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Offsetting the North Korean strategic challenge

Offsetting the North Korean strategic challenge 16 March 2023 — 9:30AM TO 10:30AM Anonymous (not verified) 8 March 2023 Online

This event explores what balance between pressure and dialogue is most likely to incentivise North Korea to limit its provocations.

With North Korea having steadily increased its nuclear and conventional security capabilities over the course of recent months, the speakers explore practical options for lowering tensions on the Korean peninsula.

They consider how best to re-engage diplomatically with North Korea, including the role of key actors such as the US, South Korea, Japan, and European states, in advancing a constructive resolution of current tensions.

The discussion explores finding a balance between pressure and dialogue which is most likely to incentivise North Korea to limit its provocations, assess the risks of a possible seventh nuclear test, and consider the viability of multilateral cooperation in enhancing regional security in north-east Asia.

This event forms part of the Korea Foundation Korea Fellowship, funded by the Korea Foundation and Taejae Academy.




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Ethics of dealing with authoritarians

Ethics of dealing with authoritarians 28 March 2023 — 12:00PM TO 1:00PM Anonymous (not verified) 20 March 2023 Chatham House

How can democracies simultaneously defend human rights and promote open societies while still engaging with leaders from non-democratic states as strategic allies?

In 2022, the Biden administration called upon the world’s democracies to unite against a rising tide of autocracy. Through its messaging, conferences, and op-eds, the US and its allies presented the public with a binary choice: democracy or autocracy.

But in today’s world, and in the practice of international relations, the choice is rarely this simple.  

Joel Rosenthal, president of Carnegie Council, joins Chatham House to discuss how democracies and multilateral institutions can leverage ethics as a tool to assess concerns and trade-offs when engaging with illiberal actors.

Can democracies afford to be adversarial with certain countries or overly selective in cooperation when facing global-scale challenges such as climate change and the emergence of AI?

How can democracies simultaneously defend human rights and promote open societies while still engaging with leaders from non-democratic states as strategic allies?




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World in brief: Ukraine and nuclear proliferation to dominate G7

World in brief: Ukraine and nuclear proliferation to dominate G7 The World Today mhiggins.drupal 28 March 2023

Following Russia’s ongoing intimidation, Japan will use its presidency of the G7 – and its history – to prioritize the dangers of nuclear threats, writes James Orr.

Two issues are expected to dominate the agenda as Japan hosts the G7 summit in Hiroshima from May 19-21. Central to talks will be the conflict in Ukraine, with member states eager to highlight a message of unity and resolve in the face of Russia’s continuing aggression.

Fumio Kishida, Japan’s prime minister, made an unannounced visit to Kyiv on March 21, meeting the Ukrainian president Volodymyr Zelenskyy.  This coincided with a visit to Moscow by China’s leader Xi Jinping, who described Russian president Vladimir Putin as a friend and partner.

‘Absolutely unacceptable’

Hosting the G7 summit in Hiroshima is significant, too, with Kishida expected to emphasize the ‘absolutely unacceptable’ threat of nuclear proliferation. Ongoing tensions between China and Taiwan, together with recent North Korean ballistic missile tests, have heightened fears of a breakdown in security in the region.

A North Korean ballistic missile recently went into the sea near the Japanese island of Hokkaido

Meanwhile, President Vladimir Putin’s menacing references to the use of nuclear weapons in Ukraine has raised the prospect of a potentially devastating conflict with NATO. ‘Kishida’s principal goal for the presidency of the G7 is to try to draw the world away from the path of destruction that is another nuclear conflict,’ said Duncan Bartlett, a research associate at SOAS, the School of Oriental and African Studies, in London.

‘Early last year, Putin warned of terrible consequences if NATO and the West interfered in the Ukraine conflict, and that was widely seen as being a nuclear threat. North Korea is also pursuing its nuclear weapons programme, and in February an intercontinental ballistic missile went into the sea just near the northern Japanese island of Hokkaido,’ said Bartlett.

After Russia invaded Ukraine in February 2022, Kishida has taken a firm position on Putin, in line with his G7 peers. President Zelenskyy has addressed the Japanese parliament via video link and Dmytro Kuleba, Ukraine’s minister of foreign affairs, was invited by his Japanese counterpart to a G7 meeting held during the Munich Security Conference earlier this year.

Kishida committed $600 million in financial support to Ukraine and his government may well announce the provision of further non-lethal assistance to Zelenskyy at the summit. The country’s constitution effectively outlaws the export of deadly weapons to foreign forces. On his visit to Kyiv, Kishida promised a further $30 million to Ukraine.

We are witnessing a shift in the identity and purpose of the G7

Tristen Naylor, University of Cambridge

‘Kishida has revised key defence documents and is pursuing a radical and controversial expansion of Japan’s defence budget and capabilities,’ said Hugo Dobson, Professor of Japan’s International Relations at the University of Sheffield.

‘He and his G7 partners have signed historic defence agreements, pledged to strengthen ties or declared the inseparability of their security in light of actual conflict in Ukraine and potential conflict in East Asia. Kishida has linked the two by emphasizing that Ukraine today may be East Asia tomorrow,’ said Dobson.

Aside from security matters, Kishida will at the summit address issues on clean energy, climate change, global health and boosting multilateral cooperation to drive post-pandemic economic recovery.

Invitation to Nagasaki

He is understood to have invited President Joe Biden to visit Nagasaki, where the second of America’s two atomic bombs is estimated to have killed 60,000 people in August 1945. No sitting US president has ever visited the city, and Kishida, who grew up in Hiroshima, may see the visit as an opportunity to boost his flagging domestic approval ratings. It may also serve as a timely reminder to Russia and others that the G7 opposes any future nuclear weapon use.

