ac Sticky pineapple and macadamia upside-down cake By www.abc.net.au Published On :: Mon, 16 Nov 2015 12:47:00 +1100 This is what I think of as an honest cake - not tizzy, just homely, buttery and ever-so more-ish with its tender, nutty crumb and sweet, caramelised pineapple topping. I particularly love the way the sides, through some kind of magical alchemy of heat and sugar, become ever-so-slightly crunchy. There are a couple of little things I've noticed when I bake it - the first is that it cooks better and looks better when baked in a regular, not a non-stick, cake tin. And the second is that it's really important not to overload the tin with pineapple or it will release too much liquid and the centre of the cake will be soggy. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ac Roasted Honey and Thyme Peaches By www.abc.net.au Published On :: Thu, 11 Feb 2016 13:19:00 +1100 Celebrate sweet, juicy peaches with this easy and delicious dessert. No ricotta? Serve peaches with vanilla ice cream and toasted almonds. Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690
ac White Chocolate and fresh peach cheesecake By www.abc.net.au Published On :: Thu, 03 Mar 2016 13:27:00 +1100 This is a glorious match! Free stone yellow and white peaches are perfect at the moment but wont last much longer so enjoy them while you can Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ac Baked figs stuffed with goat's cheese, black garlic and herbs, mint and purple basil salad By www.abc.net.au Published On :: Thu, 10 Mar 2016 05:43:00 +1100 Figs are such a versatile fruit, they can be eaten raw, cooked, and sweet or savoury. Here I am baking them with goat's curd which is truly delicious. Wrapping them in prosciutto adds texture and saltiness and the mint salad adds a lovely freshness to the dish. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ac Greek chicken with polenta and sumac crumb By www.abc.net.au Published On :: Fri, 11 Mar 2016 11:09:00 +1000 6 chicken thighs 1 egg 1/2 cup polenta 1 tbsp. sumac 1 tsp cumin seeds salt flakes and freshly ground pepper, to season 60 ml (1/4 cup) pomegranate molasses Avocado Tzatziki: 1 cup)Greek-style yoghurt 1 ripe avocado, flesh coarsely mashed with a fork 3 Lebanese cucumbers, grated, squeeze to remove excess liquid 3 garlic cloves, crushed 1/4 cup chopped coriander leaves 1 tbsp. chopped mint leaves juice of 1/2 lime pinch of Himalayan salt Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ac Easter ricotta, spinach, egg and dill pie By www.abc.net.au Published On :: Mon, 14 Mar 2016 13:37:00 +0800 This is a simplified version of a traditional Italian spinach and ricotta pie, commonly eaten on Good Friday. Full Article ABC Local southwestwa Lifestyle and Leisure:Recipes:Main Lifestyle and Leisure:Recipes:Mostly Vegetarian Lifestyle and Leisure:Recipes:Vegetarian Australia:WA:Pemberton 6260
ac Slow-cooked pork shoulder with apples and crackling By www.abc.net.au Published On :: Tue, 29 Mar 2016 12:49:00 +1100 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Justine Schofield. Justine's latest book is "Dinner With Justine". Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ac Chocolate brownies with crystallised ginger and macadamia nuts By www.abc.net.au Published On :: Wed, 27 Apr 2016 10:05:00 +0800 140g unsalted butter 200g dark chocolate 100g light brown sugar 100g caster sugar 2 teaspoons vanilla extract 2 eggs 1 egg yolk 85g plain flour 55g macadamia nuts, lightly toasted, chopped 30g crystallised ginger, chopped Sifted cocoa powder, to dust Full Article ABC Local wheatbelt Lifestyle and Leisure:Recipes:Biscuits and Slices Australia:WA:Geraldton 6530
ac Spinach and Sweet Potato Frittata By www.abc.net.au Published On :: Tue, 10 May 2016 14:38:00 +1000 The frittata has almost overtaken the classic quiche. It is a healthier option as it doesn't have the extra kilojoules of a pastry case. It's Italian in origin and a versatile dish as you can serve it hot or at room temperature for lunch or dinner, alone or with a salad or vegetables, as part of an Antipasto selection or cut in bite-size pieces to serve as a nibble with drinks. Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690
