The invention relates to a human Interleukin-2 (hIL-2) specific monoclonal antibody (mAb), or antigen binding fragment thereof, the binding of which to hIL-2 inhibits binding of hIL-2 to CD25 and the antibody is characterized by any of the parameters: the variable chain of the mAb comprises the amino acid sequence of SEQ ID NO 005 or SEQ ID NO 006; the binding to hIL-2 is characterized by a dissociation constant (KD)≦7.5 nmol/L; the binding to hIL-2 is characterized by an off-rate (Koff)≦1×10−4 s−1 and/or the antibody displays no measurable cross-reactivity to murine IL-2.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD123 monoclonal antibody, conferring specific immunity against CD123 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.

The invention provides compositions and methods for treating leukemia, for example, acute myeloid leukemia (AML) and B-cell acute lymphoid leukemia (B-ALL). The invention also relates to at least one chimeric antigen receptor (CAR) specific to CD123, vectors comprising the same, and recombinant T cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD123 binding domain. The invention also includes methods of bone marrow ablation for use in treatments necessitating bone marrow reconditioning or transplant.

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a BCMA monoclonal antibody, conferring specific immunity against BCMA positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas, multiple myeloma and leukemia.

A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.

A soy protein product having a protein content of at least 60 wt % (N×6.25) d.b., preferably an isolate having a protein content of at least about 90 wt % (N×6.25) d.b., is formed from the supernatant from the precipitation of a soy protein micellar mass. A calcium salt or other divalent salt is added to the supernatant, before concentration, after initial concentration or after final concentration, to provide a conductivity of about 2 to about 30 mS. Precipitate is removed from the resulting solution and the pH of the clear soy protein solution is optionally adjusted to about 1.5 to about 4.4. The optionally pH-adjusted clear solution is concentrated to a concentration of about 50 to about 400 g/L and the clear concentrated protein solution is optionally diafiltered prior to drying. The soy protein product is soluble in acidic media and produces transparent, heat stable solutions at low pH values and, therefore, may be used for protein fortification of soft drinks and sports drinks.

Disclosed herein is a method of setting valid output sections of a 3-axis acceleration sensor mounted within a tire of a vehicle, including setting an output signal of the 3-axis acceleration sensor in the z-axis direction as a reference signal, setting a specific section of the output signal in the z-axis direction as a valid section where a part of the tire where the 3-axis acceleration sensor is mounted contacts a road surface, and setting sections of output signals of the 3-axis acceleration sensor in the x-axis and y-axis directions corresponding to the valid section in the z-axis direction as valid sections in the x-axis and y-axis directions. The method sets precise valid sections applied to detect information between the tire and a ground surface so as to minimize a component of a noise section by connecting output signals in the x-axis, y-axis and z-axis directions.

A method for processing explosives containing a high loading of CL-20 may advantageously include a binder system having naphthenic oil and/or paraffinic oil. Solid energetic ingredients are added into the binder system and mixed to form a free-flowing suspension in which the solid energetic ingredients are homogeneously mixed and coated with the binder system. The binder system is then cured and cast to form a cross-linked explosive.

The present invention relates to a wireless communication system, and a method for determining a resource for device-to-device communication by a user equipment is disclosed. A method for determining a resource for device-to-device communication according to an embodiment of the present invention may comprise the steps of: receiving, from an eNode B (eNB), configuration information related to a resource pool configured for each level; selecting the resource pool of the device-to-device communication on the basis of the configuration information; and selecting a resource for the device-to-device communication in the resource pool. Herein, the resource pool may be configured to have two or more levels.

Provided are a device-to-device (D2D) operation method carried out by a terminal in an RRC connection state in a wireless communication system, and a terminal using the method. The method is characterized by: determining whether a radio resource control (RRC) connection establishment process is problematic; and transmitting a D2D signal using an exception resource, when the RRC connection establishment process is determined to be problematic.

