The baseball field is Rockies third baseman Nolan Arenado's refuge from contract talks. But Tuesday's breaking news -- Manny Machado's 10-year, $300 million contract with the Padres -- made its way onto the field.

What unheralded prospect could break out in 2019? Beat reporter Gregor Chisholm answers that and more in this edition of the Inbox.

At one of my first meetings as an elected council member of the Royal College of Surgeons of England, we approved a report called Access All Ages. It encouraged less ageist thinking and bias among healthcare staff that might lead to them denying older people surgery.1 But sometimes an operation isn’t the best option. Among patients who have surgery, 14% express regret and 15% experience complications, which are at least four times as likely if they’re frail or physically inactive.2 The Centre for Perioperative Care has published information on the importance of exercise before surgery,3 but that alone may not be enough.We need shared decision making,4 including asking patients what matters to them. The public should be primed to ask about BRAN—the benefits, risks, and alternatives to surgery and the likely result from doing nothing.4 A slew of data supports this approach, especially from the POPS initiative (Perioperative Care of...

A unique population of ventral tegmental area (VTA) neurons co-transmits glutamate and GABA. However, the circuit inputs to VTA VGluT2+VGaT+ neurons are unknown, limiting our understanding of their functional capabilities. By coupling monosynaptic rabies tracing with intersectional genetic targeting in male and female mice, we found that VTA VGluT2+VGaT+ neurons received diverse brainwide inputs. The largest numbers of monosynaptic inputs to VTA VGluT2+VGaT+ neurons were from superior colliculus (SC), lateral hypothalamus (LH), midbrain reticular nucleus, and periaqueductal gray, whereas the densest inputs relative to brain region volume were from the dorsal raphe nucleus, lateral habenula, and VTA. Based on these and prior data, we hypothesized that LH and SC inputs were from glutamatergic neurons. Optical activation of glutamatergic LH neurons activated VTA VGluT2+VGaT+ neurons regardless of stimulation frequency and resulted in flee-like ambulatory behavior. In contrast, optical activation of glutamatergic SC neurons activated VTA VGluT2+VGaT+ neurons for a brief period of time at high frequency and resulted in head rotation and arrested ambulatory behavior (freezing). Stimulation of glutamatergic LH neurons, but not glutamatergic SC neurons, was associated with VTA VGluT2+VGaT+ footshock-induced activity and inhibition of LH glutamatergic neurons disrupted VTA VGluT2+VGaT+ tailshock-induced activity. We interpret these results such that inputs to VTA VGluT2+VGaT+ neurons may integrate diverse signals related to the detection and processing of motivationally salient outcomes.

The AIDS Hope team encourages children in their afterschool program in Mamelodi to share the gospel with the community.

OM Philippines partners with the local church to provide water and food in areas hit by the 7.2 magnitude earthquake on 15 October.

OM responded to the needs of people affected by Typhoon Vinta, relying on military accompaniment to reach the location and deliver aid.

Short-term workers are inspired to share the good news after experiencing opportunities on outreach in Turkey.

“…to many host ministries, short-term outreaches can be a blessing or a curse,” shares OMer Ivy. “Here I would like to share some tips that help me feel less like a tour guide and more like I’m helping facilitate an exposure trip for the Kingdom.”

OM in Greece with other organizations and locals are trying to do something to help the gypsies.

Relationships form and opportunities to share Christ follow as OM workers minister to those seeking refuge in Athens and beyond.

The OM Near East Field church planting school prepares students to cross cultural and religious boundaries.

Eighty Arab believers attend training to learn how to share the Bible with their Muslim neighbours.

Taina Moisander, a 26-year-old student from Finland shares some of the lessons she learnt while serving with a Transform team in Sicily, Italy.

Bloody feet. Blisters. That wasn’t the expectation of eager Transform participants who left the conference in Rome to join OM Spain on a unique journey.

Sixty teenagers participate in a Teens in Mission outreach over the holiday season to grow in relationship with God and share about Him with others.

Since 2005, Rachel Chua (22) has been involved in TeenStreet Malaysia and she attended OCZ for the 2nd time this year. Her passion is contagious.

OM Europe hosts its third annual Youth Factors Conference in Pälkäne, Finland, in April, which offers participants an opportunity for reflection and self-discovery.

OM Ecuador team members work with people living with HIV and AIDS in a children's hospital in Guayaquil.

Fourteen from three countries participated in the cross-cultural missions training programme hosted by OM Andean Region.

Barranquilla, Colombia :: Mission organisations come together on board Logos Hope to inspire Latinos to serve God around the world.

