k Dual-functional porphyrinic zirconium-based metal–organic framework for the fluorescent sensing of histidine enantiomers and Hg2+ By pubs.rsc.org Published On :: Anal. Methods, 2024, 16,2386-2399DOI: 10.1039/D3AY02241B, PaperShili Qin, Fanshu Meng, Fenglong Jin, Xidi Xu, Ming Zhao, Hongtao Chu, Lidi Gao, Shuren LiuL-Cys/PCN-222 as a novel and dual-functional fluorescent sensor was developed. It not only showed a higher chiral fluorescent recognition of L-histidine but also performed as a visual sensor for Hg2+ in actual surface water.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k On-chip light sheet illumination for nanoparticle tracking in microfluidic channels By pubs.rsc.org Published On :: Anal. Methods, 2024, 16,2229-2240DOI: 10.1039/D3AY02290K, CommunicationThéo Travers, Gaétan Delhaye, Martinus H. V. Werts, Denis Gindre, Matthieu LoumaigneA simple and inexpensive method is presented to efficiently integrate light sheet illumination in a microfluidic chip for dark-field microscopic tracking and sizing of nanoparticles.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k A chemiluminescence immunoassay for type IV collagen as a promising marker for liver fibrosis and cirrhosis By pubs.rsc.org Published On :: Anal. Methods, 2024, 16,2248-2255DOI: 10.1039/D3AY02240D, PaperXiaoling Fu, Fan Zhang, Fangda Zhen, Lian Duan, Jian Zhou, Jianguo MaHerein, a magnetic bead-based chemiluminescence assay is reported to detect type IV collagen (col-IV) in serum samples.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k A highly sensitive and selective fluorescent biosensor for breast cancer derived exosomes using click reaction of azide–CD63 aptamer and alkyne-polymer dots By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00146J, PaperDumei Ma, Yiting Luo, Xiaoya Zhang, Zehu Xie, Yinghua Yan, Chuan-Fan DingA fluorescence method based on Cu-triggered click reaction of azide modified CD63 aptamer and alkyne capped Pdots was developed for breast cancer derived exosome detection.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k Design and fabrication of La-based perovskites incorporated with functionalized carbon nanofibers for the electrochemical detection of roxarsone in water and food samples By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00264D, PaperMariya Antony John Felix, Santhiyagu Sahayaraj Rex Shanlee, Shen-Ming Chen, Sundaresan Ruspika, Ramachandran Balaji, Narendhar Chandrasekar, Periyanayagam Arockia DossFabrication of potent electrocatalyst, La-based perovskites coupled with functionalized carbon nanofibers (LMO/f-CNF) for ultrasensitive electrochemical detection of roxarsone in edible and water samples.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k The preparation of a boronate affinity-based controlled oriented imprinting coating on a silica nanoparticle surface for the separation and purification of shikimic acid in herbal medicine By pubs.rsc.org Published On :: Anal. Methods, 2024, Advance ArticleDOI: 10.1039/D4AY00219A, PaperYumin Yang, Daojin Li, Bingqian LiuShikimic acid (SA) is one of the most effective drugs against the A (H1N1) virus and has high medicinal value.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k Solutions and Tools for Dealing with Broken Links in Web Pages By www.impressivewebs.com Published On :: Tue, 01 Dec 2020 22:19:09 +0000 A couple of months ago a post by Leo Blanchette got to the front page of Hacker News and there was an interesting discussion on dealing with broken links and external content – the main problem being links that become out of date due to paywalls, altered content, or content getting taken down. I’ve been running this blog since May 2008. If you’ve run a content-driven site for even a fraction of that, you know that link rot is a problem. In this post I’ll go over some of the suggestions in that thread along with some tools to use to check for broken links. The post Solutions and Tools for Dealing with Broken Links in Web Pages appeared first on Impressive Webs. Full Article HTML5 Web Design Articles
k Filestack: A File Uploader and Powerful APIs to Deliver and Transform App Content By www.impressivewebs.com Published On :: Wed, 11 May 2022 10:00:00 +0000 [Sponsored] If you’re building an app that requires a lot of user-generated content and media that needs to be processed, tagged, filtered, or otherwise manipulated in real-time, you definitely want a solution that’s fast and seamless and doesn’t get in the way of your app’s primary functionality. Filestack is a service you’ll want to consider. Here’s what Filestack offers: The post Filestack: A File Uploader and Powerful APIs to Deliver and Transform App Content appeared first on Impressive Webs. Full Article Sponsored Web Design Articles
