It’s not everyday we regurgitate a few old (and new!) chemistry jokes. How often do we tell them? Periodically. We told one the other day, but there was no reaction. Hahaha! Wait? How come nobody else is laughing? Ehem… well, anyways, here are a few more: When I first heard oxygen and magnesium got together […]

The post Top 20 Chemistry Jokes of Some Time appeared first on Funny & Jokes.

Date: April 23, 2020

Today’s Doodle, illustrated by British guest artist Robin Davey, commemorates St. George’s Day. On the annual celebration of the patron saint, England celebrates St. George and his representation of values like bravery, integrity, and leadership.

According to legend, St. George single-handedly slew a dragon to rescue a city under siege. For centuries, he captured the English imagination; in fact, King Henry V’s veneration for St. George was even immortalized in William Shakespeare’s eponymous play about the monarch.  

St. George was declared England’s patron saint in 1348, and in 1415 St. George’s Day was inaugurated as a national feast day in his honor. Today, the special day lives on as a testament to England’s culture and unique traditions through activities like morris dancing (a rural folk custom) and medieval jousting.

Happy St. George’s Day!

 

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Guest Artist Q&A with Robin Davey

Today’s Doodle was illustrated by British guest artist Robin Davey. Below, he shares his thoughts behind the making of this Doodle:

 

Q: Why was this topic meaningful to you personally? 

A: As a Briton living abroad, it was nice to make something connected to my home country.

 

Q: What were your first thoughts when you were approached about the project?

A: My mum, who checks the Doodle daily, will be thrilled :)

 

Q: Did you draw inspiration from anything in particular for this Doodle? 

A: I wanted to reframe the story of George and the dragon as one of friends, not adversaries.

 

Q: What message do you hope people take away from your Doodle?

A: That peaceful cooperation with our neighbours is preferable to conflict.

 

Location: United Kingdom

Tags: national day, National Holiday, history, George, dragon, toast, England

Date: April 25, 2020

As COVID-19 continues to impact communities around the world, people are coming together to help one another now more than ever. We’re launching a Doodle series to recognize and honor many of those on the front lines.

Today, we’d like to say: 

To all coronavirus helpers, thank you.
 

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Help stop the spread of COVID-19 by following these steps.  

 

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Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags: covid, Current Event, covid-19, appreciation, helpers, coronavirus

Date: April 27, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating 50 years of Kids Coding!

 

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Location: Global

Tags:

Date: April 27, 2020

Today’s Doodle commemorates what is widely revered as the Netherlands’ most popular holiday, King’s Day. Known as Koningsdag in Dutch, today honors the birthday of the first Dutch king in 123 years, His Royal Highness Willem-Alexander.

Depicted in the Doodle artwork, the red, white, and blue tricolor Dutch flag was affirmed in its current form by a royal decree in 1937. With orange as the official color of the day, the flag is often seen with a small orange stripe, or a wimpel, hovering on the top for King’s Day.

Fijne Koningsdag! (Happy King’s Day!)

Location: Netherlands

Tags: national day, National Holiday, independence, history, Netherlands, King's Day

Date: April 28, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating Cricket!

 

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Help stop the spread of COVID-19 by following these steps.  
 

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Location: Global

Tags:

Date: April 29, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating Oskar Fischinger!
 

 

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Help stop the spread of COVID-19 by following these steps.  
 

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Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

 

 

 

Location: Global

Tags:

Date: April 29, 2020

On the fifth day of the Hebrew month of Iyar, Israeli communities worldwide celebrate their Independence Day, known locally as Yom Ha’atzmaut. Today’s Doodle pays tribute to this annual holiday in recognition of the day in 1948 when the State of Israel declared its independence. 

Depicted in the Doodle artwork, the flag of Israel features two blue stripes running horizontally over the white background with the Star of David at its center. Officially adopted in 1948, the same year as independence, the flag will be waved proudly wherever Israeli’s call home. 

Happy Yom Ha’atzmaut, Israel!​

Location: Israel

Tags: national day, National Holiday, independence, history, Israel

Date: April 30, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2016 Doodle game celebrating Clara Rockmore!
 

