science and technology Amphipathic Emulsion Binder for Enhanced Performance of Lithium-Sulfur Batteries By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Accepted ManuscriptDOI: 10.1039/D4TA01037J, PaperYuan He, Xulong Jing, Tianxing Lai, Dong Jiang, Chao Wan, Pavel S Postnikov, Olga Guselnikova, Lixin Xu, Xiaojun He, Yusuke Yamauchi , Biyu JinThe application of polyvinylidene fluoride (PVDF) binder in lithium-sulfur batteries faces challenges due to inadequate adhesion, undesirable conductivities, limited lithium polysulfides absorbability, and its dependence on the use of toxic...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Green solvents in battery recycling: status and challenges By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Advance ArticleDOI: 10.1039/D3TA07905H, Review ArticleWenyuan Qiao, Ren Zhang, Yikai Wen, Xinyi Wang, Zheng Wang, Guoqiang Tang, Minghao Liu, Hyokyeong Kang, Zafar Said, Jang-Yeon Hwang, Changhui LiuA green solvent hybrid system will bring about sustainable development in the battery industry by efficiently and environmentally friendly recycling of valuable resources contained in waste batteries.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Molecular-polaron-coupling-enhanced photocatalytic CO2 reduction on copper phthalocyanine/NiMgFe layered double hydroxide nanocomposites By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Advance ArticleDOI: 10.1039/D3TA07538A, PaperYuexian Li, Wenli Su, Xiaoyan Wang, Jun Lu, Wenkai Zhang, Shuo WeiWe built CuPcS/NiMgFe-LDHs composites and probed the unique photogenerated-carrier transfer mechanism. A series of long-range Forster energy transfers prolonged the lifetime of photogenerated carriers to match the timescale of surface reaction.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Constructing vacancy-rich metal phosphates by the spatial effect of ionic oligomers for enhanced OER activity By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Advance ArticleDOI: 10.1039/D4TA01706D, PaperYida Zhao, Xinyu He, Xiaoming Ma, Zhengxi Guo, Menghui Qi, Zhaoming Liu, Ruikang TangBy rationally selecting ionic oligomers as building blocks, sub-nano-sized gaps can be constructed in the solid structure of catalysts. This can overcome the inherent limitations associated with vacancy formation of the traditional nucleation pathway.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Harvesting solar energy with a Ni-MOF-based evaporator for efficient solar thermal storage and steam generation By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Advance ArticleDOI: 10.1039/D4TA00203B, PaperYou Xu, Zhengyun Wang, Xianbao Wang, Zhenzhen Guo, Muhammad Sultan Irshad, Naila Arshad, Jiang Gong, Hongfang Liu, Guangfang LiA hybrid solar evaporator comprising a Ni-based metal–organic framework material and a phase change material composite was fabricated for high performance solar-thermal energy storage and continuous solar vapor generation.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Fluorophore branching boosted photo-induced energy transfer in UiO-66 for ultrasensitive and instant hydrazine sensing By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Advance ArticleDOI: 10.1039/D4TA01549E, PaperYing Luo, Da Lei, Maohua Li, Yuansheng Ge, Jiguang Li, Baiyi Zu, Jun Yao, Xincun DouMetal organic frameworks (MOFs) have made great progress in the field of fluorescent sensing; however, whether the electronic structure and recognized sites can be adjusted by external functionalization still remains challenging.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology S-doped TiN supported N, P, S-tridoped TiO2 with hetero-phase junctions for fuel cell startup/shutdown durability By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Advance ArticleDOI: 10.1039/D4TA01475H, PaperMitsuharu Chisaka, Jubair A. Shamim, Wei-Lun Hsu, Hirofumi DaigujiA platinum group metal-free S-doped TiN-supported N, P, S-tridoped TiO2 catalyst with anatase/rutile TiO2 hetero-phase junctions is revealed to display a high durability against fuel cell startup/shutdown cycles not to lose its anion dopants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Efficient first principles based modeling via machine learning: from simple representations to high entropy materials By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Advance ArticleDOI: 10.1039/D4TA00982G, PaperKangming Li, Kamal Choudhary, Brian DeCost, Michael Greenwood, Jason Hattrick-SimpersGeneralization performance of machine learning models: (upper panel) generalization from small ordered to large disordered structures (SQS); (lower panel) generalization from low-order to high-order systems.