science and technology

Elon Musk’s broadband ambitions in India: Why Jio and Airtel are feeling the heat

By www.thehindubusinessline.com
Published On :: Fri, 08 Nov 2024 11:27:23 +0530

Tech advancements have made it possible for satcom players to offer data services directly to the users’ smartphones, bypassing traditional cellular operators altogether


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Airtel, Jio clash with Amazon, Starlink over satcom spectrum

By www.thehindubusinessline.com
Published On :: Fri, 08 Nov 2024 21:06:27 +0530

Telcos bat for level playing field; satcom firms say customers have right to choose


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OpenAI's ChatGPT back up after brief outage

By www.thehindubusinessline.com
Published On :: Sat, 09 Nov 2024 10:27:04 +0530

Outage tracking website Downdetector.com said ChatGPT's services were down for about half an hour, affecting over 19,403 users as of 7:13 p.m. ET (0013 GMT on Saturday)


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Zuckerberg not personally liable in lawsuits over social media harm to children

By www.thehindubusinessline.com
Published On :: Sat, 09 Nov 2024 10:27:36 +0530

A US District Judge rejected accusations that Zuckerberg directed Meta's efforts to conceal from children the serious mental health risks of using Facebook and Instagram


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AppLovin CEO once spurned by VC firms now worth $11 billion

By www.thehindubusinessline.com
Published On :: Sat, 09 Nov 2024 14:41:30 +0530

Shares of Palo Alto, California-based AppLovin have surged seven-fold this year, giving co-founder Adam Foroughi a net worth of $10.9 billion


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AI agents more effective than GenAI for enterprise productivity: Deloitte study

By www.thehindubusinessline.com
Published On :: Sun, 10 Nov 2024 10:27:39 +0530

The study says that GenAI use cases have mostly been limited to standalone applications


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Infinx sets up state-of-the-art centre in Madurai; to create 700 jobs

By www.thehindubusinessline.com
Published On :: Sun, 10 Nov 2024 13:23:49 +0530

The facility would support the company's mission of optimising revenue cycle processes for US-based healthcare providers


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Customers no longer reluctant to adopt AI, says Hitachi Vantara’s Hemant Tiwari

By www.thehindubusinessline.com
Published On :: Sun, 10 Nov 2024 16:46:49 +0530

Even non-tech companies have AI requirements. If you’re manufacturing a transformer, a train engine, or a jet engine, AI goes into making them efficient: Tiwari


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Cyient to carve out semiconductor arm in Q1 2025: Ramya Mohan

By www.thehindubusinessline.com
Published On :: Mon, 11 Nov 2024 12:48:14 +0530

The new company will primarily focus on four industry segments for its ASIC turnkey offerings – automotive, industrial, telecommunications, and healthcare: Cyient VP


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AI adoption: 74% companies struggle to achieve and scale value, says BCG

By www.thehindubusinessline.com
Published On :: Mon, 11 Nov 2024 16:08:26 +0530

Report to assess firms’ AI maturity is based on a survey of 1,000 CxOs and senior executives from over 20 sectors, spanning 59 countries


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Deconstructive annulation mediated one-pot synthesis of xanthene derivatives

By pubs.rsc.org
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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00093E, Paper
Balasubramaniyam Manikandan, Subbiah Thamotharan, Olivier Blacque, Subramaniapillai Selva Ganesan
One-pot, two-step methodology utilized for the sequential C–O/C–N cleavage followed by intramolecular/intermolecular annulation reaction.
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Exploring the self-assembly dynamics of novel steroid–coumarin conjugates: a comprehensive spectroscopic and solid-state investigation

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00192C, Paper
Open Access
Claudia M. Ramírez-Lozano, Ma. Eugenia Ochoa, Pablo Labra-Vázquez, Arturo Jiménez-Sánchez, Norberto Farfán, Rosa Santillan
The design, synthesis, and characterization of seven novel steroid–coumarin conjugates with diverse steroidal nuclei as lipophilic fluorescent materials for bioimaging applications are presented.
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Electrochemical selective divergent C–H chalcogenocyanation of N-heterocyclic scaffolds