Cartagena, Colombia :: Logos Hope's crewmembers host sailors from the Colombian Navy and share their experiences in a partnership event.

In a nation filled with tribal tension, OM works toward reconciliation through youth conferences, relief outreaches and a bookshop filled with Bibles.

For a young family in Belgium Easter provided a great opportunity to invite neighbours to church.

Samson Viswanath, father of India cricketer Sanju Samson, has made a shocking claim regarding his son's international career.

Ravichandran Ashwin and Steve Smith will face off during the Border-Gavaskar Trophy starting November 22 in Perth.

DeepIntent applies AI to data to identify medical and patient audiences for healthcare marketing, track them across devices, and deliver impactful messages

1. Can Vitamin D supplements reduce blood pressure? New study's findings are promising  The Times of India
2. Vitamin D Supplements Linked with Reducing High Blood Pressure  Healthline
3. The £4 supplement that could slash blood pressure - reducing stroke, dementia and heart attack risk  Daily Mail
4. Vitamin D Supplements Could Help Lower Blood Pressure in Obese People  Therogersvillereview
5. Vitamin D can lower blood pressure in obese adults, study  Daily Jang

1. John Krasinski revealed as People magazine's Sexiest Man Alive after Benny Blanco confusion; fans are relieved  Hindustan Times
2. John Krasinski reveals wife Emily Blunt's reaction to his Sexiest Man Alive title  Hindustan Times
3. Not Shah Rukh Khan, Hrithik Roshan, Leonardo Dicaprio, Chris Evans, or Tom Cruise, THIS actor is the sexiest  India.com
4. Actor John Krasinski Named 'Sexiest Man Alive' Of 2024 By People Magazine  NDTV
5. Is Jim from The Office really the sexiest man in the world?  The Guardian

The Sandiganbayan has acquitted former Food and Drug Administration chief Nela Charade Puno of graft, which stemmed from a raid and closure by the FDA of a pharmacy and wellness center in Tarlac.

Malacañang has issued proclamations declaring local holidays in nine areas in the country.

The Jerusalem Post Podcast with Tamar Uriel-Beeri and Zvika Klein.

“Climate change continues to happen, and it is important that Israel remains part of the efforts to mitigate the effects of climate change,” Behar said.

The bill's goal is to enable the use of spyware to combat organized crime, according to the proposal's explanatory section.

There was a shift in her that many of us could relate to, a feeling that the events of Oct. 7 had flipped a switch within, prioritizing Jewish identity in ways that hadn’t been fully realized before.

Advance care planning (ACP) is a complex and iterative communication process between patients, surrogates and clinicians that defines goals of care that may include, but is not limited to, documentation of advance directives. The aim of ACP is to promote patient-centred care tailored to the patient's clinical situation through informed preparation for the future and improved communication between patient, clinicians and surrogates, if the latter need to make decisions on patient's behalf.

The aim of this article is to review research related to ACP in acute and chronic respiratory failure, regarding the process, communication, shared decision-making, implementation and outcomes.

Research has produced controversial results on ACP interventions due to the heterogeneity of measures and outcomes, but positive outcomes have been described regarding the quality of patient–physician communication, preference for comfort care, decisional conflict and patient–caregiver congruence of preferences and improved documentation of ACP or advance directives.

The main barriers to ACP in chronic respiratory failure are the uncertainty of prognosis (particularly in the organ failure trajectory), the choice of the best timing for initiation and the lack of training of healthcare workers. In acute respiratory failure, the ACP process can be very short, should include the patient whenever possible, and is based on a discussion of treatments appropriate to the patient's functional status prior to the event (e.g. assessment of frailty) and clear communication of the likely consequences of possible options.

All healthcare worker dealing with patients with serious illnesses should have training in communication skills to promote engagement in ACP discussions.

The main monogenic causes of pulmonary fibrosis in adults are mutations in telomere-related genes. These mutations may be associated with extrapulmonary signs (hepatic, haematological and dermatological) and typically present radiologically as usual interstitial pneumonia or unclassifiable fibrosis. In children, the monogenic causes of pulmonary fibrosis are dominated by mutations in surfactant-related genes. These mutations are not associated with extrapulmonary signs and often manifest radiologically as unclassifiable fibrosis with cysts that can lead to chest wall deformities in adults. This review discusses these mutations, along with most of the monogenic causes of interstitial lung disease, including interferon-related genes, mutations in genes causing cystic lung disease, Hermansky–Pudlak syndrome, pulmonary alveolar proteinosis, lysinuric protein intolerance and lysosomal storage disorders, and their pulmonary and extrapulmonary manifestations.

