2 The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independent of its catalytic activity [Cell Biology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 We previously reported that overexpression of cytochrome P450 family 24 subfamily A member 1 (CYP24A1) increases lung cancer cell proliferation by activating RAS signaling and that CYP24A1 knockdown inhibits tumor growth. However, the mechanism of CYP24A1-mediated cancer cell proliferation remains unclear. Here, we conducted cell synchronization and biochemical experiments in lung adenocarcinoma cells, revealing a link between CYP24A1 and anaphase-promoting complex (APC), a key cell cycle regulator. We demonstrate that CYP24A1 expression is cell cycle–dependent; it was higher in the G2-M phase and diminished upon G1 entry. CYP24A1 has a functional destruction box (D-box) motif that allows binding with two APC adaptors, CDC20-homologue 1 (CDH1) and cell division cycle 20 (CDC20). Unlike other APC substrates, however, CYP24A1 acted as a pseudo-substrate, inhibiting CDH1 activity and promoting mitotic progression. Conversely, overexpression of a CYP24A1 D-box mutant compromised CDH1 binding, allowing CDH1 hyperactivation, thereby hastening degradation of its substrates cyclin B1 and CDC20, and accumulation of the CDC20 substrate p21, prolonging mitotic exit. These activities also occurred with a CYP24A1 isoform 2 lacking the catalytic cysteine (Cys-462), suggesting that CYP24A1's oncogenic potential is independent of its catalytic activity. CYP24A1 degradation reduced clonogenic survival of mutant KRAS-driven lung cancer cells, and calcitriol treatment increased CYP24A1 levels and tumor burden in Lsl-KRASG12D mice. These results disclose a catalytic activity-independent growth-promoting role of CYP24A1 in mutant KRAS-driven lung cancer. This suggests that CYP24A1 could be therapeutically targeted in lung cancers in which its expression is high. Full Article
2 SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation [Protein Synthesis and Degradation] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 SUMOylation is a posttranslational modification (PTM) at a lysine residue and is crucial for the proper functions of many proteins, particularly of transcription factors, in various biological processes. Zinc finger homeobox 3 (ZFHX3), also known as AT motif-binding factor 1 (ATBF1), is a large transcription factor that is active in multiple pathological processes, including atrial fibrillation and carcinogenesis, and in circadian regulation and development. We have previously demonstrated that ZFHX3 is SUMOylated at three or more lysine residues. Here, we investigated which enzymes regulate ZFHX3 SUMOylation and whether SUMOylation modulates ZFHX3 stability and function. We found that SUMO1, SUMO2, and SUMO3 each are conjugated to ZFHX3. Multiple lysine residues in ZFHX3 were SUMOylated, but Lys-2806 was the major SUMOylation site, and we also found that it is highly conserved among ZFHX3 orthologs from different animal species. Using molecular analyses, we identified the enzymes that mediate ZFHX3 SUMOylation; these included SUMO1-activating enzyme subunit 1 (SAE1), an E1-activating enzyme; SUMO-conjugating enzyme UBC9 (UBC9), an E2-conjugating enzyme; and protein inhibitor of activated STAT2 (PIAS2), an E3 ligase. Multiple analyses established that both SUMO-specific peptidase 1 (SENP1) and SENP2 deSUMOylate ZFHX3. SUMOylation at Lys-2806 enhanced ZFHX3 stability by interfering with its ubiquitination and proteasomal degradation. Functionally, Lys-2806 SUMOylation enabled ZFHX3-mediated cell proliferation and xenograft tumor growth of the MDA-MB-231 breast cancer cell line. These findings reveal the enzymes involved in, and the functional consequences of, ZFHX3 SUMOylation, insights that may help shed light on ZFHX3's roles in various cellular and pathophysiological processes. Full Article
2 Targeting the polyamine pathway—“a means” to overcome chemoresistance in triple-negative breast cancer [Cell Biology] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Triple-negative breast cancer (TNBC) is characterized by its aggressive biology, early metastatic spread, and poor survival outcomes. TNBC lacks expression of the targetable receptors found in other breast cancer subtypes, mandating use of cytotoxic chemotherapy. However, resistance to chemotherapy is a significant problem, encountered in about two-thirds of TNBC patients, and new strategies are needed to mitigate resistance. In this issue of the Journal of Biological Chemistry, Geck et al. report that TNBC cells are highly sensitive to inhibition of the de novo polyamine synthesis pathway and that inhibition of this pathway sensitizes cells to TNBC-relevant chemotherapy, uncovering new opportunities for addressing chemoresistance. Full Article
2 Structures of the MHC-I molecule BF2*1501 disclose the preferred presentation of an H5N1 virus-derived epitope [Protein Structure and Folding] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Lethal infections by strains of the highly-pathogenic avian influenza virus (HPAIV) H5N1 pose serious threats to both the poultry industry and public health worldwide. A lack of confirmed HPAIV epitopes recognized by cytotoxic T lymphocytes (CTLs) has hindered the utilization of CD8+ T-cell–mediated immunity and has precluded the development of effectively diversified epitope-based vaccination approaches. In particular, an HPAIV H5N1 CTL-recognized epitope based on the peptide MHC-I–β2m (pMHC-I) complex has not yet been designed. Here, screening a collection of selected peptides of several HPAIV strains against a specific pathogen-free pMHC-I (pBF2*1501), we identified a highly-conserved HPAIV H5N1 CTL epitope, named HPAIV–PA123–130. We determined the structure of the BF2*1501–PA123–130 complex at 2.1 Å resolution to elucidate the molecular mechanisms of a preferential presentation of the highly-conserved PA123–130 epitope in the chicken B15 lineage. Conformational characteristics of the PA123–130 epitope with a protruding Tyr-7 residue indicated that this epitope has great potential to be recognized by specific TCRs. Moreover, significantly increased numbers of CD8+ T cells specific for the HPAIV–PA123–130 epitope in peptide-immunized chickens indicated that a repertoire of CD8+ T cells can specifically respond to this epitope. We anticipate that the identification and structural characterization of the PA123–130 epitope reported here could enable further studies of CTL immunity against HPAIV H5N1. Such studies may aid in the development of vaccine development strategies using well-conserved internal viral antigens in chickens. Full Article
