A rigid plectrum (1) for stringed instruments, of the type having a spearhead shape with a pointed front part (2) and a broadened rear part (3) in which, at the lateral walls (4) and (5) forming the pointed part, a first facet (4a) and a second facet (5a) are made, covering the entire thickness of the respective lateral wall; the facets being set at an angle α to the thickness of the respective lateral wall, each facet starting on one face of the plectrum which is opposite the face from which the other facet starts, and finishing on the other face of the plectrum; the facets also being set at an angle β to the face of the plectrum, from the rear part to the front part.

A tremolo device for a stringed instrument is described in which a base plate is configured for surface mounting to a body of the instrument. A pivot plate is pivotally coupled to the base plate along an edge of the pivot plate. Each string is associated with a string seat. The string is threaded through the string seat receiving a terminal end of the string. The string seat includes a keyed portion that slidably attaches the string seat to the pivot plate in a keyed slot provided in a bottom surface of the pivot plate. A spring disposed between the base plate and the pivot plate maintains the pivot plate in a first position relative to the base plate until a user provides an action to pivot the pivot plate relative to said base plate. The spring returns the pivot plate to the first position when the user action is terminated.

This specification describes a method and corresponding system for reducing aggregate forward link transmission power. In one arrangement, a RAN may reduce the aggregate transmission power level in a coverage area by (i) determining which WCDs in the coverage area have a communication error rate that is at least a threshold level of communication error rate, and in response to the determining, (ii) reducing the forward link transmission power level of the determined WCDs. In another arrangement, the RAN may reduce the aggregate transmission power level in a coverage area by reducing the forward link transmission power of WCDs in the coverage area that have (i) a forward link transmission power level that is at least a threshold level of forward link transmission power and (ii) a communication error rate that is at least a threshold level of communication error rate.

A mode-based method of social networking comprising storing in a database profile information for a plurality of users, event information for a plurality of events and a mode associated with each event, receiving by a plurality of computerized user devices a selection of a mode and one or more geographic proximity parameter selections from a each of plurality of users, displaying, event information for an event having a same mode as the first user, profile information for one or more other users among the plurality of users having selected the same mode as the first user and located within a geographic proximity parameter selected by the first user, and a density of a plurality of users located within the geographic proximity parameter selected by the first user wherein the density is represented by a color corresponding to the mode.

Distributed mobile device management including a plurality of management agents is disclosed. Management-related information may be retrieved from a storage location accessible to a plurality of management agents. The management-related information may have been provided to the storage location from a management agent associated with a managed application. And at least one operation may be performed based at least in part on the management-related information.

A method of detecting proximity between a media proxy and a client uses a proximity probe to query a plurality of media proxies, forcing the media proxies to respond to a proximity server. The proximity server uses an algorithm to determine which media proxy is closest to the client based on the responses. In an alternate embodiment, the same sorts of proximity probes may be used to determine if two media endpoints have a direct connection such that they may bypass a media proxy.

Methods and systems for conveying or transmitting to any given user in an OFDMA-MU-MIMO system scheduling information of other co-scheduled users to permit the user to perform error-correction on received data and/or interference reduction on its received signals. The scheduling information can include resource block assignment, modulation constellations employed, coding rates employed, power levels utilized and precoder matrix indices used. Further, the scheduling information can be conveyed in part through dedicated reference symbol layers or pilot streams. Moreover, a base station may transmit a preliminary estimate of the total number of users the base station expects to schedule, or an upper-bound on the total number of users, to the MU-MIMO users to permit the MU-MIMO users to determine preferred precoder matrix indices and indications of channel quality indices.

An abnormality detection unit provided in at least one node among a plurality of nodes included in an information processing apparatus detects abnormality in a data transmission path of data transmission using a shared memory area sharable in a single node and other node, which is included in the storage unit provided in the single node or other nodes. An error information generation unit provided in the single node generates error information, based on the abnormality detected by the abnormality detection unit, and generates an interrupt with respect to a processor within a self node. The processor provided in the single node performs recovery processing, based on the error information according to the interrupt.

