Biomater. Sci., 2024, 12,1716-1725
DOI: 10.1039/D3BM01981K, Paper

Zhongming Huang, Tongren Yang, Jie Yu, Yijian Gao, Yuhua Weng, Yuanyu Huang, Shengliang Li
Through molecular screening, ionic liquid-conjugated polymers (IL-CPs) are developed for highly efficient delivery of CRISPR/Cas9 system, which demonstrated high-performance genome editing-based tumor therapy.
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Biomater. Sci., 2024, 12,1707-1715
DOI: 10.1039/D3BM01765F, Paper

Andrew C. Murphy, Heidi F. Oldenkamp, Nicholas A. Peppas
This article demonstrates an inverse emulsion scheme to polymerize a variety of ionizable and non-ionizable monomers to form stimuli-responsive nanoparticles with potential applications in biomaterials science.
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Biomater. Sci., 2024, 12,1630-1642
DOI: 10.1039/D3BM02026F, Review Article

Beilei Sun, Limin Zhang, Mengzhen Li, Xin Wang, Weizhi Wang
To meet the precise diagnosis and treatment as well as reduce systemic toxicity and side effects, self-assembled peptides are applied to the targeting therapy, including targeting theranostics, nanocarrier delivery, immunotherapy, and combination therapy.
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Biomater. Sci., 2024, 12,1726-1737
DOI: 10.1039/D3BM01767B, Paper

Zichun Gao, Yixuan Liu, Wenjiao Lin, He Lian, Zhaoxu Meng
Hyaluronic acid microneedles loaded with polydopamine nanoparticles induce fat browning, offering innovative localized obesity treatment.
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Biomater. Sci., 2024, 12,1693-1706
DOI: 10.1039/D3BM02012F, Paper

Subin Jeong, Hyeon-Min Nam, Gun Yong Sung
We report spheroids prepared by injecting LEF1 and Wnt1 into DPCs via transfection and then adding KCs and HUVECs. Through SEM, we observed a part extending outward from the TK and TKH surfaces, as indicated by white arrows.
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Biomater. Sci., 2024, 12,1883-1897
DOI: 10.1039/D3BM01793A, Paper

Yunji Sun, Chang Su, Jinfeng Liu, Zheng He, Shengting Che, Qinglan Wan, Jingyu Cai, Hao Zhan, Chao Feng, Xiaojie Cheng, Feng Lin, Junqiang Wei, Xiguang Chen
Diatom hemostatic particles prepared by one-pot reaction have streamlined process and mass production potential, can significantly stop bleeding and reduce accidental deaths.
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Biomater. Sci., 2024, 12,1750-1760
DOI: 10.1039/D3BM01904G, Paper

Xinyi Long, Qian Yuan, Rui Tian, Wanting Zhang, Lang Liu, Minghui Yang, Xin Yuan, Zhujie Deng, Quanjiang Li, Ronghui Sun, Yuyi Kang, Yingying Peng, Xiubin Kuang, Lingfang Zeng, Zhengqiang Yuan
An alginate hydrogel loaded with mesenchymal stem-cell-derived extracellular vesicles (EVs) and a 7-amino-acid peptide (7A) constitutes a novel dressing for efficient healing of diabetic wounds with anti-inflammation and pro-angiogenesis mechanisms.
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Biomater. Sci., 2024, 12,1847-1863
DOI: 10.1039/D3BM02072J, Paper

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Beom-Seok Kim, Jeong-Uk Kim, Jae Woo Lee, Kyung Min Ryu, Rachel H. Koh, Kyoung-Ha So, Nathaniel S. Hwang
The supercritical (SC) fluid-based method were utilized for nerve tissue decellualrization. In vitro, vivo assessments underscore its potential for advanced tissue engineering and regenerative applications.
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Biomater. Sci., 2024, 12,1662-1692
DOI: 10.1039/D3BM01451G, Review Article

Qiao Li, Yuan Lianghao, Gao Shijie, Wang Zhiyi, Tang Yuanting, Chen Cong, Zhao Chun-Qin, Fu Xianjun
In this review, we have summarized the common self-assembled mechanism of NSMs-based SANDDSs. Meanwhile, the potential applications for cancer treatment and future development prospects are also prospected.
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Biomater. Sci., 2024, 12,1738-1749
DOI: 10.1039/D3BM01849K, Paper