2 The heme-regulatory motifs of heme oxygenase-2 contribute to the transfer of heme to the catalytic site for degradation [Protein Structure and Folding] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Heme-regulatory motifs (HRMs) are present in many proteins that are involved in diverse biological functions. The C-terminal tail region of human heme oxygenase-2 (HO2) contains two HRMs whose cysteine residues form a disulfide bond; when reduced, these cysteines are available to bind Fe3+-heme. Heme binding to the HRMs occurs independently of the HO2 catalytic active site in the core of the protein, where heme binds with high affinity and is degraded to biliverdin. Here, we describe the reversible, protein-mediated transfer of heme between the HRMs and the HO2 core. Using hydrogen-deuterium exchange (HDX)-MS to monitor the dynamics of HO2 with and without Fe3+-heme bound to the HRMs and to the core, we detected conformational changes in the catalytic core only in one state of the catalytic cycle—when Fe3+-heme is bound to the HRMs and the core is in the apo state. These conformational changes were consistent with transfer of heme between binding sites. Indeed, we observed that HRM-bound Fe3+-heme is transferred to the apo-core either upon independent expression of the core and of a construct spanning the HRM-containing tail or after a single turnover of heme at the core. Moreover, we observed transfer of heme from the core to the HRMs and equilibration of heme between the core and HRMs. We therefore propose an Fe3+-heme transfer model in which HRM-bound heme is readily transferred to the catalytic site for degradation to facilitate turnover but can also equilibrate between the sites to maintain heme homeostasis. Full Article
2 Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications [Immunology] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 Antibodies are widely used as cancer therapeutics, but their current use is limited by the low number of antigens restricted to cancer cells. A receptor tyrosine kinase, receptor tyrosine kinase-like orphan receptor 2 (ROR2), is normally expressed only during embryogenesis and is tightly down-regulated in postnatal healthy tissues. However, it is up-regulated in a diverse set of hematologic and solid malignancies, thus ROR2 represents a candidate antigen for antibody-based cancer therapy. Here we describe the affinity maturation and humanization of a rabbit mAb that binds human and mouse ROR2 but not human ROR1 or other human cell-surface antigens. Co-crystallization of the parental rabbit mAb in complex with the human ROR2 kringle domain (hROR2-Kr) guided affinity maturation by heavy-chain complementarity-determining region 3 (HCDR3)-focused mutagenesis and selection. The affinity-matured rabbit mAb was then humanized by complementarity-determining region (CDR) grafting and framework fine tuning and again co-crystallized with hROR2-Kr. We show that the affinity-matured and humanized mAb retains strong affinity and specificity to ROR2 and, following conversion to a T cell–engaging bispecific antibody, has potent cytotoxicity toward ROR2-expressing cells. We anticipate that this humanized affinity-matured mAb will find application for antibody-based cancer therapy of ROR2-expressing neoplasms. Full Article
2 The Histone Methyltransferase MLL1 Directs Macrophage-Mediated Inflammation in Wound Healing and Is Altered in a Murine Model of Obesity and Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2017-09-01 Andrew S. KimballSep 1, 2017; 66:2459-2471Immunology and Transplantation Full Article
2 A Variation on the Theme: SGLT2 Inhibition and Glucagon Secretion in Human Islets By diabetes.diabetesjournals.org Published On :: 2020-05-01 David J. HodsonMay 1, 2020; 69:864-866Commentaries Full Article
2 Effect of a Sustained Reduction in Plasma Free Fatty Acid Concentration on Intramuscular Long-Chain Fatty Acyl-CoAs and Insulin Action in Type 2 Diabetic Patients By diabetes.diabetesjournals.org Published On :: 2005-11-01 Mandeep BajajNov 1, 2005; 54:3148-3153Metabolism Full Article
2 The High-Fat Diet-Fed Mouse: A Model for Studying Mechanisms and Treatment of Impaired Glucose Tolerance and Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2004-12-01 Maria Sörhede WinzellDec 1, 2004; 53:S215-S219Section V: The Incretin Pathway Full Article
2 MicroRNA Networks in Pancreatic Islet Cells: Normal Function and Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2020-05-01 Lena EliassonMay 1, 2020; 69:804-812Small Noncoding RNAs in Diabetes Full Article
2 Evidence Against an Important Role of Plasma Insulin and Glucagon Concentrations in the Increase in EGP Caused by SGLT2 Inhibitors By diabetes.diabetesjournals.org Published On :: 2020-04-01 Mariam AlatrachApr 1, 2020; 69:681-688Pathophysiology Full Article
2 Mechanisms of {beta}-Cell Death in Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2005-12-01 Marc Y. DonathDec 1, 2005; 54:S108-S113Section III: Inflammation and beta-Cell Death Full Article
2 Type 2 Diabetes: Demystifying the Global Epidemic By diabetes.diabetesjournals.org Published On :: 2017-06-01 Ranjit UnnikrishnanJun 1, 2017; 66:1432-1442Perspectives in Diabetes Full Article
2 Insulin Resistance and Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2012-04-01 Roy TaylorApr 1, 2012; 61:778-779Commentary Full Article
2 PPARA Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid By diabetes.diabetesjournals.org Published On :: 2020-04-01 Mario Luca MorieriApr 1, 2020; 69:771-783Genetics/Genomes/Proteomics/Metabolomics Full Article
2 The Rise of Childhood Type 1 Diabetes in the 20th Century By diabetes.diabetesjournals.org Published On :: 2002-12-01 Edwin A.M. GaleDec 1, 2002; 51:3353-3361Perspectives in Diabetes Full Article