 




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Phosphoproteome Analysis of E. coli Reveals Evolutionary Conservation of Bacterial Ser/Thr/Tyr Phosphorylation

Boris Macek
Feb 1, 2008; 7:299-307
Research




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Relative and Absolute Quantification of Postsynaptic Density Proteome Isolated from Rat Forebrain and Cerebellum

Dongmei Cheng
Jun 1, 2006; 5:1158-1170
Datasets




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Targeted Peptide Measurements in Biology and Medicine: Best Practices for Mass Spectrometry-based Assay Development Using a Fit-for-Purpose Approach

Steven A. Carr
Mar 1, 2014; 13:907-917
Technological Innovation and Resources




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Fluorescent Proteins as Proteomic Probes

Ileana M. Cristea
Dec 1, 2005; 4:1933-1941
Research




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High Resolution Clear Native Electrophoresis for In-gel Functional Assays and Fluorescence Studies of Membrane Protein Complexes

Ilka Wittig
Jul 1, 2007; 6:1215-1225
Research




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Quantitative, Multiplexed Assays for Low Abundance Proteins in Plasma by Targeted Mass Spectrometry and Stable Isotope Dilution

Hasmik Keshishian
Dec 1, 2007; 6:2212-2229
Research




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Global Identification and Characterization of Both O-GlcNAcylation and Phosphorylation at the Murine Synapse

Jonathan C. Trinidad
Aug 1, 2012; 11:215-229
Research




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The Proteome of the Mouse Photoreceptor Sensory Cilium Complex

Qin Liu
Aug 1, 2007; 6:1299-1317
Research




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Large Scale Screening for Novel Rab Effectors Reveals Unexpected Broad Rab Binding Specificity

Mitsunori Fukuda
Jun 1, 2008; 7:1031-1042
Research




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A "Proteomic Ruler" for Protein Copy Number and Concentration Estimation without Spike-in Standards

Jacek R. Wiśniewski
Dec 1, 2014; 13:3497-3506
Research




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Time-resolved Mass Spectrometry of Tyrosine Phosphorylation Sites in the Epidermal Growth Factor Receptor Signaling Network Reveals Dynamic Modules

Yi Zhang
Sep 1, 2005; 4:1240-1250
Research




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Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics

Amelia C. Peterson
Nov 1, 2012; 11:1475-1488
Technological Innovation and Resources




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A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

Sebastian A. Wagner
Oct 1, 2011; 10:M111.013284-M111.013284
Research




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Quantitative Phosphoproteomics of Early Elicitor Signaling in Arabidopsis

Joris J. Benschop
Jul 1, 2007; 6:1198-1214
Research




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A Tandem Affinity Tag for Two-step Purification under Fully Denaturing Conditions: Application in Ubiquitin Profiling and Protein Complex Identification Combined with in vivoCross-Linking

Christian Tagwerker
Apr 1, 2006; 5:737-748
Research




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Discordant Protein and mRNA Expression in Lung Adenocarcinomas

Guoan Chen
Apr 1, 2002; 1:304-313
Research




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GPS 2.0, a Tool to Predict Kinase-specific Phosphorylation Sites in Hierarchy

Yu Xue
Sep 1, 2008; 7:1598-1608
Research




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Comparison of Label-free Methods for Quantifying Human Proteins by Shotgun Proteomics

William M. Old
Oct 1, 2005; 4:1487-1502
Research




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Quantitative Mass Spectrometric Multiple Reaction Monitoring Assays for Major Plasma Proteins

Leigh Anderson
Apr 1, 2006; 5:573-588
Research




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A Human Protein Atlas for Normal and Cancer Tissues Based on Antibody Proteomics

Mathias Uhlén
Dec 1, 2005; 4:1920-1932
Research




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A Multidimensional Chromatography Technology for In-depth Phosphoproteome Analysis

Claudio P. Albuquerque
Jul 1, 2008; 7:1389-1396
Research




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Targeted Data Extraction of the MS/MS Spectra Generated by Data-independent Acquisition: A New Concept for Consistent and Accurate Proteome Analysis

Ludovic C. Gillet
Jun 1, 2012; 11:O111.016717-O111.016717
Research




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The Paragon Algorithm, a Next Generation Search Engine That Uses Sequence Temperature Values and Feature Probabilities to Identify Peptides from Tandem Mass Spectra

Ignat V. Shilov
Sep 1, 2007; 6:1638-1655
Technology




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Highly Selective Enrichment of Phosphorylated Peptides from Peptide Mixtures Using Titanium Dioxide Microcolumns

Martin R. Larsen
Jul 1, 2005; 4:873-886
Technology




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The Human Plasma Proteome: History, Character, and Diagnostic Prospects

N. Leigh Anderson
Nov 1, 2002; 1:845-867
Reviews/Perspectives




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A Versatile Nanotrap for Biochemical and Functional Studies with Fluorescent Fusion Proteins

Ulrich Rothbauer
Feb 1, 2008; 7:282-289
Research




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Exponentially Modified Protein Abundance Index (emPAI) for Estimation of Absolute Protein Amount in Proteomics by the Number of Sequenced Peptides per Protein

Yasushi Ishihama
Sep 1, 2005; 4:1265-1272
Research




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Parts per Million Mass Accuracy on an Orbitrap Mass Spectrometer via Lock Mass Injection into a C-trap

Jesper V. Olsen
Dec 1, 2005; 4:2010-2021
Technology




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Phosphate-binding Tag, a New Tool to Visualize Phosphorylated Proteins

Eiji Kinoshita
Apr 1, 2006; 5:749-757
Technology




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Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

Jürgen Cox
Sep 1, 2014; 13:2513-2526
Technological Innovation and Resources




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Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes [Microbiology]

