es Clinical, Pathologic, and Imaging Variables Associated with Prostate Cancer Detection by PSMA PET/CT and Multiparametric MRI By jnm.snmjournals.org Published On :: 2024-10-30T08:04:14-07:00 Visual Abstract Full Article
es FAP and PSMA Expression by Immunohistochemistry and PET Imaging in Castration-Resistant Prostate Cancer: A Translational Pilot Study By jnm.snmjournals.org Published On :: 2024-10-30T08:04:15-07:00 Visual Abstract Full Article
es Oncologist, Business Leader, and Investor Arie S. Belldegrun Discusses a Career in Innovative Medical Entrepreneurship: A Conversation with Ken Herrmann and Johannes Czernin By jnm.snmjournals.org Published On :: 2024-10-30T08:04:15-07:00 Full Article
es Feasibility, Tolerability, and Preliminary Clinical Response of Fractionated Radiopharmaceutical Therapy with 213Bi-FAPI-46: Pilot Experience in Patients with End-Stage, Progressive Metastatic Tumors By jnm.snmjournals.org Published On :: 2024-10-30T08:04:15-07:00 Visual Abstract Full Article
es SPECT/CT in Early Response Assessment of Patients with Metastatic Castration-Resistant Prostate Cancer Receiving 177Lu-PSMA-617 By jnm.snmjournals.org Published On :: 2024-11-07T04:28:32-08:00 Visual Abstract Full Article
es Changed Regulation Enables Pragmatic Solution for Cancer Patients By jnm.snmjournals.org Published On :: 2024-11-07T04:28:32-08:00 Full Article
es SophosAI team presents three papers on AI applied to cybersecurity at CAMLIS By news.sophos.com Published On :: Wed, 23 Oct 2024 15:02:39 +0000 On October 24 and 25, SophosAI presents ideas on how to use models large and small—and defend against malignant ones. Full Article AI Research AI Trojans anti-phishing CAMLIS featured Google LLM small model machine learning
es Sophos Firewall hardening best practices By news.sophos.com Published On :: Fri, 25 Oct 2024 12:41:06 +0000 Make the most of your Sophos Firewall. Full Article Products & Services Firewall network Pacific Rim Defense
es From the frontlines: Our CISO’s view of Pacific Rim By news.sophos.com Published On :: Thu, 31 Oct 2024 12:41:21 +0000 On beyond “Detect and Respond” and “Secure by Design” Full Article Security Operations Pacific Rim Pacific Rim thought leadership Sophos X-Ops
es Re: Voluntary assisted death: how to ensure access and safety By www.bmj.com Published On :: Monday, November 11, 2024 - 22:52 Full Article
es "Questioning the Quantifiable: Are We Measuring What Matters in Heart Failure Care?" By www.bmj.com Published On :: Tuesday, November 12, 2024 - 10:10 Full Article
es Overdose crisis: more common sense and less ideology By www.bmj.com Published On :: Tuesday, November 12, 2024 - 10:55 Full Article
es Addressing Climate Catastrophe Concerns in Asthma Medication Delivery: Rethinking Inhaler Use for Environmental and Clinical Efficacy By www.bmj.com Published On :: Tuesday, November 12, 2024 - 13:24 Full Article
es Re: Scandal of “newborn gang” that put profits ahead of babies’ lives rocks Turkey’s health system By www.bmj.com Published On :: Tuesday, November 12, 2024 - 14:09 Full Article
es Re: Scandal of “newborn gang” that put profits ahead of babies’ lives rocks Turkey’s health system By www.bmj.com Published On :: Tuesday, November 12, 2024 - 14:09 Full Article
es Re: Scandal of “newborn gang” that put profits ahead of babies’ lives rocks Turkey’s health system By www.bmj.com Published On :: Tuesday, November 12, 2024 - 14:09 Full Article
es Re: Scandal of “newborn gang” that put profits ahead of babies’ lives rocks Turkey’s health system By www.bmj.com Published On :: Tuesday, November 12, 2024 - 14:09 Full Article
es Re: Decompression alone or with fusion for degenerative lumbar spondylolisthesis (Nordsten-DS): five year follow-up of a randomised, multicentre, non-inferiority trial By www.bmj.com Published On :: Tuesday, November 12, 2024 - 16:16 Full Article
es A Comprehensive Gender-related Secretome of Plasmodium berghei Sexual Stages By www.mcponline.org Published On :: 2020-12-01 Felicia GrassoDec 1, 2020; 19:1986-1996Research Full Article
es Citrus Vascular Proteomics Highlights the Role of Peroxidases and Serine Proteases during Huanglongbing Disease Progression By www.mcponline.org Published On :: 2020-12-01 Jessica Y. FrancoDec 1, 2020; 19:1936-1951Research Full Article