ac BORLOTTI BEAN AND TUSCAN BLACK KALE (CAVOLO NERO) SOUP By www.abc.net.au Published On :: Thu, 02 Jun 2016 10:09:00 +1000 Fortunately Tuscan black kale (cavolo nero) with its sweet, earthy flavour is readily available now, however as it's gratifyingly hardy and easy to grow, if you have a small patch or pot to put some in I can't encourage you enough to do so; it will pay you back in spades. The crinkly blue/green leaves are quite tough, but with long, slow cooking they become tender and gently sweet, and that's the quality they give to this stick-to-your-ribs soup. I usually make it on the weekend when I have a bit more time to potter around in the kitchen, and love that it makes rather a lot (I've never been one to cook by halves! Although by all means make half the recipe if you'd rather not have leftovers) as having a tub tucked away in the fridge is like gold in the bank in a busy week. There's a fair bit of chopping required to start with, however once that's done the recipe is really straightforward. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ac Cracked pepper tagliatelle with wild boar By www.abc.net.au Published On :: Tue, 21 Jun 2016 14:10:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Daniel Lucas Tonin, Pasta Classica Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ac Stir-fried water spinach with preserved bean curd - fu yu ong choy By www.abc.net.au Published On :: Tue, 28 Jun 2016 14:51:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Tony Tan Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ac Milk poached veal, beets, brassica, avocado By www.abc.net.au Published On :: Mon, 04 Jul 2016 12:05:00 +1000 A different take on veal to warm up a dinner party. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ac Malaysian chicken satay with roasted macadamia dipping sauce By www.abc.net.au Published On :: Fri, 08 Jul 2016 12:48:00 +1000 I seriously love cooking on the Weber more in winter cooler temperature make us feel more cosy and accentuate the taste buds and smell . Replaced the traditional peanuts with our wonderful local macadamias Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ac Eucalyptus smoked Marburg emu fillet, beets, macadamia plus Lilly Pilly and finger lime spritzer By www.abc.net.au Published On :: Mon, 19 Sep 2016 10:34:00 +1000 Delicious Australian dish with fresh Lilly Pilly and finger lime spritzer. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ac Calamari and fermented celeriac, barbecued peas and beef fat By www.abc.net.au Published On :: Tue, 20 Sep 2016 12:17:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Dan Hunter, chef and owner of Otways' restaurant Brae. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ac Bush food macadamia, white chocolate and pepperleaf cookies By www.abc.net.au Published On :: Fri, 21 Oct 2016 13:39:00 +1000 125g butter, softened 1 cup caster sugar 1 egg 1 tsp vanilla essence 1 and 1/2 cups plain flour, sifted 1 tsp baking powder 1/4 tsp. pepper leaf spice, ground 1 cup white chocolate chips 1/3 cup raw macadamia nuts, chopped Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ac MACADAMIA PESTO POTATO SALAD WITH CRISPY PROSCIUTTO AND MARKET CHERRY TOMATOES By www.abc.net.au Published On :: Tue, 25 Oct 2016 06:24:00 +1100 Love this time of year where our makers are abundant with the sweet aroma of fresh basil . Here is my take on a fancy potato salad of macadamia pesto , crispy prosciutto, sweet cherry tomatoes Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ac Lady finger parfait with warm chocolate sauce and crushed Honey Macadamias By www.abc.net.au Published On :: Thu, 19 Jan 2017 06:26:00 +1100 The local lady finger bananas are so sweet and moorish! Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ac Poached eggs with corn, cottage cheese and sweet potato fritters By www.abc.net.au Published On :: Fri, 10 Feb 2017 10:58:00 +1000 Summer entertaining; breakfast/lunch Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ac Raw and char-grilled broccoli salad with macadamia and semi-hard goats cheese By www.abc.net.au Published On :: Thu, 16 Feb 2017 10:33:00 +1100 This salad is inspired by a good chef friend of mine who cooked with me last weekend. Such a healthy way to enjoy broccoli which is so delicious at the moment. It's wonderful to utilize the whole vegetable and the added fibre in the stalk which we use in the salad.Feel free to explore with certain quantities in this recipe therefore I encourage you to taste and adjust to your own personal taste. You can also add chopped green olives which add an extra dimension. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ac Autumn roasted vegetables with lemon thyme and a drizzle of macadamia honey By www.abc.net.au Published On :: Thu, 16 Mar 2017 13:45:00 +1100 Nothing beats beautifully roasted vegetables caramelized in their own sugar content to accompany a simple roast dinner or even on their own with a nice salad. The addition of perfumed lemon thyme and macadamia gives a nice touch. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ac French salted caramel ganache tart By www.abc.net.au Published On :: Thu, 04 May 2017 13:39:00 +1000 An indulgent French chocolate and salted caramel tart. Decorate with fresh raspberries and pistachio nuts for great colour and a sweet zing. Full Article ABC Local widebay Lifestyle and Leisure:Food and Cooking:All Australia:QLD:Bundaberg 4670