Systems and methods provide a parameterized scheduling system that incorporates end-user application awareness and can be used with scheduling groups that contain data streams from heterogeneous applications. Individual data queues within a scheduling group can be created based on application class, specific application, individual data streams or some combination thereof. Application information and Application Factors (AF) are used to modify scheduler parameters such as weights and credits to differentiate between data streams assigned to a scheduling group. Dynamic AF settings may adjust relative importance of user applications to maximize user Quality of Experience (QoE) in response to recurring network patterns, one-time events, application characteristics, protocol characteristics, device characteristics, service level agreements, or combinations thereof. Scheduling parameters may be dynamic and incorporate the notions of “duration neglect” and “recency effect” in an end-user's perception of video quality in order to optimally manage video traffic during periods of congestion.

In general, to provide acknowledgment information by a first wireless device, the first wireless device sends repeated instances of acknowledgment information in respective first and second frame structures, in response to receipt of first information from a second wireless device. In addition, the first wireless device also sends further acknowledgment information in the second frame structure that is responsive to second information received from the second wireless device.

A communications method implemented in a transmission point (TP) used in a coordinated multipoint transmission and reception (CoMP) system is disclosed. The communications method comprises transmitting, to a user equipment (UE), attributers for up to four indicators indicating at least physical downlink shared channel (PDSCH) resource element (RE) mapping, and transmitting, to the UE, one of the four indicators, each of which is conveyed in 2 bits, wherein the four indicators comprises ‘00’, ‘01’, ‘10’, and ‘11’ corresponding to a first set, a second set, a third set, and a fourth set of parameters, respectively. Other methods, apparatuses, and systems are also disclosed.

In the present invention, one or both of an active wheel or a passive wheel is composed of an eccentric transmission wheel and is combined with a synchronous transmission belt for forming an eccentric wheel transmission wheel series, so that when the feet input forces at different angles from the treadle shafts of the treadles to an active wheel shaft combined on the active wheel through cranks, the active wheel forms different transmission speed ratios relative to the passive wheel according to the treadle angle, and random inward packing is performed to the transmission belt (100) of the engage end of the eccentric passive wheel (413) during the transmission for stabling the operation.

A continuously variable transmission for a vehicle comprises a primary pulley, a secondary pulley, and a belt entrained around both pulleys in an opposite manner between the fixed and movable sheaves thereof. One pulley carries a selectively deployable stop that may be placed into position to mechanically limit the range of motion between the fixed and movable sheaves. This establishes an actual maximum transmission ratio that is larger than the nominal minimum transmission ratio but smaller than the nominal maximum transmission ratio achievable by the transmission during normal operation thereof. When such a transmission is used on a utility vehicle attached to a substance dispensing applicator operatively driven by the vehicle's engine, the application rate stays substantially constant despite changes in engine speed when the user keeps the transmission upshifted to the actual maximum transmission ratio set by the position of the deployed stop.

An arrangement for supplying oil to a chain drive which drives a transmission oil pump that is axially offset relative to a torque converter and embedded in an intermediate plate in a vehicle having a torque converter. The driven sprocket of the chain drive is supported by a converter neck mounted in a centering plate. A seal is provided between the converter neck and the sprocket and is arranged adjacent the sliding fit between the converter neck and the sprocket. To compensate for the suppression of lubrication of the seal, the neck bearing and the chain drive, a valve is integrated in the intermediate plate, and a duct is provided in the plane, in which the centering plate is screwed to the intermediate plate, such that excess oil flowing from the valve is selectively directed to the seal, the neck bearing and the chain drive.

A method for electronically controlling a bicycle gearshift comprising at least one derailleur is disclosed, comprising the sequential steps of: a) imparting a movement on the derailleur of the gearshift until the derailleur is in an intended position;b) waiting for a predetermined time period,c) performing a check whether the derailleur is in the intended position, within a possible predetermined tolerance,d) in case said check has a negative outcome, imparting a movement on the derailleur of the gearshift until the derailleur is in the intended position. A derailleur and an electronically servo-assisted bicycle gearshift comprising control electronics comprising modules adapted to carry out the method outlined above are also disclosed.

