as ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***Pattern forming method, multi-layered resist pattern, multi-layered film for organic solvent development, manufacturing method of electronic device, and electronic device By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A pattern forming method contains: (i) a step of forming a bottom anti-reflective coating on a substrate by using a first resin composition (I), (ii) a step of forming a resist film on the bottom anti-reflective coating by using a second resin composition (II), (iii) a step of exposing a multi-layered film having the bottom anti-reflective coating and the resist film, and (iv) a step of developing the bottom anti-reflective coating and the resist film in the exposed multi-layered film by using an organic solvent-containing developer to form a negative pattern. Full Article
as Generalization of shot definitions for mask and wafer writing tools By www.freepatentsonline.com Published On :: Tue, 15 Sep 2015 08:00:00 EDT Techniques for reducing the number of shots required by a radiation beam writing tool to write a pattern, such as fractured layout design, onto a substrate. One or more apertures are employed by a radiation beam writing tool to write a desired pattern onto a substrate using L-shaped images, T-shaped images, or some combination of both. By reducing the number of shots required to write a pattern onto a substrate, various implementations of the invention may reduce the write time and/or write complexity of the write process. Full Article
as Mask blank, transfer mask, method of manufacturing a transfer mask, and method of manufacturing a semiconductor device By www.freepatentsonline.com Published On :: Tue, 09 Feb 2016 08:00:00 EST A mask blank for use in the manufacture of a binary mask adapted to be applied with ArF excimer laser exposure light has, on a transparent substrate, a light-shielding film for forming a transfer pattern. The light-shielding film has a laminated structure of a lower layer and an upper layer and has an optical density of 2.8 or more for exposure light and a thickness of 45 nm or less. The lower layer is made of a material in which the total content of a transition metal and silicon is 90 at % or more, and has a thickness of 30 nm or more. The upper layer has a thickness of 3 nm or more and 6 nm or less. The phase difference between exposure light transmitted through the light-shielding film and exposure light transmitted in air for a distance equal to the thickness of the light-shielding film is 30 degrees or less. Full Article
as Pedal Mechanism for a bass drum By www.freepatentsonline.com Published On :: Tue, 25 Sep 1990 08:00:00 EDT A pedal mechanism for a bass drum, including a pivoted primary platform connected to a beater ball so that, when the primary platform is depressed, the beater ball moves to contact a drum; and a resiliently mounted secondary platform in operative contact with the primary platform, the arrangement being such that, in use, the toe of the drummer depresses the primary platform directly and the heel of the drummer depresses the primary platform through the secondary platform. Full Article
as Quick-release cymeal mounting fastener By www.freepatentsonline.com Published On :: Tue, 02 Oct 1990 08:00:00 EDT A fastener for quick-mounting a cymbal to an upright cymbal support rod comprising a pair of half-round sleeve members arranged in face-to-face relationship forming a cylindrical surface therebetween for grasping the cymbal mounting rod; a tab extending upward from each sleeve member including means for pivoting said members near said tabs so that, by squeezing said tabs together, said sleeve members are pivoted away from each other; a pair of split flange members, one attached to the lower end of each sleeve member, spaced apart from said tab, arranged in co-planar alignment when said members are in adjacent contact to form a planar compression surface for pressing toward a cymbal placed on the cymbal mounting rod; and, means for biasing said sleeve members into full contact about the cymbal mounting rod threaded end to hold the cymbal on the rod. Full Article
as Structure of rotary valve assembly used in wind instrument By www.freepatentsonline.com Published On :: Tue, 20 Nov 1990 08:00:00 EST A rotary valve assembly incorporated in a brass instrument for changing a pitch of a tone comprises a rotary valve housed in a valve casing having two groups of aeroports, and the rotary valve is provided with two air passages, one of which interconnects the aeroports in the first group and the other of which interconnects one aeroport of the first group and one aeroport of the second group, so that various arrangements are possible for the aeroports. Full Article
as Rotary valves for brass wind instruments By www.freepatentsonline.com Published On :: Tue, 27 Nov 1990 08:00:00 EST A rotary valve for brass wind instruments with improved lubricating and durability properties is provided. The valve body 2 or both the valve body 2 and casing 1 of the rotary valve comprise(s) a machinable ceramic-resin composite material. The rotary valve can be readily produced by a method which comprises impregnating a machinable ceramic article containing substantially continuous micropores with a liquid resin material and hardening the resin material; machine-processing the resulting machinable ceramic-resin composite article into a shape of the valve body or shapes of the valve body and casing; and assembling the valve body into a rotary valve having the valve body 2 of the composite material rotatably contained in the casing 1 of the composite material or a metal material. Full Article