Provided are a device-to-device (D2D) operation method carried out by a terminal in an RRC connection state in a wireless communication system, and a terminal using the method. The method is characterized by: determining whether a communication link with a base station is problematic; and transmitting a D2D signal using an exception resource, when the communication link with the base station is determined to be problematic.

A method in a network node comprises determining (610) whether at least a first D2D capable UE is or will be performing a D2D operation, and determining whether the at least the first D2D capable UE is or will be performing cellular operation. The method comprises adapting (620) activity and/or inactivity state configurations for the at least the first D2D UE based on the determining.

Lithium silicate glass ceramics and glasses are described which can advantageously be applied to zirconium oxide ceramics in particular by pressing-on in the viscous state and form a solid bond with these.

The present invention relates to a cosmetic composition for dyeing keratin fibers, in particular human keratin fibers such as the hair, comprising: a) one or more fatty substances; b) one or more surfactants; c) one or more oxidation bases; d) one or more couplers based on 2-hydroxynaphthalene derivatives or particular phenol derivatives, acylaminophenol derivatives or quinoline derivatives; f) one or more basifying agents; e) optionally one or more chemical oxidizing agents; and the fatty substance content representing in total at least 25% by weight relative to the total weight of the formulation. The present invention also relates to a process using this composition, and to a multi-compartment device that is suitable for performing the said process.

A battery electrolyte solution contains a lithium salt dissolved in a solvent phase comprising at least 10% by weight of methyl (2,2,3,3-tetrafluoropropyl) carbonate. The solvent phase comprises optionally other solvent materials such as 4-fluoroethylene carbonate and other carbonate solvents. This battery electrolyte is highly stable even when used in batteries in which the cathode material has a high operating potential (such as 4.5V or more) relative to Li/Li+. Batteries containing this electrolyte solution therefore have excellent cycling stability.

A battery electrolyte solution contains a lithium salt dissolved in a solvent phase comprising at least 10% by weight of ethyl (2,2,3,3-tetrafluoropropyl) carbonate. The solvent phase comprises optionally other solvent materials such as 4-fluoroethylene carbonate and either or both of diethyl carbonate and ethyl methyl carbonate. This battery electrolyte is highly stable even when used in batteries in which the cathode material has a high operating potential (such as 4.5V or more) relative to Li/Li+. Batteries containing this electrolyte solution therefore have excellent cycling stability.

A battery electrolyte solution contains a lithium salt dissolved in a solvent phase comprising at least 10% by weight N of (2,2-difluoroethyl) ethyl carbonate. The solvent phase comprises optionally other solvent materials such as 4-fluoroethylene carbonate and other carbonate solvents. This battery electrolyte is highly stable even when used in batteries in which the cathode material has a high operating potential (such as 4.5V or more) relative to Li/Li+. Batteries containing this electrolyte solution therefore have excellent cycling stability.

Systems and methods are provided for combined cycle power generation while reducing or mitigating emissions during power generation. Recycled exhaust gas from a power generation combustion reaction can be separated using a staged complementary swing adsorption process so as to generate a high purity CO2 stream while reducing/minimizing the energy required for the separation and without having to reduce the temperature of the exhaust gas. This can allow for improved energy recovery while also generating high purity streams of carbon dioxide and nitrogen.

Embodiments of the present disclosure provide for metal-organic materials (MOMs), systems that exhibit permanent porosity and using hydrophobic MOMs to separate components in a gas, methods of separating CO2 from a gas, and the like.

An apparatus and method for flow management and CO2-recovery from a CO2 containing hydrocarbon flow stream, such as a post CO2-stimulation flowback stream. The apparatus including a flow control zone, a gas separation zone, a pretreatment zone, and a CO2-capture zone. The CO2-capture zone is in fluid communication with the pretreatment zone to provide CO2-capture from a pretreated flowback gas stream and output a captured CO2-flow stream. The CO2-capture zone includes a flow splitter to direct a first portion of the pretreated flowback gas stream to a CO2-enricher to provide an enriched CO2-stream for mixing with a second portion of the pretreated flowback gas to form a mixed stream. The CO2-capture zone further includes at least one condenser to output the captured CO2-flow stream.