Despite its major importance in human health, the metabolic potential of the human gut microbiota is still poorly understood. We have recently shown that biosynthesis of Ruminococcin C (RumC), a novel ribosomally synthesized and posttranslationally modified peptide (RiPP) produced by the commensal bacterium Ruminococcus gnavus, requires two radical SAM enzymes (RumMC1 and RumMC2) catalyzing the formation of four Cα-thioether bridges. These bridges, which are essential for RumC's antibiotic properties against human pathogens such as Clostridium perfringens, define two hairpin domains giving this sactipeptide (sulfur-to-α-carbon thioether–containing peptide) an unusual architecture among natural products. We report here the biochemical and spectroscopic characterizations of RumMC2. EPR spectroscopy and mutagenesis data support that RumMC2 is a member of the large family of SPASM domain radical SAM enzymes characterized by the presence of three [4Fe-4S] clusters. We also demonstrate that this enzyme initiates its reaction by Cα H-atom abstraction and is able to catalyze the formation of nonnatural thioether bonds in engineered peptide substrates. Unexpectedly, our data support the formation of a ketoimine rather than an α,β-dehydro-amino acid intermediate during Cα-thioether bridge LC–MS/MS fragmentation. Finally, we explored the roles of the leader peptide and of the RiPP precursor peptide recognition element, present in myriad RiPP-modifying enzymes. Collectively, our data support a more complex role for the peptide recognition element and the core peptide for the installation of posttranslational modifications in RiPPs than previously anticipated and suggest a possible reaction intermediate for thioether bond formation.




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Identification of a domain critical for Staphylococcus aureus LukED receptor targeting and lysis of erythrocytes [Molecular Bases of Disease]

Leukocidin ED (LukED) is a pore-forming toxin produced by Staphylococcus aureus, which lyses host cells and promotes virulence of the bacteria. LukED enables S. aureus to acquire iron by lysing erythrocytes, which depends on targeting the host receptor Duffy antigen receptor for chemokines (DARC). The toxin also targets DARC on the endothelium, contributing to the lethality observed during bloodstream infection in mice. LukED is comprised of two monomers: LukE and LukD. LukE binds to DARC and facilitates hemolysis, but the closely related Panton–Valentine leukocidin S (LukS-PV) does not bind to DARC and is not hemolytic. The interaction of LukE with DARC and the role this plays in hemolysis are incompletely characterized. To determine the domain(s) of LukE that are critical for DARC binding, we studied the hemolytic function of LukE–LukS-PV chimeras, in which areas of sequence divergence (divergence regions, or DRs) were swapped between the toxins. We found that two regions of LukE's rim domain contribute to hemolysis, namely residues 57–75 (DR1) and residues 182–196 (DR4). Interestingly, LukE DR1 is sufficient to render LukS-PV capable of DARC binding and hemolysis. Further, LukE, by binding DARC through DR1, promotes the recruitment of LukD to erythrocytes, likely by facilitating LukED oligomer formation. Finally, we show that LukE targets murine Darc through DR1 in vivo to cause host lethality. These findings expand our biochemical understanding of the LukE–DARC interaction and the role that this toxin-receptor pair plays in S. aureus pathophysiology.




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A drug-resistant {beta}-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency [Microbiology]

Lys234 is one of the residues present in class A β-lactamases that is under selective pressure due to antibiotic use. Located adjacent to proton shuttle residue Ser130, it is suggested to play a role in proton transfer during catalysis of the antibiotics. The mechanism underpinning how substitutions in this position modulate inhibitor efficiency and substrate specificity leading to drug resistance is unclear. The K234R substitution identified in several inhibitor-resistant β-lactamase variants is associated with decreased potency of the inhibitor clavulanic acid, which is used in combination with amoxicillin to overcome β-lactamase–mediated antibiotic resistance. Here we show that for CTX-M-14 β-lactamase, whereas Lys234 is required for hydrolysis of cephalosporins such as cefotaxime, either lysine or arginine is sufficient for hydrolysis of ampicillin. Further, by determining the acylation and deacylation rates for cefotaxime hydrolysis, we show that both rates are fast, and neither is rate-limiting. The K234R substitution causes a 1500-fold decrease in the cefotaxime acylation rate but a 5-fold increase in kcat for ampicillin, suggesting that the K234R enzyme is a good penicillinase but a poor cephalosporinase due to slow acylation. Structural results suggest that the slow acylation by the K234R enzyme is due to a conformational change in Ser130, and this change also leads to decreased inhibition potency of clavulanic acid. Because other inhibitor resistance mutations also act through changes at Ser130 and such changes drastically reduce cephalosporin but not penicillin hydrolysis, we suggest that clavulanic acid paired with an oxyimino-cephalosporin rather than penicillin would impede the evolution of resistance.




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Building a Fantasy Army — Strategy & Organization

This article is by Toni Šušnjar.

Strategy and Enemies

The structure of an army will depend on the strategy, as strategy will determine the army’s role and tasks. A state which carries out expansion through outright territorial conquest will have large numbers of heavy infantry, combat engineers and artillery, and possibly some heavy cavalry as well (e.g. Roman Empire, 10th century Byzantine Empire). If conquest is done by slowly destroying an opponent’s economic and social structures through constant raiding (such as chevauchee or razzia / ghazw), then majority of the army will be light cavalry, with some heavy cavalry support (e.g. Seljuk and Ottoman Empires), and light infantry will be used if terrain is unsuitable for cavalry. If a state is defending against cavalry raids, then light cavalry will be dominant (e.g. 15th century Hungary), whereas heavy cavalry will predominate if enemy raiders are primarily infantry. If enemy armies are too powerful to face in the field, light and heavy cavalry will be used to harass the invading army and cut off its supplies and foraging. In terrain unsuitable for cavalry operations, heavy infantry will be used instead.

