<p>On 25 September&nbsp;2024, the Brazilian Society of Rheumatology (SBR,&nbsp;<i>Sociedade Brasileira de Reumatologia</i>) shared its position&nbsp;and consensus&nbsp;on the interchangeability between reference products and biosimilars, a topic of great importance for clinical practice, especially in light of recent regulatory developments by&nbsp;Brazilian Health Regulatory Agency, ANVISA (<i>Agência Nacional de Vigilância Sanitária</i>)&nbsp;and other international authorities.&nbsp;</p>

<p>On 10 October 2024, the US Food and Drug Administration (FDA) approved Accord’s Imuldosa (ustekinumab-srlf), making it the fifth ustekinumab biosimilar referencing Janssen/Johnson &amp; Johnson’s Stelara.</p>

MADRID — Flood-hit towns near the eastern city of Valencia were rushing on Tuesday (Nov 12) to clear the sewage system of mud and debris, pile sandbags and cancel school classes as they prepared for another approaching storm. Two weeks after the worst floods in Spain's modern history killed more than 200 people, national weather service AEMET issued an orange alert, the second-highest, for strong or torrential rains expected on Wednesday in the same area. AEMET forecasts as much as 120mm of rain in 12 hours. While the storm is not expected to be as powerful, it could be devastating for the towns that are still recovering. The impact of the rain could be severe because of the quantities of mud already on the ground and because of the condition of the sewage system, Rosa Tauris, a spokesperson for Valencia's emergency committee, told reporters. Thousands of workers are cleaning buildings while removing the mud that accumulated on roads and sidewalks and clogged the sewage pipes and drains in towns and suburbs around Valencia.

Stay in the know with a recap of our top stories today. 1. Fugitive lawyer Charles Yeo in UK custody, awaiting extradition hearing Fugitive lawyer Charles Yeo, who is in custody in the UK, is currently awaiting an extradition hearing, reported CNA on Tuesday (Nov 12).  A court date for the extradition hearing has not been determined, but Yeo is set to attend a bail hearing on Friday, according to the report... » READ MORE 2. Vietnamese woman sells banh mi from her HDB flat, waiting time up to 1 hour during peak periods

Wedding bells rang at Trinity Methodist Church yesterday afternoon (Nov 12) as couples renewed their vows — but it was all for a scene in local director Jack Neo's upcoming movie, I Want To Be Boss. Among them, however, was an actual couple who have been married for more than six decades — Jack's very own parents. "I want to leave a beautiful memory of them in the movie," the 64-year-old actor-director told local media on the set. His mum, 86, was dressed in a white wedding gown with tulle sleeves, while Jack's father, 91, looked sharp in a black suit with a matching bowtie. Jack added: "I especially requested that my mum put on a wedding dress today for this scene, because the first time they wore their wedding outfits, I only got to see them in photos. I can see them now."

Netflix has expanded the cast of live-action series Avatar: The Last Airbender in its second season, with Singapore actor Chin Han one of the latest eight additions. He will play the role of Long Feng — leader of Dai Li, the secret police force of Ba Sing Se, or the capital of the Earth Kingdom. Another new joiner is Taiwanese-American actor Justin Chien, who starred with Malaysian actress Michelle Yeoh in the Netflix series The Brothers Sun (2024) and will play King Kuei, ruler of the Earth Kingdom in Avatar: The Last Airbender. Meanwhile, Vietnamese-Australian actor Hoa Xuande, who starred with American actor Robert Downey Jr in the HBO miniseries The Sympathizer (2024), will play Professor Zei, head of the anthropology department at Ba Sing Se University.  Other actors in the cast are Amanda Zhou as Joo Dee, Crystal Yu as Lady Beifong, Kelemete Misipeka as The Boulder, Lourdes Faberes as General Sung and Rekha Sharma as Amita.

SHOALWATER BAY, Australia - The expansion of the Shoalwater Bay Training Area (SWBTA) in Queensland has been completed after eight years of development. With the expanded training area now five times the size of Singapore, this means that the scale and complexity of overseas exercises involving the Singapore Armed Forces (SAF) can be increased in the future, Senior Minister of State for Defence Heng Chee How said on Wednesday (Nov 13). Heng was speaking to reporters after witnessing Singaporean and Australian soldiers being put through their paces during a simulated beach landing as part of Exercise Trident. He also flew on a CH-47F chinook to view the new facilities within the expanded SWBTA and interacted with SAF and the Australian Defence Force (ADF) soldiers who participated in the bilateral exercise. Jointly developed by Australia and Singapore since 2016, the expansion of the overall training area was set out in a treaty between the two countries in 2020. State-of-the-art facilities such as the combined arms air-land ranges and urban operations live-firing facilities have been included in the expansion.