The present invention is structured by using one or both of an active wheel and a passive wheel being composed of an eccentric transmission wheel and being combined with a synchronous transmission belt for forming an eccentric wheel transmission wheel series, so that in the reciprocal treadle performed by the human's feet, when the feet input forces at different angles from the treadle shafts of the treadles to an active wheel shaft combined on the active wheel through cranks, the active wheel forms different transmission speed ratios relative to the passive wheel according to the treadle angle.

A novel maize variety designated PH1W03 and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1W03 with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1W03 through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1W03 or a locus conversion of PH1W03 with another maize variety.

A novel maize variety designated PH1MBR and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1MBR with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1MBR through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1MBR or a locus conversion of PH1MBR with another maize variety.

A novel maize variety designated PH1K8P and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1K8P with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1K8P through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1K8P or a locus conversion of PH1K8P with another maize variety.

A novel maize variety designated PH1KHH and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1KHH with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1KHH through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1KHH or a locus conversion of PH1KHH with another maize variety.

A novel maize variety designated PH18WR and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH18WR with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH18WR through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH18WR or a locus conversion of PH18WR with another maize variety.

A novel maize variety designated PH1M0H and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1M0H with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1M0H through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1M0H or a locus conversion of PH1M0H with another maize variety.

A novel maize variety designated PH1KAP and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1KAP with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1KAP through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1KAP or a locus conversion of PH1KAP with another maize variety.

According to the invention, there is provided seed and plants of the corn variety designated CV052803. The invention thus relates to the plants, seeds and tissue cultures of the variety CV052803, and to methods for producing a corn plant produced by crossing a corn plant of variety CV052803 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV052803 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV052803.

A novel maize variety designated PH18PF and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH18PF with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH18PF through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH18PF or a locus conversion of PH18PF with another maize variety.

A novel maize variety designated PH1TDJ and seed, plants and plant parts thereof. Methods for producing a maize plant that comprise crossing maize variety PH1TDJ with another maize plant. Methods for producing a maize plant containing in its genetic material one or more traits introgressed into PH1TDJ through backcross conversion and/or transformation, and to the maize seed, plant and plant part produced thereby. Hybrid maize seed, plant or plant part produced by crossing the variety PH1TDJ or a locus conversion of PH1TDJ with another maize variety.

Provided herein are mitochondrial-nuclear exchanged cells and animals comprising mitochondrial DNA (mtDNA) from one subject and nuclear DNA (nDNA) from a different subject. Methods for producing a mitochondrial-nuclear exchanged animal and animals made by the methods are provided. Also provided are methods of screening for agents useful for treating a disease or disorder using mitochondrial-nuclear exchanged animals or cells, tissues or organs thereof.

In an embodiment, the invention relates to the seeds, plants, and plant parts of canola variety SCV435009 and to methods for producing a canola plant produced by crossing canola variety SCV435009 with itself or with another canola variety. The invention also relates to methods for producing a canola plant containing in its genetic material one or more transgenes and to the transgenic canola plants and plant parts produced by those methods. This invention also relates to canola varieties or breeding lines and plant parts derived from canola variety SCV435009, to methods for producing other canola varieties, lines or plant parts derived from canola variety SCV435009 and to the canola plants, varieties, and their parts derived from use of those methods. The invention further relates to hybrid canola seeds, plants and plant parts produced by crossing the variety SCV435009 with another canola variety.

According to the invention, there is provided seed and plants of the hybrid corn variety designated CH715413. The invention thus relates to the plants, seeds and tissue cultures of the variety CH715413, and to methods for producing a corn plant produced by crossing a corn plant of variety CH715413 with itself or with another corn plant, such as a plant of another variety. The invention further relates to genetic complements of plants of variety CH715413.

The present invention relates to an Osteospermum and Dimorphoteca plant, seed, variety, and hybrid. Another aspect of the present invention relates to an Osteospermum and Dimorphoteca plant having a mutant allele designated KLEDF which results in an altered flower phenotype. The invention also relates to crossing Osteospermum and Dimorphoteca plants containing the KLEDF mutant allele with other Osteospermum and Dimorphoteca plants lacking the KLEDF mutant allele to produce intergeneric and interspecific hybrids. This invention further relates to specific lines of Osteospermum varieties exhibiting the altered-flowering phenotype. Furthermore, the invention relates to pollen, seed, and sexual, as well as asexual progeny of such plants with altered flowers. In addition, the invention relates to methods for propagating said plants and to uses of said plants.