 

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Help stop the spread of COVID-19 by following these steps.
 

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Location: Global

Tags:

Date: May 1, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2018 Doodle game celebrating Garden Gnomes!
 

 

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Help stop the spread of COVID-19 by following these steps.  
 

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Location: Global

Tags:

Date: May 1, 2020

Also known as May Day or International Workers’ Day, Labour Day is celebrated on May 1st in many countries around the world. Today’s Doodle celebrates the day by illustrating a handful of the many professions across the labor force.

Recognized around the world, Labour Day originated from the 19th-century labour movement. First declared a holiday by trade unions in 1889, Labour Day commemorates worker’s rights and their fight for weekends, better working conditions, and shorter working days. 

Here’s to everyone contributing to the livelihoods of those around them each and every day. 

Happy Labour Day!

Location: Global

Tags:

Date: May 3, 2020

Location: Hungary, Lithuania, Portugal, Romania, Spain

Tags:

Date: May 4, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2016 Doodle game celebrating Wilbur Scoville!
 

 

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Location: Global

Tags:

Date: May 4, 2020

Happy US Teacher Appreciation Week!

Today (and everyday!), we honor teachers across the nation, who continue to work tirelessly to shape our future generations, even in the midst of the unprecedented COVID-19 pandemic.

Today’s Doodle was created by Doodler Kevin Laughlin who collaborated with the 54 2020 State Teachers of the Year during their visit to Google this past February. 

Below, Kevin shares more on his experience working with the teachers on today’s Doodle!

I know from firsthand experience how much of a positive impact a teacher can have on a young person's life. I can't express how happy I am to have had the opportunity to be a part of the Teacher Appreciation project this year.

When I met these teachers on campus in February, I was so inspired by their love of teaching and dedication to their students, which I felt each minute I spent with them. As they presented their own Doodle designs, they shared anecdotes about their classrooms, advocated for their students, and spoke passionately about educational equity. 

I am glad to see their work represented in the final Doodle on Google’s homepage today celebrating these often unsung heroes. To every teacher, thank you times infinity! 

 

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Learn more about the many ways Google is celebrating and supporting teachers, in classrooms or at home.

 

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See some of the teacher concepts that inspired today’s Doodle below:

 

...and all of the concepts from our 54 2020 State Teachers of the Year:

 

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Photos from the Doodle brainstorming session at the 2020 National Teacher of the Year Program

 

 

 

 

Location: U.S. Virgin Islands, United States

Tags: teachers’ day, National Holiday, education, teaching

Date: May 5, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2019 Doodle game celebrating Lotería!
 

 

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Location: Global

Tags:

Date: May 6, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2016 Doodle game celebrating Halloween!
 

 

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Help stop the spread of COVID-19 by following these steps.  
 

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Location: Global

Tags:

Date: May 7, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating the birth of Hip Hop!
 

 

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Help stop the spread of COVID-19 by following these steps.  
 

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Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

Date: May 8, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2010 Doodle game celebrating PAC-MAN!
 

 

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Help stop the spread of COVID-19 by following these steps.  
 

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Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

Location: Global

Tags:

Date: May 8, 2020

Location: South Korea

Tags: Parents' Day, carnations, flowers, stop-motion, Animation

Date: May 10, 2020

All that glitters is not gold, but sometimes it comes in handy.

Whether they're near or far, make Mom a little piece of art from your heart in today’s interactive, digital card-maker Doodle.

Learn more about the inspiration that led to the creation of this Doodle on our official Google Blog.

Happy Mother’s Day!

 

 

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Cut out some time to send a mom some love today! Search for ”GoogleDoodles” in Gboard, GIF Keyboard by Tenor, or the GIF search in your favorite social apps.

 

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Below, the Doodlers behind today’s Doodle share their own MOM-umental creations:
 

Anthony Irwin, UX Designer

 

Collin Irwin, Engineer

 

Grace Chen, Marketing

 

Perla Campos, Marketing

 

Tom Tabanao, Engineer

 

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More behind-the-scenes of the making of today’s Doodle:
 

It begins! Special thanks to the Takara and McGupta Families for materials.