es Novel Proteomic Profiling of Epididymal Extracellular Vesicles in the Domestic Cat Reveals Proteins Related to Sequential Sperm Maturation with Differences Observed between Normospermic and Teratospermic Individuals By www.mcponline.org Published On :: 2020-12-01 Tricia RowlisonDec 1, 2020; 19:2090-2103Research Full Article
es Stoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry By www.mcponline.org Published On :: 2020-12-01 Yadong YuDec 1, 2020; 19:1997-2014Research Full Article
es Identification of novel serological autoantibodies in Takayasu arteritis patients using HuProt arrays By www.mcponline.org Published On :: 2020-12-17 Xiao-Ting WenDec 17, 2020; 0:RA120.002119v1-mcp.RA120.002119Research Full Article
es Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands By www.mcponline.org Published On :: 2020-12-28 Kyle SwovickDec 28, 2020; 0:RA120.002301v1-mcp.RA120.002301Research Full Article
es OpenPepXL: An Open-Source Tool for Sensitive Identification of Cross-Linked Peptides in XL-MS By www.mcponline.org Published On :: 2020-12-01 Eugen NetzDec 1, 2020; 19:2157-2167Technological Innovation and Resources Full Article
es Kinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 as Candidate Therapeutic Target By www.mcponline.org Published On :: 2020-12-01 Alison M. KurimchakDec 1, 2020; 19:2068-2089Research Full Article
es Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation By www.mcponline.org Published On :: 2020-12-01 Litong NieDec 1, 2020; 19:2015-2029Research Full Article
es Identification of Microorganisms by Liquid Chromatography-Mass Spectrometry (LC-MS1) and in Silico Peptide Mass Libraries By www.mcponline.org Published On :: 2020-12-01 Peter LaschDec 1, 2020; 19:2125-2138Technological Innovation and Resources Full Article
es CMMB (Carboxylate Modified Magnetic Bead) -based isopropanol gradient peptide fractionation (CIF) enables rapid and robust off-line peptide mixture fractionation in bottom-up proteomics By www.mcponline.org Published On :: 2020-12-22 Weixian DengDec 22, 2020; 0:RA120.002411v1-mcp.RA120.002411Research Full Article
es Systematic identification of P. falciparum sporozoite membrane protein interactions reveals an essential role for the p24 complex in host infection By www.mcponline.org Published On :: 2020-12-22 Julia KnöckelDec 22, 2020; 0:RA120.002432v1-mcp.RA120.002432Research Full Article
es On the robustness of graph-based clustering to random network alterations By www.mcponline.org Published On :: 2020-11-04 R. Greg StaceyNov 4, 2020; 0:RA120.002275v1-mcp.RA120.002275Research Full Article
es Thyroglobulin interactome profiling defines altered proteostasis topology associated with thyroid dyshormonogenesis By www.mcponline.org Published On :: 2020-11-18 Madison T WrightNov 18, 2020; 0:RA120.002168v1-mcp.RA120.002168Research Full Article
es Proteome analysis reveals a significant host-specific response in Rhizobium leguminosarum bv viciae endosymbiotic cells By www.mcponline.org Published On :: 2020-11-19 David DuránNov 19, 2020; 0:RA120.002276v1-mcp.RA120.002276Research Full Article
es A proteomics-based assessment of inflammation signatures in endotoxemia By www.mcponline.org Published On :: 2020-12-07 Sean A BurnapDec 7, 2020; 0:RA120.002305v1-mcp.RA120.002305Research Full Article
es A potential role for the Gsdf-eEF1{alpha} complex in inhibiting germ cell proliferation: A protein-interaction analysis in medaka (Oryzias latipes) from a proteomics perspective By www.mcponline.org Published On :: 2020-12-08 Xinting ZhangDec 8, 2020; 0:RA120.002306v1-mcp.RA120.002306Research Full Article
es Proteogenomic characterization of the pathogenic fungus Aspergillus flavus reveals novel genes involved in aflatoxin production By www.mcponline.org Published On :: 2020-11-24 Mingkun YangNov 24, 2020; 0:RA120.002144v1-mcp.RA120.002144Research Full Article
es Quantitative proteomics reveal neuron projection development genes ARF4, KIF5B and RAB8A associated with Hirschsprung disease By www.mcponline.org Published On :: 2020-11-17 Qin ZhangNov 17, 2020; 0:RA120.002325v1-mcp.RA120.002325Research Full Article
es Proteomic analyses identify differentially expressed proteins and pathways between low-risk and high-risk subtypes of early-stage lung adenocarcinoma and their prognostic impacts By www.mcponline.org Published On :: 2020-11-30 Juntuo ZhouNov 30, 2020; 0:RA120.002384v1-mcp.RA120.002384Research Full Article
