On 11 February 2019, the OECD organised a webinar to learn and discuss new methodologies on liver models for induction, clearance and toxicity. The speakers presented the benefits compared to existing methods in place, the types of chemicals tested, the results obtained, the transferability and economic aspects for routine testing, and any known limitation to the technologies and their applications.

Nanomaterials have unique physical and chemical features. OECD's Decision Framework and Guiding Principles tools fill data gaps in the hazard characterisation by identifying the most useful parameters and best available methods for a given type of nanomaterial.

GHSTS is a standardised set of technical specifications for assembling electronic files for pesticide registration in a predefined manner. Once assembled according to the GHSTS, the dossier files can be transferred from a business to a regulatory authority and can be used in a regulatory process. Version 2.0 includes improved lifecycle management of documents over a series of submissions for one pesticide (or other) regulatory action.

Policy instruments can be applied to improve the sustainability of plastics, including regulations, market-based instruments, information and voluntary tools. The report reviews the use of these instruments, provides good practice examples, such as product taxes and charges, eco-design standards, extended producer responsibility and environmental product labels, as well as discussing opportunities for their future applications.

The purpose of this document is to give guidance to Receiving Authorities on the evaluation of the GLP compliance status of nonclinical safety studies submitted for regulatory purposes. This guidance does not address the scientific evaluation and interpretation of the submitted data or the risk assessment based on these data.

Latest releases: AOPs are the central element of a toxicological knowledge framework, promoted by member countries through OECD, built to support chemical risk assessment based on mechanistic reasoning. Seven New AOPs have now been published.

Two new cases have been published that focus on use of metabolism information to support read-across and use of a combination of novel methods to identify potential endocrine disruptors, respectively. In addition a considerations document includes lessons and learnings from analysis across case studies and an analysis of uncertainties in six read-across cases.

This report aims to enhance awareness for inclusion of children’s exposure in risk assessments when relevant and presents a children’s exposure decision tree that facilitates such decisions. The decision tree can be used to identify if a separate exposure assessment is needed with regard to children, and also aims to identify whether the exposure assessment conducted for adults already provides an acceptable level of safety of children.

On Thursday 26 September 2019, the OECD discussed "Finding Alternatives to Per- and Polyfluoroalkyl Substances of Concern: A Difficult and Continuing Challenge" with the participation of W.L. Gore & Associates, Inc. Presenters shared efforts, successes and challenges in eliminating per and polyfluorinated chemicals of environmental concern from the life cycle of consumer products.

On 27 September 2019, Anne Gourmelon of the Environment Directorate presented an overview of the various alternative test methods developed as OECD Test Guidelines and relevant guidance material to address eye irritation and serious eye damage for hazard classification of chemicals.

A major fruit crop of temperate regions, APPLE is consumed worldwide as fresh fruit, juice and other food products. This consensus document provides science-based key insights for the regulatory assessment of the environmental safety of genetically-engineered products: taxonomy, reproductive biology, genetics, hybridisation and introgression, and ecology.

This document is intended to provide universal Guiding Principles that should be considered when developing or augmenting systematic approaches to Weight of Evidence (WoE) for chemical evaluation and Key Elements to formulating a systematic approach to WoE. The ultimate goal is to facilitate that regulators follow a consistent, clear and transparent delivery of evidence using the Principles and Elements described in this document.

The Chemical Safety and Biosafety Progress Report is released every eight months. Its purpose is to provide an update on the projects, events and activities. Information on new publications as well as dates and venues of upcoming events and meetings are given.

We continue to look at how the coronavirus outbreak is impacting mobile apps; that big app crash caused by Facebook; new app releases from Facebook and Google; and Apple's plans to move WWDC online.

We continue to look at how the coronavirus outbreak is impacting mobile apps; that big app crash caused by Facebook; new app releases from Facebook and Google; and Apple's plans to move WWDC online.

A team of firefighters worked tirelessly for three hours to rescue a horse named Duchess who had fallen into a ditch in Great Horkesley, near Colchester on the Friday of bank holiday.

Historic Royal Palaces has argued that the project will block protected views of the tower which is part of a system introduced in 1938 to also guard views of St Paul's vistas and the Palace of Westminster.

The Italian public took to bicycles around the Piazza Venezia and the Via dei Fori Imperiali in Rome while people of all ages walked and cycled to Ruffini Park in Turin during Phase Two of lockdown.

Tekashi 6ix9ine's mastery of social media was called into question on Saturday, when the controversial rapper called on Instagram users to 'describe me in one word.'