 

Early Bead Tests

 

Angle Reference for the Doodle G

 

Turtle In-Progress

 

Glitter Star Animation Frames

 

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❤️ MOTHER’S DAY 2020 TEAM ❤️

Lead Artist | Alyssa Winans

Engineering | Brian Murray, Collin Irwin, Tom Tabanao, Jacob Howcroft, Nicole Patten, Yumi Kim

Producer | Gregory Capuano, Colin Duffy

UX Design | Anthony Irwin, Diana Tran

Sound Design | Jacob Howcroft

Marketing | Perla Campos, Grace Chen

Business Affairs Lead & Partnerships | Madeline Belliveau

Doodle Team Lead | Jessica Yu, Brian Kaas

 

Location: Global

Tags: Interactive, National Holiday, greeting card, turtles, macaroni, buttons, sequins, hearts, dragonflies, giraffes, seashells, stars, glitter

The post Reel Review: What’s New with the Shimano Stella SW 2020? appeared first on Ocean Blue Fishing Adventures.

The post New Arrivals: Top Fishing Sunglasses You Can Try this 2020 appeared first on Ocean Blue Fishing Adventures.

The post Fishing in 2030 | 7 Future Megatrends | How will it affect us as anglers? appeared first on Ocean Blue Fishing Adventures.

Посол Алексей Ерхов в статье, опубликованной в турецком издании по случаю Дня Победы, призвал тех, кто пытается переписывать историческую правду, извлечь правильные уроки из истории Второй мировой войны. В противном случае, по его мнению, мы можем столкнуться с риском снова пережить эту катастрофу.

We previously established that global deletion of the enhancer of trithorax and polycomb (ETP) gene, Asxl2, prevents weight gain. Because proinflammatory macrophages recruited to adipose tissue are central to the metabolic complications of obesity, we explored the role of ASXL2 in myeloid lineage cells. Unexpectedly, mice without Asxl2 only in myeloid cells (Asxl2ΔLysM) were completely resistant to diet-induced weight gain and metabolically normal despite increased food intake, comparable activity, and equivalent fecal fat. Asxl2ΔLysM mice resisted HFD-induced adipose tissue macrophage infiltration and inflammatory cytokine gene expression. Energy expenditure and brown adipose tissue metabolism in Asxl2ΔLysM mice were protected from the suppressive effects of HFD, a phenomenon associated with relatively increased catecholamines likely due to their suppressed degradation by macrophages. White adipose tissue of HFD-fed Asxl2ΔLysM mice also exhibited none of the pathological remodeling extant in their control counterparts. Suppression of macrophage Asxl2 expression, via nanoparticle-based siRNA delivery, prevented HFD-induced obesity. Thus, ASXL2 controlled the response of macrophages to dietary factors to regulate metabolic homeostasis, suggesting modulation of the cells’ inflammatory phenotype may impact obesity and its complications.

Levodopa-induced dyskinesia (LID) poses a significant health care challenge for Parkinson’s disease (PD) patients. Amantadine is currently the only drug proven to alleviate LID. Although its efficacy in treating LID is widely assumed to be mediated by blockade of N-methyl-D-aspartate (NMDA) glutamate receptors, our experiments demonstrate that at therapeutically relevant concentrations, amantadine preferentially blocks inward-rectifying K+ channel type 2 (Kir2) channels in striatal spiny projection neurons (SPNs) — not NMDA receptors. In so doing, amantadine enhances dendritic integration of excitatory synaptic potentials in SPNs and enhances — not antagonizes — the induction of long-term potentiation (LTP) at excitatory, axospinous synapses. Taken together, our studies suggest that the alleviation of LID in PD patients is mediated by diminishing the disparity in the excitability of direct- and indirect-pathway SPNs in the on state, rather than by disrupting LTP induction. This insight points to a pharmacological approach that could be used to effectively ameliorate LID and improve the quality of life for PD patients.