Raiding — as a strategy — is generally preferred against a peer opponent, especially if a state cannot have a developed logistical support system.

Continue reading Building a Fantasy Army — Strategy & Organization at Mythic Scribes.




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Lessons from the UFC: How to Keep Blood-Sports Interesting

It sounds like an oxymoron: “How to keep blood-sports interesting?” You’ve got blood and you’ve got sports, the term does its own advertising! And yet, fighting promotions rise and fall, where Pride and Strikeforce once reigned, now stand One and Bellator, but one promotion stands above all its competitors. The world of MMA knows one promotion which has clawed its way to the international top and established itself as the gold standard upon whose hallowed surface skulls are crushed and blood is poured. I’m talking about none other than the UFC.

Having established itself over the years as a beacon of both quality matches and consistent drama, the UFC attracts the lion’s share of international talent in the MMA world, and with it the eyes and ears of MMA fans everywhere. Having well and truly stroked the ego of the promotion, you might be wondering what on earth any of this has to do with writing or fantasy?

Well, does your world happen to feature prizefighting, ritual combat, or the eternally popular fantasy fixture called the gladiatorial arena? If so, there are a lot of writing and worldbuilding lessons you can learn from observing the biggest promotion in the biggest modern blood-sport of the world.

Continue reading Lessons from the UFC: How to Keep Blood-Sports Interesting at Mythic Scribes.




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Questions for Worldbuilding the Concept of Wisdom

Wisdom to my mind is a bit of a paradox. It is subjective and context-dependent, but inherently universal. I say this, because for something to be wise it ought to be applicable across time and space, yet whether the claims are appraised as being “wise” hinges on the perception of a past, present or future audience. It is beyond the self, yet dependent upon the self. So that then begs the fantasy writing question: What if the self is not human? If culture already morphs the form and substance of wisdom, what effect might a different state of being have on it?

That would be terribly dull to prescribe, but I can help get some readers’ creativity going. Below I have listed relevant questions with examples you might consider when building your setting, so you may merrily thread into your fantastic realms to shape oddities rich and strange.

I would advise readers of this article to try and let go of their own presumptions on what is wise for the sake of worldbuilding. There are few cultures in our modern, human world whose philosophers deem obtuse narcissists dressed in mink robes as being wise, but why wouldn’t a race of bobcat-folk?

Continue reading Questions for Worldbuilding the Concept of Wisdom at Mythic Scribes.




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New essay anthology examines the future of the international order

New essay anthology examines the future of the international order News release jon.wallace 7 May 2021

Featuring a new essay by Robin Niblett, Chief Executive of Chatham House, and Leslie Vinjamuri, Director of the US and Americas programme.

Anchoring the World”, a new anthology, features an important new essay by Robin Niblett, Chief Executive of Chatham House, and Leslie Vinjamuri, Director of the US and Americas programme. The essay, “The Liberal Order Begins At Home”, argues powerfully for the revival of a liberal international order.

The essay collection has been produced by the Lloyd George Study Group on World Order, and celebrates the centennial years of Chatham House, Georgetown University’s School of Foreign Service, and the Council on Foreign Relations.

Robin Niblett said:

“In this excellent collection, some authors argue that the United Nations should continue to anchor the international system, while others argue for the creation of a new Concert of Powers.

“Our essay argues that it is both necessary and possible to revive the idea of a liberal international order: necessary (and urgent) because of heightened global competition with China, and possible only if western democracies repair their deep social and economic problems at home.

“We hope this volume carries forward the fortitude and creative spirit that the School of Foreign Service, Chatham House, and the Council on Foreign Relations have brought to the study and practice of international affairs over the past century.”

The Lloyd George Study Group and book were made possible by the generosity of the family of Robert Lloyd George, the great-grandson of British Prime Minister, David Lloyd George.

Anchoring the World is published by Foreign Affairs magazine.




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Cross-border conflict, evidence, policy and trends (XCEPT)

Cross-border conflict, evidence, policy and trends (XCEPT)

This five-year policy-focused research programme seeks to respond to the challenges of long-term cross-border conflicts by exploring the drivers behind them.

dora.popova 26 August 2021

Protracted conflicts in the Middle East and North Africa, Horn of Africa and parts of Asia, although usually arising from intra-state disputes, rarely remain contained within national borders. Their effects reverberate outward and external actors are drawn in.

The longer these wars last, the more difficult they are to resolve as the interests of international actors collide and the web of economic and political interactions which sustain violence and connect conflict across borders expand and deepen.

The Cross-border conflict, evidence, policy and trends (XCEPT) research programme brings together world-leading experts to examine conflict-affected borderlands, how conflicts connect across borders, and the drivers of violent and peaceful behaviour.

Chatham House provides research leadership to the programme, as part of the wider consortium, and our research explores:

  • the intersection of conflict supply chains which sustain and embed violence
  • coping supply chains for survival-based economic activity which occurs in the context of violence

Three geographic case studies will be supported by cross-cutting workstreams on gender and social inclusion, livelihoods, and border security. Each will produce analysis and recommendations to inform international policy responses to conflict across borders.

These case studies will focus on:

  • armed actors and financial flows through Iraq and the Levant
  • human smuggling across Libya, East and West Africa
  • gold mining and weapons flows across Sudanese borderlands

The consortium is made up of a range of other organizations, including the Asia Foundation, the Malcolm H. Kerr Carnegie Middle East Center, the Rift Valley Institute, Chemonics UK and King’s College London.

XCEPT is funded by UK Aid from the UK government.