2 ACE2 and Diabetes: ACE of ACEs? By diabetes.diabetesjournals.org Published On :: 2010-12-01 Daniel BatlleDec 1, 2010; 59:2994-2996Commentaries Full Article
2 Effect of a High-Protein, Low-Carbohydrate Diet on Blood Glucose Control in People With Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2004-09-01 Mary C. GannonSep 1, 2004; 53:2375-2382Pathophysiology Full Article
2 Mechanisms of Pancreatic {beta}-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities By diabetes.diabetesjournals.org Published On :: 2005-12-01 Miriam CnopDec 1, 2005; 54:S97-S107Section III: Inflammation and beta-Cell Death Full Article
2 Protecting the Heart in Obesity: Role of ACE2 and Its Partners By diabetes.diabetesjournals.org Published On :: 2016-01-01 Rhian M. TouyzJan 1, 2016; 65:19-21Commentaries Full Article
2 Low-Grade Systemic Inflammation and the Development of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study By diabetes.diabetesjournals.org Published On :: 2003-07-01 Bruce B. DuncanJul 1, 2003; 52:1799-1805Pathophysiology Full Article
2 From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus By diabetes.diabetesjournals.org Published On :: 2009-04-01 Ralph A. DeFronzoApr 1, 2009; 58:773-795Banting Lecture Full Article
2 Correction: Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase. [Additions and Corrections] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 VOLUME 295 (2020) PAGES 4079–4092There was an error in the abstract. “The pyridinium cation hampers uptake of OPs into the central nervous system (CNS)” should read as “The pyridinium cation hampers uptake into the central nervous system (CNS).” Full Article
2 Courageously critiquing sexual violence: responding to the 2018 Nobel Peace Prize By feedproxy.google.com Published On :: Wed, 06 Nov 2019 08:42:19 +0000 6 November 2019 , Volume 95, Number 6 Read online Maria Stern Marysia Zalewski's work has taught us, as a collective of feminist scholars, to be cautious of neat instruction manuals and coherently set out plans of action; of claims to sure knowledge about danger, violence, and its subjects and remedies; of the fanfare of grand arrivals; and of the quieter staking of ground that has been seemingly won. Zalewski has persistently reminded us in different ways that we/she does ‘not even know what gender is or does’. Far from a flippant response to the emptiness of gender mainstreaming policies, this seemingly simple statement instead serves as a glaring post-it note on the margins of our texts about International Relations theory, feminism, sex/gender and violence— both those that we read, as well as those that we write. However, this lesson is often forgotten in our rush to understand and establish gendered harms as valid and important, and to seek their redress. Gleaning insights from Zalewski's work, this article critically considers possible responses to the 2018 Nobel Peace Prize. Its aim is not to delve into a discussion of the politics or effects of the Peace Prize as such, but to instead use the 2018 Peace Prize as a marker—a moment to consider the possibility for critique in relation to sexual violence. Full Article
2 China and Russia in R2P debates at the UN Security Council By feedproxy.google.com Published On :: Thu, 07 May 2020 09:36:16 +0000 7 May 2020 , Volume 96, Number 3 Zheng Chen and Hang Yin Read online While China and Russia's general policies towards the Responsibility to Protect (R2P) are similar, the two reveal nuanced differences in addressing specific emergencies. Both express support for the first two pillars of R2P while resisting coercive intervention under its aegis, as they share anxieties of domestic political security and concerns about their international image. Nonetheless, addressing cases like the Syrian crisis, Russian statements are more assertive and even aggressive while Chinese ones are usually vague and reactive. This article highlights the two states’ different tones through computer-assisted text analyses. It argues that diplomatic styles reflect Russian and Chinese perceptions of their own place in the evolving international order. Experiences in past decades create divergent reference points and status prospects for them, which leads to their different strategies in signalling Great Power status. As Beijing is optimistic about its status-rising prospects, it exercises more self-restraint in order to avoid external containments and is reluctant to act as an independent ‘spoiler’. Meanwhile, Moscow interprets its Great Power status more from a frame of ‘loss’ and therefore is inclined to adopt a sterner approach to signal its status. Although their policies complement each other on many occasions, there is nothing akin to a Sino–Russian ‘bloc’. Full Article
2 Mathematical Reviews at JMM 2020 in Denver By blogs.ams.org Published On :: Sun, 12 Jan 2020 00:34:28 +0000 Mathematical Reviews will be at the JMM in Denver, January 13-18, 2020. The Joint Mathematical Meetings is the largest gathering of mathematicians in the world. There are lots of great activities: invited lectures, special sessions, editorial meetings, exhibits, and the chance to … Continue reading → Full Article Conferences
2 MSC2020 By blogs.ams.org Published On :: Tue, 18 Feb 2020 20:37:37 +0000 The editors of Mathematical Reviews and zbMATH have finished the latest revision of the Mathematics Subject Classification, MSC2020. The official announcement is published jointly in the March 2020 issue of the Notices of the American Mathematical Society and the March … Continue reading → Full Article Announcements
