health and food

Limitations of Retrospective Study Design and Potential Bias in the PRECISE-MDT Study




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Improved Localization of Insulinomas Using 68Ga-NODAGA-Exendin-4 PET/CT

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health and food

MIRD Pamphlet No. 31: MIRDcell V4--Artificial Intelligence Tools to Formulate Optimized Radiopharmaceutical Cocktails for Therapy

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Modeling PET Data Acquired During Nonsteady Conditions: What If Brain Conditions Change During the Scan?

Researchers use dynamic PET imaging with target-selective tracer molecules to probe molecular processes. Kinetic models have been developed to describe these processes. The models are typically fitted to the measured PET data with the assumption that the brain is in a steady-state condition for the duration of the scan. The end results are quantitative parameters that characterize the molecular processes. The most common kinetic modeling endpoints are estimates of volume of distribution or the binding potential of a tracer. If the steady state is violated during the scanning period, the standard kinetic models may not apply. To address this issue, time-variant kinetic models have been developed for the characterization of dynamic PET data acquired while significant changes (e.g., short-lived neurotransmitter changes) are occurring in brain processes. These models are intended to extract a transient signal from data. This work in the PET field dates back at least to the 1990s. As interest has grown in imaging nonsteady events, development and refinement of time-variant models has accelerated. These new models, which we classify as belonging to the first, second, or third generation according to their innovation, have used the latest progress in mathematics, image processing, artificial intelligence, and statistics to improve the sensitivity and performance of the earliest practical time-variant models to detect and describe nonsteady phenomena. This review provides a detailed overview of the history of time-variant models in PET. It puts key advancements in the field into historical and scientific context. The sum total of the methods is an ongoing attempt to better understand the nature and implications of neurotransmitter fluctuations and other brief neurochemical phenomena.




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Head-to-Head Comparison of [68Ga]Ga-NOTA-RM26 and [18F]FDG PET/CT in Patients with Gastrointestinal Stromal Tumors: A Prospective Study

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[18F]F-AraG Uptake in Vertebral Bone Marrow May Predict Survival in Patients with Non-Small Cell Lung Cancer Treated with Anti-PD-(L)1 Immunotherapy

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Intraarterial Administration of Peptide Receptor Radionuclide Therapy in Patients with Advanced Meningioma: Initial Safety and Efficacy

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Comparison of Posttherapy 4- and 24-Hour [177Lu]Lu-PSMA SPECT/CT and Pretherapy PSMA PET/CT in Assessment of Disease in Men with Metastatic Castration-Resistant Prostate Cancer

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Comparison Between Brain and Cerebellar Autoradiography Using [18F]Flortaucipir, [18F]MK6240, and [18F]PI2620 in Postmortem Human Brain Tissue

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Outcomes for Patients with Metastatic Castration-Resistant Prostate Cancer and Liver Metastasis Receiving [177Lu]Lu-PSMA-617

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Clinical, Pathologic, and Imaging Variables Associated with Prostate Cancer Detection by PSMA PET/CT and Multiparametric MRI

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CT Enhancement of a Nasal Leech After Thrombectomy




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FAP and PSMA Expression by Immunohistochemistry and PET Imaging in Castration-Resistant Prostate Cancer: A Translational Pilot Study

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Oncologist, Business Leader, and Investor Arie S. Belldegrun Discusses a Career in Innovative Medical Entrepreneurship: A Conversation with Ken Herrmann and Johannes Czernin




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Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted 18F-Fluorthanatrace PET in Breast Cancer

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[18F]FDG and [68Ga]Ga-FAPI-04-Directed Imaging for Outcome Prediction in Patients with High-Grade Neuroendocrine Neoplasms

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Feasibility, Tolerability, and Preliminary Clinical Response of Fractionated Radiopharmaceutical Therapy with 213Bi-FAPI-46: Pilot Experience in Patients with End-Stage, Progressive Metastatic Tumors

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Performance Characteristics of a New Generation 148-cm Axial Field-of-View uMI Panorama GS PET/CT System with Extended NEMA NU 2-2018 and EARL Standards

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SPECT/CT in Early Response Assessment of Patients with Metastatic Castration-Resistant Prostate Cancer Receiving 177Lu-PSMA-617

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CD70-Targeted Immuno-PET/CT Imaging of Clear Cell Renal Cell Carcinoma: A Translational Study

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Feasibility of 177Lu-PSMA Administration as Outpatient Procedure for Prostate Cancer




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International Metabolic Prognostic Index Is Superior to Other Metabolic Tumor Volume-Based Prognostication Methods in a Real-Life Cohort of Diffuse Large B-Cell Lymphoma

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Changed Regulation Enables Pragmatic Solution for Cancer Patients




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A swollen painful foot




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An ankle that just didn’t look right




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Developing a vaccine against Zika




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How changes to drug prohibition could be good for the UK—an essay by Molly Meacher and Nick Clegg




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The war on drugs has failed: doctors should lead calls for drug policy reform




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Risks of duloxetine for stress incontinence outweigh benefits, say researchers




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Chronic insomnia: diagnosis and non-pharmacological management




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Babies with microcephaly in Brazil are struggling to access care




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US adults are more likely to have poor health than those in 10 similar countries, survey finds




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Supervised physiotherapy for mild or moderate ankle sprain




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US must address addiction as an illness, not as a moral failing, Surgeon General says




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Thiazide diuretics seem to protect against fracture




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NHS spent 8% more on medicines last year




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Zika related microcephaly may appear after birth, study finds




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Should adults take vitamin D supplements to prevent disease?




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Trial of novel leukaemia drug is stopped for second time after two more deaths




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First case of Zika virus spread through sexual contact is detected in UK




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UK clinics may be able to offer mitochrondrial donation next spring




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Doctors face manslaughter charge for failing to raise alarm over killer nurse




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Chemoprevention of colorectal cancer in individuals with previous colorectal neoplasia: systematic review and network meta-analysis




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Covid-19: NHS staff will be offered vaccine this autumn, but JCVI recommends more limited rollout




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HIV: Breakthrough study raises hopes of effective prevention if drug’s cost can be lowered




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Whooping cough: Health officials urge pregnant women to get vaccinated as another infant dies




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Test for syphilis in people with possible symptoms, says UKHSA, as cases rise




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Condom use in adolescents has fallen notably since 2014, warns WHO




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First mpox vaccines arrive in Africa as officials work “blindly” to contain outbreaks




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Whooping cough: Why have vaccination rates plummeted in pregnant women?