Arterial cardiovascular events are the leading cause of death in patients with JAK2V617F myeloproliferative neoplasms (MPNs). However, their mechanisms are poorly understood. The high prevalence of myocardial infarction without significant coronary stenosis or atherosclerosis in patients with MPNs suggests that vascular function is altered. The consequences of JAK2V617F mutation on vascular reactivity are unknown. We observe here increased responses to vasoconstrictors in arteries from Jak2V617F mice resulting from a disturbed endothelial NO pathway and increased endothelial oxidative stress. This response was reproduced in WT mice by circulating microvesicles isolated from patients carrying JAK2V617F and by erythrocyte-derived microvesicles from transgenic mice. Microvesicles of other cellular origins had no effect. This effect was observed ex vivo on isolated aortas, but also in vivo on femoral arteries. Proteomic analysis of microvesicles derived from JAK2V617F erythrocytes identified increased expression of myeloperoxidase as the likely mechanism accounting for their effect. Myeloperoxidase inhibition in microvesicles derived from JAK2V617F erythrocytes suppressed their effect on oxidative stress. Antioxidants such as simvastatin and N-acetyl cysteine improved arterial dysfunction in Jak2V617F mice. In conclusion, JAK2V617F MPNs are characterized by exacerbated vasoconstrictor responses resulting from increased endothelial oxidative stress caused by circulating erythrocyte-derived microvesicles. Simvastatin appears to be a promising therapeutic strategy in this setting.

BACKGROUND Neurofibroma/schwannoma hybrid nerve sheath tumors (N/S HNSTs) are neoplasms associated with larger nerves that occur sporadically and in the context of schwannomatosis or neurofibromatosis type 2 or 1. Clinical management of N/S HNSTs is challenging, especially for large tumors, and established systemic treatments are lacking.METHODS We used next-generation sequencing and array-based DNA methylation profiling to determine the clinically actionable genomic and epigenomic landscapes of N/S HNSTs.RESULTS Whole-exome sequencing within a precision oncology program identified an activating mutation (p.Asp769Tyr) in the catalytic domain of the ERBB2 receptor tyrosine kinase in a patient with schwannomatosis-associated N/S HNST, and targeted treatment with the small-molecule ERBB inhibitor lapatinib led to prolonged clinical benefit and a lasting radiographic and metabolic response. Analysis of a multicenter validation cohort revealed recurrent ERBB2 mutations (p.Leu755Ser, p.Asp769Tyr, p.Val777Leu) in N/S HNSTs occurring in patients who met diagnostic criteria for sporadic schwannomatosis (3 of 7 patients), but not in N/S HNSTs arising in the context of neurofibromatosis (6 patients) or outside a tumor syndrome (1 patient), and showed that ERBB2-mutant N/S HNSTs cluster in a distinct subgroup of peripheral nerve sheath tumors based on genome-wide DNA methylation patterns.CONCLUSION These findings uncover a key biological feature of N/S HNSTs that may have important diagnostic and therapeutic implications.FUNDING This work was supported by grant H021 from DKFZ-HIPO, the University Cancer Center Frankfurt, and the Frankfurt Research Funding Clinician Scientist Program.

Curing HIV infection will require the elimination of a reservoir of infected CD4+ T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir-harboring cells to CTL killing. This resistance may have contributed to negative outcomes of clinical trials, where pharmacologic latency reversal has thus far failed to drive reductions in HIV reservoirs. Through transcriptional profiling, we herein identified overexpression of the prosurvival factor B cell lymphoma 2 (BCL-2) as a distinguishing feature of CD4+ T cells that survived CTL killing. We show that the inducible HIV reservoir was disproportionately present in BCL-2hi subsets in ex vivo CD4+ T cells. Treatment with the BCL-2 antagonist ABT-199 was not sufficient to drive reductions in ex vivo viral reservoirs when tested either alone or with a latency-reversing agent (LRA). However, the triple combination of strong LRAs, HIV-specific T cells, and a BCL-2 antagonist uniquely enabled the depletion of ex vivo viral reservoirs. Our results provide rationale for novel therapeutic approaches targeting HIV cure and, more generally, suggest consideration of BCL-2 antagonism as a means of enhancing CTL immunotherapy in other settings, such as cancer.