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G20's lack of progress highlights challenge for COP26

G20's lack of progress highlights challenge for COP26 Expert comment NCapeling 1 November 2021

A positive outcome from the G20 summit was committing to end international financing for coal projects but, on other issues, the communique was ultimately weak.

Success at Glasgow depends on bridging fault lines

Renata Dwan

The G20 summit’s lack of progress on climate highlights the scale of the challenge – and the stakes – for COP26.  The countries responsible for 80 per cent of global emissions recognized but failed to agree concrete action to limit global warming to 1.5C.

The G20 might seem disappointing to some, but a lot will depend on expectations

This year’s G20 leaders’ summit marks a stark contrast with the past four years when much of the group’s energy was exhausted simply trying to maintain a consensus

But the principles are in the document, and mostly everyone turned up – if some by video. That is a good outcome for this kind of multilateralism in 2021. The G20 communique is a floor not a ceiling, and it’s a launching pad for activism and mobilisation by individual states, but also by corporates, civil society, and subnational actors. 

Now we need to hope that those on the right side of progress, whether on climate, health, or development, will use this language to drive forward concrete actions towards net zero, climate finance, vaccine distribution, and debt relief.

Specifics are for the most part missing

Creon Butler




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Chatham House appoints new director and chief executive

Chatham House appoints new director and chief executive News release jon.wallace 5 April 2022

Bronwen Maddox will take up the role at the end of August, succeeding Dr Robin Niblett CMG.

The Royal Institute of International Affairs (Chatham House) is delighted to announce that its new director and chief executive will be Bronwen Maddox, who joins from the Institute for Government.

Bronwen Maddox has been the director of the Institute for Government, an independent think tank based in London promoting better government, since September 2016. 

She joined the institute from the current affairs magazine Prospect, where she spent six years as editor and CEO.

Bronwen was previously foreign editor, chief foreign commentator and US editor at The Times, and before that, she ran award-winning investigations and wrote economics editorials for the Financial Times, after a career as an investment analyst in the City. She writes frequent op-ed columns for the Financial Times and broadcasts widely.

She is also visiting professor in the Policy Institute at King’s College London, a non-executive board member of the Law Commission, and has just been appointed a council member of Research England, one of the research councils of UK Research & Innovation.

Ms Maddox succeeds Dr Robin Niblett CMG who is standing down in the summer after 15 years in the role. She will take up the role at the end of August.

Chair of Chatham House, Sir Nigel Sheinwald said:

‘This is an exciting appointment for the future of Chatham House and for London as a global hub. Russia’s invasion of Ukraine and the unprecedented response of the rest of the world reminds us that organizations like Chatham House, with its outstanding record of independent analysis and new ideas on how to build a secure and prosperous world, are needed more than ever.

‘Bronwen Maddox has an international reputation as a compelling commentator and analyst on world affairs, with a proven ability to spot emerging issues and frame them in ways which will provoke intelligent debate and fresh thinking. She has provided successful and innovative leadership at the IFG, Prospect and The Times, and is committed to continuing to broaden Chatham House’s diverse appeal and impact. She is the ideal person to lead the institute into the next stage of its development at this crucial time for the future of international relations.’

Bronwen Maddox said:

‘I am honoured and delighted to become Chatham House’s next director. It’s a momentous period in international affairs and Chatham House, with its reputation for rigour, independence and expert analysis, has a unique role to play in assessing these changes and prompting solutions to confront them – as it shows every day. I look forward to the privilege of working with its teams, and the many others who have come together to advance its work.’

Sir Nigel also paid tribute to Dr Niblett:

‘Robin Niblett has transformed Chatham House in his fifteen years as its head. The institute’s research, activities and impact have grown considerably in that time thanks to Robin’s own high-quality commentary, his productive relationships with our stakeholders, partners, supporters and members and his commitment to the institute’s staff. He leaves an institute which has a much wider and fresher appeal and has strengthened London’s standing as a great centre for international affairs.’

Dr Niblett said:

‘This appointment is excellent news for Chatham House. Bronwen Maddox is ideally placed to ensure the institute continues to play its part in helping governments, business and civil society tackle the serious challenges we face, not just from the return of geopolitical competition and interstate conflict, but also from climate change, unsustainable economic activity and growing inequality, priorities for the institute that have been underlined by the COVID-19 pandemic.’




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Professor Sir Laurence Martin (1928-2022)

Professor Sir Laurence Martin (1928-2022) News release NCapeling 3 May 2022

Professor Sir Laurence Martin, director of Chatham House from 1991-96, has died aged 93.

Professor Sir Laurence Martin, director of Chatham House from 1991-96.

Professor Sir Laurence Martin was one of the UK’s leading experts on international security with a particular interest in nuclear strategy.

Before joining Chatham House, he was Professor of War Studies at King’s College, London and Vice Chancellor of Newcastle University. He was also appointed Deputy Lieutenant of Tyne and Wear as well as holding several distinguished professorships.

His most well-known work was Two-Edged Sword: Armed Forces in the Modern World which was also the subject of the BBC’s Reith Lectures he gave in 1981.

Sir Laurence led Chatham House as the world was entering the post-Cold War era, a time when international relations were in a state of flux which, as he wrote in International Affairs, provided grounds for optimism that ‘the objective conditions exist to eliminate violent and mutually harmful conflict at least between the major powers’.

Professor Martin worked hard to ensure the financial sustainability of the institute following the loss of core funding from the UK government in the 1980s. By modernizing its approach to fundraising, he was able to invest in a much-needed refurbishment of the House, as well as the institute’s first foray onto the internet.

This enabled Chatham House to communicate with new audiences beyond its members, event attendees, and readers of printed reports, The World Today magazine, and International Affairs journal. He paid particular attention to the need for the institute to communicate its ideas to those making policy as well as wider audiences.

