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[ASAP] Truncating the Structure of Lipopolysaccharide in <italic toggle="yes">Escherichia coli</italic> Can Effectively Improve Poly-3-hydroxybutyrate Production

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Published On :: Thu, 30 Apr 2020 04:00:00 GMT

ACS Synthetic Biology

DOI: 10.1021/acssynbio.0c00071

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[ASAP] A Chemical Switch System to Modulate Chimeric Antigen Receptor T Cell Activity through Proteolysis-Targeting Chimaera Technology

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Published On :: Thu, 30 Apr 2020 04:00:00 GMT

ACS Synthetic Biology

DOI: 10.1021/acssynbio.9b00476

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[ASAP] Translation Related Factors Improve the Productivity of a <italic toggle="yes">Streptomyces</italic>-Based Cell-Free Protein Synthesis System

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Published On :: Wed, 06 May 2020 04:00:00 GMT

ACS Synthetic Biology

DOI: 10.1021/acssynbio.0c00140

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[ASAP] Bacteriophage Inspired Growth-Decoupled Recombinant Protein Production in <italic toggle="yes">Escherichia coli</italic>

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Published On :: Thu, 07 May 2020 04:00:00 GMT

ACS Synthetic Biology

DOI: 10.1021/acssynbio.0c00028

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A Model Mother

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4 characteristics we can learn from Eunice.

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[ASAP] MymA Bioactivated Thioalkylbenzoxazole Prodrug Family Active against <italic toggle="yes">Mycobacterium tuberculosis</italic>

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Published On :: Sun, 19 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00003

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[ASAP] Molecule Property Analyses of Active Compounds for <italic toggle="yes">Mycobacterium tuberculosis</italic>

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Published On :: Mon, 20 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02075

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[ASAP] Imidazo[1,2-<italic toggle="yes">a</italic>]pyridine Derivatives as Aldehyde Dehydrogenase Inhibitors: Novel Chemotypes to Target Glioblastoma Stem Cells

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Published On :: Mon, 20 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b01910

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[ASAP] Pyridine-Embedded Phenothiazinium Dyes as Lysosome-Targeted Photosensitizers for Highly Efficient Photodynamic Antitumor Therapy

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Published On :: Tue, 21 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00280

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[ASAP] Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation

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Published On :: Wed, 22 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00035

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[ASAP] Discovery of Peptide Boronate Derivatives as Histone Deacetylase and Proteasome Dual Inhibitors for Overcoming Bortezomib Resistance of Multiple Myeloma

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Published On :: Thu, 23 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02161

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[ASAP] Correction to Toggling Preassembly with Single-Site Mutation Switches the Cytotoxic Mechanism of Cationic Amphipathic Peptides

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Published On :: Fri, 24 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00608

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[ASAP] Molecular Interactions of Pyrazine-Based Compounds to Proteins

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Published On :: Fri, 24 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b02021

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[ASAP] Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists

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Published On :: Fri, 24 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00388

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[ASAP] Discovery and Structure–Activity Relationship Study of (<italic toggle="yes">Z</italic>)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00227

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[ASAP] Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin–MLL Interaction with Strong <italic toggle="yes">In Vivo</italic> Antitumor Activity

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00547

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[ASAP] Discovery of (2<italic toggle="yes">R</italic>)-<italic toggle="yes">N</italic>-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1<italic toggle="yes">H</italic>-indol-7

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.9b01392

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[ASAP] Correction to Photoactivatable Prolyl Hydroxylase 2 Inhibitors for Stabilizing the Hypoxia-Inducible Factor with Light

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00599

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[ASAP] Structure-Based Design of Highly Potent HIV-1 Protease Inhibitors Containing New Tricyclic Ring P2-Ligands: Design, Synthesis, Biological, and X-ray Structural Studies

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Published On :: Wed, 29 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00202

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[ASAP] Design and Characterization of the First Selective and Potent Mechanism-Based Inhibitor of Cytochrome P450 4Z1

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Published On :: Thu, 30 Apr 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00101

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[ASAP] Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

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Published On :: Mon, 04 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00339

