery of phenylpyrazole based amides as potent S6K1 inhibitors

RSC Med. Chem., 2020, Advance Article
DOI: 10.1039/C9MD00537D, Research Article
Yan Yin, Yuxing Sun, Lianhua Zhao, Jinpeng Pan, Yangbo Feng
Ribosomal protein S6 kinase beta-1 (S6K1) is an attractive therapeutic target.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




science and technology

Lockdown | Farmers’ group demands waiver of all crop loans

AIKSCC flags impact of lockdown on procurement, sales




science and technology

Against Grade Span Testing: Data as a Flashlight, Not a Strobelight

Grade span testing dramatically reduces the number of tests students would take over the course of their education. Unfortunately, it also sacrifices the ability to measure students’ growth from year to year in a content area and dramatically reduces what we would know about what works in education.




science and technology

AERA Sets a Low Bar for Teacher Evaluation

The recent public statement by the American Educational Research Association (AERA) on the use of value-added measures has a lot of scary language about “scientific and technical limitations,” and lists requirements that they say value-added models should meet. But do these requirements represent the “very high technical bar” the AERA claims it is setting? We don’t think so.




science and technology

It's Time to Phase Out Teacher "Value Added"

"Value-added" is an unfortunate term. It suggests that we’ve measured the sum of all that teachers contribute or the sum of their value, which is dehumanizing as well as inaccurate.




science and technology

Welcome to the Educator Impact Laboratory

The Educator Impact Laboratory is a center at Mathematica designed to expand our collaborations with state and local education agencies around the challenging task of measuring the impact that teachers and principals have on their students and using this information in creative ways to improve outcomes.




science and technology

To Do ESSA Accountability Right, Focus on Classrooms, Not Just Schools

The Every Student Succeeds Act presents a challenge and an opportunity. It changes the question from “what do we have to do?” to “what new opportunities exist?” as states can now design their accountability systems to accomplish their own goals rather than complying with federal demands.




science and technology

The False Dichotomy of School Inspections vs. Test-Based Accountability

In a recent post on the Brookings Brown Center Chalkboard, Helen Ladd urges states to experiment with replacing test-based accountability with school inspections, visits by trained experts who rate the schools they visit and then issue reports.




science and technology

“I Am Someone Who Tends to Be Lazy”: The Importance of Soft Skills, and How Not to Measure Them in Schools

Guided by the recent Every Student Succeeds Act (ESSA), states are scrambling to incorporate nonacademic skills into school measurement systems, raising the question: “What measures should schools use and for which purpose?”




science and technology

Beware Hyped Claims of WMD

Alex Resch, Mathematica's associate director, Human Services Research, counters the claims in a new book, which argues that algorithms and mathematical models are destructive and harm society’s most vulnerable members.




science and technology

Meaningful Feedback Helps Invisible Teachers Move Out of the Shadows

Senior Researcher Elias Walsh looks into helping provide meaningful feedback to "invisible teachers" - those who leave the profession feeling as though they have made no progress with their students.




science and technology

Value Added Is a Chainsaw

On the one hand, value-added measures, like chainsaws, can be powerful tools and really useful for the right problem, like cutting down a tree. On the other hand, chainsaws, like VAMs, can do a lot of damage if you’re not careful and don’t know what you’re doing.




science and technology

Measuring Principal Performance Is Hard - But We Need to Try

Principals have almost as much of an impact on student achievement as teachers do. Indeed, we found in a study of school reform in Washington, D.C., that replacing ineffective principals improves student achievement. But how do we distinguish good principals from bad ones?




science and technology

Why Is the Achievement Gap So Large? It’s Not the Teachers

The academic achievement gap in the United States is large. A low-income child has less than a 1 in 10 chance of graduating from college, compared to nearly 8 in 10 high-income children.




science and technology

Experimenting with Multiple Measures of Teacher Effectiveness

How do we identify great teachers and help all teachers improve their craft? The best option may be to combine student growth measures, observations of teachers in the classroom, and student surveys.




science and technology

National Teacher Day: What’s the Value of a Good Teacher?

National Teacher Day honors teachers for the lasting contributions they make to students’ lives.




science and technology

High-Stakes Evaluation: Does It Scare Teachers Away?

Does high-stakes evaluation scare teachers away? And if so, which teachers? Does this help or harm students? High-stakes evaluation does affect who comes into the classroom and who stays there, and research indicates that this flux may actually be good for students.




science and technology

VisualizED: Comparing Schools with Benchmarks

The world of education is becoming inundated with data, and the growing use of technology in schools has made it even easier to collect and report data continuously.




science and technology

Mathematica Survey/Data RSS Feed




science and technology

Instagram: Visual Social Media Cultures


 
Instagram is at the heart of global digital culture, having made selfies, filters and square frames an inescapable part of everyday life since it was launched in 2010.

In the first book-length examination of Instagram, Tama Leaver, Tim Highfield and Crystal Abidin trace how this quintessential mobile photography app has developed as a platform and a culture. They consider aspects such as the new visual social media aesthetics, the rise of Influencers

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science and technology

The Music Industry: Music in the Cloud


 
Since the first edition was published in 2009, Patrik Wikström's The Music Industry has become a go-to text for students and scholars. This thoroughly updated third edition provides an international overview of the music industry and its future prospects in the world of global entertainment.

The music industry has experienced two turbulent decades of immense change brought about in part by the digital revolution. How has the industry been transformed

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science and technology

Critical Media Studies: An Introduction, 3rd Edition


 

An engaging and accessible introduction to a broad range of critical approaches to contemporary mass media theory and research 

A decade after its first publication, Critical Media Studies continues toshape and define the field of media studies, offering innovative approaches that enable readers to explore the modern media landscape from a wide variety of perspectives. Integrating foundational theory and contemporary research, this groundbreaking text



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science and technology

Beyond Journalism


 

In the context of profound transformations in the professional, business, technological and social context of journalism, it is crucial for journalism studies and education to move beyond limited approaches to the discipline. Among the most significant changes affecting journalism worldwide is the emergence of startup culture, as more and more journalists strike out on their own.

In Beyond Journalism



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science and technology

Instagram: Visual Social Media Cultures


 
Instagram is at the heart of global digital culture, having made selfies, filters and square frames an inescapable part of everyday life since it was launched in 2010.

In the first book-length examination of Instagram, Tama Leaver, Tim Highfield and Crystal Abidin trace how this quintessential mobile photography app has developed as a platform and a culture. They consider aspects such as the new visual social media aesthetics, the rise of Influencers

Read More...




science and technology

Beyond Journalism


 

In the context of profound transformations in the professional, business, technological and social context of journalism, it is crucial for journalism studies and education to move beyond limited approaches to the discipline. Among the most significant changes affecting journalism worldwide is the emergence of startup culture, as more and more journalists strike out on their own.

In Beyond Journalism



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science and technology

Effective SEO and Content Marketing: The Ultimate Guide for Maximizing Free Web Traffic


 

Get beyond the basics and see how modern-day users are reimaging the SEO process

SEO is often underutilized and overlooked across the marketing realm today. SEO is not merely trying to improve your website ranking on Google, but it can spark and optimize ideas.  Above all it can help improve the amount of free traffic coming to your web properties.  This book provides you with a comprehensive approach to make sure marketing spend is utilized as effectively



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science and technology

The Handbook of Public Sector Communication


 

A multidisciplinary collection on global public entity strategic communication

Research into public sector communication investigates the interaction between public and governmental entities and citizens within their sphere of influence. Today’s public sector organizations are operating in environments where people receive their information from multiple sources. Although modern research demonstrates the immense impact public entities have on democracy



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