2 Trade Tensions Set to Continue in 2020 By feedproxy.google.com Published On :: Tue, 14 Jan 2020 10:13:33 +0000 14 January 2020 Megan Greene Dame Deanne Senior Fellow in International Economics @economistmeg LinkedIn As the US faces off over trade with both China and the EU, expect another year of uncertainty. 2020-01-14-Zhangjiagang.jpg Unloading at a port in Zhangjiagang. Photo: Getty Images. Global trade policy is not going back to the consensus that prevailed over the past few decades. Even if the growing cycle of tariffs and trade threats is tamed in 2020, the economic consensus that underpinned broad support for open trade is breaking down, and escalation in trade tensions is likely.What next for the US and China?The US and China are currently at the centre of these tensions. The equity and bond markets started 2020 off euphorically as news of a ‘phase one’ trade deal between the two dominated headlines. Such a deal involves the US reducing some previously imposed tariffs and tabling another round of threatened ones, while China agrees to buy more US goods, including agriculture. This represents a détente of sorts, but don’t expect it to last; trade between the two countries is not actually at the heart of their trade war.The question instead is which country will have the biggest economy, based on excellence in industries such as artificial intelligence, machine learning and quantum computing. There is a national security component to this issue as well, given how much these high-tech industries feed into military and national security operations. This has increasingly become a concern for the United States as China has adopted a more aggressive regional stance, particularly in the South China Sea.Tariffs have been used as a tool by both countries to try to prevent the other from dominating the global economy, and while they have dented both economies, they aren’t a particularly effective tool. In particular, tariffs do nothing to address US concerns about intellectual property rights in China, forced technology transfers and state subsidies for high tech industries. The phase one deal, therefore, is a superficial one that fails to get at the heart of the matter.US–EU tensionsHowever, with a temporary US-China détente, the US may turn its attention to Europe. The EU and US are in the midst of negotiating a trade deal, but obstacles have been present from the start.Last July, France adopted a 3% digital tax that applies to firms with global revenues over €750 million per annum generated from digital activities, of which €25 million are made in its territory. A US investigation determined that the digital tax discriminates against US companies such as Google, Amazon, Apple and Facebook, and so the US has threatened France with 100% tariffs on luxury exports, including wine.The long-standing tensions between the US and EU over their aircraft manufacturing behemoths, Boeing and Airbus, make reaching a US–EU trade deal more complicated. They also risk undermining US–EU collaboration on some joint concerns regarding China’s trade policies and practices.The United States recently threatened to increase its punitive measures against European goods as retaliation for Airbus subsidies. The World Trade Organization (WTO) gave the US the green light to impose tariffs of up to 100% on $7.5 billion of EU exports last October, but the US had limited them to 10% on aircraft and 25% on industrial and agricultural products. Now, the US is threatening to escalate.Finally, the US has repeatedly threatened to impose tariffs on imported cars from the EU. This threat looms large for Germany in particular, which is a significant producer of automobiles and whose industry is still recovering from the diesel emissions scandal. Germany has for the past two decades been the powerhouse economy in the EU, but has more recently seen sclerotic growth.US election implicationsIt is an election year in the United States, and while it is too early to call the election (or even guess who the Democratic candidate might be), the ballot could bring about change on trade. Protectionism has historically been more of a Democrat policy than a Republican one, so there won’t be a complete reversal of Trump’s trade policy if a Democrat were to win. But there might be some changes.If a Democrat controlled the White House, the US would still want to pressure China, but it might adopt a more international approach in that effort. The US might also reverse the steel and aluminium tariffs that kicked off these heightened trade tensions.Most importantly, the US might stop hindering the WTO by appointing judges to the appellate body (without which the WTO cannot address rulings that are being appealed) and would likely work with other countries to reform the WTO. The focus would shift from confrontation to negotiation. This, of course, depends on which Democrat is in the White House.In the meantime, President Trump has a difficult balancing act. Being tough on China and bringing home American jobs were successful slogans in his first presidential bid. He will want to indicate he has delivered on both and will continue to do so. At the same time, tariffs have sparked dips in the markets that have caused the president to de-escalate trade tensions. As the 2020 election approaches, expect the administration to balance these two concerns.Looking beyond the vote, there may be some changes to the US approach to trade over the next decade, depending on which party is in government. The most pernicious aspect of the trade tensions on the global economy has been the uncertainty they have caused; businesses have deferred and delayed investment as they wait to see what the new rules of the global order are. They know the old consensus on trade won’t come back, but don’t yet know what the new consensus is.As long as the limbo persists, and it probably will for at least a few more years, trade issues will remain a risk for the global economy.This article is the first in a series of publications and roundtable discussions, part of the Chatham House Global Trade Policy Forum. Full Article