as Pedal assembly for musical instruments By www.freepatentsonline.com Published On :: Tue, 03 Apr 2007 08:00:00 EDT A pedal assembly for a bass drum or high hat cymbals. A flat base plate has a resilient pedal board clamped to it with the pedal board inclined to receive a foot. A beater stick is connected with the toe end of the pedal board by a linkage that drives the beater stick against a bass drum when the pedal is depressed. The resiliency of the pedal board returns it to its normal position when foot pressure is withdrawn. The material of which the pedal board is constructed has a modulus of elasticity between about one million and about six million. A striker pad limits the depression of the pedal board to limit the force that the beater stick can apply to the drum. Full Article
as Modular automated assistive guitar By www.freepatentsonline.com Published On :: Tue, 23 Oct 2007 08:00:00 EDT A modular automated assistive guitar is described comprising a base assembly, a pick assembly, a strumming mechanism and a fretting mechanism which, in combination with a standard guitar or similar stringed musical instrument (e.g., banjo, steel guitar, ukulele), forms a musical device that can be played by an individual with a range of independence, cognitive and physical abilities. The base assembly accepts, positions, and secures a standard guitar. The pick assembly includes quick attach and spring-loaded features for attaching and detaching picks, in addition to flexibility for smooth interaction with the guitar strings. The strumming mechanism provides cyclic motion and speed control to create pleasant and variable rhythm from the mounted guitar. The fretting mechanism allows a user to change chords and tone. An unmodified, traditional guitar is preferably used in the musical device. The guitar is easily interchangeable with another guitar or other stringed instrument, at the convenience of the user. The modular automated assistive musical device, with or without the guitar, is compact, light, portable, and easily adjustable to different individual's needs, motor skills, and dexterity. Full Article
as Beater bracket and variable drive lever system with variable pivot point spring rotor for bass drum foot pedals By www.freepatentsonline.com Published On :: Tue, 04 Jun 2013 08:00:00 EDT Described is a bass drum foot pedal having a variable drive lever linkage with variable arc ratios connecting the foot pedal to a beater bracket. The beater bracket is formed with a mounting surface that tips a beater shaft forward to create a forward beater angle that maximizes the beater impact against a bass drum. Full Article
as Method for performing handover, user equipment, base station, and radio communication system By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Provided is a method for performing a handover from a first base station to a second base station by a user equipment that is performing a radio communication over a communication channel formed by aggregating a plurality of component carriers. The method includes a step of transmitting a handover command for a component carrier for which a handover has been approved by the second base station among the plurality of component carriers from the first base station to the user equipment and a step of trying to make an access from the user equipment to the second base station for each component carrier in response to the handover command. Full Article
as System and method for mode-based social networking By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A mode-based method of social networking comprising storing in a database profile information for a plurality of users, event information for a plurality of events and a mode associated with each event, receiving by a plurality of computerized user devices a selection of a mode and one or more geographic proximity parameter selections from a each of plurality of users, displaying, event information for an event having a same mode as the first user, profile information for one or more other users among the plurality of users having selected the same mode as the first user and located within a geographic proximity parameter selected by the first user, and a density of a plurality of users located within the geographic proximity parameter selected by the first user wherein the density is represented by a color corresponding to the mode. Full Article