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00448E, Communication
Kusum Ucheniya, Pooja Kumari Jat, Amreen Chouhan, Lalit Yadav, Satpal Singh Badsara
An electrochemical direct selective C–H chalcogenocyanation approach for indolizine derivatives under mild conditions has been described.
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Fine bubble technology for the green synthesis of fairy chemicals

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00237G, Paper
Arun Kumar Manna, Mizuki Doi, Keiya Matsuo, Hiroto Sakurai, Ch. Subrahmanyam, Kohei Sato, Tetsuo Narumi, Nobuyuki Mase
Fairy chemicals (FCs) such as 2-azahypoxanthine (AHX), isolated from naturally occurring sources, are potential phytohormones in plants and efficiently synthesized by fine bubble technology consisting of micro- to nano-sized bubbles.
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Synthesis of 3,5-disubstituted isoxazoles by domino reductive Nef reaction/cyclization of β-nitroenones

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00232F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Muhammad Ehtisham Ibraheem Khan, Tomas Lighuen Cassini, Marino Petrini, Alessandro Palmieri
β-Nitroenones were converted into 3,5-disubstituted isoxazoles via a domino reaction promoted by tin(II) dichloride. The protocol efficiently works under both microwave and flow conditions.
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Siloxane-containing phosphine (oxide) ligands for enhanced catalytic activity of cobalt complexes for hydrosilylation reactions

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00333K, Paper
Peng Liu, Jiajian Peng, Ying Bai, Jiayun Li
A series of siloxane-containing phosphine (oxide) ligands have been designed and synthesized.
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Click synthesis of dendronized malonates for the preparation of amphiphilic dendro[60]fullerenes

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D3OB01986A, Paper
Carlos Cruz-Hernández, Perla Y. López-Camacho, Gustavo Basurto-Islas, Aaron Rojas, Patricia Guadarrama, Melchor Martínez-Herrera
Click chemistry is a valuable methodology for obtaining dendronized malonate derivatives to derivatize C60 using the Bingel–Hirsch reaction.
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BODIPY(aryl)iodonium salts in the efficient synthesis of diversely functionalized BODIPYs and selective detection of serum albumin

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00336E, Paper
Open Access
Bintu Kumar, Anindita Bhatta, Prakriti Saraf, Taur Prakash Pandurang, Krishnan Rangan, Madhushree Sarkar, Sivaprasad Mitra, Dalip Kumar
Using readily available BODIPY and iodoarenes various BODIPY(aryl)iodonium salts were prepared and successfully utilized for the direct syntheses of functionalized BODIPYs, bis-BODIPYs and for the selective detection of serum protein.
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Coumarin–azasugar–benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00312H, Paper
I. Caroline Vaaland Holmgard, Aday González-Bakker, Eleonora Poeta, Adrián Puerta, Miguel X. Fernandes, Barbara Monti, José G. Fernández-Bolaños, José M. Padrón, Óscar López, Emil Lindbäck
Coumarin–azasugar–benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activity in vitro and no neurotoxicity.
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Catalytic asymmetric construction of helicenes via transformation of biaryls

By pubs.rsc.org
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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00012A, Review Article
Peiling Fan, Lun Li, Deyun Qian
Chiral helicenes can be built by catalytic asymmetric transformation of pre-existing, easily accessible biaryl precursors using conceptually novel strategies such as olefin metathesis, alkyne hydroarylation, C–X coupling, and C–H functionalization.
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Metal- and light-free decarboxylative direct C–H alkylation of heteroarenes at room temperature

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00187G, Paper
Tong-Bo Zhang, Xi-Dong Guan, Yan Gao, Shi-Chao Lu, Bing-Long Li
This study reports a metal- and light-free decarboxylative C–H alkylation of heteroarenes at room temperature.
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A water mediated multicomponent reaction for the synthesis of novel spirooxindole derivatives and their antifungal activity

