2 CBS orders first seasons of 'Clarice,' 'Equalizer,' 'B Positive' for 2020-21 By www.upi.com Published On :: Sat, 09 May 2020 11:08:24 -0400 CBS said it has ordered first seasons of three new shows -- "Clarice," "The Equalizer" and "B Positive" for the 2020-21 television season. Full Article
2 Psychology Around the Net: May 9, 2020 By psychcentral.com Published On :: Sat, 09 May 2020 10:30:47 +0000 From the benefits of living a joyful life alongside sadness and tips to practice letting go of unhelpful ideals to how employers can better support workers during COVID-19 and the... Full Article Psychology Around the Net coronavirus COVID-19 employees employers Meat Eater pandemic vegetarian
2 [ Credit ] Open Question : I'm 23 with a 536 credit score because I was stupid from ages 18-20. Is there any way to make it higher? ? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:16:58 +0000 I have 2500 worth of debt and most of it has been turned over into collections Full Article
2 [ United States ] Open Question : Is my $1,200 stimulus check taxable as income? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:18:26 +0000 Full Article
2 [ Politics ] Open Question : Libtards, don't get your panties in a bunch when those two Georgia 2nd amendment warriors are found innocent of killing that black guy? By answers.yahoo.com Published On :: Sat, 09 May 2020 17:20:10 +0000 He shouldn't have fought back when the guy pointed the shot gun at him Full Article
2 Understanding the Creation of Public Consensus: Migration and Integration in Germany, 2005 to 2015 By www.migrationpolicy.org Published On :: Wed, 01 Jun 2016 09:20:31 -0400 As immigrant-skeptic movements gained salience, and even political representation, in several European countries in recent years, Germany remained a relative outlier until mid-2015. This report explains how a pro-immigrant consensus evolved and persisted in Germany during the period from 2005—as the country emerged from recession and embarked on a reform of its immigration laws—through to the events of mid-2015. Full Article
2 Farm to Table: The Role of Immigrants in U.S. Farm Labor in 2016 By www.migrationpolicy.org Published On :: Thu, 06 Oct 2016 12:58:18 -0400 A discussion featuring data on immigration trends and farm labor that could help inform future reform debates, including what adjustments farm employers are making, including increased mechanization, improved wages and benefits, and the increased use of the H-2A program. Full Article
2 Chronicling Migration in the 21st Century Through One Family's Journey By www.migrationpolicy.org Published On :: Tue, 06 Aug 2019 18:44:31 -0400 This event marked the launch of New York Times reporter Jason DeParle's book tracing the arc of migration as a phenomenon, witnessed through three decades observing a particular Filipino family moving from Manila to Texas. The conversation explored both the human and policy aspects of migration and development. Full Article
2 Swing State: Immigration's Impact on the 2020 U.S. Election By www.migrationpolicy.org Published On :: Thu, 20 Feb 2020 13:30:11 -0500 This event will feature a screening of the short documentary The Fields of Immokalee, and include a discussion on immigration and politics in Florida and other swing states in the run-up to the 2020 election. Full Article
2 Why Being the GOP's No. 2 Isn't So Bad By www.washingtonpost.com Published On :: Mon, 18 Feb 2008 00:00:00 EST Through much of the Republican presidential primary, Sen. John McCain and former Massachusetts governor Mitt Romney could barely restrain their contempt for each other. During one Republican debate in New Hampshire in early January, McCain landed a zinger that summed up Romney's opportunistic... Full Article Opinions Why Being the GOP's No. 2 Isn't So Bad
2 Happiness on the Medal Stand? It's as Simple as 1-3-2. By www.washingtonpost.com Published On :: Mon, 18 Aug 2008 00:00:00 EDT Nearly a century ago, American middle-distance runner Abel Kiviat entered the Stockholm Olympics as the odds-on favorite to win the 1,500-meter race, an event in which he held the world record. Kiviat had the lead 1,492 meters into the race but was passed in the final eight meters by Britain's... Full Article Opinions Happiness on the Medal Stand? It's as Simple as 1-3-2.