The body of a 52-year-old man was discovered in his Toa Payoh flat last Sunday (Nov 10), several days after his death. The police told AsiaOne they were alerted to the case at 11.15am on Sunday, where they pronounced the man dead at the scene. It is not known when he died.  The man, Bai Zongren (transliteration), had been living alone in his unit at Block 157 Toa Payoh Lorong 1 for several years after divorcing his wife, according to a neighbour who spoke to Shin Min Daily News. He also had a daughter, who moved out with his ex-wife after they split.  The neighbour, who did not want to be named, added that Bai would occasionally get visits from relatives. "His mother used to live on the fifth floor, but she died a few years ago."  The neighbour told Shin Min that she was unaware of Bai's death when she passed by his unit several days ago. As Bai's door was locked, she assumed the flat was empty.  When she passed by his unit again on Saturday, she detected a foul smell but thought that it was from wastewater. She said she only found out about his death when she saw the police at his door.

After their rental agreement with a sublessor fell through, a couple asked for their deposit to be returned. They waited three weeks to no avail and decided to visit the sublessor's home for discussions. But the negotiations turned physical, with the woman brandishing a knife at the couple after she was attacked. The incident occurred at about 7pm last Sunday (Nov 10) at a condominium in Yishun, reported Shin Min Daily News. Chen, 41, said he had seen an advertisement for the four-bedroom unit on Oct 13 and contacted the poster, who said she had rented the apartment from the original tenant. The woman told Chen she could sublet the unit to him and his wife if the homeowner was agreeable to it.  After viewing pictures and videos of the apartment, the man immediately made a PayNow transfer of $1,000 to the woman as deposit. The couple viewed the unit the next day, where both parties discussed the rental agreement in detail. A week later, however, the woman told them that she had not gotten the approval of the condo owner to sublet the apartment.

NEW DELHI — A toxic haze enveloped India's national capital on the morning of Nov 13 as temperatures dropped and pollution surged, reducing visibility in some parts and prompting a warning from airport authorities that flights may be affected. Delhi overtook Pakistan's Lahore as the world's most polluted city in Swiss group IQAir's live rankings, with an air quality index (AQI) score of more than 1,000, considered "hazardous", but India's pollution authority said the AQI was around 350. Officials were not immediately available to explain the variation. Vehicles drive on a highway on a polluted smoggy morning in New Delhi, India, Nov 7, 2024. PHOTO: Reuters file The India Meteorological Department (IMD) said the pollution had reduced visibility to 100 metres in some places by around 8am local time.

DENPASAR, Indonesia — Several international airlines cancelled flights to and from Indonesia's resort island of Bali on Wednesday (Nov 13), after further eruptions of a volcano that has spewed ash clouds as high as 10km and forced thousands to evacuate. Jetstar and Qantas said they had stopped flights to Bali on Wednesday for safety reasons because of volcanic ash, while plane tracking website Flightradar24 showed flights to the island by AirAsia and Virgin were also cancelled. Bali is Indonesia's top tourist hotspot and is a popular destination for Australian visitors. The first eruption of the Mount Lewotobi Laki-laki on Nov 3 in the East Nusa Tenggara province, about 800 km from Bali, killed at least nine people. It has since erupted repeatedly, including multiple times on Tuesday. From Nov 4 to Nov 12, 80 flights in Bali were cancelled, including from Singapore, Hong Kong, and several Australian cities, said Ahmad Syaugi Shahab, general manager of Bali's Ngurah Rai airport. Indonesia has close to 130 active volcanoes and sits on the Pacific "Ring of Fire", an area of high seismic activity atop various tectonic plates.

COLOMBO — Chanu Nimesha is contesting Sri Lanka's parliamentary election on Thursday (Nov 14) as the first openly transgender candidate, hoping to forge a more inclusive and tolerant political culture on the South Asian island. Transgender people are estimated to make up about one per cent of Sri Lanka's 22 million people, according to Equal Ground, a local civil society group. They frequently face social rejection, lack legal protection and have almost no representation in political parties. Nimesha, who is contesting from Kegalle — about 80km east of Colombo — said she was the first transgender person to run for a seat in the 225-strong parliament and that her message of social justice had been well received. "I'm not concerned about winning or losing," she said, sitting in her one-bedroom flat. "But it is important for me to be present in this space, to be seen, to inspire others like me. I want to help everyone, not just my community."