Disclosed are compositions and methods of making non-glycosylated transferrin protein in transgenic monocot plants.

A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.

A method and apparatus for conveying a cellulosic feedstock are disclosed. The apparatus, such as a holding tank, has a passage. At the outlet to the passage, a conveyance member is provided to convey the cellulosic feedstock laterally across the outlet. The conveyance member, e.g., at least one screw conveyor, may have a variable pitch along its length. The method comprises passing the cellulosic feedstock through an impregnation chamber to an outlet of the impregnation chamber; passing the cellulosic feedstock from the outlet of the impregnation chamber to an inlet of a holding tank; passing the cellulosic feedstock downwardly through the holding tank; maintaining a generally constant residence time in the holding tank; and subsequently subjecting the cellulosic feedstock to a hydrolysis process.

An apparatus for conveying a cellulosic feedstock is disclosed. The apparatus comprises an enclosed volume having a lower surface comprising a plurality of longitudinally extending portions. Each longitudinally extending portion has an inner surface that is arcuate in transverse section. A plurality of conveyance members are provided within the enclosed volume. Each conveyance member is associated with one of the inner surfaces and configured to sweep the one of the inner surfaces. Additionally, a method for treating a cellulosic feedstock is disclosed. The method comprises providing a cellulosic feedstock being less than 100% saturated moisture. The cellulosic feedstock is introduced into a longitudinally extending enclosed volume, and conveyed longitudinally through the enclosed volume while being mixed.

A cartridge for squeezing-out a cartridge content, like a cement, or a medical cement, having a cylindrical hollow space bordered by a cartridge wall, a feed plunger arranged in the hollow space to be mobile along the cylinder axis of the hollow space and abutting the cartridge wall, and at least one snap-in means for locking the feed plunger in place at the cartridge wall, to a locking device arranged on the feed plunger and comprises at least a snap-in means which is accessible from outside when the feed plunger is locked. The invention also provides a cartridge system with a cartridge for squeezing out content and a method for dispensing such cartridge content, preferably a cement, through the use of a cartridge of said type.

The disclosed apparatus, system and method relate to a shaft-actuated spindle mixer where the spindle mixer includes a motor and at least one motor switch enclosed in a mixer housing. A spindle shaft extends from the housing and is mechanically connected to the motor. The motor is mounted to a moveable mixer component such that the spindle shaft can be displaced to thereby causing the associated movement of the enclosed motor and moveable mixer component to which the motor is mounted. Movement of the movable mixer component actuates a switch. Actuating the switch causes the selective activation of the mixer motor. Activating the mixer motor rotates the spindle shaft. The disclosed apparatus and method provide for the optional one-handed operation of a spindle mixer, eliminate the need for a user or a cup to directly contact a switch to engage the spindle mixer, and further provides for the sanitary operation of a spindle mixer.

A machine for continuous casting of pre-mortared masonry panels includes a rotatable continuous mold for continuously forming pre-mortared masonry panels and an application system for applying polymeric material to the continuous mold as the continuous mold rotates. The machine also includes a brick setter system for setting bricks onto the polymeric material as the continuous mold rotates. The machine further includes a cutting device for cutting the bricks and polymeric material into panels to form the pre-mortared masonry panels.

An eddy-current-minimizing flow plug has an outer radial wall with open flow channels formed between the plug's inlet and outlet. The plug has a central region coupled to the inner surface of the outer radial wall. Each open flow channel includes (i) a first portion originating at the inlet and converging to a location in the plug where convergence is contributed to by changes in thickness of the outer radial wall and divergence of the central region, and (ii) a second portion originating in the plug and diverging to the outlet where divergence is contributed to by changes in thickness of the outer radial wall and convergence of the central region. For at least a portion of the open flow channels, a central axis passing through the first and second portions is non-parallel with respect to the given direction of the flow.