2 Mathematics at 2019 SACNAS By blogs.ams.org Published On :: Tue, 12 Nov 2019 09:00:19 +0000 Below I share some details about SACNAS and some of the mathematical events that happened at this year’s SACNAS National Conference. I hope that this may also serve as an invitation/motivation for anyone interested in diversity and mathematics to participate … Continue reading → Full Article Conferences Diversity Mathematicians Mathematics in Society
2 The COVID-19 Pandemic Suggests the Lessons Learned by European Asylum Policymakers After the 2015 Migration Crisis Are Fading By www.migrationpolicy.org Published On :: Wed, 22 Apr 2020 17:28:04 -0400 As European asylum systems are tested again by the COVID-19 pandemic, which has injected the need for social distancing during processing and in reception centers, it appears lessons learned during the 2015-16 migration and refugee crisis may be fading. Chief among them: A number of Member States have phased out their buffer capacity. This MPI Europe commentary explores the diametrically different approaches taken to asylum during the pandemic. Full Article
2 On the Brink: Prospects for UK Nationals in the EU-27 after a No-Deal Brexit By www.migrationpolicy.org Published On :: Thu, 19 Sep 2019 16:24:06 -0400 Six months on from the original March 2019 Brexit date and staring a new deadline in the face, many EU countries still had only skeletal plans for how to adjust the status of their resident UK nationals should a no-deal Brexit come to pass. This policy brief highlights critical gaps in these plans, the groups most likely to be affected by them, and strategies Member States and the United Kingdom could adopt to soften the impact. Full Article
2 Invertir en el vecindario: Cambios en los patrones de migración entre México y Estados Unidos y oportunidades para una cooperación sostenible By www.migrationpolicy.org Published On :: Fri, 20 Sep 2019 11:03:45 -0400 La migración entre México y Estados Unidos ha cambiado dramáticamente en los últimos años, pero las políticas y la retórica política en ambos países no se han actualizado a este contexto a la misma velocidad. Este reporte explora esta nueva realidad migratoria y cómo los dos gobiernos podrían trabajar juntos para abordar los desafíos de políticas públicas que tienen en común. Full Article
2 K-12 Instructional Models for English Learners: What They Are and Why They Matter By www.migrationpolicy.org Published On :: Wed, 27 Jun 2018 19:58:24 -0400 Marking the release of an MPI brief, experts on this webinar examine the key features of English Learner (EL) instructional models and discuss state- and district-level approaches to supporting schools in implementing effective EL program models, with a particular focus on what is being done in New York and Madison Wisconsin. Full Article
2 Silt Part 2 - Fighting the sea By brooklynbooktalk.blogspot.com Published On :: Thu, 07 Feb 2013 16:27:00 +0000 On October 29th, 2012, Hurricane Sandy hit the tri-state area. I was lucky enough to be unaffected as I live on a hill in a central portion of Queens but I had two family members who lost power for a week. I also had co-workers who live in some of the most hard-hit areas of Brooklyn and Queens. Rereading Macfarlane's "Silt" chapter after Sandy was a sobering experience as I wondered what such a walk in parts of Queens or New Jersey would involve. In the aftermath of Sandy, I've listened to radio interviews with Dutch engineers who have advocated sea gates and houses on stilts. I've read proposals about sea walls. In the past week, Governor Cuomo has suggested a buyout of homes in areas likely to flooded again in the future. Once the state buys the land, the homes will be demolished and the land left empty. To quote Governor Cuomo, "there are some parcels that Mother Nature owns...She may only visit once every few years...but she owns the parcel and when she comes to visit, she visits."However, people who live in flooded and devastated areas such as Freeport, Breezy Point or the Rockaways are reluctant to say goodbye to their communities and shore-based lifestyles. Mr. Cuomo accepts that man cannot ultimately defeat nature, which is why, for example, parts of the English coast are crumbling away without the UK spending billions on sea walls or sea gates (although London is protected by the Thames Barrier). Inhabitants of New York and New Jersey seem more willing to fight nature with man-made barriers, artificially-created natural shorelines, and architectural changes such as in the Netherlands. In the end, residents of NYC will have to decide how much money they wish to spend to protect and maintain their current lifestyles and residences. Full Article Governor Cuomo housing buyout Hurricane Sandy Robert Macfarlane THe Old Ways: A Journey on Foot