In addition to strengthening the institute’s research, he was keen to continue engaging its members in discussions to develop a well- informed understanding of international affairs.

On the 75th anniversary of Chatham House in 1995, he wrote that its role was ’providing the evidence and, above all, encouraging the habit of mind, to facilitate prudent, if possible optimistic, but never utopian judgements about world affairs’. Today’s staff would agree this role remains at the heart of delivering the institute’s mission.

Selected works




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Mark Carney to chair Chatham House senior advisers

Mark Carney to chair Chatham House senior advisers News release NCapeling 17 May 2022

Former Bank of England Governor Mark Carney will succeed Sir John Major as chair of Chatham House’s Panel of Senior Advisers.

Chatham House is pleased to announce Mark Carney will succeed Sir John Major as chair of the institute’s Panel of Senior Advisers.

Chatham House senior advisers bring deep, first-hand experience of the policy and business worlds and use their experience, knowledge and networks to advise the institute’s research agenda and disseminate its policy ideas.

Mark Carney is currently United Nations (UN) Special Envoy on Climate Action and Finance, UK prime minister Boris Johnson’s special finance adviser on COP26, as well as vice chairman and head of transition investing at Brookfield Asset Management.

We are delighted to benefit from Mark Carney’s wealth of experience at the highest levels of decision-making on international financial policy, crisis management, and sustainability.

Robin Niblett, director and chief executive of Chatham House

He served as Governor of the Bank of England between 2013 and 2020 and as Governor of the Bank of Canada between 2008 and 2013.

Robin Niblett, director and chief executive of Chatham House says: ‘We are delighted to benefit from Mark Carney’s wealth of experience at the highest levels of decision-making on international financial policy, crisis management, and sustainability.

‘His personal commitment to leveraging economic and finance policies to combat climate change aligns with a central plank of the institute’s mission to help governments and societies build a sustainable future.

‘I also want to thank Sir John Major for his invaluable advice and support through such a pivotal time in the institute’s history; we are delighted that he will retain an affiliation as a President Emeritus of Chatham House.’

Sir Nigel Sheinwald, chair of Chatham House, says: ‘Mark Carney is perfectly placed to lead the institute’s Panel of Senior Advisers and help ensure our research is focused on improving international relations in practical ways.

‘His experience and expertise will be of great value as the institute undertakes a leadership transition and welcomes Bronwen Maddox as its new director in the autumn.

‘The Chatham House council greatly appreciates Mark Carney’s engagement in our future success, as we do Sir John’s commitment to the institute these past thirteen years.’

Mark Carney says: ‘I have long respected Chatham House as one of the world’s leading independent institutes on international policy and am honoured to take up the reins from Sir John Major of chairing its eminent Panel of Senior Advisers. Alongside other members of the panel, I look forward to contributing to the relevance and impact of Chatham House’s important work.’

In addition to having been Governor of the Bank of England and the Bank of Canada, Mark Carney also chaired the Financial Stability Board from 2011 to 2018 and, in 2015, established the Task Force on Climate Related Financial Disclosures.

In 2021, he launched the Glasgow Financial Alliance for Net Zero, to unite net-zero financial sector-specific alliances from across the world into one industry-wide strategic alliance.

Chatham House established the Panel of Senior Advisers in 2009, under Sir John’s Major’s chairmanship, to support the institute in achieving its mission to build a sustainably secure, prosperous and just world.

Individually and collectively, members of the panel support the institute in achieving its mission by advising on new topics for debate, offering input to the institute’s research, contributing to its private and public meetings, and disseminating the institute’s ideas across their networks.

The panel does not have governance responsibilities, which reside fully with the Chatham House council.




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How the world has changed on my watch

How the world has changed on my watch The World Today mhiggins.drupal 25 May 2022

As Robin Niblett steps down from his role as Director of Chatham House he reflects on the past 15 years of international affairs

International relations had resumed a steadier rhythm in January 2007 when I became Director of Chatham House. The aftershock of the 2001 terrorist attacks on the United States and the Bush administration’s contentious responses in Iraq and its ‘global war on terror’ had settled down somewhat.

With hindsight, 2007 was the fulcrum between a cautiously optimistic post-Cold War world and the contested environment we live in today

That year President George W Bush’s second administration was mending fences with its European allies. China’s GDP growth hit a three-decade peak of 14 per cent, and the idea that this could drive a ‘win-win’ economic cycle did not yet grate. Financial regulators had not woken up to the credit crisis that they had enabled. And the European Union was still obsessed with ‘widening versus deepening’, while Britain tried to have its cake and eat it on the sidelines.

With hindsight, 2007 acted as the fulcrum between a cautiously optimistic post-Cold War world and the contested environment we live in today. Russian President Vladimir Putin chose that year’s Munich Security Conference to deliver a tirade against the injustices of a US-led world, with arguments that presaged this year’s invasion of Ukraine.

By the start of 2008, Alan Greenspan’s belief in the rationality of financial markets turned out to be a fallacy as US and European banks imploded. The subsequent economic turmoil, followed by monetary easing and fiscal austerity, sowed the seeds for the populist politics that emerged on both sides of the Atlantic.

Robin Niblett with the Queen, Patron of Chatham House, and Sir John Major

Nevertheless, world leaders did not give up on the promise of international cooperation. The global financial crisis led to the elevation of the G20 as the premier forum for coordinating global economic policy between the world’s major economies.

By 2015, with Barack Obama in the White House, two landmark deals were reached: the Paris Agreement and the Joint Comprehensive Plan of Action, an example of truly global cooperation between all five permanent members of the UN Security Council. The next year, China’s first female chair of the Foreign Affairs Committee of the National People’s Congress, Fu Ying, pointed to a ‘decentralization of world power’ that might lead to a more inclusive world order.