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Gauthier Menassol, Boudewijn van der Sanden, Laetitia Gredy, Capucine Arnol, Thibaut Divoux, Donald K. Martin, Olivier Stephan
Immediate care of skin wounds and burns is essential to repair this mechanical and chemical barrier to infections.
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Biomater. Sci., 2024, 12,1788-1800
DOI: 10.1039/D4BM00034J, Paper

Jingjing Cheng, Haixin Zhang, Kunyan Lu, Yi Zou, Dongxu Jia, Hong Yang, Hong Chen, Yanxia Zhang, Qian Yu
A bi-functional antibiofilm nanoplatform was developed based on a complex of quercetin and copper integrating bactericidal and anti-quorum sensing properties.
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Biomater. Sci., 2024, 12,1871-1882
DOI: 10.1039/D3BM01922E, Paper

Meng Zhang, Hongjin Xue, Jiaxin Yang, Xin Zhao, Mei Xue, Wei Sun, Jianfeng Qiu, Zhihong Zhu
A Cu/ZIF-8/Vc-Ca/HA nanosystem synchronously releases Fenton catalytic Cu²⁺ and Vc-Ca to achieve improved chemodynamic therapy via H₂O₂ self-supply and GSH depletion.
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Biomater. Sci., 2024, 12,1822-1840
DOI: 10.1039/D3BM01931D, Paper

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Robert J. Cavanagh, Patrícia F. Monteiro, Cara Moloney, Alessandra Travanut, Fatemeh Mehradnia, Vincenzo Taresco, Ruman Rahman, Stewart G. Martin, Anna M. Grabowska, Marianne B. Ashford, Cameron Alexander
Combinations of the topoisomerase II inhibitor doxorubicin and the poly (ADP-ribose) polymerase inhibitor olaparib offer potential drug–drug synergy for treatment of triple negative breast cancers (TNBC) both in free drug form and when delivered by oxidation-responsive nanoparticles.
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Biomater. Sci., 2024, 12,1617-1629
DOI: 10.1039/D3BM01894F, Review Article

Mengjun Huang, Qiliang Teng, Fei Cao, Jinsheng Huang, Jun Pang
Existing treatments could be sensitized by targeting the ferroptosis pathway in prostate cancer.
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Biomater. Sci., 2024, 12,1761-1770
DOI: 10.1039/D3BM02035E, Paper

Hao Deng, Yuheng Jiang, Junhao Deng, Feifan Chang, Junyu Chen, Xinyu Sun, Dongliang Cheng, Zhongqi Wang, Ran Li, Jiang Liu, Yi Li, Licheng Zhang, Pengbin Yin
Extracellular vesicles (EVs) produced by 3D-cultured MSCs can modulate macrophage activation through ANXA1, thereby promoting wound healing.
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Biomater. Sci., 2024, 12,1801-1821
DOI: 10.1039/D3BM01688A, Paper

Manju Sharma, Samraggi Choudhury, Anand Babu, Varun Gupta, Dipanjan Sengupta, Syed Afroz Ali, Mrunali D. Dhokne, Ashok Kumar Datusalia, Dipankar Mandal, Jiban Jyoti Panda
The graphical abstract portraying the utility of peizoactive polydopamine-coated PVDF nanospheres as potential therapeutic modalities for Alzheimer's disease. The nanospheres induced fibril disaggregation and neuroprotection upon acoustic activation in neural cells and animal model.
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Biomater. Sci., 2024, 12,1914-1923
DOI: 10.1039/D3BM01675G, Paper

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Pei Wei, Lijiao Wu, Hongteng Xie, Zhaohong Chen, Rongwei Tan, Zhaorong Xu
A novel meshed ADS combined with NPWT can reduce the risk of scaffold-related complications, which helps to improve the quality of wound repair and promotes a broader range of applications.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM01875J, Review Article

Yingxue Jiang, Chenhui Zhu, Xiaoxuan Ma, Daidi Fan
In recent years, the design and synthesis of Janus hydrogels have advanced significantly, overcoming single-performance material limitations and broadening applications in tissue engineering and regenerative medicine.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM01338C, Review Article

