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Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

RSC Med. Chem., 2024, 15,3817-3836
DOI: 10.1039/D4MD00477A, Research Article
Maha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa Matboli
ZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.
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Hydrophobic CPP/HDO conjugates: a new frontier in oligonucleotide-warheaded PROTAC delivery

RSC Med. Chem., 2024, 15,3695-3703
DOI: 10.1039/D4MD00546E, Research Article
Miyako Naganuma, Nobumichi Ohoka, Motoharu Hirano, Daishi Watanabe, Genichiro Tsuji, Takao Inoue, Yosuke Demizu
A novel hydrophobic cell-penetrating peptide (CPP) and heteroduplex oligonucleotide (HDO)-conjugated PROTAC, CPP/HDO-PROTAC, was designed to enhance its intracellular delivery and degradation efficiency.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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Anticancer potential of copper(I) complexes based on isopropyl ester derivatives of bis(pyrazol-1-yl)acetate ligands

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00610K, Research Article
Open Access
Maura Pellei, Carlo Santini, Miriam Caviglia, Jo' Del Gobbo, Chiara Battocchio, Carlo Meneghini, Simone Amatori, Chiara Donati, Eleonora Zampieri, Valentina Gandin, Cristina Marzano
In this paper, the isopropyl ester derivatives LOiPr and L2OiPr of bis(pyrazol-1-yl)acetic acid and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid were used as chelators for the preparation of the new Cu(I) phosphane complexes 1-4....
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Supreme Court stays order for CBI probe into sexual assault of minor in Chennai

Calls for a list of five to seven direct recruit IPS officers, including three women, who hail from other States but are now serving in Tamil Nadu cadre




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Tamil Nadu CM Stalin to launch Phase II of nutritional intervention programme for malnourished children, mothers

Mothers of over 76,700 babies in the age group of zero to six months, identified as malnourished, would be covered under Phase II of the programme




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CM Stalin inaugurates 27 new projects at temples across T.N.




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Godrej Industries Q2 net profit surges over three fold to ₹288 crore




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SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka

Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities




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New road proposed from IIT-Tirupati campus to Rachagunneri

Rachagunneri is home to the massive 400/220/132kV electrical substation and also a private steel plant




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Andhra Pradesh govt. reaffirms commitment to ‘irrigating every acre of farmland’ in State through river-interlinking projects




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Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam




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Supreme Court sets pan-India guidelines against ‘bulldozer justice,’ calls demolitions without due process unconstitutional

The Apex court maintains that these guidelines do not apply in cases of unauthorized public land construction or where demolition is mandated by a court ruling




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Karnataka Chief Minister Siddaramaiah says no proposal to ease night traffic ban through Bandipur

Deputy Chief Minister D.K. Shivakumar had stated, in Wayanad in Kerala, that the government would take all possible measures to lift night traffic ban through Bandipur, which had riled wildlife conservationists in Karnataka




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Karnataka to roll out e-khatas for all properties in GPs, ULBs to avoid fictitious transactions




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SoftBank swings to profit of $7.7 billion for September quarter on back of strong listings

Vision Funds (SVF1 and SVF2) sold investments totalling $1.85 billion for the six-month period ended September 30




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Delhi HC sets aside Centre’s order cancelling U.S.-based professor’s OCI card

On the govt.’s allegation of his being involved in “anti-India activities”, the court says the notice lacks specific details or evidence supporting these claims




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U.T. seeks Centre’s nod to implement Smart Meter Project with post-paid plan option

There is stiff resistance from various quarters for the pre-paid Smart Meter Project. It will be difficult to introduce the prepaid functionality at the beginning stages of the implementation, says Minister for Home A. Namassivayam in his memorandum submitted to Union Minister for Power Manohar Lal Khattar




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Gokaldas Exports posts 19% growth in Q2 net profit




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Pro Kabaddi League: Gujarat Giants return to winning ways with big win over Bengal Warriorz

In the second match of the night, Haryana Steelers moved to the top of the table and extended their winning run to four games after defeating the Patna Pirates 37-32




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Villagers oppose proposal for quarry near Sathanur dam at a public hearing

Tiruvannamalai Collector D. Bhaskara Pandian chaired the hearing organised by the TNPCB on Wednesday. The black granite quarry is proposed to be set up on about 8.46 hectares of government land in Sathanur




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Unorganised workers federation protests New Labour Codes with demonstration




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UPPSC aspirants protest continues for third day over exam format 

The job aspirants protest multiple shifts and score normalisation in exams, demanding a fair and unified testing process




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Tambaram Corporation begins population survey and area mapping for improved coverage of UPHCs




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ED initiates restitution of properties of Heera Group of Companies’ investors




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Two men arrested for producing forged demand draft




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Telangana’s Congress government is busy implementing programmes without thought

There is a wide gap between planning and implementation.