But this sense of relative optimism about the future masked two fundamental changes. The first was the erosion of the cohesion of democratic societies under the pressures of globalization and the aftershocks of the financial crisis.

Instant access to unintermediated and often manipulated information ended up stimulating and polarizing societies in equal measure, deepening the divide between those searching for the certainties of the past and those open to the uncertainties of a more globalized future.

The second change is the end of the global hierarchy that followed the Second World War, in which the US and the West remained at the top, even with the advent of a more polycentric world. This change is driven by several factors, above all the growing economic and technological parity between China and the US, and by America’s schizophrenic response.

The Obama administration sought to restore a more inclusive form of global leadership, but it unwittingly revealed the limits of US power by breaking its red lines over Bashir al-Assad’s use of chemical weapons in Syria and by turning a blind eye to China’s takeover of disputed islands in the South China Sea. Donald Trump’s America First policies then flipped the US into an overbearing version of other self-interested powers. After this zigzagging by the US, leaders in the Middle East have developed their own assertive foreign policies, while two nascent democracies in Southeast Asia, Thailand and Myanmar, are again ruled by military juntas.

EU leaders became obsessed with the idea of strategic autonomy. And, although Joe Biden’s election was welcomed across most of Europe, it could not assuage concerns about the potentially transitory nature of his claim that ‘America is back’.

As I step down, I’m torn between fury at the senseless tragedy of the war in Ukraine and hope that human courage will sustain us

Putin has seized on this moment of transatlantic uncertainty and post-Covid navel-gazing to try to create a personal legacy as the leader who reunited a greater Russia out of the rubble of the Soviet Union. Instead, he has united Ukrainians and reunited the world’s liberal democracies in opposition to his brutal invasion and blatant rupture of international law. His actions have also drawn the contours of a new, trilateral international system.

Some 40 democracies across North America, Europe and the Indo-Pacific now see Putin and Xi Jinping – given China’s rhetorical support for Putin’s invasion – as interconnected threats to their long-term security. They are organizing to resist, using a re-energized Nato, new structures for Indo-Pacific cooperation and cross-linkages between these two spheres. For their part, Putin and Xi, though not formal allies, are tied together by each one’s need that the other survives and prospers while they are in confrontation with the liberal democracies.

The third, largest and most diverse group of countries are the newly non-aligned. India stands proudly in the foreground, but other major democracies such as Brazil, Indonesia and South Africa, and non-democracies such as Egypt and Vietnam, are triangulating strategically between the world’s dominant democratic and authoritarian poles. Multilateral institutions will be weaker as a result.

Portrait of Robin Niblett by Sarah Tanat-Jones

Does this more divided world presage major conflict between the great powers? Hopefully not; after all, nuclear weapons remain a potent deterrent. Does global division herald the end of economic globalization and of the international cooperation needed to manage shared global challenges? Not necessarily.

While Russia will be excluded from liberal democratic markets for as long as Putin is in the Kremlin, China’s reliance on global markets and the importance of its market to the world make it unlikely that we will return to a new Cold War. Global supply chains and foreign investment will be more tightly circumscribed than today, but they will persist. And international cooperation to combat climate change and manage the environment will continue.

Meanwhile, technological innovation will accelerate, opening new prospects for sustainable development and employment, even as it sharpens the facets of geopolitical competition. And we may soon cross the tipping point at which women hold a critical mass of positions of political and community leadership in many parts of the world. Given that male leaders are, once again, the instigators of the latest spasms of violence, a more gender-balanced approach to leadership holds the prospect of greater political stability and more inclusive and sustainable development.

As I step down as Chatham House Director, I find myself torn between fury at the senseless human tragedy of a drawn-out war in Ukraine and the way its spillover effects are devastating the welfare of hundreds of millions across the globe, and hope that human courage, resilience and ingenuity will nevertheless sustain us on the path to a better future.

I am reassured in this by the knowledge that Chatham House’s researchers, professional staff and increasingly diverse membership mean that it is well placed to help decision-makers and societies navigate this complex world.




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Europe should become the top priority for Liz Truss

Europe should become the top priority for Liz Truss Expert comment NCapeling 3 September 2022

Liz Truss has the chance to be a better prime minister than Boris Johnson was, not least in the UK’s foreign policy.

For all the smoke-and-mirrors talk now commonplace about Brexit opportunities, there is real potential that Liz Truss could extract from the aftermath of that upheaval as well as from the turmoil in the world.

But the approach and priorities she revealed during her one year as a better UK foreign secretary than Boris Johnson was – although he did set a low bar – as well as the past three months campaigning for the leadership of her party contain a warning.

She has shown a willingness to aggravate relationships with allies in pursuit of the support of her party faithful, and of a vision of British independence as well as a tendency to dismiss economic analysis when it inconveniently questions her assertions about favoured policies.

At the heart of her political identity is a notion which is both a strength and a potentially calamitous weakness – a love of the notion of being a disrupter which injects a deliberate unpredictability into her approach towards a world in extreme flux.

If she indulges this without good judgment, she could do real damage to Britain’s prospects and standing in the world.

Ukraine and the energy crisis

In foreign policy, Europe should be her starting point and the opportunity here for the UK is clear. The war in Ukraine and crisis in the cost of energy gives it a role – despite having left the European Union (EU) – in talking to EU governments about the future of the continent on many fronts.

Johnson’s emphatic support of President Zelensky gave the UK a position of moral and strategic clarity which Truss can build on through what will be an exceptionally difficult winter for Europe’s governments.