2 Iran Crisis Pushes Foreign Policy to Top of 2020 Election Debate By feedproxy.google.com Published On :: Tue, 14 Jan 2020 16:41:52 +0000 14 January 2020 Dr Lindsay Newman Senior Research Fellow, US and the Americas Programme @lindsayrsnewman LinkedIn Democrats would be wise to communicate a clear alternative to Trump’s ‘America First’ policy in the Middle East. 2020-01-14-Trump.jpg Donald Trump speaks to the media in front of the White House on Monday. Photo: Getty Images. Conventional wisdom says that foreign policy takes a backseat role in US elections. But last autumn’s Democratic primary debates suggest a potential shift is taking place in the conventional view. While healthcare dominated the discussion (Democrats attribute their 2018 midterm gains to the issue), through November foreign policy followed closely behind in second place in terms of minutes devoted to the discussion.This trend is consistent with President Donald Trump’s America First approach to foreign policy, in which an eye is always kept on how decisions abroad play for the domestic audience. One former Trump administration official has called this dynamic the ‘recoupling’ of foreign policy with domestic policy.The US–China trade conflict, which commanded headlines throughout 2019, is perhaps the best example of this recoupling, tying trade imbalances less with the geopolitical than with domestic impact on farmers. Immigration is another policy area in which Trump has linked domestic implications and indeed domestic opinion with foreign policy. It’s in the title: America First.Now, for better or worse, the targeted killing of Qassem Soleimani, Iran’s response and the subsequent fallout may make US foreign policy towards Iran and the US role in the Middle East a central issue for the 2020 US elections. As it comes just ahead of the Democratic presidential primaries, voters will be looking to the candidates to differentiate their foreign policy experience and proposals for America’s Middle East policy.To President Donald Trump, Soleimani’s assassination represents a campaign promise kept to confront Iran’s aggression.The Trump administration initially justified the action by citing intelligence of an imminent threat to US personnel and targets, but after Defense Secretary Mark Esper called this into question, Trump tweeted that ‘it doesn’t really matter because of [Soleimani’s] horrible past’. Ultimately, Trump’s message, on the campaign trail and any general debate stage he agrees to be on, is that he has overseen a new national security strategy for Iran.Soleimani’s removal from the Iranian calculus is just a part of this broader policy, which also includes neutralizing the Iranian government’s destabilizing influence in the Middle East, denying Iran and especially the Islamic Revolutionary Guard Corps’ access to funding for its malign activities, and rallying the international community against domestic human rights violations and unjust detentions.To counter Trump, Democrats and democratic presidential candidates would be best-served by offering a simple argument that too links domestic interests and foreign policy: the killing of Soleimani and Trump’s national security strategy for Iran have not made the US or its interests safer.Iran’s ballistic missile attack on US forces in Iraq, which Iran’s Supreme Leader Ayatollah Ali Khamenei called a ‘slap in the face’ for the US, makes the risks to US assets and personnel abundantly clear. Even if Iran reverts entirely to covert, proxy efforts to counter US interests, the current US–Iran tensions remain unresolved and will likely continue to persist through the 2020 elections in November.As a matter of the first order, Soleimani was replaced by his deputy Brigadier General Esmail Ghaani within a day of the former’s death, with Khamenei saying that the Quds Force will be ‘unchanged’.At the second order, Iraq’s parliament voted in favour of a nonbinding resolution to rescind the invitation to US forces, which led Trump to threaten sanctions and demands for reimbursement. Whether US troops will ultimately leave Iraq (following a ‘mistaken’ report that the US was preparing to depart) remains to be seen, but the destabilization of the US military presence in Iraq fulfils a key Iranian objective.In the interim, the US-led coalition in Iraq and Syria fighting ISIS announced that it would at least temporarily cease its counterterrorism efforts to instead fortify its outposts and prepare for Iranian retaliation, opening a wider door for the resurgence of the terror group.By arguing that the US, its troops and interest have not been made safer by Trump’s Middle East policy – from withdrawing from the Iran nuclear deal to the imposition of a ‘maximum pressure campaign’ to Soleimani’s killing – Democrats will be able to point to every post-Soleimani US injury, death, regional terrorism attack, asset compromise, cyberattack and shipping disruption as evidence.Democratic presidential candidates also ought to be explicit about how they plan to manage tensions with Iran – strategic, diplomatic and military – particularly their position on the future of the nuclear deal.Iran has made clear that the path to de-escalation is through sanctions relief. Asserting leverage need not always involve taking away all of your counterparty’s options (‘maximum pressure’). It also involves knowing what your adversary wants (sanctions relief) and showing a willingness to offer it (especially where it means less to you) in exchange for something of greater worth (avoiding war/a non-nuclear Iran).Clarity around future policy of a potential Democratic president may bring de-escalation forward in a way that Trump’s statement of Iran standing down are unlikely to do. Full Article
2 US 2020: America’s National Security Strategy and Middle East Policy By feedproxy.google.com Published On :: Tue, 28 Jan 2020 14:00:02 +0000 Invitation Only Research Event 10 February 2020 - 10:30am to 11:30am Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Dr Kori Schake, Resident Scholar and Director of Foreign and Defense Policy Studies, American Enterprise Institute Chair: Dr Leslie Vinjamuri, Director, US and Americas Programme In the run-up to the 2016 US presidential election, then-candidate Donald Trump made a series of campaign promises concerning US foreign policy towards the Middle East. Since assuming office, President Trump has withdrawn the US from the Joint Comprehensive Plan of Action, withdrawn troops from Syria, relocated the US embassy in Israel to Jerusalem and orchestrated the strike against ISIS leader Abu Bakr al-Baghdadi.Against a backdrop of Trump's inclination towards withdrawing from the region, countries across the Middle East are being rocked by protests, Turkey’s purchase of Russia’s S-400 missile has threatened to undermine cohesion within NATO and