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L-G approves proposal to deploy former bus marshals on anti-pollution duties




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ED files Prosecution Complaint against Jaffer Sadiq before Additional CBI Court

A release said 20 persons had been arraigned as accused in the case, and Jaffer Sadiq was identified as the mastermind




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Catering services should only be provided by those having trade licence, says association




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Lanthanum-doped nickel-based composite metal oxide catalyst for hydrogenation of isophthalonitrile to produce meta-xylenediamine

Catal. Sci. Technol., 2024, Advance Article
DOI: 10.1039/D4CY00802B, Paper
Heng Shao, Jing Guo, Rulong Li, Dekun Ji, Long Huang, Haibin Chu
Lanthanum-doped nickel-based composite metal oxide catalysts exhibited excellent activity in IPN hydrogenation reactions with remarkable stability in fixed-bed reactors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Centre approves widening of Rajahmundry-Anakapalli and Rayachoti-Kadapa national highways to six lanes, says MP




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There is an urgent need to build metro rail project in Visakhapatnam, say local MLAs in the State Assembly

People have been facing severe traffic problems in the and there is a need for rapid transport system like metro rail, says Gajuwaka MLA




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Jana Sena Party corporator alleges neglect of crematorium facelift, stages protest




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VSEA expresses concern over iron ore supply to VSP due to proposed ArcelorMittal & Nippon Steel plant in Anakapalli

We have appealed to the governments to take a note of RINL’s iron ore issue before finalising anything on Mittal’s steel plant in Anakapalli, says association general secretary




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Gokaldas Exports net profit up by 19%, at ₹28.2 crore for Q2FY25

The total income stood at ₹941.8 crore, reflecting an 85 per cent increase from ₹509 crore and the EBITDA margin for Q2 was 8.7 percent




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Favourable winter, kharif produce may temper inflation surge, says QuantEco

October’s inflation peak may soon be followed by a moderation, supported by a favourable winter season and increased availability of kharif produce




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EIH hopes to complete 20 properties by 2029

EIH reported around 41 per cent surge in consolidated net profit to ₹132.70 crore for Q2FY25




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Torrent Power reports 8.5% decline in Q2 net profit

Its revenue from operations rose 3 per cent to ₹7,176 crore in the second quarter




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Kalyan Jewellers posts ₹308 crore profit in H1

Revenue rises to ₹11,601 crore during H1




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R K Swamy’s Q2 profit decline, announces new customer facility launch

Shekar Swamy, Group CEO, said that despite the dip in revenue, the company’s new business pipeline remains strong




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Is boosting revenue via higher property taxes viable?

In India, there are hordes of unauthorised residential units, and levying even a low tax on these may be politically challenging




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Google grants $1 million to Indian non-profit AI startup Karya

The startup has helped over 50,000 people in rural India in the past two years by offering them data annotation jobs




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Macquarie sees bright prospects for India’s power utilities and lenders: Buy calls for PFC, REC, NTPC, PGCIL

With strong balance sheets, PFC, REC, NTPC, and PGCIL are well-prepared to increase capital expenditure




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Sterlite Technologies secures ₹2,600 crore BharatNet project in Jammu and Kashmir 

Sterlite Technologies to implement an automation-led fibre deployment approach, utilising drone surveys, GIS mapping, and AI-led network design




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Anupamaa producer Rajan Shahi breaks silence over Rupali Ganguly's dispute with stepdaughter Esha Verma: 'You have...'

Anupamaa producer Rajan Shahi has supported Rupali Ganguly after the actress slapped her stepdaughter Esha Verma with a legal notice, seeking Rs 50 crore in damages.




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Stars Buying Property After Property!

'Just this year alone, close to 40 major transactions involving Bollywood stars have been recorded.'




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VideoProc Converter AI Review

What's one of the best one-stop video/image quality enhancement and editing software available for Windows? Answer: Digiarty's VideoProc Converter AI! From the makers of WinX DVD Ripper and WinX Video Converter comes VideoProc Converter: a multi-award winning software program that is a one-stop video/image processing program that allows you to restore and enhance video image quality in 1 click, convert video/audio, rip DVDs, edit video, download videos, video to GIF maker ... plus much more! The latest version of VideoProc Converter AI includes the ability to upscale old pictures and video ... (view more)




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Infopackets to Launch YouTube Tech Support Pilot Program

Dear Infopackets Readers, I would like to introduce the launch of an exciting, new video-based tech support Q ... (view more)




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Broadband Subsidy Program Ends But Debate Continues

Four months after the end of a subsidy program for home broadband, individual states are figuring out if and how they can expand access. Meanwhile the debate over the value and impact of the Affordable Connectivity Program (ACP) continues to rage. The program launched in 2021 as part of a wider infrastructure package. It was available to households earning up to double the federal poverty level or with somebody in a government assistance program. Under the program, households would get a government-funded discount of up to $30 a month on broadband services and a one-off discount of $100 for a ... (view more)