At the heart of her political identity is a notion which is both a strength and a potentially calamitous weakness – a love of the notion of being a disrupter

She is in a position to persuade European leaders to remain united in Ukraine’s support while planning better how they are going to source energy. She could expand on that to help the EU find a way through its many other problems, such as upholding democratic values throughout the bloc or finding a response to migration.

There is also a chance for the UK to shape Europe’s thinking on the development and regulation of digital technology and medicine, energy, and the environment.

Truss’s declaration that the UK should now spend three per cent of its GDP on defence could help her in taking that kind of role. However this campaign declaration is not yet credible, given the pressures on the national finances and her silence so far on support for households on energy costs.

But that is the opportunity in theory and the signs are this is not her approach to Europe. Her provocative and opportunistic comment that the ‘jury’s out’ on whether President Macron (and France) was a friend or foe shocked both Britain’s allies and opponents.

For those keen to see divisions among democracies, it gave unexpected, heady encouragement, and to those within those countries, it injected a doubt about shared values which was deeply damaging. The chilly poise of Macron’s response – that the UK and France would always be allies – showed how far she had departed from normal protocol.

The episode encapsulated one of the sources of unease about the Truss style – improvisation under the banner of ‘disruption’ without thought of consequences.

Her instinctive liking for the US will help Truss in relations with Washington at a difficult time, and her apparent intention to designate China as ‘a threat’ will support that relationship too

However, she has shown consistency over the Northern Ireland Protocol with little sign of compromise, and that alone could cause much unnecessary damage to UK interests. It also puts her on a collision course with the EU and the UK House of Lords, due to consider controversial legislation again in early October after the Conservative party conference.

There is huge opposition in the Lords to two aspects of the legislation. The first target is the intention of the Johnson government – likely to be repeated by a Truss government – to use the bill to jettison aspects of the protocol, which many argue breaks international law. The second is the delegated power the bill would give ministers.

The cost of a new, serious clash – or worse, a full trade war – with the EU is high. There is the loss of trade, the increase in friction for business, which is consistently underestimated by the UK government, and the loss of scientific and research partnerships.

More than that, though, there is the weakening of ties to a set of allies with common values sharing an increasingly troubled neighbourhood.

US, China, and others remain important

And to say Europe should come first is not to dismiss other claims on the UK’s foreign policy. Her instinctive liking for the US will help Truss in relations with Washington at a difficult time, and her apparent intention to designate China as ‘a threat’ will support that relationship too.




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Independent Thinking: China protests, North Korea missile tests

Independent Thinking: China protests, North Korea missile tests Audio NCapeling 1 December 2022

Episode seven of our new weekly podcast examines the civil unrest in China and the ongoing development of North Korea’s nuclear weapons programme.



Anti-lockdown protests are sweeping the cities of Beijing, Shanghai, and Guangzhou. What does the unrest say about China’s response to COVID-19? How serious a challenge is it to Xi Jinping’s legitimacy so soon after the Party Congress?

Meanwhile, 2022 has been a record year for Pyongyang’s ballistic missile launches. How far has North Korea’s nuclear programme and its missile systems developed, and what does it mean for the country’s neighbours?

Joining Bronwen Maddox in the studio this week from the Chatham House Asia-Pacific programme are its director Ben Bland and senior research fellow Dr Yu Jie. Joining the panel is special guest Ankit Panda, the Stanton senior fellow at the Carnegie Endowment for International Peace, and editor-at-large for The Diplomat magazine.

About Independent Thinking

A weekly podcast hosted by Chatham House director Bronwen Maddox, in conversation with leading policymakers, journalists, and Chatham House experts providing insight on the latest international issues.




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Independent Thinking: Reporting Putin’s wars

Independent Thinking: Reporting Putin’s wars Audio NCapeling 8 December 2022

Episode eight of our new weekly podcast reflects on almost one year of war in Ukraine, and 12 years of war in Syria.

In the studio with Bronwen Maddox is special guest Oz Katerji, a war correspondent and freelance journalist who in the early stages of the Syrian uprising reported on the brutality of the regime of Bashar al-Assad and its impact on neighbouring Lebanon and Turkey.

Having written extensively on Syria and the Middle East, in January 2022 he journeyed to Ukraine and was in Kyiv on 24 February as Russia began its invasion. He has reported extensively on the battle for Ukraine’s capital, and later the Donbas, in Foreign Policy magazine, the New Statesman and Rolling Stone.

Joining Bronwen and Oz to discuss the conflicts in Ukraine and Syria from Chatham House are James Nixey, director of the Russia and Eurasia programme, and Lina Khatib, director of the Middle East and North Africa programme.




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Independent Thinking: Western tanks head for Ukraine

Independent Thinking: Western tanks head for Ukraine Audio NCapeling 26 January 2023

Episode 12 of our weekly podcast analyses the deployment of international battle tanks to Ukraine and the contentious diplomacy putting pressure on Germany.

The panel examines what kind of capabilities will new weapons give to Ukraine amid fears of a new Russian offensive looming in the spring, and the intense pressure Olaf Scholz’s German government has been under since the invasion of Ukraine started.

How has Germany’s standing changed over the past 12 months, and what are the challenges facing the country in its relations with Russia as a long and cold winter sets in?   

Joining Bronwen Maddox this week from Chatham House are Orysia Lutsevych, head of the Ukraine Forum, and Marion Messmer, senior research fellow in the International Security programme, along with Jeremy Cliffe, writer-at-large for The New Statesman magazine, and Ed Arnold, research fellow for European security at the Royal United Services Institute (RUSI).

About Independent Thinking

A weekly podcast hosted by Chatham House director Bronwen Maddox, in conversation with leading policymakers, journalists, and Chatham House experts providing insight on the latest international issues.