2 Visiting Lucy Boston's House, Part 2 By brooklynbooktalk.blogspot.com Published On :: Sat, 25 May 2013 19:00:00 +0000 Since we were early for our 2 PM house tour, we decided to explore the gardens. Lucy talks about designing and building the gardens in her memoir Memory in a House, which also contains some black and white photos of the gardens back when she published the book. However, I did not realize until her daughter-in-law Diana Boston gave us the tour how much of the gardens Lucy build from scratch. Apparently most of the yard was just meadow until she set to work. What stunned me, Val, and Dave was how large the gardens were in size. We split up in the gardens, and they saw only the more cultivated side: until I took them to see the the other side of the house, which has a moat that surrounds three sides of it, a flowering meadow, and a bamboo thicket:The bamboo thicket is where the gorilla Hanno lives in A Stranger at Green Knowe. The moat is a a constant presence in the books because when it floods, the house is cut off on an island, the way it was originally designed to be by its Norman builder, Payne Osmundson. The story of the builders of the house is told in The Stones of Green Knowe, which is the last of the series. The River Ouse features in The River at Green Knowe, and can be seen from the yard and the windows of the house.One of my friends commented that the house and garden must be smaller than I expected since I had read the books first as a child and was now an adult. This is not quite true. Although the house was small - the walls are three feet thick so the exterior is larger than the interior, the gardens were bigger than expected. Boston gardened in the warm weather and wrote and created patchwork in the cold weather. It is amazing to see the variety of garden sections that she created. In my next post, I will discuss the gardens in terms of the books and of my experiences as a child both as her reader and as someone who grew up in a decent-sized yard and in fine public parks. Full Article Children of Green Knowe Diana Boston Lucy Maria Boston Manor at Hemingford Grey
2 Las puertas abiertas para los migrantes venezolanos y nicaragüenses en América Latina y el Caribe se cierran un poco a medida que aumenta la escala de los flujos y la presión en los servicios públicos By www.migrationpolicy.org Published On :: Mon, 10 Feb 2020 18:22:00 -0500 WASHINGTON – A pesar de que los gobiernos de América Latina y el Caribe han tomado medidas generosas e innovadoras para lidiar con el desplazamiento forzado desde Venezuela y más recientemente desde Nicaragua, la cálida bienvenida se ha enfriado en algunos lugares a medida que el número de entradas, la presión sobre los servicios públicos y la preocupación del público aumenta. Full Article
2 Respuestas latinoamericanas a las crisis migratorias venezolanas y nicaragüenses By www.migrationpolicy.org Published On :: Fri, 01 Nov 2019 17:38:50 -0400 Responsables de políticos principales y partes interesadas de América Latina, así como representantes de instituciones internacionales claves, ofrecen sus puntos de vista sobre los desafíos futuros mientras gobiernos latinoamericanos buscan establecer las estrategias para responder a flujos migratorios forzados a gran escala, como los de Venezuela y Nicaragua. Full Article
2 La Bienvenida Se Agota para Colombianos en Ecuador Mientras Venezolanos Se Hacen Más Visibles By www.migrationpolicy.org Published On :: Thu, 09 Jan 2020 10:42:56 -0500 Aunque colombianos encontraron un refugio cálido en Ecuador después de ser desplazados de su país por una guerra civil que duro décadas, la vida se ha vuelto más difícil para ellos en los últimos años, en parte como resultado del flujo de venezolanos que buscan seguridad. Este artículo se basa en encuestas de migrantes en Quito, comparando y contrastando las experiencias de colombianos y venezolanos, y evaluando sus percepciones de discriminación, victimización y esperanzas para el futuro. Full Article
2 ¿Se Están Cerrando las Puertas? Respuestas a la Migración Venezolana en América Latina y el Caribe By www.migrationpolicy.org Published On :: Mon, 03 Feb 2020 12:33:28 -0500 MPI llevó a cabo un seminario en línea para marcar el lanzamiento de: Un portal sobre Migración en América Latina y el Caribe; y un informe que examina los efectos de las políticas migratorias y de integración en 11 países en América Latina y el Caribe ante el aumento de la migración venezolana y nicaragüense. Full Article