ac Rice and macadamia salad By www.abc.net.au Published On :: Thu, 01 Jun 2017 13:38:00 +1000 This salad is our go-to staple. Everyone loves it. It's healthy, colourful and so, so easy. It can also be made entirely with local ingredients. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ac How to cook a leatherjacket By www.abc.net.au Published On :: Thu, 24 Aug 2017 10:37:00 +1000 This method is moist and magic! Throw out every notion you might have had about leatherjackets being anything other than juicy and flavoursome. This little trick cooks the fish from within. Usually salt draws but in this case its responsible for keeping every bit of moisture in the fish. Leatherjacket is an inexpensive fish, the presentation is great, and you'll bowl over your dinner guests every time. What's not to love? Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ac La Bienvenida Se Agota para Colombianos en Ecuador Mientras Venezolanos Se Hacen Más Visibles By www.migrationpolicy.org Published On :: Thu, 09 Jan 2020 10:42:56 -0500 Aunque colombianos encontraron un refugio cálido en Ecuador después de ser desplazados de su país por una guerra civil que duro décadas, la vida se ha vuelto más difícil para ellos en los últimos años, en parte como resultado del flujo de venezolanos que buscan seguridad. Este artículo se basa en encuestas de migrantes en Quito, comparando y contrastando las experiencias de colombianos y venezolanos, y evaluando sus percepciones de discriminación, victimización y esperanzas para el futuro. Full Article
ac ¿Se Están Cerrando las Puertas? Respuestas a la Migración Venezolana en América Latina y el Caribe By www.migrationpolicy.org Published On :: Mon, 03 Feb 2020 12:33:28 -0500 MPI llevó a cabo un seminario en línea para marcar el lanzamiento de: Un portal sobre Migración en América Latina y el Caribe; y un informe que examina los efectos de las políticas migratorias y de integración en 11 países en América Latina y el Caribe ante el aumento de la migración venezolana y nicaragüense. Full Article
ac Bienvenidas asimétricas: Respuestas de América Latina y el Caribe a la migración venezolana y nicaragüense By www.migrationpolicy.org Published On :: Mon, 10 Feb 2020 10:44:38 -0500 El gran desplazamiento forzado de personas en Venezuela y Nicaragua está transformando el panorama migratorio en gran parte de América Latina y el Caribe. Este informe examina las respuestas de las políticas de inmigración e integración de once países, incluyendo vías de regularización y medidas para integrar a los recién llegados en las escuelas y mercados laborales. Este informe acompaña el lanzamiento de un Portal Sobre Migración que ofrece investigación y análisis actualizados sobre tendencias y políticas de inmigración en la región. Full Article
ac COVID-19 in Latin America: Tackling Health Care & Other Impacts for Vulnerable Migrant Populations By www.migrationpolicy.org Published On :: Fri, 27 Mar 2020 10:58:29 -0400 This MPI webinar brought together public health and migration experts to analyze the impact that COVID-19 preventative measures will have on vulnerable immigrants and refugees in Latin America, with a particular look at Colombia as a case study. Speakers also discussed how policymakers and international organizations can include migrant populations in their emergency response plans. Full Article
