science and technology

A Highly Diastereoselective One-Pot Ugi/Radical Spirocyclization/Aza-Michael Addition Sequence

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00610K, Communication
Chandra Volla, Salman Khan, Abhradeep Chatterjee, Akshay Murali Nair
We hereby report a highly diastereoselective synthesis of chalcogenated azaspirotricycles via a one-pot Ugi/spirocyclization/ aza-Michael addition sequence. The reaction proceeded via a key visible light mediated spirocyclization step under mild,...
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science and technology

New Generation of Highly Reactive Allylborating Agents For Cu(I)-Catalyzed Allylation of Chiral Sulfinylimines

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00291A, Paper
Michael S. Alexeev, Tatyana V. Strelkova, Michail M. Ilyin, Jr., Yulia V. Nelyubina, Ivan A. Bespalov, Michael Medvedev, Victor N Khrustalev, Nikolai Kuznetsov
The implementation of selective catalytic processes with highly active reagents is an attractive strategy that meets modern principles of sustainable development of chemistry. In the current study, we for the...
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science and technology

N-Functionalization of beta-aminophosphonates; Cytotoxic effect of the new derivatives

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00243A, Paper
György Keglevich, Petra Regina Varga, Emőke Dinnyési, Zsuzsanna Szalai, Szilvia Bősze, Rita Oláhné Szabó, Laszlo Drahos, Konstantin Karaghiosoff
Beta-Aminophosponates obtained by the Michael addition of primary amines to the double bond of diethyl vinylphosphonate proved to be suitable starting materials (amine components) in the Kabachnik–Fields reaction with formaldehyde...
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science and technology

Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00315B, Paper
Shoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang Huang
A series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.
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science and technology

Regioselective synthesis of 4-arylamino-1,2-naphthoquinones in eutectogel as a confined reaction medium using LED light

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00140K, Communication
R. Vara Prasad, Yogendra Kumar, R. Arun Kumar, Tohira Banoo, Subbiah Nagarajan
The use of a simple carbohydrate-derived eutectogel facilitating a LED-light-induced regioselective synthesis of 4-arylamino-1,2-naphthoquinones in good yields is reported.
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science and technology

Tetrabutylammonium decatungstate (TBADT), a compelling and trailblazing catalyst for visible-light-induced organic photocatalysis

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00171K, Review Article
Bor-Cherng Hong, Ranadheer Reddy Indurmuddam
This review summarizes recent developments in visible-light or near-visible-light photocatalysis reactions enabled by the TBADT catalyst.
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science and technology

Efficient synthesis of SCF3-containing 3-alkenylquinoxalinones via three-component radical cascade reaction

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00363B, Paper
Si-Yu Wang, Chu Liu, Wei Yang, Zhong-Ying Tian, Lin Yuan, Long-Yong Xie
A three-component cascade reaction of quinoxalinones, alkynes and AgSCF3 toward complete E-selective SCF3-containing 3-alkenylquinoxalinones was developed.
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science and technology

Base- and sulfur-promoted oxidative lactonization of chalcone-acetate Michael adducts: access to pyran-2-ones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00479E, Communication
Cao Nguyen Nguyen, Duc Toan Nguyen, Ha An Tran, Dinh Hung Mac, Thi Thu Tram Nguyen, Pascal Retailleau, Thanh Binh Nguyen
A cost-effective, practical, straightforward and scalable synthesis of α-pyrones via base- and sulfur-promoted annulation of phenylacetates and chalcones is reported.
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science and technology

Visible light-driven photocatalytic sulfonative oxidation of benzyl secondary amines

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00348A, Paper
Yong-Xiang Lü, Xinqian Wang, Ying-Ming Pan, Keyume Ablajan
A method for the α-oxidation and sulfonation of benzyl secondary amines was developed utilizing Ir(III) or Eosin Y as the photocatalyst in the presence of O2 as a green oxidant....
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science and technology

K2CO3-Mediated (3+3-1) Annulation of 1,3-Acetonedicarboxylates with 2-Fluoro-1-nitroarenes: Synthesis of Indoles

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00488D, Paper
Meng-Yang Chang, Chin-Huey Ho, Hsing-Yin Chen
The K2CO3-mediated one-pot reaction of 1,3-acetonedicarboxylates with 2 equiv. of substituted 2-fluoro-1-nitrobenzenes has been developed to synthesize various 2,3-dicarboxylate indoles via a tandem (3 + 3 − 1) annulation pathway....
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science and technology

DevTools Digest - Chrome 35: Updates to the Developer Tools in Chrome 35

Updates to the Chrome Developer Tools: CSS property quick search, memory stats for heap snapshots, CodeMirror upgrade and more.




science and technology

Built-in Browser Support for Responsive Images

Take advantage of the new element and new features of in your next responsive website.




science and technology

Getting Started with CSS Shapes: Wrapping content around custom paths

Using CSS Shapes we can create experiences that we have never been able to create on the web before.




science and technology

The Hobbit Experience 2014: Adding WebRTC gameplay to the Hobbit Experience

Learn how North Kingdom built an immersive multimedia experience optimized for modern mobile browsers using Web RTC




science and technology

Introduction to Service Worker: How to use Service Worker

Service Worker will revolutionize the way we build for the web. Learn about what it is, why it is important and how to use it.




science and technology

Rolling out Public Key Pinning with HPKP Reporting




science and technology

Tab Discarding in Chrome: a Memory-Saving Experiment




science and technology

History API: Scroll Restoration




science and technology

Updates to the service worker cache API




science and technology

The EME Logger extension




science and technology

Youtube introduces shopping affiliate programme for eligible Indian creators via Flipkart and Myntra

