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Nanopore sequencing and the Shasta toolkit enable efficient de novo assembly of eleven human genomes




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Surrogate endpoints for overall survival for patients with metastatic hormone-sensitive prostate cancer in the CHAARTED trial




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Exposure to direct-to-consumer advertising is associated with overestimation of benefits regarding ultrahypofractionated radiation therapy for prostate cancer




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Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in <i>Drosophila</i>




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Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration




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High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission




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Phase I trial of maintenance selinexor after allogeneic hematopoietic stem cell transplantation for patients with acute myeloid leukemia and myelodysplastic syndrome




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Oral health in allogeneic hematopoietic stem cells transplantation survivors




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Rituximab for desensitization during HLA-mismatched stem cell transplantation in patients with a positive donor-specific anti-HLA antibody




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Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR




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QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism




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WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2




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LncRNA <i>SNORD3A</i> specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression




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Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest inhibiting PGF could help treat hypertension.




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Topoisomerase II binding protein 1 (TOPBP1)

Mouse and cell culture studies suggest inhibiting TOPBP1 could help treat cancer.




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In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states




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Bridging naïve and primed pluripotency




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Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis




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MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




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Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




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TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials




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Author Correction: Quantum wave–particle superposition in a delayed-choice experiment




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Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism




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Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation




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Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy




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Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression




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Supporting sexual adjustment from the perspective of men living with spinal cord injury




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Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus




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Decelerated epigenetic aging associated with mood stabilizers in the blood of patients with bipolar disorder




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Rodent models of post-traumatic stress disorder: behavioral assessment




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Genomic characterization of patients with polycythemia vera developing resistance to hydroxyurea




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Pomalidomide, dexamethasone, and daratumumab in relapsed refractory multiple myeloma after lenalidomide treatment




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Monogenic small vessel diseases — rare but still important




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Evaluation of an AI system for the detection of diabetic retinopathy from images captured with a handheld portable fundus camera: the MAILOR AI study




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Design, implementation, and evaluation of a nurse-led intravitreal injection programme for retinal diseases in Singapore




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Possible consequences of the COVID-19 pandemic on the use of biospecimens from cancer biobanks for research in academia and bioindustry




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Protecting the population with immune individuals




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COVID-19's Painful Lesson About Strategy and Power

Joseph Nye writes that while trade wars have set back economic globalization,  the environmental globalization represented by pandemics and climate change is unstoppable. Borders are becoming more porous to everything from drugs to infectious diseases to cyber terrorism, and the United States must use its soft power of attraction to develop networks and institutions that address these new threats.




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So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




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To Pressure Iran, Pompeo Turns to the Deal Trump Renounced

The secretary of state is preparing an argument that the U.S. remains a participant in the Obama-era nuclear deal, with the goal of extending an arms embargo or destroying the accord.




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Poll: What the American Public Likes and Hates about Trump's Nuclear Policies

The authors conducted a study which highlights how the U.S. public as a whole and various demographic groups view President Donald Trump's positions on nuclear weapons.




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How the Pentagon Is Struggling to Stay out of Politics

 Gen. Mark. A. Milley’s job is to provide sound military advice to the president. But at a deeper level, his responsibility is to safeguard the independence and integrity of the armed forces. The last thing the country needs is a military leadership that’s trying to curry favor with any commander in chief, particularly one who’s hungry for affirmation.




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Oil's Collapse Is a Geopolitical Reset In Disguise

The world is on the cusp of a geopolitical reset. The global pandemic could well undermine international institutions, reinforce nationalism and spur de-globalization. But far-sighted leadership could also rekindle cooperation, glimmers of which appeared in the G-20’s offer of debt relief for some of the world’s poorest countries, a joint plea from more than 200 former national leaders for a more coordinated pandemic response and an unprecedented multinational pact to arrest the crash in oil markets.  




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Cutoff point estimation for serum vitamin D concentrations to predict cardiometabolic risk in Brazilian children




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The Strategic Postures of China and India: A Visual Guide

Fueled by aggressive rhetoric from both capitals, Indian and Chinese ground forces engaged in a standoff between June and August 2017. The Doklam crisis, as it became known, stimulated introspection among officials and experts in both states about the future of their relationship. Politically, both strategic communities largely concluded that the peaceful resolution of border disputes is now less likely, forecasting more rivalry than cooperation. Militarily, Indian discussions on the strength of its military position against China in their disputed ground frontier areas have converged on the view that China holds the conventional and nuclear edge over India in this domain.

Based on our analysis of data on the location and capabilities of Indian and Chinese strategic forces and related military units, we conclude that this assessment of the balance of forces may be mistaken and a poor guide for Indian security and procurement policies. We recommend that instead of investing in new nuclear weapons platforms that our analysis suggests are not likely to be required to deter China, New Delhi should improve the survivability of its existing forces and fill the gap in global arms control leadership with an initiative on restraint and transparency.




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Organizational Responses to COVID-19 and Climate Change: A Conversation with Rebecca Henderson

Rebecca Henderson, the John and Natty McArthur University Professor at Harvard University, shared her perspectives on how large organizations are changing in response to the coronavirus pandemic and climate change in the newest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program.”




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What Policymakers Should Ask Modelers

With decision-makers relying on a growing torrent of forecasts regarding COVID-19 and other important issues, it is more important than ever that they ask questions about how the projections were made. To use predictive tools more effectively, policymakers should ask four questions in particular.




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Poll: What the American Public Likes and Hates about Trump's Nuclear Policies

The authors conducted a study which highlights how the U.S. public as a whole and various demographic groups view President Donald Trump's positions on nuclear weapons.




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Next Moves on Climate Policy: A Conversation with Sue Biniaz

Sue Biniaz, former lead climate negotiator for the United States, shared her thoughts on the postponement of COP-26, and on the possible re-engagement of the U.S. in the international effort to address climate change in the newest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program,” a podcast produced by the Harvard Environmental Economics Program.




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How Do Past Presidents Rank in Foreign Policy?

How do presidents incorporate morality into decisions involving the national interest? Moral considerations explain why Truman, who authorized the use of nuclear weapons in Japan during World War II, later refused General MacArthur's request to use them in China during the Korean War. What is contextual intelligence, and how does it explain why Bush 41 is ranked first in foreign policy, but Bush 43 is found wanting? Is it possible for a president to lie in the service of the public interest? In this episode, Professor Joseph S. Nye considers these questions as he explores the role of morality in presidential decision-making from FDR to Trump.