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Machine Learning Enabled Exploration of Multicomponent Metal Oxides for Catalyzing Oxygen Reduction in Alkaline Media By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Accepted ManuscriptDOI: 10.1039/D4TA01884B, Paper Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Xue Jia, Hao LiLow-cost metal oxides have emerged as promising candidates used as electrocatalysts for oxygen reduction reaction (ORR) due to their remarkable stability under oxidizing conditions, particularly in alkaline media. Recent studies...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Insight into piezoelectricity modulation mechanism of ZnO doped with Y ions By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Accepted ManuscriptDOI: 10.1039/D4TA01317D, PaperZihan Wang, Yue Sun, Shenglong Wang, Da Xiong, Guo Tian, Longchao Huang, Boling Lan, Long Jin, Weiqing Yang, Weili DengZnO is a performance-rich material due to its unique coupling of piezoelectricity and semiconductor properties. However, the intrinsic piezoelectric screening effect of ZnO weakens the electromechanical conversion efficiency and greatly...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology The Role of Mn in Boosting Wide Potential Window on Solid Solution Derived Electrodes for Aqueous Supercapacitors By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Accepted ManuscriptDOI: 10.1039/D4TA00979G, PaperZiying Shi, Enzuo Liu, Biao Chen, Junwei Sha, Lihua Qian, Zhijia Zhang, Xiaopeng Han, Wenbin Hu, Chunnian He, Naiqin Zhao, Jianli KangThe interaction mechanism of the multi-element oxide electrodes remains a challenge, despite the fact that their synergy can not only improve the electronic structure, but also broaden the working potential...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Highly selective and high-performance sulfonated poly(ether ether ketone)-based hybrid membrane enabled by complexed UiO-66-NH2 and sulfonated graphitic carbon nitride for vanadium flow battery By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Accepted ManuscriptDOI: 10.1039/D4TA00988F, PaperCaiyuan Zhao, Haixia Wang, Lang Li, Liping Liu, Xinrui Cui, Haifeng ShiA series of sulfonated poly(ether ether ketone) (SPEEK) hybrid membranes (SPEEK/NF) with a constant 1 wt% complexed nanofillers (NF) comprising of UiO-66-NH2 and sulfonated graphitic carbon nitride (s-g-C3N4) are prepared...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Enhanced surface reconstruction of V-Doped Ni3N driven by strong OH adsorption to boost 5-hydroxymethylfurfural electrooxidation for energy-saving H2 production By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Accepted ManuscriptDOI: 10.1039/D4TA01543F, PaperQi Zhou, Juan Wang, Ga Jin, Huiling Liu, Cheng WangCoupling biomass electrooxidation with hydrogen evolution reaction (HER) provides an alternative approach for simultaneously increasing the energy efficiency of H2 production and producing high value-added chemicals. Here, a V-doped Ni3N...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Toward record high Zn2+ storage in carbon electrodes via pore confinement engineering By pubs.rsc.org Published On :: J. Mater. Chem. A, 2024, Advance ArticleDOI: 10.1039/D4TA01191K, PaperXiubo Zhang, Chang Yu, Yuanyang Xie, Jinhe Yu, Yingbin Liu, Yi Yang, Jianjian Wang, Shuqin Lan, Siyi Hou, Kunlun Liu, Jieshan QiuThe effective specific surface area is proposed and well correlated with Zn2+ storage, guiding maximum Zn2+ storage within carbon. Multiple in situ spectroscopy techniques clarify the co-adsorption mechanism of hydrated Zn2+, SO42−, and H+.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology The fluorescence distinction of chiral enantiomers: a Zn coordination polymer sensor for the detection of cinchonine and cinchonidine By pubs.rsc.org Published On :: J. Mater. Chem. C, 2024, Advance ArticleDOI: 10.1039/D4TC03506B, PaperWenping Hu, Nan Wu, Dechao Li, Yefang Yang, Shaowen Qie, Shuai Su, Ruijie Xu, Wenting Li, Ming HuA Zn coordination polymer was constructed to identify chiral cinchonine and cinchonidine with high sensitivity, selectivity, and reproducibility.