“Gravest International Crimes”: U.N. Aid Chief Blasts Israel’s Deadly Siege on Gaza , Biden Won’t Enforce U.S. Law Requiring Halt of Arms to Israel Despite Clear Human Rights Abuses, Israeli Strikes Kill Dozens in Beirut Suburbs and Mount Lebanon Governorate, National Press Club’s Press Freedom Award Goes to Wael al-Dahdouh for Gaza Coverage, Mike Huckabee, Who Declared “There’s No Such Thing as a Palestinian,” Named U.S. Ambassador to Israel, Trump Nominates Fox News TV Personality Pete Hegseth as Defense Secretary, John Ratcliffe, Who Defended Trump During Impeachment Hearings, Nominated as CIA Director, Trump Picks Elon Musk and Vivek Ramaswamy to Lead Drastic Overhaul of Federal Bureaucracy, Senate GOP Meets to Pick New Leader; House Freedom Caucus May Challenge Speaker Mike Johnson, House Fails to Pass Bill Granting President Sweeping Powers to Target Nonprofits, Jury Orders Military Contractor CACI to Pay $42 Million to Abu Ghraib Torture Survivors, Climate Campaigners Ask Scottish Court to Halt Development of Rosebank Oil Field

Immigrant rights lawyers are preparing to fight back against Donald Trump’s plans to carry out the largest mass deportation in U.S. history once he takes office again in January. The president-elect has already named some leading anti-immigration figures for his incoming administration who will lead the plan, including former ICE head Tom Homan and his longtime aide Stephen Miller. Trump’s picks were central in family separations, the Muslim ban, attacks on Deferred Action for Childhood Arrivals, or DACA, and other anti-immigrant policies during the first Trump administration. Trump is also reportedly planning to greatly expand immigrant detention in private for-profit prisons, and during the campaign he spoke of invoking the Alien Enemies Act of 1798 to speed up deportations. “We have been preparing nearly a year for this,” says attorney Lee Gelernt, deputy director of the ACLU Immigrants’ Rights Project, who argued some of the most high-profile immigration cases during the first Trump administration. He stresses that while groups like the ACLU will challenge the Trump administration in the courts, “it needs to be a national effort” to prevent abuses. “We are not opposed to basic immigration reform, but this cannot be a situation where we’re just going after immigrants left and right.”

Arizona voters on Election Day approved a sweeping ballot measure that would allow state and local law enforcement to arrest immigrants suspected of crossing the U.S.-Mexico border outside of ports of entry, while empowering state judges to order deportations. Proposition 314, which creates a series of state crimes targeting immigrants, is modeled after a similar measure in Texas known as S.B. 4 that is currently under review by the U.S. Supreme Court. Only certain portions of Prop 314 are scheduled to go into effect later this month, while the most harmful parts won’t be enforced until the Supreme Court rules on the constitutionality of the Texas law. The measure has drawn comparisons to Arizona’s controversial S.B. 1070, a 2010 law that also gave local police authority to arrest immigrants suspected of being undocumented, though large parts of it were later struck down by the Supreme Court. For more, we speak with Tucson-based activist Alejandra Pablos, who was targeted by Immigration and Customs Enforcement for her activism and has been facing deportation proceedings for years. “People who are speaking out are the first to feel the chills,” Pablos says of Trump’s looming anti-immigrant crackdown. She urges the Biden administration to do what it can to mitigate the harm, including by closing deportation cases against people like her.

Environmental defenders are raising alarm over Donald Trump’s pick to lead the Environmental Protection Agency, former New York Congressmember Lee Zeldin, who has a history of opposing critical environmental protections and clean energy job investments. Zeldin’s nomination comes as Trump is reportedly discussing moving the EPA headquarters outside of Washington, D.C., which could lead to an exodus of staff and expertise from the agency. “I really don’t think this is about government efficiency. I think this is about terrorizing the career staff,” says Judith Enck, who served as a regional administrator of the EPA in the Obama administration.

The U.N. climate summit known as COP29 is underway in Baku, Azerbaijan, where negotiators are trying to make progress on reducing emissions and preventing the worst impacts of the climate crisis. Many activists, however, have criticized the decision to hold the talks in an authoritarian petrostate. The host country is also facing accusations that it is using the climate talks for business, after the head of the talks, Elnur Soltanov, was caught in a secret recording promoting oil and gas deals. That sting was organized by the group Global Witness, which put forward a fake investor. “In exchange for just the promise of sponsorship money, that got us to the heart of the COP29,” says Lela Stanley, an investigator at Global Witness. “We need the U.N. to ban petro interests from sitting at the table, from influencing the COP.”