2 Bienvenidas asimétricas: Respuestas de América Latina y el Caribe a la migración venezolana y nicaragüense By www.migrationpolicy.org Published On :: Mon, 10 Feb 2020 10:44:38 -0500 El gran desplazamiento forzado de personas en Venezuela y Nicaragua está transformando el panorama migratorio en gran parte de América Latina y el Caribe. Este informe examina las respuestas de las políticas de inmigración e integración de once países, incluyendo vías de regularización y medidas para integrar a los recién llegados en las escuelas y mercados laborales. Este informe acompaña el lanzamiento de un Portal Sobre Migración que ofrece investigación y análisis actualizados sobre tendencias y políticas de inmigración en la región. Full Article
2 Visit-to-Visit HbA1c Variability Is Associated With Cardiovascular Disease and Microvascular Complications in Patients With Newly Diagnosed Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE To investigate the association between visit-to-visit HbA1c variability and cardiovascular events and microvascular complications in patients with newly diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS This retrospective cohort study analyzed patients from Tayside and Fife in the Scottish Care Information–Diabetes Collaboration (SCI-DC) who were observable from the diagnosis of diabetes and had at least five HbA1c measurements before the outcomes were evaluated. We used the previously reported HbA1c variability score (HVS), calculated as the percentage of the number of changes in HbA1c >0.5% (5.5 mmol/mol) among all HbA1c measurements within an individual. The association between HVS and 10 outcomes was assessed using Cox proportional hazards models. RESULTS We included 13,111–19,883 patients in the analyses of each outcome. The patients with HVS >60% were associated with elevated risks of all outcomes compared with the lowest quintile (for example, HVS >80 to ≤100 vs. HVS ≥0 to ≤20, hazard ratio 2.38 [95% CI 1.61–3.53] for major adverse cardiovascular events, 2.4 [1.72–3.33] for all-cause mortality, 2.4 [1.13–5.11] for atherosclerotic cardiovascular death, 2.63 [1.81–3.84] for coronary artery disease, 2.04 [1.12–3.73] for ischemic stroke, 3.23 [1.76–5.93] for heart failure, 7.4 [3.84–14.27] for diabetic retinopathy, 3.07 [2.23–4.22] for diabetic peripheral neuropathy, 5.24 [2.61–10.49] for diabetic foot ulcer, and 3.49 [2.47–4.95] for new-onset chronic kidney disease). Four sensitivity analyses, including adjustment for time-weighted average HbA1c, confirmed the robustness of the results. CONCLUSIONS Our study shows that higher HbA1c variability is associated with increased risks of all-cause mortality, cardiovascular events, and microvascular complications of diabetes independently of high HbA1c. Full Article
2 Genetic Susceptibility Determines {beta}-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76) By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Previous studies suggested that childhood prediabetes may develop prior to obesity and be associated with relative insulin deficiency. We proposed that the insulin-deficient phenotype is genetically determined and tested this hypothesis by longitudinal modeling of insulin and glucose traits with diabetes risk genotypes in the EarlyBird cohort. RESEARCH DESIGN AND METHODS EarlyBird is a nonintervention prospective cohort study that recruited 307 healthy U.K. children at 5 years of age and followed them throughout childhood. We genotyped 121 single nucleotide polymorphisms (SNPs) previously associated with diabetes risk, identified in the adult population. Association of SNPs with fasting insulin and glucose and HOMA indices of insulin resistance and β-cell function, available from 5 to 16 years of age, were tested. Association analysis with hormones was performed on selected SNPs. RESULTS Several candidate loci influenced the course of glycemic and insulin traits, including rs780094 (GCKR), rs4457053 (ZBED3), rs11257655 (CDC123), rs12779790 (CDC123 and CAMK1D), rs1111875 (HHEX), rs7178572 (HMG20A), rs9787485 (NRG3), and rs1535500 (KCNK16). Some of these SNPs interacted with age, the growth hormone–IGF-1 axis, and adrenal and sex steroid activity. CONCLUSIONS The findings that genetic markers influence both elevated and average courses of glycemic traits and β-cell function in children during puberty independently of BMI are a significant step toward early identification of children at risk for diabetes. These findings build on our previous observations that pancreatic β-cell defects predate insulin resistance in the onset of prediabetes. Understanding the mechanisms of interactions among genetic factors, puberty, and weight gain would allow the development of new and earlier disease-management strategies in children. Full Article