the much hoped for ceasefire in Libya between UN-backed government leader, Fayez al-Sarraj, and opposition leader, Khalifa Haftar, failed to materialize.In light of the upcoming US elections in November 2020, the future of US national security policy promises to be a prominent issue for the next administration. In this vein, the US and Americas Programme at Chatham House plans a yearlong focus on the pivotal US 2020 elections.At this event, Dr Kori Schake, director of foreign and defense policy studies at the American Enterprise Institute will discuss the future of US foreign policy towards the Middle East. How have domestic and party politics in the US – and the unfolding presidential campaign – shaped recent policy decisions by the Trump administration? Should we expect policy objectives in the Middle East to remain consistent or shift under a second Trump term? And what direction could US foreign policy towards the region take under a Democratic administration?Attendance at this event is by invitation only. Event attributes Chatham House Rule Department/project US and the Americas Programme US and Americas Programme Email Full Article
2 Chatham House US 2020 Election Series By feedproxy.google.com Published On :: Thu, 30 Jan 2020 12:30:08 +0000 A year-long project focused on what is at stake in the pivotal 2020 US presidential and congressional elections, considering the future of US policy on trade, global economy and technology, national security, transatlantic relations, climate, migration and Latin America. As part of this initiative, we are launching the Chatham House US Foreign Policy Forum as an incubator for foreign policy dialogue and shared expertise outside of the Washington DC framework.Meeting regularly, in its inaugural year the Forum will largely focus on the 2020 elections, facilitating discussions around developments in the election and critical policy insights.These activities support the development of a multi-authored volume outlining the current state of play and potential priorities of a second Trump term, as well as a Democratic administration. The text will contribute to the public debate and research considering the resiliency of US institutions as well as the future of US policy engagement abroad.Situated in London, this project leverages Chatham House’s world-leading, independent foreign policy institute and unparalleled experience in convening multi-stakeholder discussions to provide a unique, international perspective on the 2020 elections. Past events (3) Research Event Webinar: US Foreign Policy in a Post COVID-19 World 29 April 2020 Research Event Virtual Roundtable: Tectonic Plates of 2020 – Developments in the US Presidential Race 18 March 2020 Research Event US 2020: Super Tuesday and Implications for the General Election 5 March 2020 Full Article
2 US 2020: Super Tuesday and Implications for the General Election By feedproxy.google.com Published On :: Mon, 17 Feb 2020 10:10:01 +0000 Invitation Only Research Event 5 March 2020 - 12:00pm to 1:30pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Dr Lindsay Newman, Senior Research Fellow, US and the Americas Programme, Chatham HouseProfessor Peter Trubowitz, Professor of International Relations, London School of Economics and Political Science; Associate Fellow, US and the Americas Programme, Chatham HouseAmy Pope, Associate Fellow, US and the Americas Programme, Chatham House; Deputy Homeland Security Advisor, US National Security Council, 2015-17Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme, Chatham House The US 2020 election season enters a potentially decisive next phase with the Super Tuesday primaries on 3 March. With these fifteen, simultaneously-held state elections, the Democrats hope to have greater clarity about their party’s likely nominee for the general race against President Donald Trump in November. Concerns around intraparty divisions in the Democratic party between progressives (represented by Senators Elizabeth Warren and Bernie Sanders) and moderates (represented by former Vice President Joe Biden and former mayor Pete Buttigieg) have surrounded the primary races so far, and are unlikely to dissipate even if one candidate emerges from the field on 3 March.Against this backdrop, Chatham House brings together a panel of experts to discuss the state of the Democratic primary race, implications for the general election, and the Trump campaign’s priorities ahead of its re-election bid. Will the Democratic party resolve its divisions and unite behind a progressive or moderate in light of the Super Tuesday election results? How is Trump positioned to fair against the Democratic candidates left in the race? Did Former Mayor of New York Michael Bloomberg’s primary gamble to focus on Super Tuesday pay off? And what policy priorities are likely to be pursued under either a Trump 2.0 or a Democratic administration? Event attributes Chatham House Rule Department/project US and the Americas Programme, Chatham House US 2020 Election Series US and Americas Programme Email Full Article
2 Virtual Roundtable: Tectonic Plates of 2020 – Developments in the US Presidential Race By feedproxy.google.com Published On :: Mon, 16 Mar 2020 12:00:01 +0000 Invitation Only Research Event 18 March 2020 - 1:00pm to 1:45pm Event participants John Zogby, Founder and Senior Partner, John Zogby StrategiesChair: Dr Lindsay Newman, Senior Research Fellow, US and Americas Programme, Chatham House This event is part of the Inaugural Virtual Roundtable Series on the US, Americas and the State of the World and will take place virtually only. Participants should not come to Chatham House for these events. Department/project US and the Americas Programme, Chatham House US 2020 Election Series US and Americas Programme Email Full Article
2 Diabetes Core Update – July 2019 By diabetescoreupdate.libsyn.com Published On :: Wed, 19 Jun 2019 21:28:16 +0000 Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This month we review articles on: Prognostic Significance of Unrecognized MI in Patients with Diabetes Driving and Glucose Variability Fournier Gangrene Associated with SGLT-2 Inhibitors Faster Acting Insulin Aspart vs. Insulin Aspart Sleep and Glycemia Flash Glucose Monitoring and Effect on Glycemic Control For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health Full Article