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Adam Shearer, Matthew Molinaro, Maziar Montazerian, Jessica J. Sly, Marta Miola, Francesco Baino, John C. Mauro
Alkali and alkaline earth elements play a crucial role in the structure, processing, and properties of bioactive glasses, widely used in medical applications since their inception in 1969.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM02111D, Paper

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Hohyeon Han, Minji Kim, Uijung Yong, Yeonggwon Jo, Yoo-mi Choi, Hye Jin Kim, Dong Gyu Hwang, Dayoon Kang, Jinah Jang
This study introduces gelatinized dECM, a tissue-specific rheological modifier, enabling high-resolution printing of flexible tissue constructs with enhanced resilience.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00061G, Paper

Hang Ren, Peng Wang, Hanwen Huang, Junshen Huang, Yuheng Lu, Yanfeng Wu, Zhongyu Xie, Youchen Tang, Zhaopeng Cai, Huiyong Shen
Modified Ti with a porous N-halaminated spermidine-containing polymeric coating is constructed, and it has both excellent antibacterial and osteogenic abilities to enhance osseointegration, making it potentially applicable in orthopedics.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00155A, Review Article

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Yungang Hu, Lu Yu, Qiang Dai, Xiaohua Hu, Yuming Shen
Due to their distinctive physical and chemical properties as well as their biological functionalities, multifunctional antibacterial hydrogels possess significant advantages in the treatment of chronic wounds.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00159A, Paper

Shulei Zhang, Bo Zheng, Yiqi Wei, Yuhao Liu, Lan Yang, Yujiao Qiu, Jing Su, Mingfeng Qiu
Breast cancer, a pervasive malignancy affecting women, demands a diverse treatment approach including chemotherapy, radiotherapy, and surgical interventions.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D3BM01900D, Paper

Veronika Sarnatskaya, Yuliia Shlapa, Denis Kolesnik, Olexandra Lykhova, Dmytro Klymchuk, Serhii Solopan, Svitlana Lyubchyk, Iuliia Golovynska, Junle Qu, Yurii Stepanov, Anatolii Belous
Nano-dispersed cerium dioxide is promising for use in medicine due to its unique physicochemical properties, low toxicity, the safety of in vivo usage, active participation in different redox processes occurring in living cells, and its regenerative potential.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM90027H, Correction

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Safieh Boroumand, Faraz Sigaroodi, Seyed Mohsen Ahmadi Tafti, Keyvan Khoshmaram, Masoud Soleimani, Mohammad-Mehdi Khani
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM90029D, Correction

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Ee Taek Hwang, Yeahwa Yoon, Ka Ram Kim, Chan Hee Lee, Kyung Chan Jeon, Ji Ho Min, Jae Won Lee, Jangyong Kim
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM90028F, Correction

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Keqin Ji, Mingrui Fan, Dong Huang, Lingna Sun, Bingqin Li, Ruoting Xu, Jiajing Zhang, Xuan Shao, Yanzuo Chen
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00357H, Paper

Bin Zhang, Rui Yang, Hongwei Yu, Yamin Peng, Haoyu Huang, Meera Moydeen Abdul Hameed, Han Wang, Guixiang Zhang, Mohamed EL-Newehy, Mingwu Shen, Xiangyang Shi, Shaojun Peng
Macrophage membrane-camouflaged nanoclusters of ultrasmall iron oxide nanoparticles can be developed to cross the blood–brain barrier for magnetic resonance imaging and chemo/chemodynamic therapy.
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Biomater. Sci., 2024, Advance Article
DOI: 10.1039/D4BM00158C, Paper

Yiduo Chen, Yirong Guo, Xinyi Li, Yanchen Chen, Jiarong Wang, Honglin Qian, Jing Wang, Youxiang Wang, Xinyang Hu, Jian'an Wang, Jian Ji
Three surface-initiated hydrogel coatings (pMPC, pAMPS, pHEMA) are constructed on polymeric heart valves. The zwitterionic pMPC coating displays optimal performances, including durable anti-coagulation, anti-inflammation, and anti-calcification.
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Biomater. Sci., 2024, 12,1950-1964
DOI: 10.1039/D3BM01733H, Review Article