2 Confirming the Bidirectional Nature of the Association Between Severe Hypoglycemic and Cardiovascular Events in Type 2 Diabetes: Insights From EXSCEL By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE We sought to confirm a bidirectional association between severe hypoglycemic events (SHEs) and cardiovascular (CV) event risk and to characterize individuals at dual risk. RESEARCH DESIGN AND METHODS In a post hoc analysis of 14,752 Exenatide Study of Cardiovascular Event Lowering (EXSCEL) participants, we examined time-dependent associations between SHEs and subsequent major adverse cardiac events (CV death, nonfatal myocardial infarction [MI] or stroke), fatal/nonfatal MI, fatal/nonfatal stroke, hospitalization for acute coronary syndrome (hACS), hospitalization for heart failure (hHF), and all-cause mortality (ACM), as well as time-dependent associations between nonfatal CV events and subsequent SHEs. RESULTS SHEs were uncommon and not associated with once-weekly exenatide therapy (hazard ratio 1.13 [95% CI 0.94–1.36], P = 0.179). In fully adjusted models, SHEs were associated with an increased risk of subsequent ACM (1.83 [1.38–2.42], P < 0.001), CV death (1.60 [1.11–2.30], P = 0.012), and hHF (2.09 [1.37–3.17], P = 0.001), while nonfatal MI (2.02 [1.35–3.01], P = 0.001), nonfatal stroke (2.30 [1.25–4.23], P = 0.007), hACS (2.00 [1.39–2.90], P < 0.001), and hHF (3.24 [1.98–5.30], P < 0.001) were all associated with a subsequent increased risk of SHEs. The elevated bidirectional time-dependent hazards linking SHEs and a composite of all CV events were approximately constant over time, with those individuals at dual risk showing higher comorbidity scores compared with those without. CONCLUSIONS These findings, showing greater risk of SHEs after CV events as well as greater risk of CV events after SHEs, validate a bidirectional relationship between CV events and SHEs in patients with high comorbidity scores. Full Article
2 Association Between the Use of Antidepressants and the Risk of Type 2 Diabetes: A Large, Population-Based Cohort Study in Japan By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE This study aimed to reveal the associations between the risk of new-onset type 2 diabetes and the duration of antidepressant use and the antidepressant dose, and between antidepressant use after diabetes onset and clinical outcomes. RESEARCH DESIGN AND METHODS In this large-scale retrospective cohort study in Japan, new users of antidepressants (exposure group) and nonusers (nonexposure group), aged 20–79 years, were included between 1 April 2006 and 31 May 2015. Patients with a history of diabetes or receipt of antidiabetes treatment were excluded. Covariates were adjusted by using propensity score matching; the associations were analyzed between risk of new-onset type 2 diabetes and the duration of antidepressant use/dose of antidepressant in the exposure and nonexposure groups by using Cox proportional hazards models. Changes in glycated hemoglobin (HbA1c) level were examined in groups with continuous use, discontinuation, or a reduction in the dose of antidepressants. RESULTS Of 90,530 subjects, 45,265 were in both the exposure and the nonexposure group after propensity score matching; 5,225 patients (5.8%) developed diabetes. Antidepressant use was associated with the risk of diabetes onset in a time- and dose-dependent manner. The adjusted hazard ratio was 1.27 (95% CI 1.16–1.39) for short-term low-dose and 3.95 (95% CI 3.31–4.72) for long-term high-dose antidepressant use. HbA1c levels were lower in patients who discontinued or reduced the dose of antidepressants (F[2,49] = 8.17; P < 0.001). CONCLUSIONS Long-term antidepressant use increased the risk of type 2 diabetes onset in a time- and dose-dependent manner. Glucose tolerance improved when antidepressants were discontinued or the dose was reduced after diabetes onset. Full Article