The invention provides a M.2 interface memory device and a M.2 interface connection seat insertedly provided thereof. The M.2 interface memory device comprises a M.2 interface card and a housing provided with at least one guide groove. The M.2 interface connection seat is disposed on a circuit board, and comprises two arms and a base comprising a M.2 interface slot. At least one arm is provided with a guide rail. An opening direction of the M.2 interface slot is horizontal to a surface of the circuit board. When the M.2 interface card is inserted into the M.2 interface slot in a horizontal direction, the M.2 interface memory device will be fixed within the M.2 interface connection seat by embedding between the guide groove and the guide rail. Thus, M.2 interface memory devices of a variety of specification lengths are able to be inserted into the M.2 interface connection seat.

A 2×2 MIMO array antenna is provided which includes two separate radiating elements mounted to an antenna reflector. Each element is linear polarized with two orthogonal polarizations, one polarization excited by a transmit port and the other polarization receiving radiated signals destined for a receive port. The two elements are aligned that the polarizations excited by the transmit ports of the two elements are along a common axis, or the polarizations received by the receive ports of the two elements are along a common axis.

A multiplexer structure includes a passive substrate. The multiplexer structure may also include a high band filter on the passive substrate. The high band filter may include a 2D planar spiral inductor(s) on the passive substrate. The multiplexer structure may further include a low band filter on the passive substrate. The low band filter may include a 3D through-substrate inductor and a first capacitor(s) on the passive substrate. The multiplexer structure may also include a through substrate via(s) coupling the high band filter and the low band filter.

Disclosed herein are methods for treating solid mass tumors with direct delivery of an anti-tumor immunotherapeutic agent to the tumor site. In one aspect, this invention encompasses methods of treating solid mass tumors by direct microinjection via a microcatheter of an anti-tumor immunotherapeutic agent into the microvasculature leading into tumor thereby providing high levels of contact with the tumor while minimizing the degree of systemic buildup of the immunotherapeutic agent.

John Waters, the venerable sultan of sleaze who we recently visited at home in San Francisco, presided over this year's Burger Boogaloo festivities in Oakland's Mosswood Park. He was the consummate host.…

Here are photos from today's Warriors' championship parade.

The Best Covers of the Past Ten Years

The invention concerns soluble and antigenic HTLV p24 variants that can be fused to chaperones and their use in diagnostic applications such as immunoassays for detecting antibodies against HTLV-I or HTLV-II in an isolated biological sample. In particular, the invention relates to a soluble HTLV-I or HTLV-II p24 antigen comprising either the N- or the C-terminal domain of p24 and lacking the other domain. Moreover, the invention covers recombinant DNA molecules encoding these HTLV-I and -II fusion antigens as well as their recombinant production using expression vectors and host cells transformed with such expression vectors. In addition, the invention focuses on compositions of these HTLV p24 antigens with HTLV gp21 antigen and on an immunoassay method for detection of HTLV antibodies using the antigens of the invention. Also the use of HTLV p24 antigens in an in vitro diagnostic assay as well as a reagent kit for detection of anti-HTLV-antibodies comprising said HTLV antigens is encompassed.

Provided are a detection agent for detecting hydroxy vitamin D, preparation method thereof, and use thereof in 25-hydroxy vitamin D immunological detection. The detection agent comprises a conjugate formed by a 25-hydroxy vitamin D antigen derivative and protein carrier, and magnetic spheres coated by the conjugate. Also provided is a 25-hydroxy vitamin D detection kit comprising the detection agent.

Just in time to celebrate its ten-year anniversary, popular Filipino-fusion food truck Señor Sisig has established a long-term location in Oakland.