k Facebook Home is here. Now what? By www.thehindubusinessline.com Published On :: Fri, 05 Apr 2013 16:59:04 +0530 Full Article R Dinakaran
k Location tracking - do you need it? By www.thehindubusinessline.com Published On :: Sat, 17 Aug 2013 16:31:13 +0530 Full Article R Dinakaran
k Unrealistic expectations: On India and Russia-Ukraine peace By www.thehindu.com Published On :: Mon, 16 Sep 2024 00:37:00 +0530 India’s efforts at peacemaking between Russia and Ukraine have limited potential Full Article Editorial
k For a fair probe: On the Kejriwal bail order and CBI conduct By www.thehindu.com Published On :: Mon, 16 Sep 2024 00:47:00 +0530 Kejriwal bail order is a reminder to CBI to dispel perception of bias Full Article Editorial
k Staunch the breach: On India, Pakistan and the Indus Waters Treaty By www.thehindu.com Published On :: Sat, 21 Sep 2024 00:20:00 +0530 India and Pakistan need to drop their hard line stances on the Indus Waters Treaty Full Article Editorial
k Sri Lanka’s verdict: On the Island nation’s ninth Presidential election By www.thehindu.com Published On :: Mon, 23 Sep 2024 00:10:00 +0530 The spirit of the mandate of the presidential poll was clear — for change Full Article Editorial
k Unwarranted curbs: On the Centre’s move on a ‘fact-checking unit’ By www.thehindu.com Published On :: Mon, 23 Sep 2024 00:20:00 +0530 Fact-checking cannot be an excuse to impose censorship Full Article Editorial
k Kashmir conflict: On the J&K elections By www.thehindu.com Published On :: Thu, 26 Sep 2024 00:20:00 +0530 The political divide between national parties and regional parties is clear Full Article Editorial
k Embattled CM: On Karnataka Chief Minister Siddaramaiah By www.thehindu.com Published On :: Fri, 27 Sep 2024 00:20:00 +0530 Anti-graft moves should not be overshadowed by political motive Full Article Editorial
k Healthy sign: On the voting in the 2024 J&K Assembly elections By www.thehindu.com Published On :: Thu, 03 Oct 2024 00:10:00 +0530 Turnout numbers in the Assembly elections show distinct patterns in south Kashmir Full Article Editorial
k Flipping scripts: On the Haryana and J&K election results By www.thehindu.com Published On :: Wed, 09 Oct 2024 00:20:00 +0530 BJP and INDIA bloc emerge clear winners in Haryana and Jammu & Kashmir Full Article Editorial
k Respect the mandate: On the 2024 Jammu and Kashmir elections By www.thehindu.com Published On :: Fri, 11 Oct 2024 00:20:00 +0530 With elections done and dusted, J&K now must return to statehood Full Article Editorial
k Take the gauntlet: On safety and the Indian Railways By www.thehindu.com Published On :: Mon, 14 Oct 2024 00:38:00 +0530 ‘Kavach’ implementation is a priority but will not be a silver bullet Full Article Editorial
k A Korean win: On the 2024 Nobel Prize in Literature By www.thehindu.com Published On :: Tue, 15 Oct 2024 00:20:00 +0530 A Nobel raises Korean prose to success levels of its drama and music Full Article Editorial
k Taking guard: On the RBI and growth concerns By www.thehindu.com Published On :: Tue, 15 Oct 2024 00:26:00 +0530 The central bank’s price worries may be warranted but growth concerns are emerging Full Article Editorial
k Abject failure: On India’s Global Hunger Index ranking By www.thehindu.com Published On :: Thu, 17 Oct 2024 00:10:00 +0530 India’s ranks 105 out of 127 countries in the Global Hunger Index, 2024 Full Article Editorial
k Battle of wits: On the Maharashtra and Jharkhand elections By www.thehindu.com Published On :: Fri, 18 Oct 2024 00:20:00 +0530 The Maharashtra and Jharkhand polls will witness intense political battles Full Article Editorial
k Allow for deliberation: On the legitimate demands of Ladakh By www.thehindu.com Published On :: Tue, 22 Oct 2024 00:15:00 +0530 The lack of a legislature and regional autonomy in Ladakh has led to the current protests Full Article Editorial
k Celebration and vigil: On India, kala-azar and trachoma By www.thehindu.com Published On :: Thu, 24 Oct 2024 00:10:00 +0530 India must not let its guard down on kala-azar Full Article Editorial