BACKGROUND Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate and compare the immunological features of severe and moderate COVID-19.METHODS In this retrospective study, the clinical and immunological characteristics of 21 patients (17 male and 4 female) with COVID-19 were analyzed. These patients were classified as severe (11 cases) and moderate (10 cases) according to the guidelines released by the National Health Commission of China.RESULTS The median age of severe and moderate cases was 61.0 and 52.0 years, respectively. Common clinical manifestations included fever, cough, and fatigue. Compared with moderate cases, severe cases more frequently had dyspnea, lymphopenia, and hypoalbuminemia, with higher levels of alanine aminotransferase, lactate dehydrogenase, C-reactive protein, ferritin, and D-dimer as well as markedly higher levels of IL-2R, IL-6, IL-10, and TNF-α. Absolute numbers of T lymphocytes, CD4+ T cells, and CD8+ T cells decreased in nearly all the patients, and were markedly lower in severe cases (294.0, 177.5, and 89.0 × 106/L, respectively) than moderate cases (640.5, 381.5, and 254.0 × 106/L, respectively). The expression of IFN-γ by CD4+ T cells tended to be lower in severe cases (14.1%) than in moderate cases (22.8%).CONCLUSION The SARS-CoV-2 infection may affect primarily T lymphocytes, particularly CD4+ and CD8+ T cells, resulting in a decrease in numbers as well as IFN-γ production by CD4+ T cells. These potential immunological markers may be of importance because of their correlation with disease severity in COVID-19.TRIAL REGISTRATION This is a retrospective observational study without a trial registration number.FUNDING This work is funded by grants from Tongji Hospital for the Pilot Scheme Project, and partly supported by the Chinese National Thirteenth Five Years Project in Science and Technology for Infectious Disease (2017ZX10202201).

The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.

Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer therapeutics. The most advanced of these are small molecules that target the HIF-2 isoform through binding the PAS-B domain of HIF-2α. These molecules are undergoing clinical trials with promising results in renal and other cancers where HIF-2 is considered to be driving growth. Nevertheless, a central question remains as to whether such inhibitors affect physiological responses to hypoxia at relevant doses. Here, we show that pharmacological HIF-2α inhibition with PT2385, at doses similar to those reported to inhibit tumor growth, rapidly impaired ventilatory responses to hypoxia, abrogating both ventilatory acclimatization and carotid body cell proliferative responses to sustained hypoxia. Mice carrying a HIF-2α PAS-B S305M mutation that disrupts PT2385 binding, but not dimerization with HIF-1β, did not respond to PT2385, indicating that these effects are on-target. Furthermore, the finding of a hypomorphic ventilatory phenotype in untreated HIF-2α S305M mutant mice suggests a function for the HIF-2α PAS-B domain beyond heterodimerization with HIF-1β. Although PT2385 was well tolerated, the findings indicate the need for caution in patients who are dependent on hypoxic ventilatory drive.

Директор по связям с общественностью ФК «Локомотив» Кирилл Брейдо подтвердил информацию о том, что у двух сотрудников клуба был выявлен коронавирус. Об этом 7 мая сообщил телеграм-канал «Мутко против».

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Time for a break is here - the new Weekday Escape arrived! This week we get typical escape games only - four rooms with firmly closed door. The first comes Amajeto who locked you in their nice living room and... Tagged as: amajeto, blog, browser, escape, free, gotmail, japanese, pixelkobo, pointandclick, puzzle, rating-g, smartcode, spiceapp, weekday-escape

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I’ve got a new re-release! The title and cover for Road to the Sun were a little too dreamy and not really indicative of the actiony-suspensey vibe of the plot. Dar Albert designed an awesome new cover, and the brilliant Annabeth Albert (no relation!) suggested the new title. You can borrow in KU for the next three months […]

This week saw a couple of big announcements, led by the launch of an update for the 13-inch MacBook Pro line. Most notably, the update brought the improved Magic Keyboard previously introduced on its 16-inch sibling and the MacBook Air, with high-end models also receiving updated processors.

Subscribe to the MacRumors YouTube channel for more videos.
The second significant announcement this week was that Apple's first all-digital Worldwide Developers Conference will kick off on June 22. Other news this week included a firmware update for the AirPods Pro, an update on Apple's Mini-LED efforts, and more.