5 rare supernova images captured by NASA's Hubble Space Telescope  India.com

1. Garena Free Fire MAX Redeem Codes for November 12: Claim Exclusive Rewards Today!  The Hans India
2. Garena Free Fire MAX redeem codes for November 12: Win free diamonds, skins, and more  The Times of India
3. Garena Free Fire MAX Redeem Codes Today, November 13: Win Free Gifts, Skins And Much More  Jagran English
4. Free Fire Mystery Shop: Rewards, duration, and more  Sportskeeda
5. Garena Free Fire MAX redeem codes for November 13, 2024: Win bundles, new outfits, and more rewards...  Moneycontrol

Singer was one of the early favourites to win the talent show

The kids from the BBC sitcom are all in their twenties now

The series has transcended expectations in a huge way

The rise of generative AI (gen AI) and ChatGPT has brought large language models (LLMs) to the forefront of technological innovation. Unlike traditional AI, these LLMs can process and generate language in a way that mimics human reasoning. Businesses are leveraging this technology in various ways, including content generation, customer service interactions, and document summarization. Gen AI offers businesses a chance to streamline operations and improve efficiency. However, LLMs are not universally…

Wedding bells rang at Trinity Methodist Church yesterday afternoon (Nov 12) as couples renewed their vows — but it was all for a scene in local director Jack Neo's upcoming movie, I Want To Be Boss. Among them, however, was an actual couple who have been married for more than six decades — Jack's very own parents. "I want to leave a beautiful memory of them in the movie," the 64-year-old actor-director told local media on the set. His mum, 86, was dressed in a white wedding gown with tulle sleeves, while Jack's father, 91, looked sharp in a black suit with a matching bowtie. Jack added: "I especially requested that my mum put on a wedding dress today for this scene, because the first time they wore their wedding outfits, I only got to see them in photos. I can see them now."

SHOALWATER BAY, Australia - The expansion of the Shoalwater Bay Training Area (SWBTA) in Queensland has been completed after eight years of development. With the expanded training area now five times the size of Singapore, this means that the scale and complexity of overseas exercises involving the Singapore Armed Forces (SAF) can be increased in the future, Senior Minister of State for Defence Heng Chee How said on Wednesday (Nov 13). Heng was speaking to reporters after witnessing Singaporean and Australian soldiers being put through their paces during a simulated beach landing as part of Exercise Trident. He also flew on a CH-47F chinook to view the new facilities within the expanded SWBTA and interacted with SAF and the Australian Defence Force (ADF) soldiers who participated in the bilateral exercise. Jointly developed by Australia and Singapore since 2016, the expansion of the overall training area was set out in a treaty between the two countries in 2020. State-of-the-art facilities such as the combined arms air-land ranges and urban operations live-firing facilities have been included in the expansion.

Immigrant rights lawyers are preparing to fight back against Donald Trump’s plans to carry out the largest mass deportation in U.S. history once he takes office again in January. The president-elect has already named some leading anti-immigration figures for his incoming administration who will lead the plan, including former ICE head Tom Homan and his longtime aide Stephen Miller. Trump’s picks were central in family separations, the Muslim ban, attacks on Deferred Action for Childhood Arrivals, or DACA, and other anti-immigrant policies during the first Trump administration. Trump is also reportedly planning to greatly expand immigrant detention in private for-profit prisons, and during the campaign he spoke of invoking the Alien Enemies Act of 1798 to speed up deportations. “We have been preparing nearly a year for this,” says attorney Lee Gelernt, deputy director of the ACLU Immigrants’ Rights Project, who argued some of the most high-profile immigration cases during the first Trump administration. He stresses that while groups like the ACLU will challenge the Trump administration in the courts, “it needs to be a national effort” to prevent abuses. “We are not opposed to basic immigration reform, but this cannot be a situation where we’re just going after immigrants left and right.”

Respected Members I have a genuine question regarding Equity Shares in the Secondary Markets in India .Mr. A and his wife Mrs A have DEMAT account since 2007 and both of them have invested in BSE and NSE listed companies' equity shares over the years since 2007 .

With bad economy and tough lifestyles- we folks have all the more reason to pay God a visit. But people no longer take the pains to dress up for the occasion. Going to church is an itinerary that is squeezed into our hectic schedules. We...

Handbags are not only useful for carrying indispensable items, but they are also considered accoutrements. Some handbags work well with a number of outfits, while other handbags are saved for more conventional junctures. No matter which ...