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Plasticity tunable artificial synapses based on organic electrochemical transistors with aqueous electrolytes By pubs.rsc.org Published On :: J. Mater. Chem. C, 2024, Advance ArticleDOI: 10.1039/D4TC03569K, PaperRuhua Wu, Miao Xie, Yuhua Cheng, Dan Zhao, Liang-Wen Feng, Jianhua Chen, Wei HuangBy regulating ion transporting kinetics and ion diffusion distances in organic mixed ionic–electronic conductor channels, highly tunable short- and long-term plasticity are obtained in vOECTs with aqueous electrolytes.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Pi-extended hypervalent iodine macrocycles and their supramolecular assembly with Buckminsterfullerene By pubs.rsc.org Published On :: J. Mater. Chem. C, 2024, Advance ArticleDOI: 10.1039/D4TC04251D, PaperKrishna Pandey, Samsul Arafin, Grayson Venus, Eli Jones, Yachu Du, Mina Dumre Pandey, Tahir Awais, Lichang Wang, Kyle N. PlunkettHypervalent iodine based macrocycles with enlarged aromatic cores can form extended supramolecular assemblies with Buckminsterfullerene.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Superconductivity above 30 K due to the introduction of oxygen element in CaFeAsF By pubs.rsc.org Published On :: J. Mater. Chem. C, 2024, Accepted ManuscriptDOI: 10.1039/D4TC03994G, PaperYixin Liu, Teng Wang, Zulei Xu, Da Jiang, Yi Zhao, Yanpeng Qi, Xiaoni Wang, Ming Yang, Mao Ye, Wei Peng, Gang MuExploring new unconventional superconductors is of great value for both fundamental research and practical applications. It is a long-term challenge to develop and study more hole-doped superconductors in 1111 system...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Breaking the Trade-off Between ∆EST and Oscillator Strength in Hybrid LR/SR-CT Compounds for Enhanced TADF Performance By pubs.rsc.org Published On :: J. Mater. Chem. C, 2024, Accepted ManuscriptDOI: 10.1039/D4TC04549A, PaperNikhitha R., Anirban MondalAchieving an ideal thermally activated delayed fluorescence (TADF) emitter requires balancing a minimal singlet-triplet energy gap (∆EST) with a considerable oscillator strength (f), which are typically mutually exclusive. By strategically...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Multimodal anti-counterfeiting inks: modern use of an ancient pigment in synergy with a persistent phosphor By pubs.rsc.org Published On :: J. Mater. Chem. C, 2024, Accepted ManuscriptDOI: 10.1039/D4TC04228J, PaperALESSANDRO LO BIANCO, Francesco Armetta, Vitalii Boiko, Dariusz Hreniak, Maria Luisa SaladinoA multi-level luminescent, transparent and not-permanent inks for anti-counterfeiting systems and security was developed. The inks emit a radiation of different wavelength depending on the radiation used to illuminate them,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Stronger Polar Ferromagnetism and Narrower Optical Band Gaps in Two-Dimensional Hybrid Copper Perovskites Induced by Bromine-Substitution By pubs.rsc.org Published On :: J. Mater. Chem. C, 2024, Accepted ManuscriptDOI: 10.1039/D4TC03532A, PaperCeng Han, Jason Allan McNulty, Alasdair Bradford, Alexandra Slawin, Stephen Lee, Philip LightfootTwo-dimensional (2D) organic–inorganic hybrid perovskites are attracting great interest due to their structural tunability and rich functional characteristics. Here, we report a series 2D layered hybrid copper (II) halide perovskites...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Dopant-free Tert-butyl Zn (II) Phthalocyanines: Impact of Substitution on Photo-Physical Properties in Their Role in Perovskite Solar Cells By pubs.rsc.org Published On :: J. Mater. Chem. C, 2024, Accepted ManuscriptDOI: 10.1039/D4TC04013A, PaperMahdi Gassara, Jose Garcés-Garcés, Luis Lezama, Javier Ortiz, Fernando Fernandez-Lazaro, Samrana Kazim, Angela Sastre-Santos, Shahzada AhmadWe synthesized molecular hole-transporting materials (HTMs) featuring a zinc phthalocyanine (ZnPc) central core and modulated the non-perypheral position with different numbers of tert-butyl groups. The synthesized molecules were also integrated...