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00256C, Paper
Min Zhang, Liang Shi, Li Chen, Zhengyu Liu, Ting Zhao, Chunyin Zhu, Liuqing Yang
A total of 27 novel spirooxindoles were synthesized through a water mediated three-component reaction of isatin, 4-aminocoumarin, and 1,3-cyclodicarbonyl compounds. Several compounds showed excellent antifungal activity against Physalospora piricola.
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New 2-pyridone-based donor–acceptor dyes: the effect of the donor group position, type of π-linker and acid–base characteristics of the medium on the photophysical properties

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00177J, Paper
Saveliy P. Sorokin, Mikhail Yu. Ievlev, Oleg V. Ershov
Synthesis of a series of new donor–acceptor dyes based on 2-pyridone and the study of the effect of the position of the donor group, the type of π-linker and the acid–base characteristics of the medium on their photophysical properties.
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Dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00190G, Paper
Kai-Cheng Yang, Shi-Lu Zheng, Zhong Wen, Yu-Shan Zhang, Hai-Liang Ni, Long Chen
A HOTf or Fe(OTf)3-catalyzed dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes was developed, which represents a brand-new procedure for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones.
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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00112E, Paper
Debojyoti Bag, Sanghapal D. Sawant
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade.
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Kinetic resolution of 1,1'-binaphthyl-2,2'-diamine derivatives by chiral calcium phosphate-catalyzed acylation

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00355A, Paper
Tatsuhiro Uchikura, Yuki Kanno, Yukino Fukuda, Mikoto Sato, Takahiko Akiyama
Chiral calcium phosphate-catalyzed kinetic resolution of BINAM derivatives.
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Copper catalyzed dehydrogenative cyclization, alkenylation towards dihydroquinolinones

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Published On ::

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00134F, Paper
Pari Keerthana, Fazlur-Rahman Nawaz Khan
An efficient copper-catalysized one-pot sequential synthesis of alkenylated quinolinyldihydroquinolinones is reported utilizing ketones, 1,3-cyclohexanediones, and benzyl alcohols via dehydrogenative cyclisation, followed by alkenylation. This highly straightforward method provides a mild...
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Rapid in situ generation of 2-(halomethyl)-5-phenylfuran and nucleophilic addition in a microflow reactor

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00358F, Paper
Open Access
Yuma Matsuura, Shinichiro Fuse
Various 2,5-disubstituted furans were synthesized via 5-substituted 2-halomethylfurans using microflow technology.
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On the mechanism of carboxylate elimination from carbohydrate monoester-derived radicals

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00241E, Communication
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Julia A. Turner, Hendrik Zipse, Mark S. Taylor
Computational analysis of the HAT-induced expulsion of carboxylic acids from monoacylated pyranosides implicates concerted elimination through a hydrogen-bonded transition state.
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Selective recognition between aromatics and aliphatics by cage-shaped borates supported by a machine learning approach

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00408F, Paper
Open Access
Yuya Tsutsui, Issei Yanaka, Kazuhiro Takeda, Masaru Kondo, Shinobu Takizawa, Ryosuke Kojima, Akihito Konishi, Makoto Yasuda
Exploration of a Lewis acid with high selectivity for hydrocarbon moieties is assisted by a machine learning approach. Molecular polarizability is an essential factor, leading to design guidelines for Lewis acid catalysts with dispersion forces.
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Use of ionic liquids in amidation reactions for proteolysis targeting chimera synthesis

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00304G, Paper
Michela Eleuteri, Jenny Desantis, Gabriele Cruciani, Raimondo Germani, Laura Goracci
Selective degradation of disease-causing proteins using proteolysis targeting chimeras (PROTACs) has gained great attention, thanks to its several advantages over traditional therapeutic modalities.
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An efficient synthesis of mono-, di-, and tri-substituted 1,3-thiazoles employing functionalized thioamides as thiocarbonyl precursors