2 Epigenetic Link Between Statin Therapy and Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To investigate the role of epigenetics in statins’ diabetogenic effect comparing DNA methylation (DNAm) between statin users and nonusers in an epigenome-wide association study in blood. RESEARCH DESIGN AND METHODS Five cohort studies’ participants (n = 8,270) were classified as statin users when they were on statin therapy at the time of DNAm assessment with Illumina 450K or EPIC array or noncurrent users otherwise. Associations of DNAm with various outcomes like incident type 2 diabetes, plasma glucose, insulin, and insulin resistance (HOMA of insulin resistance [HOMA-IR]) as well as with gene expression were investigated. RESULTS Discovery (n = 6,820) and replication (n = 1,450) phases associated five DNAm sites with statin use: cg17901584 (1.12 x 10–25 [DHCR24]), cg10177197 (3.94 x 10–08 [DHCR24]), cg06500161 (2.67 x 10–23 [ABCG1]), cg27243685 (6.01 x 10–09 [ABCG1]), and cg05119988 (7.26 x 10–12 [SC4MOL]). Two sites were associated with at least one glycemic trait or type 2 diabetes. Higher cg06500161 methylation was associated with higher fasting glucose, insulin, HOMA-IR, and type 2 diabetes (odds ratio 1.34 [95% CI 1.22, 1.47]). Mediation analyses suggested that ABCG1 methylation partially mediates the effect of statins on high insulin and HOMA-IR. Gene expression analyses showed that statin exposure and ABCG1 methylation were associated with ABCG1 downregulation, suggesting epigenetic regulation of ABCG1 expression. Further, outcomes insulin and HOMA-IR were significantly associated with ABCG1 expression. CONCLUSIONS This study sheds light on potential mechanisms linking statins with type 2 diabetes risk, providing evidence on DNAm partially mediating statins’ effects on insulin traits. Further efforts shall disentangle the molecular mechanisms through which statins may induce DNAm changes, potentially leading to ABCG1 epigenetic regulation. Full Article
2 Predicting 10-Year Risk of End-Organ Complications of Type 2 Diabetes With and Without Metabolic Surgery: A Machine Learning Approach By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To construct and internally validate prediction models to estimate the risk of long-term end-organ complications and mortality in patients with type 2 diabetes and obesity that can be used to inform treatment decisions for patients and practitioners who are considering metabolic surgery. RESEARCH DESIGN AND METHODS A total of 2,287 patients with type 2 diabetes who underwent metabolic surgery between 1998 and 2017 in the Cleveland Clinic Health System were propensity-matched 1:5 to 11,435 nonsurgical patients with BMI ≥30 kg/m2 and type 2 diabetes who received usual care with follow-up through December 2018. Multivariable time-to-event regression and random forest machine learning models were built and internally validated using fivefold cross-validation to predict the 10-year risk for four outcomes of interest. The prediction models were programmed to construct user-friendly web-based and smartphone applications of Individualized Diabetes Complications (IDC) Risk Scores for clinical use. RESULTS The prediction tools demonstrated the following discrimination ability based on the area under the receiver operating characteristic curve (1 = perfect discrimination and 0.5 = chance) at 10 years in the surgical and nonsurgical groups, respectively: all-cause mortality (0.79 and 0.81), coronary artery events (0.66 and 0.67), heart failure (0.73 and 0.75), and nephropathy (0.73 and 0.76). When a patient’s data are entered into the IDC application, it estimates the individualized 10-year morbidity and mortality risks with and without undergoing metabolic surgery. CONCLUSIONS The IDC Risk Scores can provide personalized evidence-based risk information for patients with type 2 diabetes and obesity about future cardiovascular outcomes and mortality with and without metabolic surgery based on their current status of obesity, diabetes, and related cardiometabolic conditions. Full Article
2 Coronary Artery Disease and Type 2 Diabetes: A Proteomic Study By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE Coronary artery disease (CAD) is a major challenge in patients with type 2 diabetes (T2D). Coronary computed tomography angiography (CCTA) provides a detailed anatomic map of the coronary circulation. Proteomics are increasingly used to improve diagnostic and therapeutic algorithms. We hypothesized that the protein panel is differentially associated with T2D and CAD. RESEARCH DESIGN AND METHODS In CAPIRE (Coronary Atherosclerosis in Outlier Subjects: Protective and Novel Individual Risk Factors Evaluation—a cohort of 528 individuals with no previous cardiovascular event undergoing CCTA), participants were