Mingjun Xie, Ji Wang, Sufan Wu, Sheng Yan, Yong He
This review introduces different methods used to generate microgels and the microgel-based bioink for bioprinting. Besides, the further tendency of microgel development in future is predicted.
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Biomater. Sci., 2024, 12,2041-2056
DOI: 10.1039/D3BM01674A, Paper

David A. McBride, James S. Wang, Wade T. Johnson, Nunzio Bottini, Nisarg J. Shah
The study develops a computational framework to model factors that lead to the evolution of autoreactive T cells in inflammatory arthritis. The results provide a tool for planning immunomodulatory strategies focused on new disease-modifying agents.
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Biomater. Sci., 2024, 12,2121-2135
DOI: 10.1039/D3BM01901B, Paper

Ruideng Wang, Xi He, Zhengyang Chen, Shilong Su, Jinwu Bai, Haifeng Liu, Fang Zhou
A photo-crosslinked nanocomposite hydrogel was prepared by incorporating an osteo-inductive inorganic nanoparticle for endogenous bone regeneration.
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Biomater. Sci., 2024, 12,1981-2006
DOI: 10.1039/D3BM01841E, Review Article

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Ali Zareein, Mina Mahmoudi, Shruti Sunil Jadhav, Joel Wilmore, Yaoying Wu
Biomaterials enhance B cell immunity by modulating the delivery approach, crosslinking B cell receptors, and promoting T cell help, while inhibitory co-receptor engagement via biomaterial design suppresses B cell function.
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Biomater. Sci., 2024, 12,2096-2107
DOI: 10.1039/D4BM00125G, Paper

Yimeng Zhao, Xuefei Lv, Yu Chen, Chen Zhang, Di Zhou, Yulin Deng
Neuroinflammatory response on a novel combinatorial cell–cell interaction chip.
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Biomater. Sci., 2024, 12,2019-2032
DOI: 10.1039/D3BM02070C, Review Article

Zheng Wang, Zilong Chen, Zhenhao Zhang, Hongzhen Wang, Haichang Zhang
Organic fluorescent materials (OFMs) play a crucial role in the development of biosensors, enabling the extraction of biochemical information within cells and organisms, extending to the human body.
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Biomater. Sci., 2024, 12,1943-1949
DOI: 10.1039/D3BM02008H, Minireview

Yang Song
Biological liquid–liquid phase separation (LLPS) provides novel insights for the assembly of biomaterials with tailored structure and intrinsic functionality.
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Biomater. Sci., 2024, 12,2067-2085
DOI: 10.1039/D3BM01466E, Paper

Akansha Dixit, Aman Mahajan, Rakshita Saxena, Saptomee Chakraborty, Dhirendra S. Katti
In this study, we combined the β-sheet mediated self-stiffening ability of silk with growth factor presenting ability of sulphated carboxymethyl cellulose in an injectable interpenetrating network hydrogel for repair of articular cartilage defects.
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Biomater. Sci., 2024, 12,2108-2120
DOI: 10.1039/D3BM02107F, Paper

Oscar Ceballos-Sanchez, Diego E. Navarro-López, Jorge L. Mejía-Méndez, Gildardo Sanchez-Ante, Vicente Rodríguez-González, Angélica Lizeth Sánchez-López, Araceli Sanchez-Martinez, Sergio M. Duron-Torres, Karla Juarez-Moreno, Naveen Tiwari, Edgar R. López-Mena
The antioxidant capabilities of nanoparticles are contingent upon various factors, including their shape, size, and chemical composition.
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Biomater. Sci., 2024, 12,2136-2148
DOI: 10.1039/D3BM01912H, Paper

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Edina Sehic, Lucía de Miguel Gómez, Hardis Rabe, Emy Thorén, Ingigerdur Gudmundsdottir, Mihai Oltean, Randa Akouri, Mats Brännström, Mats Hellström
Innovative bioengineering strategies utilizing extracellular matrix (ECM) based scaffolds derived from decellularized tissue offer new prospects for restoring damaged uterine tissue.
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Biomater. Sci., 2024, 12,2033-2040
DOI: 10.1039/D4BM00004H, Review Article

Yifan Zheng, Yudi Du, Ling Chen, Wei Mao, Yuan Pu, Steven Wang, Dan Wang
Shape memory polymers (SMPs), which initiate shape transformation in response to environmental stimuli, have attracted significant attention in both academic research and technological innovation.
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