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00229F, Paper
Kalleshappa Sheela, Chikkappaiahnayaka Santhosh, Krishna Ravi Singh, Kalleshappa Sharath, Maralinganadoddi P. Sadashiva
Herein, we report an efficient strategy to synthesize functionalized 1,3-thiazoles using alkyl 2-amino-2-thioxoacetates.
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Electrochemical and photochemical reaction of isatins: a decade update

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00202D, Review Article
Nandini M. Gotgi, J. Saurab Jain, Rita Pal, Debashis Ghosh
This review presents all the recent reports on electro- and photochemical reactions of isatins over the last decade.
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A rhodium-catalyzed cascade C–H activation/annulation strategy for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00193A, Paper
Yinsong Wu, Guanghao Shi, Yanan Liu, Yangzilin Kong, Mengdi Wu, Demao Wang, Xiaobing Wu, Yongjia Shang, Xinwei He
We have developed a cascade annulation strategy triggered by rhodium(III)-catalyzed C–H activation for the expeditious assembly of pyrrolidinedione-fused 1,2-benzothiazines from free NH-sulfoximines with maleimides under mild conditions.
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Generation of sulfones utilizing β-sulfinyl esters as masked aryl sulfinates under redox-neutral conditions

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00238E, Communication
Yixin Zhang, Zhu Yang, Hongjun Yang, Xuefeng Li, Lu Yang
A method for generation of SVI sulfones from β-sulfinyl esters (SIV) under transition-metal-free non-oxidative mild conditions is presented.
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Correction: Recent progress of core-substituted naphthalenediimides: highlights from 2010

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB90045F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sheshanath V. Bhosale, Sidhanath V. Bhosale, Suresh K. Bhargava
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Photoinduced decatungstate-catalyzed C(sp3)–H thioetherification by sulfinate salts

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00394B, Paper
Pengcheng Li, Jia-Lin Tu, Ao-Men Hu, Lin Guo, Chao Yang, Wujiong Xia
A visible light photoinduced decatungstate-catalyzed C(sp3)–H thioetherification of hydrocarbons by sodium sulfite is herein reported.
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HFIP-mediated C-3-alkylation of indoles and synthesis of indolo[2,3-b]quinolines & related natural products

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00414K, Paper
Auqib Rashid, Waseem I. Lone, Preeti Dogra, Showkat Rashid, Bilal A. Bhat
An expeditious metal free C-3 alkylation of indoles and its NIS-mediated deviation to indolo[2,3-b]quinolines is reported. Applications of these strategies in accessing bioactive natural products have also been demonstrated.
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A copper-catalyzed asymmetric Friedel–Crafts hydroxyalkylation of pyrazole-4,5-diones with 5-aminoisoxazoles

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00322E, Communication
Siyu Gao, Xiang Sun, Sijie Peng, Zhenggen Zha, Qi Sun, Zhiyong Wang
An asymmetric Friede-Crafts hydroxyalkylation reaction was developed under the catalysis of chiral copper complexes. A variety of pyrazolone derivatives were obtained with excellent yields and enantioselectivities.
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Copper-catalyzed ortho-thiocyanation of aromatic amines

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00137K, Communication
Monak Patel, Nitish Kumar, Hussain Bhukya, Bharatkumar Z. Dholakiya, Togati Naveen
Here, we described an efficient ortho- C(sp2)-H thiocyanation of anilines for the synthesis of aryl thiocyanates. This protocol tolerates a variety of aromatic amines to provide the desired products in good to excellent yields.
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Synthesis of fluorescent 5-heteroarylpyrimidine-containing oligonucleotides via post-synthetic trifluoromethyl conversion

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00402G, Paper
Yuta Ito, Hisato Tanaka, Ayana Murakami, Yasufumi Fuchi, Yoshiyuki Hari
5-(Benzimidazol-2-yl)- and 5-(benzothiazol-2-yl)-pyrimidine bases-modified oligonucleotides were prepared by post-synthetic trifluoromethyl conversion and their fluorescence properties were measured.
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Chemoenzymatic total synthesis of rotigotine via IRED-catalyzed reductive amination