As more platforms allow creators to earn from viewers’ purchases of featured products, YouTube also announced its Shopping affiliate programme in India




science and technology

Zomato users can now schedule order 2 days in advance

Zomato’s order scheduling is available at more than 35,000 restaurants across 30 cities




science and technology

Google to develop AI that takes over computers: Report

Google is developing AI technology that takes over a web browser to complete tasks such as research and shopping, The Information reported




science and technology

Sarvam AI launches Sarvam 1 for Indic languages

The custom training corpus, Sarvam-2T comprised of 20 percent datasets in Hindi as well as English and programming languages so the AI model can perform multilingual tasks




science and technology

Hong Kong unveils responsible AI framework for financial sector

Hong Kong’s responsible AI framework comes amid increasing international competition and tensions affecting access to AI technology




science and technology

Apple Intelligence launches the iPhone into the AI era

Apple has released a free software update that will inject its first dose of artificial intelligence into its iPhone 16 line-up as the trendsetting company tries to catch up with technology’s latest craze




science and technology

Apple AirPods Pro’s new hearing aid feature could help people face a problem they’d rather ignore

Millions who could benefit from hearing aids have never tried them, but the Apple AirPods could change this




science and technology

OpenAI chair's AI startup Sierra gets $4.5 billion valuation in latest funding round

One-year-old Sierra focuses on selling artificial intelligence-powered customer service chatbots to enterprises




science and technology

Meta builds AI search engine to cut Google, Bing reliance, the Information reports

The Facebook-owner currently relies on Google and Bing search engines to give users answers on news, stocks and sports




science and technology

Microsoft Teams to launch threaded conversations, combined chats and channels features

The app has also added other changes in the interface so users can organise their chats better




science and technology

 Instagram downgrades quality of less popular videos

Last year, Meta had admitted in a blog to having separate encoding configurations for different videos based on how popular they were




science and technology

Jio’s Diwali Dhamaka plan offers year-long prepaid plan for ₹3,599

Jio is offering a prepaid plan of 2.5 GB of data per day for an entire year, priced at₹3,599, as part of a Diwali offer




science and technology

Google brings AI-powered Gmail writing tools and ‘Polish’ to more users

Google is expanding its generative AI-powered email drafting tools to more users with new and enhanced shortcuts on web and mobile




science and technology

GitHub unveils multi-model Copilot, Spark for AI developers

Anthropic’s Claude 3.5 Sonnet will be available via GitHub Copilot starting today and Google’s Gemini 1.5 Pro will be available in the coming weeks




science and technology

Google’s moneymaking machine still pumping out massive profits despite multiple threats

Google is still thriving while the company navigates through a pivotal shift to artificial intelligence and battles regulators trying to topple its internet empire




science and technology

OpenAI builds first chip with Broadcom and TSMC, scales back foundry ambition

OpenAI is working with Broadcom and TSMC to build its first in-house chip designed to support its artificial intelligence systems, per sources




science and technology

Google ad change could affect millions of small businesses

Google is changing the way its Google Local Services ads work, which could affect millions of small businesses




science and technology

Elon Musk's xAI in talks to raise funding valuing it at $40 billion: Report

Earlier in October, OpenAI raised $6.6 billion in funding from investors which could value the company at $157 billion




science and technology

Crypto firm Consensys to cut 20% of workforce amid macroeconomic, regulatory headwinds

The crypto firm added that elevated interest rates, inflationary pressures, and tightening liquidity have created a more “cautious macroeconomic environment”




science and technology

Google expands AI Overviews in Search to more than 100 countries

Earlier this month, the search giant rolled out ads in AI Overviews on mobile but only in the U.S.




science and technology

As Bitcoin nears all-time high, WazirX investors are in pain over their locked crypto funds

Bitcoin was inching towards its March 2024 all-time-high price of $73,750.07, but those whose crypto assets are locked with the WazirX exchange after a cyberattack are anxious about missing out




science and technology

Google CEO confirms the next Gemini model coming soon

Gemini 1.5, their last iteration had been released in February this year




science and technology

ChatGPT will now work as a search engine as OpenAI partners with some news outlets

OpenAI is launching a ChatGPT-powered search engine that could put the artificial intelligence company in direct competition with search giant Google




science and technology

Google Maps adds AI features to help users explore and navigate the world around them

Google Maps is heading down a new road steered by artificial intelligence




science and technology

Microsoft, Meta, Apple, Amazon, and the burden of expectations knock Wall Street sharply lower

Drops for Big Tech companies including Microsoft and Facebook’s parent company Meta Platforms led Wall Street lower




science and technology

Chinese researchers develop AI model for military use on back of Meta's Llama

ChatBIT was fine-tuned and "optimised for dialogue and question-answering tasks in the military field", the paper said




science and technology

Amazon's improving retail sales boost third-quarter profit, revenue beats estimates

Like its tech peers, Amazon said it expected higher capital expenditures for the foreseeable future to help develop artificial intelligence software




science and technology

OpenAI CEO Sam Altman says next big AI model launch pushed due to compute challenges

Altman also said that the next update for DALL-E was still in the works with no release date yet




science and technology

Amazon won’t release new Alexa until 2025: Report

Until sometime ago, users were able to access the beta version of Alexa using an Echo but that has been cut off now




science and technology

Indonesia bans sales of Google phones days after blocking Apple's iPhone 16

Indonesia said it has banned sales of smartphones made by Alphabet's Google due to rules requiring the use of locally manufactured components