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[ASAP] Both <sc>d</sc>- and <sc>l</sc>-Glucose Polyphosphates Mimic <sc>d</sc>-<italic toggle="yes">myo</italic>-Inositol 1,4,5-Trisphosphate: New Synthetic Agonists and Partial Agonists at the Ins

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Published On :: Wed, 06 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00215

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[ASAP] Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity

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Published On :: Wed, 06 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00245

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[ASAP] Optimization of Potent ATAD2 and CECR2 Bromodomain Inhibitors with an Atypical Binding Mode

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Published On :: Wed, 06 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00021

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[ASAP] Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00337

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[ASAP] Discovery of <italic toggle="yes">N</italic>-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1<italic toggle="yes">H</italic>-pyrrolo[2,3-<italic toggle=&q

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00628

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[ASAP] Discovery of a Silicon-Containing Pan-Genotype Hepatitis C Virus NS5A Inhibitor

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00082

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[ASAP] Ruthenium(II) Complex Containing a Redox-Active Semiquinonate Ligand as a Potential Chemotherapeutic Agent: From Synthesis to <italic toggle="yes">In Vivo</italic> Studies

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Published On :: Thu, 07 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00431

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[ASAP] Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00192

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[ASAP] Exploration of the Structural Space in 4(3<italic toggle="yes">H</italic>)-Quinazolinone Antibacterials

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00153

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[ASAP] Molecular Basis for Omapatrilat and Sampatrilat Binding to Neprilysin—Implications for Dual Inhibitor Design with Angiotensin-Converting Enzyme

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Published On :: Fri, 08 May 2020 04:00:00 GMT

Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.0c00441

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[ASAP] Progress in the Field of Aldehyde Dehydrogenase Inhibitors: Novel Imidazo[1,2-<italic toggle="yes">a</italic>]pyridines against the 1A Family

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Published On :: Tue, 31 Mar 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00686

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[ASAP] Cancer Immunotherapy through the Inhibition of Diacylglycerol Kinases Alpha and Zeta

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Published On :: Wed, 01 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00118

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[ASAP] Therapeutic Potential of Targeted Nanoparticles and Perspective on Nanotherapies

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00075

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[ASAP] Synthesis of Novel G Factor or Chloroquine-Artemisinin Hybrids and Conjugates with Potent Antiplasmodial Activity

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00669

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[ASAP] Novel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants

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Published On :: Thu, 02 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00043

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[ASAP] Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents

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Published On :: Wed, 08 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00639

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[ASAP] Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR?t Inverse Agonist

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00063

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[ASAP] New Dual CK2/HDAC1 Inhibitors with Nanomolar Inhibitory Activity against Both Enzymes

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00561

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[ASAP] Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents

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Published On :: Fri, 10 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00129

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[ASAP] Design and Synthesis of Tetrazole- and Pyridine-Containing Itraconazole Analogs as Potent Angiogenesis Inhibitors

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Published On :: Mon, 13 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.9b00438

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[ASAP] Potential Cancer Treatment by Agonists of the Stimulator of Interferon Genes

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Published On :: Mon, 13 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00117

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[ASAP] Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00008

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[ASAP] Characterization of Specific <italic toggle="yes">N</italic>-a-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00029

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[ASAP] Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif

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Published On :: Wed, 15 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00095

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[ASAP] Discovery of CPI-1612: A Potent, Selective, and Orally Bioavailable EP300/CBP Histone Acetyltransferase Inhibitor

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Published On :: Mon, 27 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00155

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[ASAP] PROTAC Compounds Targeting a-Synuclein Protein for Treating Neurogenerative Disorders: Alzheimer’s and Parkinson’s Diseases

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Published On :: Tue, 28 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00192

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[ASAP] Development of Selective Steroid Inhibitors for the Glucose-6-phosphate Dehydrogenase from <italic toggle="yes">Trypanosoma cruzi</italic>

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Published On :: Wed, 29 Apr 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00106

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[ASAP] Discovery of RO7185876, a Highly Potent ?-Secretase Modulator (GSM) as a Potential Treatment for Alzheimer’s Disease

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Published On :: Fri, 01 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00109

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[ASAP] Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors

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Published On :: Fri, 01 May 2020 04:00:00 GMT

ACS Medicinal Chemistry Letters

DOI: 10.1021/acsmedchemlett.0c00025