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00072B, Communication
Dongyu Tang, Yaqing Ma, Jinping Bao, Shushan Gao, Shuli Man, Chengsen Cui
An engineered imine reductase (IRED) was developed specifically for 2-tetralone substrate, and utilized in the total synthesis of rotigotine.
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Rh(III)-catalysed C-H annulation of cis-stilbene acids with 2-diazo-1,3-diketones: A facile access to 6,7-dihydrobenzofuran-4(5H)-one and α-pyrone scaffolds

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Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00151F, Paper
Shankaraiah Nagula, Mary Sravani Galla, Nandini B. Kale, Akshay Kumawat, Darshana Bora
An efficient Rh(III)-catalysed C-H functionalization, tandem annulation of cis-stilbene acids using 2-diazo-1,3-diketones was devised. The protocol has solely afforded 6,7-dihydrobenzofuran-4(5H)-ones using alicyclic diazocarbonyls via decarbonylation and α-pyrones with aliphatic diazo...
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The synthesis of alk-2-ynl Weinreb amides via Pd/Cu-catalysed oxidative carbonylation of terminal alkynes

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00290C, Paper
Bharati Mourya, Sandip T. Gadge, Bhalchandra M. Bhanage
Synthesis of alk-2-ynl-Weinreb amides via Pd-catalyzed oxidative carbonylation of terminal alkynes and N,O-dimethylhydroxylamine hydrochloride at room temperature under low CO/O2 pressure is reported for the first time.
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DMSO promoted catalyst-free oxidative C–N/C–O couplings towards synthesis of imidazoles and oxazoles

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00383G, Paper
Debasish Bera, Rajib Sarkar, Tiyasa Dhar, Pinaki Saha, Prasanta Ghosh, Chhanda Mukhopadhyay
Dimethyl sulfoxide (DMSO)-promoted catalyst-free oxidative C–N coupling and C–O coupling under oxidant-free conditions are outlined.
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Synthesis of Asp-based lactam cyclic peptides using an amide-bonded diaminodiacid to prevent aspartimide formation

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00472H, Communication
Wen-Jie Li, Jun-You Chen, Hui-Xia Zhu, Yi-Ming Li, Yang Xu
A diaminodiacid (DADA) containing an amide bond can be used in Fmoc solid-phase peptide synthesis (SPPS) of an Asp-based lactam cyclic peptide with no aspartimide formation.
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Synthesis of alkenylphosphine oxides via Tf2O promoted addition–elimination of ketones and secondary phosphine oxides

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00318G, Communication
Jiangkai Ma, Lianjie Wang, Anjiang Qiao, Zhongxian Li, Fengqian Zhao, Junliang Wu
An efficient method for the synthesis of alkenylphosphine oxides via the addition-elimination of SPOs to ketones has been developed. The reaction exhibits good yields and compatibility. Several conversions have also proven the value of this method.
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DFT investigation of the DDQ-catalytic mechanism for constructing C–O bonds

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00346B, Paper
Xiu-Fang Zheng, Da-Gang Zhou, Li-Jun Yang
The DDQ-catalytic mechanisms for constructing C–O bonds via H2O and CH3OH as oxygen sources have been investigated with DFT.
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Friedel–Crafts reactions for biomolecular chemistry

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00406J, Review Article
Open Access
Jun Ohata
This review demonstrates advances in Friedel–Crafts alkylation and acylation reactions in a variety of biomolecular chemistry fields.
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Electrochemical nickel-catalyzed cross-coupling of glycosyl thiols with preactivated phenols and ketones

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Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00442F, Communication
Fuxin Li, Hui Liu, Wanyu Xing, Qingju Zhang, Liming Wang
Here we report an efficient electrochemical nickel-catalyzed cross-coupling reaction for the synthesis of S-glycosides from preactivated phenols and ketones.
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