as Dynamically configuring and verifying routing information of broadcast networks using link state protocols in a computer network By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A technique dynamically configures and verifies routing information of broadcast networks using link state protocols in a computer network. According to the novel technique, a router within the broadcast network receives a link state protocol routing information advertisement from an advertising router, e.g., a designated router or other adjacent neighbor. The router learns of a next-hop router (“next-hop”) to reach a particular destination from the advertisement, and determines whether the next-hop is located within the same broadcast network (e.g., subnet) as the designated router. If so, the router further determines whether the next-hop is directly addressable (i.e., reachable), such as, e.g., by checking for link adjacencies to the next-hop or by sending request/reply messages (e.g., echo messages or “ping” messages) to the next-hop. In the event the next-hop for the destination is not directly addressable by the router (e.g., no adjacency or reply), the router installs a route to the destination via the designated router. Otherwise, the router installs a route to the destination via the next-hop. Full Article
as System and method for using a multicast group to support a flooding mechanism in a middleware machine environment By www.freepatentsonline.com Published On :: Tue, 09 Jun 2015 08:00:00 EDT A system and method can support a flooding mechanism using a multicast group in a middleware machine environment. The middleware machine environment can comprise a gateway instance that includes an external port for receiving one or more data packets from an external network. The middleware machine environment also comprises one or more host servers, each of which is associated with one or more virtual machines that can process the data packets. Furthermore, said host servers can provide virtual interfaces that belong to a virtual hub associated with the gateway instance. At least one said packet is a flooded packet that is specified with an unknown destination address when it is received at the external port. The gateway instance operates to send the flooded packet to the multicast group that operates to forward the flooded packet to one or more said host servers in the multicast group. Full Article
as Method and apparatus for measurement for inter-cell interference coordination in radio communication system By www.freepatentsonline.com Published On :: Tue, 13 Oct 2015 08:00:00 EDT A wireless communication system and, more specifically, a measurement method and apparatus for inter-cell interference coordination in a wireless communication system are disclosed. Herein, a method for supporting measurement of a User Equipment (UE) by a first base station in a wireless communication system includes the steps of acquiring information of downlink subframe configuration of a second base station, determining measurement objects of downlink resource of the first base station based on the downlink subframe configuration of the second base station; transmitting information of the measurement objects to the UE, and receiving measurement result for the measurement objects from the UE. Full Article
as Channel-sounding method using a plurality of antennas, and apparatus for same By www.freepatentsonline.com Published On :: Tue, 23 Feb 2016 08:00:00 EST The present invention relates to a wireless communication system. More particularly, the present invention relates to a method and to an apparatus for transmitting an SRS in a multi-antenna system. The method comprises the steps of: acquiring specific information for discriminating a first antenna group and a second antenna group from among a plurality of antennas, wherein said first antenna group includes one or more antennas which are set to a turned-on state to perform communication with a base station, and said second antenna group includes one or more other antennas which are set to a turned-off state; transmitting an SRS to the base station if a predetermined condition is satisfied, under the condition that the second antenna group is set to the turned-off state; and setting the second antenna group to a turned-off state after the transmission of the SRS. Full Article
as Mobile user terminal, mobile communication system, base station, and communication method By www.freepatentsonline.com Published On :: Tue, 03 May 2016 08:00:00 EDT A mobile user terminal, which communicates with a base station in an intermittent fashion, the mobile user terminal includes a radio transmitter which transmits downlink channel quality information indicating downlink channel quality and an uplink pilot signal to a base station in an intermittent fashion; and a transmit time controller which synchronizes transmit time of the downlink quality information and transmit time of the uplink pilot signal relative to each other, such that the downlink quality information and the uplink pilot signal are sent in adjacent different timings in a period corresponding to a state of intermittent communicate. Full Article
as Bicycle sprocket for use with a multi-gear rear cassette By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A rear bicycle sprocket for use with a multi-gear rear cassette is provided. The sprocket includes a chain engaging portion and a mounting portion having generally annular shape about a central axis and a plurality of support arms, integrally formed with the chain engaging portion and with the mounting portion. The sprocket further includes a plurality of space maintaining protrusions, each space maintaining protrusion extending axially forwardly from an axially forward surface of a corresponding support arm and integrally formed therewith. A multi-gear rear cassette having a plurality of sprockets coaxially mounted together wherein the plurality of sprockets includes the rear bicycle sprocket mounted axially rearmost and a bicycle including the multi-gear rear cassette are further provided. Full Article