2 Diabetes Core Update – August 2019 By diabetescoreupdate.libsyn.com Published On :: Wed, 24 Jul 2019 18:30:00 +0000 Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This month we review articles on: Dapagliflozin Plus Saxagliptin Add-on Therapy Compared with Insulin Dulaglutide and Cardiovascular Outcomes in Type 2 Diabetes (REWIND) Mediterranean Diet and the Need for Glucose- Lowering Medications Oral Semaglutide versus Subcutaneous Liraglutide and Placebo Vitamin E and Pioglitazone for Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes Durability of Insulin Degludec plus Liraglutide versus Insulin Glargine U100 For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health Full Article
2 Diabetes Core Update – September 2019 By diabetescoreupdate.libsyn.com Published On :: Sat, 24 Aug 2019 19:00:00 +0000 Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This month we review articles on: Oral Semaglutide Monotherapy in Type 2 Diabetes Lifestyle Counseling and Long-term Clinical Outcomes Economic Burden of Diabetes in the United States Microvascular Disease and Heart Failure with Preserved Ejection Fraction Optimal Blood Pressure Target for Patients with Type 1 Diabetes Lack of Durable Improvements in Beta-Cell Function after Medication Withdrawal in Prediabetes For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health Full Article
2 Diabetes Core Update – October 2019 By diabetescoreupdate.libsyn.com Published On :: Tue, 24 Sep 2019 18:30:00 +0000 Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This month we review articles on: Nasal Glucagon Incidence of type 2 diabetes in people with a history of hospitalization for major mental illness Achievement of Target A1C <7.0% after treatment with basal insulin in Randomized Controlled Trials and Clinical Practice Metformin effect on Coronary endothelial Dysfunction in prediabetic patients with stable angina Change in cardiovascular health risk and the development of type 2 diabetes and impaired fasting glucose Association between diabetes HbA1c, glycaemia and development of frailty in the elderly For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health Full Article
2 Diabetes Core Update – November 2019 By diabetescoreupdate.libsyn.com Published On :: Fri, 25 Oct 2019 12:46:30 +0000 Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This month we review articles on: Glycemia Reduction Approaches in Diabetes (GRADE) Trial The Effect of Disasters on Patients with Diabetes Fixed Ratio GLP-1/Basal Insulin in Patients Uncontrolled on GLP-1 Mechanisms of CV Protection for SGLT-2 Inhibitors Oral Semaglutide and Cardiovascular Outcomes Trends in Pancreatitis and Pancreatic Cancer in patients started on DPP-4 Inhibitors For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health Full Article
2 Diabetes Core Update – December 2019 By diabetescoreupdate.libsyn.com Published On :: Sun, 24 Nov 2019 20:00:00 +0000 Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This month we review articles on: Combination Basal Insulin/GLP-1 RA vs Basal Bolus for Persons with Very Elevated A1c Changes in Consumption of Sugary Beverages and Artificially Sweetened Beverages and the Risk of Type 2 Diabetes Oral Semaglutide vs. Placebo added to Insulin : The PIONEER 8 Trial Residual Hypertriglyceridemia and Estimated Atherosclerotic CV Risk by Stain Use in U.S. Adults with Diabetes A1c Variability and the Risk of Poor Outcomes in People with Type 2 Diabetes Oral Semaglutide vs. Empagliflozin in Persons with Type 2 Diabetes Uncontrolled on Metformin For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health Full Article
2 Diabetes Core Update – January 2019 By diabetescoreupdate.libsyn.com Published On :: Thu, 26 Dec 2019 20:41:53 +0000 Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This month we review articles on: Linagliptin in Older adults on Insulin Lactic Acidosis from Metformin – FDA analysis Glucagon Receptor Antagonist RV-1502 – Efficacy and Safety Early Identification of MODY SGLT-2 Inhibitors and the Development of Mycotic Infections and UTIs SFLT-2 Inhibitors in Patients with Type 1 Diabetes and the Rate of Diabetic Ketoacidosis For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health Full Article
2 Diabetes Core Update – February 2019 By diabetescoreupdate.libsyn.com Published On :: Sat, 25 Jan 2020 11:33:45 +0000 Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This month we review articles on: Efficacy and safety of dapagliflozin in the elderly Lactic Acidosis from Metformin – FDA analysis Economic and Clinical Burden of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes in the United States 2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Transitioning to Fixed-Ratio Combination Therapy: Practical Advice General practitioner advice associated with greater physical activity in adults with type 2 diabetes Empagliflozin Effectively Lowers Liver Fat Content For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health Full Article
2 Diabetes Core Update – March 2019 By diabetescoreupdate.libsyn.com Published On :: Mon, 24 Feb 2020 20:30:00 +0000 Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This month we review articles on: Association of body mass index, fitness, and mortality in patients with diabetes Cognitive deficits and traditional diabetic complications in the severely obese Late Relapse of Diabetes after Bariatric Surgery Hypoglycemia in Type 1 Diabetes and Subsequent Cognitive Deficits Nutrient Induced Beta Cell Stress Topical Oxygen Therapy in the Treatment of Diabetic Foot Ulcers For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health Full Article
2 Diabetes Core Update – COVID-19 UPDATE: March 2019 By diabetescoreupdate.libsyn.com Published On :: Tue, 24 Mar 2020 12:58:08 +0000 This is a special issue focusing on Covid-19 and Diabetes: Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China Clinical course and risk factors for mortality Diabetes and Hypertension: Are ACE’s, ARBs and NSAIDs OK to Use? Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Abington Jefferson Health Full Article