es A proteomic approach to understand the clinical significance of acute myeloid leukemia-derived extracellular vesicles reflecting essential characteristics of leukemia By www.mcponline.org Published On :: 2020-11-30 Ka-Won KangNov 30, 2020; 0:RA120.002169v1-mcp.RA120.002169Research Full Article
es Prediction and validation of mouse meiosis-essential genes based on spermatogenesis proteome dynamics By www.mcponline.org Published On :: 2020-11-30 Kailun FangNov 30, 2020; 0:RA120.002081v1-mcp.RA120.002081Research Full Article
es The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases By www.mcponline.org Published On :: 2020-12-02 Ryan J LumpkinDec 2, 2020; 0:RA120.002414v1-mcp.RA120.002414Research Full Article
es Imaging Mass Spectrometry and Lectin Analysis of N-linked Glycans in Carbohydrate Antigen Defined Pancreatic Cancer Tissues By www.mcponline.org Published On :: 2020-11-24 Colin T. McDowellNov 24, 2020; 0:RA120.002256v1-mcp.RA120.002256Research Full Article
es Peptidomics-driven strategy reveals peptides and predicted proteases associated with oral cancer prognosis By www.mcponline.org Published On :: 2020-11-11 Leandro Xavier NevesNov 11, 2020; 0:RA120.002227v1-mcp.RA120.002227Research Full Article
es Spatially Resolved Activity-based Proteomic Profiles of the Murine Small Intestinal Lipases By www.mcponline.org Published On :: 2020-12-01 Matthias SchittmayerDec 1, 2020; 19:2104-2114Research Full Article
es Proteome Turnover in the Spotlight: Approaches, Applications & Perspectives By www.mcponline.org Published On :: 2020-11-30 Alison B. RossNov 30, 2020; 0:R120.002190v1-mcp.R120.002190Review Full Article
es Accelerating the field of epigenetic histone modification through mass spectrometry-based approaches By www.mcponline.org Published On :: 2020-11-17 Congcong LuNov 17, 2020; 0:R120.002257v1-mcp.R120.002257Review Full Article
es PTM-Shepherd: analysis and summarization of post-translational and chemical modifications from open search results By www.mcponline.org Published On :: 2020-12-01 Daniel J. GeiszlerDec 1, 2020; 0:TIR120.002216v1-mcp.TIR120.002216Technological Innovation and Resources Full Article
es Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy By www.mcponline.org Published On :: 2020-12-01 Tirsa L. E. van WesteringDec 1, 2020; 19:2047-2067Research Full Article
es Protein modification characteristics of the malaria parasite Plasmodium falciparum and the infected erythrocytes By www.mcponline.org Published On :: 2020-11-04 Jianhua WangNov 4, 2020; 0:RA120.002375v1-mcp.RA120.002375Research Full Article
es Pluripotency of embryonic stem cells lacking clathrin-mediated endocytosis cannot be rescued by restoring cellular stiffness [Molecular Biophysics] By www.jbc.org Published On :: 2020-12-04T00:06:06-08:00 Mouse embryonic stem cells (mESCs) display unique mechanical properties, including low cellular stiffness in contrast to differentiated cells, which are stiffer. We have previously shown that mESCs lacking the clathrin heavy chain (Cltc), an essential component for clathrin-mediated endocytosis (CME), display a loss of pluripotency and an enhanced expression of differentiation markers. However, it is not known whether physical properties such as cellular stiffness also change upon loss of Cltc, similar to what is seen in differentiated cells, and if so, how these altered properties specifically impact pluripotency. Using atomic force microscopy (AFM), we demonstrate that mESCs lacking Cltc display higher Young's modulus, indicative of greater cellular stiffness, compared with WT mESCs. The increase in stiffness was accompanied by the presence of actin stress fibers and accumulation of the inactive, phosphorylated, actin-binding protein cofilin. Treatment of Cltc knockdown mESCs with actin polymerization inhibitors resulted in a decrease in the Young's modulus to values similar to those obtained with WT mESCs. However, a rescue in the expression profile of pluripotency factors was not obtained. Additionally, whereas WT mouse embryonic fibroblasts could be reprogrammed to a state of pluripotency, this was inhibited in the absence of Cltc. This indicates that the presence of active CME is essential for the pluripotency of embryonic stem cells. Additionally, whereas physical properties may serve as a simple readout of the cellular state, they may not always faithfully recapitulate the underlying molecular fate. Full Article