ac Efficacy and Safety of Dapagliflozin in the Elderly: Analysis From the DECLARE-TIMI 58 Study By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Data regarding the effects of sodium–glucose cotransporter 2 inhibitors in the elderly (age ≥65 years) and very elderly (age ≥75 years) are limited. RESEARCH DESIGN AND METHODS The Dapagliflozin Effect on Cardiovascular Events (DECLARE)–TIMI 58 assessed cardiac and renal outcomes of dapagliflozin versus placebo in patients with type 2 diabetes. Efficacy and safety outcomes were studied within age subgroups for treatment effect and age-based treatment interaction. RESULTS Of the 17,160 patients, 9,253 were <65 years of age, 6,811 ≥65 to <75 years, and 1,096 ≥75 years. Dapagliflozin reduced the composite of cardiovascular death or hospitalization for heart failure consistently, with a hazard ratio (HR) of 0.88 (95% CI 0.72, 1.07), 0.77 (0.63, 0.94), and 0.94 (0.65, 1.36) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.5277). Overall, dapagliflozin did not significantly decrease the rates of major adverse cardiovascular events, with HR 0.93 (95% CI 0.81, 1.08), 0.97 (0.83, 1.13), and 0.84 (0.61, 1.15) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.7352). The relative risk reduction for the secondary prespecified cardiorenal composite outcome ranged from 18% to 28% in the different age-groups with no heterogeneity. Major hypoglycemia was less frequent with dapagliflozin versus placebo, with HR 0.97 (95% CI 0.58, 1.64), 0.50 (0.29, 0.84), and 0.68 (0.29, 1.57) in age-groups <65, ≥65 to <75, and ≥75 years, respectively (interaction P value 0.2107). Safety outcomes, including fractures, volume depletion, cancer, urinary tract infections, and amputations were balanced with dapagliflozin versus placebo, and acute kidney injury was reduced, all regardless of age. Genital infections that were serious or led to discontinuation of the study drug and diabetic ketoacidosis were uncommon, yet more frequent with dapagliflozin versus placebo, without heterogeneity (interaction P values 0.1058 and 0.8433, respectively). CONCLUSIONS The overall efficacy and safety of dapagliflozin are consistent regardless of age. Full Article
ac Microvascular and Cardiovascular Outcomes According to Renal Function in Patients Treated With Once-Weekly Exenatide: Insights From the EXSCEL Trial By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE To evaluate the impact of once-weekly exenatide (EQW) on microvascular and cardiovascular (CV) outcomes by baseline renal function in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL). RESEARCH DESIGN AND METHODS Least squares mean difference (LSMD) in estimated glomerular filtration rate (eGFR) from baseline between the EQW and placebo groups was calculated for 13,844 participants. Cox regression models were used to estimate effects by group on incident macroalbuminuria, retinopathy, and major adverse CV events (MACE). Interval-censored time-to-event models estimated effects on renal composite 1 (40% eGFR decline, renal replacement, or renal death) and renal composite 2 (composite 1 variables plus macroalbuminuria). RESULTS EQW did not change eGFR significantly (LSMD 0.21 mL/min/1.73 m2 [95% CI –0.27 to 0.70]). Macroalbuminuria occurred in 2.2% of patients in the EQW group and in 2.5% of those in the placebo group (hazard ratio [HR] 0.87 [95% CI 0.70–1.07]). Neither renal composite was reduced with EQW in unadjusted analyses, but renal composite 2 was reduced after adjustment (HR 0.85 [95% CI 0.74–0.98]). Retinopathy rates did not differ by treatment group or in the HbA1c-lowering or prior retinopathy subgroups. CV outcomes in those with eGFR <60 mL/min/1.73 m2 did not differ by group. Those with eGFR ≥60 mL/min/1.73 m2 had nominal risk reductions for MACE, all-cause mortality, and CV death, but interactions by renal function group were significant for only stroke (HR 0.74 [95% CI 0.58–0.93]; P for interaction = 0.035) and CV death (HR 1.08 [95% CI 0.85–1.38]; P for interaction = 0.031). CONCLUSIONS EQW had no impact on unadjusted retinopathy or renal outcomes. CV risk was modestly reduced only in those with eGFR ≥60 mL/min/1.73 m2 in analyses unadjusted for multiplicity. Full Article
ac Impact of Glucose Level on Micro- and Macrovascular Disease in the General Population: A Mendelian Randomization Study By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To evaluate whether high glucose levels in the normoglycemic range and higher have a causal genetic effect on risk of retinopathy, neuropathy, nephropathy, chronic kidney disease (CKD), peripheral arterial disease (PAD), and myocardial infarction (MI; positive control) in the general population. RESEARCH DESIGN AND METHODS This study applied observational and one-sample Mendelian randomization (MR) analyses to individual-level data from 117,193 Danish individuals, and validation by two-sample MR analyses on summary-level data from 133,010 individuals from the Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), 117,165 from the CKDGen Consortium, and 452,264 from the UK Biobank. RESULTS