as Recirculating ball screw assembly By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT Ball screws are described that may be incorporated into other devices such as a pulley assembly or a differential device. The ball screws include a threaded shaft defining a central longitudinal axis with a threaded nut threadedly coupled thereto to define at least one track in between them. Each track forms a continuous loop around an infield protrusion and is filled with a plurality of rolling elements filling. Each rolling element has the same radius from the central longitudinal axis such that the nut can rotate at higher speeds without the rolling elements locking up as a result of centripetal force. Full Article
as Secondary assembly drive of an internal combustion engine and method for operating same By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A secondary assembly drive of an internal combustion engine and a method for operating same are provided. The secondary assembly drive includes: a first drive wheel (1) which can be rotatably connected to a crank shaft (CR) of the internal combustion engine, an electric machine which can be operated either as a generator (AL) of as a motor (M) and a second drive wheel (2) which can be rotatably connected to the electric machine (AL, M), an air-conditioning compressor (A/C) and a third drive wheel (3) which can be rotatably connected to the air-conditioning compressor, a traction element (4) which rotates infinitely and which wraps around the drive wheels, and an actuable clutch (7) for disconnecting the drive of the electric machine and of the air-conditioning compressor from the crankshaft when necessary. In addition, the air-conditioning compressor is designed for operation in both rotational directions, and a reversal of the rotational direction between the generator operating mode and the motor operating mode of the electric machine is provided. Full Article
as Method for electronically controlling a bicycle gearshift and electronically servo-assisted bicycle gearshift By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A method for electronically controlling a bicycle gearshift comprising at least one derailleur is disclosed, comprising the sequential steps of: a) imparting a movement on the derailleur of the gearshift until the derailleur is in an intended position;b) waiting for a predetermined time period,c) performing a check whether the derailleur is in the intended position, within a possible predetermined tolerance,d) in case said check has a negative outcome, imparting a movement on the derailleur of the gearshift until the derailleur is in the intended position. A derailleur and an electronically servo-assisted bicycle gearshift comprising control electronics comprising modules adapted to carry out the method outlined above are also disclosed. Full Article
as Secondary assembly drive of an internal combustion engine and method for operating same By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A secondary assembly drive of an internal combustion engine and a method for operating same are provided. The secondary assembly drive includes, in two drive planes, an assembly drive (2) and a starter drive (12) and permits, in addition to a normal operating mode, the following operating modes: —starting of the internal combustion engine, —boosting of the internal combustion engine, —air-conditioning, and —deactivation of the assembly drive (2). Full Article
as Modalities for the treatment of degenerative diseases of the retina By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells. Full Article
as Nonhuman mammal whose mtDNA is from a nonhuman mammal resistant to a selected disease or disorder and whose nDNA is from a nonhuman donor mammal more susceptible to the selected disease or disorder By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a mitochondrial-nuclear exchanged animal and animals made by the methods are provided. Also provided are methods of screening for agents useful for treating a disease or disorder using mitochondrial-nuclear exchanged animals or cells, tissues or organs thereof. Full Article
as Method for modifying plant architecture and enhancing plant biomass and/or sucrose yield By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates to methodology and constructs for modifying plant architecture and enhancing plant biomass and/or sucrose yield. Full Article
as Machine for continuous casting of pre-mortared masonry panels By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A machine for continuous casting of pre-mortared masonry panels includes a rotatable continuous mold for continuously forming pre-mortared masonry panels and an application system for applying polymeric material to the continuous mold as the continuous mold rotates. The machine also includes a brick setter system for setting bricks onto the polymeric material as the continuous mold rotates. The machine further includes a cutting device for cutting the bricks and polymeric material into panels to form the pre-mortared masonry panels. Full Article