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Giant Magnetocaloric Effect in Fe doped Rare earth Orthochromite GdCr0.5Fe0.5O3 By pubs.rsc.org Published On :: J. Mater. Chem. C, 2024, Accepted ManuscriptDOI: 10.1039/D4TC03873H, PaperAbinash Prusty, Sudipta Mahana, B. Sheetal Priyadarshini, Andrei Gloskovskii, Dinesh Topwal, Unnikrishnan ManjuIn this manuscript we present the magnetic and magnetocaloric property investigations of Fe doped orthochromite system GdCr0.5Fe0.5O3, along with the structural, electronic and thermal properties. Manifestations of orbital mediated electron-phonon...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Chemical synthetic approaches to mimic the TRAIL: promising cancer therapeutics By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3639-3651DOI: 10.1039/D4MD00183D, Review ArticleAbdullah-Al Masum, Shin Aoki, Md. Mahbubur Rahman, Yosuke HisamatsuTRAIL induced apoptosis signalling by death receptors (DR4/DR5).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3674-3694DOI: 10.1039/D4MD00580E, Research ArticleJinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin JinOridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3759-3777DOI: 10.1039/D4MD00498A, Research ArticleLucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. EnrizA diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Furoxan–piplartine hybrids as effective NO donors and ROS inducers in PC3 cancer cells: design, synthesis, and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3778-3794DOI: 10.1039/D4MD00281D, Research ArticleCarolyne Brustolin Braga, Julio Cesar Milan, Matheus Andrade Meirelles, Bruno Zavan, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Marisa Ionta, Ronaldo A. PilliA novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Preventing SARS-CoV-2 infection using Fv-antibodies targeting the proprotein convertase (PPC) cleavage site By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3704-3710DOI: 10.1039/D4MD00552J, Research ArticleJaeyong Jung, Jeong Soo Sung, Soonil Kwon, Hyung Eun Bae, Min-Jung Kang, Joachim Jose, Misu Lee, Jae-Chul PyunFv-antibodies targeting the PPC region of SARS-CoV-2 to prevent infection, screened from an Fv-antibody library (displayed on outer membrane of E. coli cell).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3711-3727DOI: 10.1039/D4MD00584H, Research ArticleSara C. Silva-Reis, Vera M. Costa, Daniela Correia da Silva, David M. Pereira, Xavier Cruz Correia, Xerardo García-Mera, José E. Rodríguez-Borges, Ivo E. Sampaio-DiasA series of bicyclic-based Glypromate conjugates with reduction of protein aggregation elicited by Aβ25–35 and neuroprotective activity against paraquat-induced toxicity is reported, paving the way for the discovery of novel neurotherapeutics.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3652-3673DOI: 10.1039/D4MD00425F, Review ArticleSemim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra BorahMetabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology A photoswitchable CENP-E inhibitor with single blue-green light to control chromosome positioning in mitotic cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3795-3799DOI: 10.1039/D4MD00458B, Research ArticleKazuya Matsuo, Takashi Kikukawa, Tomonori Waku, Akio Kobori, Nobuyuki TamaokiA photoswitchable centromere-associated protein E (CENP-E) inhibitor based on the 4-methylaminoazobenzene photoswitch is reported, which is characterized with cis–trans photoisomerization with blue-green light and fast thermal relaxation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3728-3745DOI: 10.1039/D4MD00476K, Research ArticleVincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien FortinNew water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3837-3852DOI: 10.1039/D4MD00426D, Research ArticleAbdrrahman Shemsu Surur, Chin Fung Chan, Frieda-Marie Bartz, Iris L. K. Wong, Van T. D. Nguyen, Lukas Schulig, Andreas Link, Tak Hang Chan, Larry M. C. Chow, Patrick J. BednarskiStructure-guided optimization of fexinidazole led to analog (S)-51, a promising lead compound with superior activity, improved metabolic stability, and enhanced hERG safetyThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3800-3816DOI: 10.1039/D4MD00585F, Research ArticleMarwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-KarmalawyNovel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Asymmetric imidazole-4,5-dicarboxamide derivatives as SARS-CoV-2 main protease inhibitors: design, synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3880-3888DOI: 10.1039/D4MD00414K, Research ArticlePhuong Nguyen Hoai Huynh, Phatcharin Khamplong, Minh-Hoang Phan, Thanh-Phuc Nguyen, Phuong Ngoc Lan Vu, Quang-Vinh Tang, Phumin Chamsodsai, Supaphorn Seetaha, Truong Lam Tuong, Thien Y. Vu, Duc-Duy Vo, Kiattawee Choowongkomon, Cam-Van T. VoNovel asymmetric imidazole-4,5-dicarboxamide derivatives were synthesized, evaluated for SARS-CoV-2 MPro inhibitory activity in vitro, and investigated for binding ability in silico.