grouped into CAD– (clean coronaries) and CAD+ (diffuse lumen narrowing or plaques). Plasma proteins were screened by aptamer analysis. Two-way partial least squares was used to simultaneously rank proteins by diabetes status and CAD. RESULTS Though CAD+ was more prevalent among participants with T2D (HbA1c 6.7 ± 1.1%) than those without diabetes (56 vs. 30%, P < 0.0001), CCTA-based atherosclerosis burden did not differ. Of the 20 top-ranking proteins, 15 were associated with both T2D and CAD, and 3 (osteomodulin, cartilage intermediate-layer protein 15, and HTRA1) were selectively associated with T2D only and 2 (epidermal growth factor receptor and contactin-1) with CAD only. Elevated renin and GDF15, and lower adiponectin, were independently associated with both T2D and CAD. In multivariate analysis adjusting for the Framingham risk panel, patients with T2D were "protected" from CAD if female (P = 0.007), younger (P = 0.021), and with lower renin levels (P = 0.02). CONCLUSIONS We concluded that 1) CAD severity and quality do not differ between participants with T2D and without diabetes; 2) renin, GDF15, and adiponectin are shared markers by T2D and CAD; 3) several proteins are specifically associated with T2D or CAD; and 4) in T2D, lower renin levels may protect against CAD. Full Article
2 Effects of MK-0941, a Novel Glucokinase Activator, on Glycemic Control in Insulin-Treated Patients With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2011-11-21T22:32:39-08:00 OBJECTIVE To assess the efficacy and safety of MK-0941, a glucokinase activator (GKA), when added to stable-dose insulin glargine in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS In this double-blind study, 587 patients taking stable-dose insulin glargine (±metformin ≥1,500 mg/day) were randomized (1:1:1:1:1) to MK-0941 10, 20, 30, or 40 mg or matching placebo t.i.d. before meals (a.c.). This study included an initial 14-week, dose-ranging phase followed by a 40-week treatment phase during which patients were to be uptitrated as tolerated to 40 mg (or placebo) t.i.d. a.c. The primary efficacy end point was change from baseline in A1C at Week 14. RESULTS At Week 14, A1C and 2-h postmeal glucose (PMG) improved significantly versus placebo with all MK-0941 doses. Maximal placebo-adjusted least squares mean changes from baseline in A1C (baseline A1C 9.0%) and 2-h PMG were –0.8% and –37 mg/dL (–2 mmol/L), respectively. No significant effects on fasting plasma glucose were observed at any dose versus placebo. By 30 weeks, the initial glycemic responses noted at 14 weeks were not sustained. MK-0941 at one or more doses was associated with significant increases in the incidence of hypoglycemia, triglycerides, systolic blood pressure, and proportion of patients meeting criteria for predefined limits of change for increased diastolic blood pressure. CONCLUSIONS In patients receiving stable-dose insulin glargine, the GKA MK-0941 led to improvements in glycemic control that were not sustained. MK-0941 was associated with an increased incidence of hypoglycemia and elevations in triglycerides and blood pressure. Full Article
2 Chronicling Migration in the 21st Century Through One Family’s Journey By www.migrationpolicy.org Published On :: Tue, 20 Aug 2019 19:01:34 -0400 Marking the launch of New York Times reporter Jason DeParle's book tracing the arc of migration and its impacts through the life of an extended family of Filipino migrants over a three-decade period, from Manila and through Dubai to the Houston area, this conversation with MPI's Andrew Selee and the World Bank's Dilip Ratha explores migration at both a global and very personal level. Full Article
2 Respuestas latinoamericanas a las crisis migratorias venezolanas y nicaragüenses By www.migrationpolicy.org Published On :: Mon, 04 Nov 2019 08:58:25 -0500 Responsables de políticos principales y partes interesadas de América Latina, así como representantes de instituciones internacionales claves, ofrecen sus puntos de vista sobre los desafíos futuros mientras gobiernos latinoamericanos buscan establecer las estrategias para responder a flujos migratorios forzados a gran escala, como los de Venezuela y Nicaragua. Full Article
2 ¿Se Están Cerrando las Puertas? Respuestas a la Migración Venezolana en América Latina y el Caribe By www.migrationpolicy.org Published On :: Thu, 13 Feb 2020 13:08:48 -0500 MPI llevó a cabo un seminario en línea para marcar el lanzamiento de: Un portal sobre Migración en América Latina y el Caribe; y un informe que examina los efectos de las políticas migratorias y de integración en 11 países en América Latina y el Caribe ante el aumento de la migración venezolana y nicaragüense. Full Article