as Method and devices for sonicating liquids with low-frequency high energy ultrasound By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A method and devices comprise a low frequency high energy ultrasound system having at least one sonotrode projecting into a reactor vessel through which the liquid passes via at least one inlet orifice and at least one outlet orifice. To avoid cavitation at the sonotrode, in a close region of the oscillation-transducing sonotrode surface a pressure/amplitude combination close to or above the pressure-amplitude characteristic line is generated at which considerably reduced or no cavitation occurs and in the adjacent region in the vessel at least in a region and at least at times a pressure/amplitude combination is maintained below the pressure-amplitude characteristic line at which cavitation is generated. A device has an inlet orifice arranged such that the liquid impacts directly onto the oscillation-transducing sonotrode surface, and is shaped that in the close region of the oscillation-transducing sonotrode surface a pressure close to or above the pressure-amplitude characteristic line prevails. Full Article
as Mixer for biphasic compounds By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT Mixer for biphasic compounds, including a chamber for containing a solid phase and a cartridge containing a phial of a liquid phase, said chamber and said cartridge being able to communicate through respective channels, wherein said cartridge includes an external casing made in a deformable material and said phial is of the breakable type. Full Article
as Method and apparatus for high intensity ultrasonic treatment of baking materials By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT The present invention discloses a high intensity ultrasonic treatment method and apparatus that is used in conjunction with an existing commercial dough or batter mixer to enhance the rheological, aeration and textural properties of the dough or batter. This change in properties is a result of the phenomenon of acoustic cavitation induced in the dough or batter by treatment with high intensity ultrasonic waves. The present invention discloses a mixing bowl (20) of an existing mixer system that is preloaded with dough or batter, the bowl (20) is located at the center of an ultrasonic bath tank (101) filled with a working fluid. The effect of ultra-sonic waves with power levels above 1 kW can be observed over the entire or partial mixing period of the dough or batter. The ultra-sonic waves of the present invention are generated by a plurality of ultrasonic wave generators (104A, 104B) and piezoelectric transducers (1) mounted on a stainless steel tank (101). The electrical energy received in each transducer (1) will be converted into appropriate mechanical expansion and contractions in the piezoelectric ceramics of the transducer (1) thus leading to pressure waves being transmitted to the dough or batter to be mixed. The generation and transmission of high intensity ultrasonic waves to the dough or batter affects its rheological, aeration and textural properties. Full Article
as Agitator for abrasive media By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT An agitator, particularly for abrasive media includes a support disk to which agitator blades are connected substantially perpendicular to the support disk. The blades are arranged substantially in a radial direction. The support disk also includes a hub that receives an agitator shaft which is preferably motor-driven. The trailing faces of the blades of the agitator and/or the area of the blade connections to the support disk are designed to largely prevent vortex shedding. This is accomplished by implementing a specific geometry for the agitator blades, the support disk, and the connection of the blades to the support disk. Full Article
as Changing and measuring consistency By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A measuring device comprising at least one mixer structure to receive a fiber suspension sample from at least one process part. Each mixer structure is provided with a measuring unit, a feeding valve for feeding feed liquid into a sample line for pushing the sample in the sample line towards the measuring unit, a mixing valve structure for feeding dilution liquid into the mixer structure The mixer structure mixes the flowing sample and the dilution liquid with one another in order to reduce the consistency of the sample. The measuring device measures from the first part of the mixed sample one property of the fiber suspension and the measuring device measures from the second part of the mixed sample a further property. Full Article
as Compounds as rearranged during transfection (RET) inhibitors By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity. Full Article
as N-(1,2,5-oxadiazol-3-yl)pyridinecarboxamides and use thereof as herbicides By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A description is given of N-(1,2,5-oxadiazol-3-yl)pyridinecarboxamides of the general formula (I) as herbicides. R in this formula (I) stands for radicals such as hydrogen, organic radicals, and other radicals such as halogen. W stands for a substituted pyridyl radical. Full Article