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3853-3861DOI: 10.1039/D4MD00165F, Research ArticleJiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang LiuThe synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3746-3758DOI: 10.1039/D4MD00122B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong LiWe designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3817-3836DOI: 10.1039/D4MD00477A, Research ArticleMaha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa MatboliZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3862-3879DOI: 10.1039/D4MD00313F, Research ArticleDaniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro AccettaThis study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3695-3703DOI: 10.1039/D4MD00546E, Research ArticleMiyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke DemizuA novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00610K, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina MarzanoIn this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Advances in Detecting Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Using Molecular Receptors and Nanostructured Assemblies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00661E, Review ArticleAvijit Kumar DasThe detection and quantification of non-steroidal anti-inflammatory drugs (NSAIDs) are crucial due to their widespread use and potential impact on human health and the environment. This review provides a comprehensive...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
science and technology Affordable generics will stay relevant amid a premiumisation trend: Bhushan Akshikar By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:50:51 +0530 GSK will keep its existing portfolios while entering areas like oncology, said company officials at its centenary celebrations Full Article Health
science and technology Afghanistan attends U.N. climate talks for first time since Taliban return to power By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:33:16 +0530 Afghanistan’s first delegation at United Nations climate talks since the Taliban’s return to power in 2021 has arrived in Baku, Azerbaijan Full Article World
science and technology Doctor stabbed at Kalaignar Centenary Super Speciality Hospital in Chennai; one arrested By www.thehindu.com Published On :: Wed, 13 Nov 2024 12:24:15 +0530 The oncologist who was attacked has been identified as Balaji Jagannath. He has been admitted in the ICU, and his condition is said to be critical Full Article Chennai
science and technology Why are countries fighting over climate finance at COP29? By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:12:52 +0530 Here is what you need to know about the November 11-22 summit talks on finance. Full Article Environment
science and technology COP29: India, other developing countries demand fair climate finance commitments By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:33:21 +0530 India, LMDCs advocate for equitable climate finance at COP29, pushing for transparency, fairness, and flexibility in financial commitments Full Article World
science and technology Millions of Nigerians go hungry as floods compound hardship By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:07:00 +0530 Torrential rains and floods in 29 of Nigeria's 36 states this year have destroyed more than 1.5 million hectares of cropland, affecting more than nine million people Full Article Environment
science and technology 29th Climate Conference (COP) tracker | Day 2 LIVE: Key speeches, UK NDC, and India’s reaction at 5 p.m. on November 13 By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:01:23 +0530 Vibhuti Garg, an Associate and Senior Energy Specialist with over 13 years of experience in the energy sector, will guide us through the implications of these financial negotiations and the potential impacts on global energy transitions and climate commitments at 5 p.m. on November 13 Full Article Environment