This invention is directed to a stirring apparatus comprising: a plurality of blades having between a 5° to 180° twist along the length of their axis attached perpendicularly to a shaft so that a downward fluid flow is created when the shaft is rotated by a rotary drive; and, a plurality of standards attached to the plurality of blades separating the plurality of blades and arranged parallel to the shaft and rotated between 0° and 25° relative to a plane defined by the blades and the standards so that an inward fluid flow is created when the shaft is rotated and a bottom blade connected to the standards.

Provided are a fluid agitation apparatus using a structure which is simple in shape and short in a fluid passage direction without a movable part so as to produce a sufficient effect from the viewpoint of reducing temperature fluctuation, and a thermostatic apparatus using the fluid agitation apparatus. The fluid agitation apparatus is installed in a fluid passage and includes, in an order from an upstream side thereof: a dividing part for dividing a flow of a fluid into a plurality of flows; a circumvolving part for circumvolving the fluid about an axis in a flow direction of the fluid; and an accelerating part for increasing a flow rate of the fluid.

An improved dual-shaft preconditioner (10) of simplified design is provided giving increased moisturization and partial cooking of food or feed ingredients. The preconditioner (10) includes an elongated, tapered housing (12) presenting a pair of side-by-side, communicating housing sections (58, 60), with a corresponding pair of converging shafts (20, 22) within the sections (58, 60) and having a series of elongated, outwardly extending mixing elements (24, 26) secured to the shafts (20, 22). The preconditioner (10) is designed for use in a system including a downstream processing device, such as an extruder (146).

An agitator, particularly for abrasive media includes a support disk to which agitator blades are connected substantially perpendicular to the support disk. The blades are arranged substantially in a radial direction. The support disk also includes a hub that receives an agitator shaft which is preferably motor-driven. The trailing faces of the blades of the agitator and/or the area of the blade connections to the support disk are designed to largely prevent vortex shedding. This is accomplished by implementing a specific geometry for the agitator blades, the support disk, and the connection of the blades to the support disk.

The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns Dinitroxide-type Biradical polarizing agents characterized by a rigid linkage between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.

There are provided compounds represented by the following general formula (I) or pharmaceutically acceptable salts of thereof, which have a superior monoacylglycerol acyltransferase 2 inhibitory action: wherein Ring A represents a partially saturated heteroaryl group, an aryl group or a heteroaryl group,RB represents a C4-18 alkyl group, a C3-8 cycloalkyl group, a partially saturated aryl group, an aryl group, or the following formula (II): wherein V represents the formula —CR11R12—, —CO—, —CO—O—, or —CO—NH—,W represents a single bond or a C1-3 alkylene group, andRing B represents a C3-8 cycloalkyl group, a C3-8 cycloalkenyl group, a partially saturated heteroaryl group, a saturated heterocyclyl group, an aryl group, or a heteroaryl group,Y represents a nitrogen atom or the formula N+(RF),RF represents a C1-4 alkyl group, andm and n, which may be the same or different, each represent an integer of 0 or 1.

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.

This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

This disclosure is directed to fused tetracyclic pyrido[4,3-b>]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

The present disclosure relates to Oxime-Substituted Quinoxaline-Type Piperidine Compounds, such as those of Formula (I): and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R20, R21, Q, Y1, Z, A, B, and a are as defined herein; compositions comprising an effective amount of an Oxime-Substituted Quinoxaline-Type Piperidine Compound, and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of an Oxime-Substituted Quinoxaline-Type Piperidine Compound.

The invention is directed to novel substituted benzylamino quinolines, compounds comprising substituted benzylamino quinolines, methods of making substituted benzylamino quinolines, the use of substituted benzylamino quinolines for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism, and the use of substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors.

Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6 alkyl, sulfoalkyl, carboxyalkyl or C1-C6 alkoxy; each R2 is independently selected from the group consisting of H, C1-C6 alkyl, C1-C6 alkoxy, fused benzo, trifluoromethyl, amino, sulfo, carboxy and halogen, that is optionally further substituted; at least one of R3, R4, and R5 is an alkyl, aryl, heteroaryl, cyclic, or heterocyclic moiety that is optionally substituted by alkyl, amino, aminoalkyl, carboxy, nitro, or halogen; and the remaining R3, R4 or R5 are hydrogen; X is S, O, or Se; and D is a substituted or unsubstituted pyridinium, quinolinium or benzazolium moiety.