Read on below and check out our video above for recaps of all of this week's most important stories!

New 13-Inch MacBook Pro Announced With Magic Keyboard, 10th-Gen Processors, Up to 32GB RAM and 4TB SSD, and More

Apple this week refreshed its 13-inch MacBook Pro lineup, with key features including the same Magic Keyboard as the 16-inch MacBook Pro, up to 80 percent faster Intel graphics than the previous generation, up to 32GB of RAM, up to 4TB of SSD storage, and 6K display support.


First introduced on the 16-inch MacBook Pro last year, the Magic Keyboard features a far more reliable scissor mechanism with 1mm of key travel. After five years, Apple has finally transitioned its entire notebook lineup away from its issue-prone butterfly keyboard.

10th-generation Intel processor options are only available on higher-end models, with the $1,799 configuration proving to be up to 16.5% faster than the $1,299 base model with an older 8th-generation processor.

Apple's Virtual WWDC Event to Kick Off on June 22

Apple has announced that its first-ever online-only WWDC will begin Monday, June 22 via the Apple Developer app and website. The weeklong event will include a virtual keynote, sessions, and labs, with more details to be shared in June. And it's free!


Apple is expected to introduce iOS 14, iPadOS 14, macOS 10.16, tvOS 14, and watchOS 7 at WWDC 2020, with beta testing to take place over the summer.

Student developers from all over the world can enter Apple's Swift Student Challenge by creating an interactive scene in Swift Playgrounds that can be experienced in three minutes. Winners will receive an exclusive WWDC20 jacket and pin set. Submissions are open through May 17.

Apple Updates AirPods Pro Firmware to Version 2D15

Apple this week released a new firmware version 2D15 for the AirPods Pro, replacing version 2C54.


In recent months, some AirPods Pro owners have been complaining about reduced noise cancellation and crackling or static sounds, so users have listened for any improvements following the update.

Perhaps proving how subjective sound quality can be, feedback has been decidedly mixed, with some users noticing an improvement, some noticing no change, and some noticing further degradation to noise cancellation.

Apple has offered some help in the form of two new support documents for users to troubleshoot noise cancellation or crackling sound issues.

10 Tips and Tricks for the iPad Pro Magic Keyboard

Have you recently picked up a new Magic Keyboard for the iPad Pro? Here's a list of our favorite tips and tricks that you need to know.


The tips and tricks relate to adjusting the backlight brightness, customizing the cursor's behavior, enabling tap-to-click on the trackpad, other trackpad gestures, accessing the Emoji keyboard, and more.

Apple's Mini-LED Product Roadmap May Have Been Pushed Back to 2021

Disappointed that the new 13-inch MacBook Pro was not the rumored 14-inch model? That may be due to a slight delay in Apple's plans to release a range of new products with Mini-LED backlit displays.

Kuo believes Apple's first Mini-LED products might not launch until 2021. The analyst has previously said these products would include a new 14.1-inch MacBook Pro, 16-inch MacBook Pro, 12.9-inch iPad Pro, and more.


Kuo has previously said that Mini-LED displays will allow for thinner and lighter product designs, while offering many of the same benefits of OLED displays used on the latest iPhones, including good wide color gamut performance, high contrast and dynamic range, and local dimming for truer blacks.

NFC-Based Digital Key Specification Released Ahead of Apple's Rumored CarKey Feature on iPhone

Amid rumors that Apple is working on a digital "CarKey" feature for iPhone, the Car Connectivity Consortium has announced that its NFC-based Digital Key Release 2.0 specification has been finalized and made available to its members, which includes Apple.


"CarKey" will allow an iPhone or Apple Watch to unlock, lock, and start an NFC-compatible vehicle. Just like credit cards and boarding passes, users will be able to add a digital car key to the Wallet app, eliminating the need to use a physical car key or key fob.

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This article, "Top Stories: New 13" MacBook Pro, WWDC Starts June 22, AirPods Pro Firmware Update, and More" first appeared on MacRumors.com

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Contributors this month include 2cross2affliction, dronon, GreenReaper, Rakuen Growlithe, and Sonious.

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