The brand-new spot is at 3331 Fruitvale Ave. in the Dimond District.…

The UK-based mixer-maker and audiophile favorite MasterSounds has a small piece of joy to brighten up DJs’ days. They’ve released the third generation of their Radius 2 and Radius 4 mixers, and have adjusted their price points to cater to artists with a lower spending budget (especially now). These mixers are homegrown, too—MasterSounds mixers are […]

The post A third generation of Radius 2 + 4 rotary mixers: New tech upgrades, lower price appeared first on DJ TechTools.

If you haven’t looked at Traktor DJ, Native Instruments’ iOS app (it runs on Mac and PC too) recently, a new update and the concurrent global stay-home happening seems like the perfect time to do it. The update to Traktor DJ 2.4 has a bunch of features that look like they’re straight out of a […]

The post Traktor DJ 2.4: Transport Control UI Improvements, Genre Sorting appeared first on DJ TechTools.

Be extra kind to kind people. ARIES (March 21-April 19): Your oracle comes from Aries poet Octavio Paz: "The path the ancestors cleared is overgrown, unused. The other path, smooth and broad, is crowded with travelers.…

ARIES (March 21-April 19) In the future, when the coronavirus crisis has a diminished power to disrupt our lives, I would love for you to have more of the money you need to finance interesting new experiences that help you learn and thrive.…

A gas separation process for treating exhaust gases from combustion processes. The invention involves routing a first portion of the exhaust stream to a carbon dioxide capture step, while simultaneously flowing a second portion of the exhaust gas stream across the feed side of a membrane, flowing a sweep gas stream, usually air, across the permeate side, then passing the permeate/sweep gas back to the combustor.

An apparatus and method for flow management and CO2-recovery from a CO2 containing hydrocarbon flow stream, such as a post CO2-stimulation flowback stream. The apparatus including a flow control zone, a gas separation zone, a pretreatment zone, and a CO2-capture zone. The CO2-capture zone is in fluid communication with the pretreatment zone to provide CO2-capture from a pretreated flowback gas stream and output a captured CO2-flow stream. The CO2-capture zone includes a first CO2-enricher and at least one additional CO2 enricher disposed downstream of the first CO2 enricher and in cascading relationship to provide a CO2-rich permeate stream, the CO2-capture zone further including at least one condenser to condense the enriched CO2-stream and output the captured CO2-flow stream.

'Tax-Free Childcare' is a confusing and inaccurately named scheme that launched in April 2017. It can be worth thousands of pounds, but only 250,000 of the 1.5 million eligible families are collecting it.

HE'S BEEN an integral part of Saints' rise from League 1 to European football - and to mark his birthday, we've got a special José Fonte photo gallery.

Eastleigh came from behind to defeat struggling Chesterfield and move themselves safely into midtable in the National League.

EASTLEIGH are through to the FA Cup first round after two penalties for Scott Rendell.

Scott Rendall admitted his confidence is sky high after his fine goalscoring continued with a match winning hat-trick.

Eastleigh are facing an unwanted FA Cup replay after being held to a 2-2 draw at Stourbridge.

EASTLEIGH warmed up for Saturday’s FA Cup tie at home to League Two Crewe Alexandra with a fourth successive victory at the Silverlake - thanks to three goals in ten first-half minutes.

Pictures from Saints' victory over Burnley at St Mary's Stadium.

Check out our picture gallery from Saints v Hull.

Despite Morgan Schneiderlin drawing first blood at Britannia Stadium, two second-half goals from Stoke sends Saints away without a point.

Two goals from Graziano Pelle ensured that Saints took the lead twice at St Mary's Stadium, but equalisers from Erik Lamela and Nacer Chadli meant both teams came away with a point.

Despite an equaliser from Sadio Mane, Saints suffer a 2-1 defeat to Sunderland The Stadium of Light.

Saints had a battle on their hands after Leicester scored two goals in the first 19 minutes of play. No further goals were scored.

Pictures from the Barclays Premier League clash between Manchester City and Southampton.