k Growth prescription: On the latest World Economic Outlook By www.thehindu.com Published On :: Thu, 24 Oct 2024 00:20:00 +0530 The IMF’s ‘mediocre’ medium-term outlook merits policy attention Full Article Editorial
k Building blocks: On the 16th BRICS Summit in Kazan By www.thehindu.com Published On :: Fri, 25 Oct 2024 00:24:00 +0530 The BRICS Summit showed that Russia was not without friends Full Article Editorial
k Neck and neck: On the U.S. presidential election By www.thehindu.com Published On :: Sat, 26 Oct 2024 00:10:00 +0530 Trump and Harris offer U.S. voters vastly different choices Full Article Editorial
k Fair trade: On the 29th COP and India’s carbon market By www.thehindu.com Published On :: Sat, 26 Oct 2024 00:20:00 +0530 India must develop a transparent carbon trade policy Full Article Editorial
k Beautifully vague: On the Tamilaga Vettri Kazhagam’s inaugural conference By www.thehindu.com Published On :: Wed, 30 Oct 2024 00:10:00 +0530 Actor Vijay seems to be targeting both the BJP and the DMK Full Article Editorial
k Tough task: On the battle lines in the Jharkhand Assembly election By www.thehindu.com Published On :: Wed, 30 Oct 2024 00:20:00 +0530 Coalitional incoherence could stymie the INDIA bloc’s effort to retain power in Jharkhand Full Article Editorial
k What Makes <I>Andaz Apna Apna</I> Such Fun Even Today By www.rediff.com Published On :: Andaz Apna Apna is practically the most quoted film since Sholay, observes Sukanya Verma, as she celebrates 30 years of this cult classic movie. Full Article
k Why Kriti Is So Grateful By www.rediff.com Published On :: Kriti Kharbanda took a trip down memory lane when her rom-com Shaadi Mein Zaroor Aana clocked seven years since its release. Full Article
k The Raj & DK Line-Up You Cannot Miss By www.rediff.com Published On :: Sukanya Verma looks at their eclectic career of over two decades as their latest offering Citadel: Honey Bunny, the Indian leg of the Russo Brothers globetrotting spy universe series, drops on Amazon Prime Video on November 7. Full Article
k Why Abhishek Missed Aishwarya's Birthday By www.rediff.com Published On :: When Aishwarya celebrated her birthday in Dubai on November 1, the speculation regarding the Abhishek-Aishwarya marital rift ran even higher. Full Article
k 'He Doesn't Have The Air He Is Raj Thackeray's Son' By www.rediff.com Published On :: 'I love to meet people.' Full Article
k Look Who Just Met Tom Cruise! By www.rediff.com Published On :: Kartik wants to savour Litti Chokha in Patna... Amyra holidays in Phuket... Karishma in Italy... Full Article
k Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3495-3506DOI: 10.1039/D4MD00275J, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. RussellThe optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3576-3596DOI: 10.1039/D4MD00438H, Research ArticleRuolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang ChenRho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3444-3459DOI: 10.1039/D4MD00318G, Research ArticleAnuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar MaitiNiloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3460-3468DOI: 10.1039/D4MD00405A, Research ArticleXiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli BiSchematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3485-3494DOI: 10.1039/D4MD00246F, Research ArticleShouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng XuA novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024) By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3371-3394DOI: 10.1039/D4MD00384E, Review ArticleDebasis Das, Lingzhi Xie, Jian HongProspects of novel fourth-generation EGFR-TKIs overcoming C797S-mediated resistance in non-small cell lung cancer.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3597-3608DOI: 10.1039/D4MD00378K, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. JenkinsIn silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00537F, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry LombergetA series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00645C, Research ArticleGeetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra BorahVirtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00579A, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-BrocetaA ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
k Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00555D, Research ArticleShenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong LiuThe continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article