2 Evaluating the Effect of U-500 Insulin Therapy on Glycemic Control in Veterans With Type 2 Diabetes By clinical.diabetesjournals.org Published On :: 2015-01-01 Joseph A. GranataJan 1, 2015; 33:14-19Feature Articles Full Article
2 Diabetes Self-management Education and Support in Type 2 Diabetes: A Joint Position Statement of the American Diabetes Association, the American Association of Diabetes Educators, and the Academy of Nutrition and Dietetics By clinical.diabetesjournals.org Published On :: 2016-04-01 Margaret A. PowersApr 1, 2016; 34:70-80Position Statements Full Article
2 Clarifying the Role of Insulin in Type 2 Diabetes Management By clinical.diabetesjournals.org Published On :: 2003-01-01 John R. WhiteJan 1, 2003; 21:Feature Articles Full Article
2 SGLT-2 Inhibitors: A New Mechanism for Glycemic Control By clinical.diabetesjournals.org Published On :: 2014-01-01 Edward C. ChaoJan 1, 2014; 32:4-11Feature Articles Full Article
2 Stigma in People With Type 1 or Type 2 Diabetes By clinical.diabetesjournals.org Published On :: 2017-01-01 Nancy F. LiuJan 1, 2017; 35:27-34Feature Articles Full Article
2 Hypoglycemia in Type 1 and Type 2 Diabetes: Physiology, Pathophysiology, and Management By clinical.diabetesjournals.org Published On :: 2006-07-01 Vanessa J. BriscoeJul 1, 2006; 24:115-121Feature Articles Full Article
2 Standards of Medical Care in Diabetes--2019 Abridged for Primary Care Providers By clinical.diabetesjournals.org Published On :: 2019-01-01 American Diabetes AssociationJan 1, 2019; 37:11-34Position Statements Full Article
2 Amylin Replacement With Pramlintide in Type 1 and Type 2 Diabetes: A Physiological Approach to Overcome Barriers With Insulin Therapy By clinical.diabetesjournals.org Published On :: 2002-07-01 John B. BuseJul 1, 2002; 20:Feature Articles Full Article
2 Standards of Medical Care in Diabetes--2016 Abridged for Primary Care Providers By clinical.diabetesjournals.org Published On :: 2016-01-01 American Diabetes AssociationJan 1, 2016; 34:3-21Position Statements Full Article
2 What's So Tough About Taking Insulin? Addressing the Problem of Psychological Insulin Resistance in Type 2 Diabetes By clinical.diabetesjournals.org Published On :: 2004-07-01 William H. PolonskyJul 1, 2004; 22:147-150Practical Pointers Full Article
2 Standards of Medical Care in Diabetes--2018 Abridged for Primary Care Providers By clinical.diabetesjournals.org Published On :: 2018-01-01 American Diabetes AssociationJan 1, 2018; 36:14-37Position Statements Full Article
2 Standards of Medical Care in Diabetes--2017 Abridged for Primary Care Providers By clinical.diabetesjournals.org Published On :: 2017-01-01 American Diabetes AssociationJan 1, 2017; 35:5-26Position Statements Full Article
2 Standards of Medical Care in Diabetes--2015 Abridged for Primary Care Providers By clinical.diabetesjournals.org Published On :: 2015-04-01 American Diabetes AssociationApr 1, 2015; 33:97-111Position Statements Full Article
2 Best Business Books of 2019 – Strategy+Business By feeds.feedblitz.com Published On :: Wed, 06 Nov 2019 19:48:24 +0000 Friction made strategy+business's 2019 list of Best Business Books, one of just three in the management category. The post Best Business Books of 2019 – Strategy+Business appeared first on Neuromarketing. Full Article Neuroscience and Marketing Books business books friction management strategy
2 12 Cognitive Biases E-commerce Marketers Need to Know By feeds.feedblitz.com Published On :: Tue, 26 Nov 2019 12:05:15 +0000 Understand how customer brains work - these are the most important cognitive biases for e-commerce marketers. The post 12 Cognitive Biases E-commerce Marketers Need to Know appeared first on Neuromarketing. Full Article Neuromarketing Cognitive Biases conversion optimization cro e-commerce machine learning user experience website experiments
2 History of Spanish Psychology, 1800–2000 By ahp.apps01.yorku.ca Published On :: Thu, 30 Apr 2020 14:11:00 +0000 AHP readers may be interested in a recent piece on “History of Spanish Psychology, 1800–2000” in the Oxford Research Encyclopedia of Psychology. Full details below. “History of Spanish Psychology, 1800–2000,” by Javier Bandrés. Abstract: In the history of Spanish psychology in the 19th century, three stages can be distinguished. An eclectic first stage was defined … Continue reading History of Spanish Psychology, 1800–2000 → Full Article General