Observationally, glucose levels in the normoglycemic range and higher were associated with high risks of retinopathy, neuropathy, diabetic nephropathy, PAD, and MI (all P for trend <0.001). In genetic causal analyses, the risk ratio for a 1 mmol/L higher glucose level was 2.01 (95% CI 1.18–3.41) for retinopathy, 2.15 (1.38–3.35) for neuropathy, 1.58 (1.04–2.40) for diabetic nephropathy, 0.97 (0.84–1.12) for estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2, 1.19 (0.90–1.58) for PAD, and 1.49 (1.02–2.17) for MI. Summary-level data from the MAGIC, the CKDGen Consortium, and the UK Biobank gave a genetic risk ratio of 4.55 (95% CI 2.26–9.15) for retinopathy, 1.48 (0.83–2.66) for peripheral neuropathy, 0.98 (0.94–1.01) for eGFR <60 mL/min/1.73 m2, and 1.23 (0.57–2.67) for PAD per 1 mmol/L higher glucose level. CONCLUSIONS Glucose levels in the normoglycemic range and higher were prospectively associated with a high risk of retinopathy, neuropathy, diabetic nephropathy, eGFR <60 mL/min/1.73 m2, PAD, and MI. These associations were confirmed in genetic causal analyses for retinopathy, neuropathy, diabetic nephropathy, and MI, but they could not be confirmed for PAD and seemed to be refuted for eGFR <60 mL/min/1.73 m2. Full Article
ac Risk Factors for First and Subsequent CVD Events in Type 1 Diabetes: The DCCT/EDIC Study By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE The Diabetes Control and Complications Trial (DCCT) and its observational follow-up Epidemiology of Diabetes Interventions and Complications (EDIC) demonstrated the dominant role of glycemia, second only to age, as a risk factor for a first cardiovascular event in type 1 diabetes (T1D). We now investigate the association between established risk factors and the total cardiovascular disease (CVD) burden, including subsequent (i.e., recurrent) events. RESEARCH DESIGN AND METHODS CVD events in the 1,441 DCCT/EDIC participants were analyzed separately by type (CVD death, acute myocardial infarction [MI], stroke, silent MI, angina, percutaneous transluminal coronary angioplasty/coronary artery bypass graft [PTCA/CABG], and congestive heart failure [CHF]) or as composite outcomes (CVD or major adverse cardiovascular events [MACE]). Proportional rate models and conditional models assessed associations between risk factors and CVD outcomes. RESULTS Over a median follow-up of 29 years, 239 participants had 421 CVD events, and 120 individuals had 149 MACE. Age was the strongest risk factor for acute MI, silent MI, stroke, and PTCA/CABG, while glycemia was the strongest risk factor for CVD death, CHF, and angina, second strongest for acute MI and PTCA/CABG, third strongest for stroke, and not associated with silent MI. HbA1c was the strongest modifiable risk factor for a first CVD event (CVD: HR 1.38 [95% CI 1.21, 1.56] per 1% higher HbA1c; MACE: HR 1.54 [1.30, 1.82]) and also for subsequent CVD events (CVD: incidence ratio [IR] 1.28 [95% CI 1.09, 1.51]; MACE: IR 1.89 [1.36, 2.61]). CONCLUSIONS Intensive glycemic management is recommended to lower the risk of initial CVD events in T1D. After a first event, optimal glycemic control may reduce the risk of recurrent CVD events and should be maintained. Full Article
ac Predicting 10-Year Risk of End-Organ Complications of Type 2 Diabetes With and Without Metabolic Surgery: A Machine Learning Approach By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To construct and internally validate prediction models to estimate the risk of long-term end-organ complications and mortality in patients with type 2 diabetes and obesity that can be used to inform treatment decisions for patients and practitioners who are considering metabolic surgery. RESEARCH DESIGN AND METHODS A total of 2,287 patients with type 2 diabetes who underwent metabolic surgery between 1998 and 2017 in the Cleveland Clinic Health System were propensity-matched 1:5 to 11,435 nonsurgical patients with BMI ≥30 kg/m2 and type 2 diabetes who received usual care with follow-up through December 2018. Multivariable time-to-event regression and random forest machine learning models were built and internally validated using fivefold cross-validation to predict the 10-year risk for four outcomes of interest. The prediction models were programmed to construct user-friendly web-based and smartphone applications of Individualized Diabetes Complications (IDC) Risk Scores for clinical use. RESULTS The prediction tools demonstrated the following discrimination ability based on the area