I am Indian Resident but I have foreign assets, just to know where in the ITR should foreign properties be reported?How much penalty will be imposed if fail to disclose foreign property?

Can a NBFC issue unsecured NCD?

Hello everyone,I've recently transitioned into freelancing in IT (software development & support) after a decade in a salaried role. I've learned that I may need to register for GST and apply for an LUT. Could anyone guide me on the key steps I should take? I currently have one US-ba

when personal Investment is matured, can we show as capital as the amount directly credited into sole propertiorship current account

This is regarding the document required for a change of address on the GST portal. The partnership firm conducts business from a location owned by one of the partners. Would an electricity bill suffice as a document for proof of address? Additionally, should it be mentioned as 'owned property' un

Dept issued notice u/s. 142[1] and we have appointed Partner of one CA Firm ad our Authorised signatory by Power of Attorney. Query is that which letter head is to be used by him- ours/ plain sheet/CA firm letterhead. Please guide

How to change additional place of business as main place of business in gst portal

For the first year of filing after Incorporation of a company do we need to provide the subscribed capital details at time of incorporation In Form AOC 4 , tab " Share capital raised during the reporting period ". Or its only meant for additional capital raised

One client local purchased from maharashtra and paid cgst and sgst, and he sold such goods to Gujarat and charged IGST to the customer, Now Can my client Use CGST and SGST (Purchased ITC) against IGST liability under GSTR-3B?

Hello all,
i need tds on salary calculator for FY 24-25 which will compare old and new regime.

Sir,

remuneration payable is outstanding for years. Can we disallow the same in income tax as the losses are high while making the computation. Also there is no sufficient funds for the remuneration to be paid. Pls guide

what is capital gain tax rate on flat sale by nri? Is it 12.5% without indexation or 20% with indexation?

my ivew--> only 12.5% wo indexation as per section 115E (b)ii
am i wrong?

I along with my wife (both senior citizens of India by birth) moved to USA for permanent residence on Green Card at the end of Oct 2023. We are now on a visit to India since 8th July 2024 and will return to USA on 13th Dec 2024 and will not visit India again during the AY2025-26.
we were in India for 211 days (from 1April 2023 to 29th Oct 2023) in the financial year 2023-24 hence filed our returns for AY2024-25 as “Resident”
We will be staying in India for 158 days (from 8th July 2024 to 13th Dec 2024) in the financial year 2024-25.
We are filing Tax returns to IRS USA on global income as resident.
Grateful for advice what should be our status for returns to be filed for AY2025-26 in India.

FOOD OUTLET IS PAYING GST AT 5% WITH NO ITC CLAIM. NOW AFTER 1ST OCTOBER RCM ON RENT PAID IS TO BE PAID BY THE RESTAURANT @ 18%. SO CAN HE CLAIM RCM CREDIT OR NOT

we are paying stall rent in exhibition to be held out of india, whether 15CB required

Sir, for annual returns filing for the F.Y. 2019-2020 was 31-03-2021- is it correct sir

A If I have 3 flats and i sell all 3 during a financial year, am I entitled to exemption of Rs 10 Cr in each of these 3 flats. In other words the exemption of Rs 10 Cr is for each flat and not in totality during a financial year.

B Direct Tax Code is expected during the next financial year(FY 25-26). Is the benefit of Sec 54 and Sec 54F likely to be discontinued ?

Компания Microsoft представила проект Hyperlight, развивающий гипервизор, предназначенный для встраивания в приложения с целью изолированного выполнения кода, не заслуживающего доверия или требующего особой защиты. Гипервизор оформлен в виде разделяемой библиотеки, обеспечивающей выполнение отдельных функций в легковесных виртуальных машинах (micro-VM) и организующей обмен данными с этими функциями. Код проекта написан на языке Rust и распространяется под лицензией Apache 2.0.

FiveThirtyEight founder and editor-in-chief Nate Silver said in a blog post

Hillary Clinton and Donald Trump today scrambled to make their final pitch to voters in the closely-contested U.S. presidential race dogged by controversies like the Democratic nominee's email scandal.

Democratic presidential nominee Hillary Clinton leads her Republican rival Donald Trump by 4% points, a latest national opinion poll said on Sunday, two days ahead of the crucial US general elections.

As Donald Trump and Hillary Clinton slug it out for the most coveted and powerful seat, the entire world waits with abated breath to see who becomes the next US president on November 9th 2016 and gets their name inked among the pantheon.