as Compositions of protein receptor tyrosine kinase inhibitors By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, Tropomysosin Related Kinases (Trk), in particular the nerve growth factor (NGF) receptor, TrkA. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, or a disease, disorder or injury relating to dysmyelination or demyelination or the disease or disorder associated with abnormal activities of NGF receptor TrkA. Full Article
as Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present disclosure relates to Oxime-Substituted Quinoxaline-Type Piperidine Compounds, such as those of Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R20, R21, Q, Y1, Z, A, B, and a are as defined herein; compositions comprising an effective amount of an Oxime-Substituted Quinoxaline-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of an Oxime-Substituted Quinoxaline-Type Piperidine Compound. Full Article
as [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention is directed to a compound of Formula (I) and to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention. Full Article
as Pyrimidines as novel therapeutic agents By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention features compounds having the Formula (Ia) and (Ib) (e.g., a compound of any of Formulas ((Ia-2)-(Ia-21)), including other tautomers, stereoisomers, E/Z stereoisomers, prodrugs, pharmaceutically acceptable salts, and compositions thereof. The invention also features methods for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient by administering an effective amount of a compound of Formula (Ia) or (Ib). The invention also features a method for treating or preventing pain (e.g., neuropathic pain), inflammation, or epilepsy in a patient that includes administering to a patient in need thereof an effective amount of a compound of Formula (IIa) or (IIb) (e.g., a compound of any of Formulas ((IIa-2)-(IIa-6)). The compounds described herein (e.g., a compound of Formulas (Ia), (Ib), (IIa), or (IIb)) can also be used as anticonvulsants. Full Article
as Small molecule inhibitors of polynucleotide kinase/phosphatase, poly(ADP-ribose) polymerase and uses thereof By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention generally relates to use of compounds and compositions as a chemosensitizers and/or radiosensitizers and/or inhibitors of PNKP phosphatase activity. The present invention provides pharmaceutical combinations and/or a pharmaceutically acceptable salt thereof, kits containing such compounds and/composition and methods of using such compounds and/or compositions. Full Article
as Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The invention is directed to novel substituted benzylamino quinolines, compounds comprising substituted benzylamino quinolines, methods of making substituted benzylamino quinolines, the use of substituted benzylamino quinolines for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism, and the use of substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors. Full Article
as Dual inhibitors of farnesyltransferase and geranylgeranyltransferase I By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Many GTPases such as Ras, Ral and Rho require post-translational farnestylation or geranylgeranylation for mediating malignant transformation. Dual farnesyltransferase (FT) (FTI) and geranylgeranyltransferase-I (GGT-1) inhibitors (GGTI) were developed as anticancer agents from based on an ethylenediamine scaffold. On the basis of a 4-fold substituted ethylenediamine scaffold, the inhibitors are structurally simple and readily derivatized, facilitating extensive structure-activity relationship studies. The most potent inhibitor is compound exhibited an in vitro hFTase IC50 value of 25 nM and a whole cell H-Ras processing IC50 value of 90 nM. Several of the inhibitors proved highly selective for hFTase over the related prenyltransferase enzyme geranylgeranyltransferase-I (GGTase-I). A crystal structure of an inhibitor cocrystallized with farnesyl pyrophosphate in the active site of rat FTase illustrates that the para-benzonitrile moiety is stabilized by a π-π stacking interaction with the Y361β residue, suggesting an importance of this component of the inhibitors. Full Article
as 1H-benzimidazole-5-carboxamides as anti-inflammatory agents By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT There are provided compounds of formula (I), wherein R1, R6, R8, Q2, Q3, Q3a, Q4, L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation and/or cancer. Full Article
as Substituted pyridine and pyrazine compounds as PDE4 inhibitors By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, R4, Y and Z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting PDE4, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating peripheral disorders, including inflammatory and renal disorders. Full Article
as Inhibitors of arginase and their therapeutic applications By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: where R1, R2, R3, R4, R5, R6, R7, R8, R9, D, M, X, and Y are defined as set forth in the specification. The invention also provides pharmaceutical compositions of the compounds and methods of their use for treating or preventing a disease or a condition associated with arginase activity. Full Article