under the receiver operating characteristic curve (1 = perfect discrimination and 0.5 = chance) at 10 years in the surgical and nonsurgical groups, respectively: all-cause mortality (0.79 and 0.81), coronary artery events (0.66 and 0.67), heart failure (0.73 and 0.75), and nephropathy (0.73 and 0.76). When a patient’s data are entered into the IDC application, it estimates the individualized 10-year morbidity and mortality risks with and without undergoing metabolic surgery. CONCLUSIONS The IDC Risk Scores can provide personalized evidence-based risk information for patients with type 2 diabetes and obesity about future cardiovascular outcomes and mortality with and without metabolic surgery based on their current status of obesity, diabetes, and related cardiometabolic conditions. Full Article
ac A fresh look for your Microblogs, Twitter and Facebook Feeds By blog.inoreader.com Published On :: Mon, 25 Nov 2019 12:15:00 +0000 If you’ve browsed your Twitter or Facebook page feeds in the last week, you have probably noticed that we changed… Full Article facebook Microblog new Twitter Uncategorized
ac Effects of MK-0941, a Novel Glucokinase Activator, on Glycemic Control in Insulin-Treated Patients With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2011-11-21T22:32:39-08:00 OBJECTIVE To assess the efficacy and safety of MK-0941, a glucokinase activator (GKA), when added to stable-dose insulin glargine in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS In this double-blind study, 587 patients taking stable-dose insulin glargine (±metformin ≥1,500 mg/day) were randomized (1:1:1:1:1) to MK-0941 10, 20, 30, or 40 mg or matching placebo t.i.d. before meals (a.c.). This study included an initial 14-week, dose-ranging phase followed by a 40-week treatment phase during which patients were to be uptitrated as tolerated to 40 mg (or placebo) t.i.d. a.c. The primary efficacy end point was change from baseline in A1C at Week 14. RESULTS At Week 14, A1C and 2-h postmeal glucose (PMG) improved significantly versus placebo with all MK-0941 doses. Maximal placebo-adjusted least squares mean changes from baseline in A1C (baseline A1C 9.0%) and 2-h PMG were –0.8% and –37 mg/dL (–2 mmol/L), respectively. No significant effects on fasting plasma glucose were observed at any dose versus placebo. By 30 weeks, the initial glycemic responses noted at 14 weeks were not sustained. MK-0941 at one or more doses was associated with significant increases in the incidence of hypoglycemia, triglycerides, systolic blood pressure, and proportion of patients meeting criteria for predefined limits of change for increased diastolic blood pressure. CONCLUSIONS In patients receiving stable-dose insulin glargine, the GKA MK-0941 led to improvements in glycemic control that were not sustained. MK-0941 was associated with an increased incidence of hypoglycemia and elevations in triglycerides and blood pressure. Full Article
ac ¿Se Están Cerrando las Puertas? Respuestas a la Migración Venezolana en América Latina y el Caribe By www.migrationpolicy.org Published On :: Thu, 13 Feb 2020 13:08:48 -0500 MPI llevó a cabo un seminario en línea para marcar el lanzamiento de: Un portal sobre Migración en América Latina y el Caribe; y un informe que examina los efectos de las políticas migratorias y de integración en 11 países en América Latina y el Caribe ante el aumento de la migración venezolana y nicaragüense. Full Article
ac An Uneven Landscape: The Differing State Approaches to English Learner Policies under ESSA By www.migrationpolicy.org Published On :: Wed, 19 Feb 2020 10:14:45 -0500 Experts share how states have approached Every Student Succeeds Act (ESSA) implementation, areas where the law and state efforts to support English Learners can be improved, and findings from the compendium, The Patchy Landscape of State English Learner Policies under ESSA. Full Article
ac COVID-19 in Latin America: Tackling Health Care & Other Impacts for Vulnerable Migrant Populations By www.migrationpolicy.org Published On :: Mon, 06 Apr 2020 12:44:50 -0400 This MPI webinar brought together public health and migration experts to analyze the impact that COVID-19 preventative measures will have on vulnerable immigrants and refugees in Colombia and Latin America. Speakers also discussed how policymakers and international organizations can include migrant populations in their emergency response plans. Full Article