Neil Simpson takes an in-depth look at how to ensure you are ready to travel for when the world reopens. Advice includes checking passports and insurance policies are still valid.

From travelogues to films and even webcams, Neil Simpson reveals how you can still explore the world from your own home during the lockdown.

Official figures show for the first time the true scale of offending by criminals who were born male but were allowed to move into female jails after changing gender. Convicted rapist Karen White pictured.

Householders are being warned that the surge in energy usage will come at a price - with bills set to increase by an average of £32 a month.

Britain is home to works of art by some of the most important painters of all time, from J.M.W Turner to Salvador Dali. Here we pick nine unmissable masterpieces and show you where to find them...

Single parent Beverley Cohen, 55, from Brighton, pictured with her seriously disabled daughter Liora, left, has felt abandoned by the care system since the start of the Covid-19 outbreak.

Singa, an African lion living in Pakawi Park Zoo in Belgium struggled to look after his five cubs who screamed every time he tried to move them while mum was recovering from an injury at the vet.

Neighbour Steve Frankel said the enclave's peace and quiet has been shattered by the new arrivals. The area is known for ultra privacy and neighbours say they do not welcome the attention.

Jenni Murray has hosted BBC Woman's Hour at the BBC's studios throughout the coronavirus crisis but will have to start doing so at home once she turns 70 because she will be classified vulnerable.

Ms Nandy has raised the case with the UK ambassador to the US, Karen Pierce. Harry, 19, was killed when his motorbike crashed into a car outside a US military base in Northamptonshire.

PETER HITCHENS: We will not escape from this misery until the Government has been forced to admit that it made a foolish mistake and over-reacted wildly to Covid-19.

At the moment it feels like there are only two types of country: nations that have handled coronavirus well and those facing criticism because they have not.

We give you the lowdown on those investment trusts where family money still influences the way that they are managed.

Consultant anaesthetist Dr Paul Trafford, pictured with his wife and nieces, almost suffered a major heart attack after returning to his home in Glasgow following a shift in his hospital due to an undiagnosed issue.

Anne Pitcher, the Selfridges managing director, replies bluntly when asked how it felt to turn the lights out and pull up the shutters on Oxford Street's most iconic store. 'Awful,' she says.

RBS forecasts a big fall in home ownership and experts expect the trend to accelerate as house sales resume.

Pin the blame where it belongs. This is not the fault of the Chinese people. It is the Chinese Communist dictatorship which hold the responsibility for the spread of the coronavirus.

Tony Cooke's eyes were drawn to a photograph of a group of women in pinafores hailing the end of war, conveying the relief, pride and exultant joy of VE Day.

Unable to put on a show of military might in the Red Square today due to surging coronavirus infections, Russia indulged in a series of spectacular fireworks displays over the capital as night fell.

The annual list of awards for celebrities and community heroes - due to be released in June - has fallen victim to Whitehall 'bandwidth' issues as officials are swamped by virus battle.

One study found this virus spreads so fast that if officials had acted three weeks sooner, they would have reduced cases by 95 per cent. Even one week faster could have cut numbers by two-thirds.

A advertising company from Bogotá, Colombia, created hospital beds with metal railings that designers say can double as a casket if a patient dies.

In a video posted on the event's Twitter account, the Duke of Sussex urged the 'Invictus family' to look out for each other and encouraged them to get involved with virtual activities.

The Good Morning Britain presenter has previously accused the Duchess of Sussex of having 'ditched' her own relatives and splitting her husband Prince Harry from the Royal Family.

This newspaper revealed last week how hackers linked to Russia and Iran were behind 'utterly reprehensible' hits on British institutions.

Paedophile Jeffrey Epstein arranged for three young women to meet Prince Andrew at his notorious New York mansion, a former model involved in Epstein's inner circle claimed last night.

Kirstin Coutney, pictured with her daughter Tilly, contracted Covid-19.  The 49-year-old mother of two from Bath is still suffering crippling fatigue, six weeks after developing the virus.

ROBERT MUIR-WOOD: Containment - isolating those who are ill and infectious - is the oldest known response to mass infection, dating back thousands of years.

The landmark judgment - which risks throwing the Government's deportation policy into chaos - has already delayed the case of gang rapist Yaqub Ahmed, who was supposed to be deported.

Few relationships would be immune to the pressures wrought by their ordeal: the strain of caring for their desperately sick child, their brief life as fugitives, the draining legal battles.

Thousands of vital coronavirus 'contact tracers' are only now being recruited by the Government - two weeks after the Health Secretary first announced they would be hired.