2 Diabetes Core Update – April 2019 By diabetescoreupdate.libsyn.com Published On :: Tue, 31 Mar 2020 15:50:29 +0000 Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 20 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. This issue will review: Normalization of functional beta cell capacity after weight loss in type 2 diabetes Screening for glucose intolerance and diabetes in patients with coronary artery disease Trends Prescribing Preferences for SGLT2 Inhibitors and GLP-1 Receptor Agonists, 2013–2018 Impact of a Telephone Intervention to Improve Diabetes Control on Healthcare Utilization and Cost for Adults in South Bronx, New York – Efficacy and Safety of Dapagliflozin Plus Saxagliptin Versus Insulin Glargine Over 52 Weeks as Add‐on to Metformin With or Without Sulfonylurea in Patients With Type 2 Diabetes The Association Between Poor Glycemic Control and Health Care Costs in People With Diabetes For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health Full Article
2 Diabetes Core Update: Therapeutic Inertia – April 2020 By diabetescoreupdate.libsyn.com Published On :: Tue, 14 Apr 2020 19:00:00 +0000 In this first episode of a three-part series on “Disrupting Therapeutic Inertia in Diabetes Management,” Drs. John Russell and Neil Skolnik examine a case study of a 55-year-old man with type 2 diabetes (3 years duration, A1C 8.2%). In so doing, they review six articles that define achievement gaps in reaching A1C goals and the reasons for why those gaps exist. In episodes 2 and 3 of this series, Drs. Russell and Skolnik we will look at additional causes of therapeutic inertia and solutions for overcoming it. This special three-part series on therapeutic inertia is supported by independent educational grant from Sanofi (https://www.sanofi.com). This issue will review: Achievement of target therapeutic goals in persons with T2DM Achievement of therapeutic goals from 2005 – 2015 Clinical Inertia in Newly Diagnosed Type 2 DM Clinical Inertia over Time in Type 2 DM Gap Between Efficacy in Randomized Controlled Trials and Effectiveness in Real-World Use Difference between Clinical Trial and Real-World Studies Achievement of Target A1C <7.0% in Patients Treated with Basal Insulin in RCTs and Clinical Practice For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health Full Article
2 Diabetes Core Update: Covid-19 - Planning Sick Days April 2019 By diabetescoreupdate.libsyn.com Published On :: Mon, 20 Apr 2020 23:47:13 +0000 This special issue focuses on Diabetes, Covid-19 and managing patient’s diabetes when they are sick. Recorded April 1, 2020. This podcast will cover: How do we help our patients with diabetes stay safe Helping patient negotiate safety issues in the workplace Safety Issues when people do not come in for care Managing SGLT-2 inhibitors during the pandemic Home detection and care of DKA Renewing Medications Telemedicine Visits Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. Presented by: Louis Philipson, MD, PhD, ADA Past President, Medicine & Science, University of Chicago Anne Peters, MD, Diabetologist, University of Southern California Full Article
2 Diabetes Core Update: Covid-19 – Inpatient Management of Persons with Diabetes April 2019 By diabetescoreupdate.libsyn.com Published On :: Tue, 21 Apr 2020 16:44:58 +0000 This special issue focuses on Diabetes, Covid-19 and Inpatient Management. Recorded April 3, 2020. This podcast will cover: Risk with Diabetes of Covid-19 and Complications of Covid-19 Management of Hyperglycemia during Covid-19 Infection Sub-cutaneous Insulin for DKA CGM in the Hospital Setting Diabetes Education in the Hospital During Covid-19 Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. Presented by: Irl Hirsch, MD, Professor of Medicine, University of Washington, Seattle Guillermo E. Umpierrez, MD, CDE, Professor of Medicine, Emory University, Atlanta Georgia Full Article
2 Diabetes Core Update: Covid-19 – Deep Dive into Medication Management April 2019 By diabetescoreupdate.libsyn.com Published On :: Wed, 22 Apr 2020 18:00:00 +0000 This special issue focuses on Diabetes, Covid-19 and Inpatient Management. Recorded April 14, 2020. This podcast will cover: Inpatient Medication Management for Persons Admitted with Diabetes Outpatient Medication Management for Persons with Diabetes Hypoglycemic Medication Management ACE and ARBs NSAIDs Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. Presented by: Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Associate Director, Family Medicine Residency Program, Abington Jefferson Health Dr. Joshua Neumiller, Vice Chair & Allen I. White Distinguished Associate Professor of Pharmacotherapy at Washington State University Full Article
2 Diabetes Core Update: Covid-19 and Diabetes – Considerations for Health Care Professionals - April 2019 By diabetescoreupdate.libsyn.com Published On :: Thu, 23 Apr 2020 18:00:00 +0000 Diabetes Core Update: Covid-19 and Diabetes – Considerations for Health Care Professionals - April 2019 This special issue is an audio version of the American Diabetes Associations Covid-19 leadership team discussing a range of issues on Covid-19 and Diabetes. Recorded March 31, 2020. Topics include: Access to medications Effect on Diabetes Self-management Can Patients take their own Supplies if they are an inpatient in the hospital – particularly insulin pumps and CGM Considerations for Specific Hypoglycemic Medications during Inpatient Hospitalization Differences in Management for Persons with Type 1 and Type 2 Diabetes SGLT-2 inhibitors and GLP-1 Receptor Agonists use During Covid-19 Infection Diabetes and Cardiovascular Disease during Covid-19 ACEs and ARBs Stress among Healthcare Professionals Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting. Presented by: Robert Eckel, MD ADA President, Medicine & Science University of Colorado Mary de Groot, PhD ADA President, Health Care & Education Indiana University Irl Hirsch, MD University of Washington Anne Peters, MD University of Southern California Louis Philipson, MD, PhD ADA Past President, Medicine & Science University of Chicago Neil Skolnik, MD Abington Jefferson Health Full Article