ac In the Age of Trump: Populist Backlash and Progressive Resistance Create Divergent State Immigrant Integration Contexts By www.migrationpolicy.org Published On :: Wed, 17 Jan 2018 10:26:51 -0500 As long-simmering passions related to federal immigration policies have come to a full boil, less noted but no less important debates are taking place at state and local levels with regards to policies affecting immigrants and their children. As states are increasingly diverging in their responses, this report examines how some of the key policies and programs that support long-term integration success are faring in this volatile era. Full Article
ac Chilling Effects: The Expected Public Charge Rule and Its Impact on Legal Immigrant Families’ Public Benefits Use By www.migrationpolicy.org Published On :: Fri, 08 Jun 2018 14:09:59 -0400 According to leaked drafts, the Trump administration is considering a rule that could have sweeping effects on both legal immigration to the United States and the use of public benefits by legal immigrants and their families. This report examines the potential scale of the expected rule’s impact, including at national and state levels and among children, as well as Hispanic and Asian American/Pacific Islander immigrants. Full Article
ac Chilling Effects: The Expected Public-Charge Rule and Its Impact on Immigrant Families By www.migrationpolicy.org Published On :: Tue, 12 Jun 2018 17:57:14 -0400 This webinar highlights findings from an MPI report examining the potential impacts of expected changes to the public charge rule by the Trump administration. Leaked draft versions suggest the rule could sharply expand the number of legally present noncitizens facing difficulty getting a green card or extending a visa as a result of their family's use of public benefits. The rule likely would discourage millions from accessing health, nutrition, and social services for which they or their U.S.-citizen dependents are eligible. Full Article
ac Through the Back Door: Remaking the Immigration System via the Expected “Public-Charge” Rule By www.migrationpolicy.org Published On :: Thu, 23 Aug 2018 11:11:59 -0400 A Trump administration “public-charge” rule expected to be unveiled soon could create the potential to significantly reshape family-based legal immigration to the United States—and reduce arrivals from Asia, Latin America, and Africa—by imposing a de facto financial test that 40 percent of the U.S. born themselves would fail, as this commentary explains. Full Article
ac The Public-Charge Rule: Broad Impacts, But Few Will Be Denied Green Cards Based on Actual Benefits Use By www.migrationpolicy.org Published On :: Tue, 03 Mar 2020 17:57:09 -0500 While the Trump administration public-charge rule is likely to vastly reshape legal immigration based on its test to assess if a person might ever use public benefits in the future, the universe of noncitizens who could be denied a green card based on current benefits use is quite small. That's because very few benefit programs are open to noncitizens who do not hold a green card. This commentary offers estimates of who might be affected. Full Article
ac Diabetes and Back Pain: Markers of Diabetes Disease Progression Are Associated With Chronic Back Pain By clinical.diabetesjournals.org Published On :: 2017-07-01 Lorenzo RinaldoJul 1, 2017; 35:126-131Feature Articles Full Article
ac Diabetes Self-management Education and Support in Type 2 Diabetes: A Joint Position Statement of the American Diabetes Association, the American Association of Diabetes Educators, and the Academy of Nutrition and Dietetics By clinical.diabetesjournals.org Published On :: 2016-04-01 Margaret A. PowersApr 1, 2016; 34:70-80Position Statements Full Article
ac PROactive: A Sad Tale of Inappropriate Analysis and Unjustified Interpretation By clinical.diabetesjournals.org Published On :: 2006-04-01 Jay S. SkylerApr 1, 2006; 24:63-65Commentary Full Article
ac Interdisciplinary Team Care for Diabetic Patients by Primary Care Physicians, Advanced Practice Nurses, and Clinical Pharmacists By clinical.diabetesjournals.org Published On :: 2011-04-01 David WillensApr 1, 2011; 29:60-68Feature Articles Full Article
ac Engaging Patients in Education for Self-Management in an Accountable Care Environment By clinical.diabetesjournals.org Published On :: 2011-07-01 Christine A. BeebeJul 1, 2011; 29:123-126Practical Pointers Full Article
ac Cardiac Manifestations of Congenital Generalized Lipodystrophy By clinical.diabetesjournals.org Published On :: 2016-10-01 Vani P. SanonOct 1, 2016; 34:181-186Feature Articles Full Article