as Bicyclic thiazoles as allosteric modulators of mGluR5 receptors By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT The present invention relates to novel bicyclic thiazoles which are positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (“mGluR5”) and which are useful for the treatment or prevention of disorders associated with glutamate dysfunction and diseases in which the mGluR5 subtype of receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes for preparing such compounds and compositions, and to the use of such compounds and compositions for the prevention and treatment of disorders in which mGluR5 is involved. Full Article
as BCL-2 selective apoptosis-inducing agents for the treatment of cancer and immune diseases By www.freepatentsonline.com Published On :: Tue, 07 Jul 2015 08:00:00 EDT Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein. Full Article
as Substituted naphthyridine and quinoline compounds as MAO inhibitors By www.freepatentsonline.com Published On :: Tue, 06 Oct 2015 08:00:00 EDT The invention provides a chemical entity of Formula (I) wherein R1, R2, R3, Y, and n have any of the values described herein and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies, detection and imaging techniques, and radioactive treatments; and therapies, including inhibiting MAO, and MAO-B selectively, enhancing neuronal plasticity, treating neurological disorders, providing neuroprotection, treating a cognitive impairment associated with a CNS disorder, enhancing the efficiency of cognitive and motor training, providing neurorecovery and neurorehabilitation, enhancing the efficiency of non-human animal training protocols, and treating treating peripheral disorders (including obesity, diabetes, and cardiometabolic disorders) and their associated co-morbidities. Full Article
as Mounting apparatus for heat sink and fastening assembly of the mounting apparatus By www.freepatentsonline.com Published On :: Tue, 08 Jan 2013 08:00:00 EST A fastening assembly includes a connecting member, a mounting member mounted to the connecting member, and a sliding member. The mounting member includes a first fixing portion. The sliding member is slidably received in the mounting member and the connecting member. The sliding member includes a first end exposed out of the first fixing portion, and a second end slidably received in the connecting member. The second end of the sliding member is operable to be extended out of or substantially coplanar with an end of the connecting member. The fastening assembly can be utilized to mount a heat sink to a board. Full Article
as Electronic device, washer and method for manufacturing washer By www.freepatentsonline.com Published On :: Tue, 19 Feb 2013 08:00:00 EST An electronic device includes, a circuit board including a through hole, a member including a screw hole, a screw including a screw body having an outer diameter smaller than an inner diameter of the through hole and a screw head having an outer diameter larger than the inner diameter of the through hole, wherein the screw body penetrates through the through hole to engage with the screw hole and the screw head is disposed on an opposite side of the circuit board to the member, and a first washer provided between the screw head and the circuit board, the first washer including a first washer body and a plurality of first washer legs extending from the first washer body toward the circuit board, the first washer legs being in contact with the circuit board and having a characteristic of reducing stress on the circuit board upon being heated. Full Article
as Method and device for manufacturing fastenings or fasteners with radial outer contours, especially screws or threaded bolts By www.freepatentsonline.com Published On :: Tue, 26 Feb 2013 08:00:00 EST A method of manufacturing fastenings or fasteners with radial outer contours, especially screws or threaded bolts, made of solid metal is performed by a device. The method manufactures the fastenings or fasteners preferably on a multi-stage press. Several recesses running in an axial direction at a fixed radial distance are formed in the shank-shaped section of a blank. The prefabricated blank with the recesses is inserted into a multi-part split mold within a multi-stage press, whose die stocks have an inner profiling forming the outer contour, and are opened in the starting position, that at the places where the die stocks are opened, there are the recesses. During the closing movement of the die stocks, at least one radial outer contour is pressed on the shank-shaped section of the blank by radial action of forces, with the recesses preventing material from getting between the die stocks during the pressing process. Full Article
as Magnetized nut for fastening a compressor wheel of an exhaust turbocharger to the turbo shaft, and method for the production thereof By www.freepatentsonline.com Published On :: Tue, 16 Apr 2013 08:00:00 EDT A magnetized nut for fastening a compressor wheel of an exhaust turbocharger to a turbo shaft. The nut has a base body made of a non-magnetic material forming a hollow space for accommodating a magnetic material, and a method for the production of the magnetized nut. In order to provide a magnetized nut that is produced in a simple and cost-effective manner and ensures as equal a distribution of mass as possible with regard to the rotational axis of the nut, the magnetic material is introduced into the hollow space using injection molding. Full Article