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Genomics data analysis: false discovery rates and empirical Bayes methods / David R. Bickel, University of Ottawa, Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Department of Mathematics and Statistics

Dewey Library - QH438.4.S73 B53 2019




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An Event Apart: Content Performance Quotient

In his Beyond Engagement: the Content Performance Quotient presentation at An Event Apart in Chicago, Jeffrey Zeldman introduced a new metric for tracking how well Web sites are performing. Here's my notes from his talk:

  • The number one stakeholder request for Web sites is engagement: we need people using our services more. But is it the right metric for all these situations?
  • For some apps, engagement is clearly the right thing to measure. Think Instagram, long-form articles, or gaming sites. For others, more time spent might be a sign of customer frustration.
  • Most of the Web sites we work on are like customer service desks where we want to give people what they need and get them on their way. For these experiences, speed of usefulness should matter more than engagement.
  • Content Performance Quotient (Design CPQ) is a measure of how quickly we can get the right content to solve the customer's problem. The CPQ is a goal to iterate against and aim for the shortest distance between problem & solution. It tracks your value to the customer by measuring the speed of usefulness.
  • Pretty garbage: when a Web site looks good but doesn't help anyone. Garbage in a delightfully responsive grid is still garbage. A lot of a Web designer's job is bridging the gap between what clients say they need and what their customers actually need.
  • Marlboro's advertising company (in the 50s) rethought TV commercials by removing all the copy and focusing on conveying emotions. They went from commercials typically full of text to just ten words focused on their message.
  • Mobile is a great forcing function to re-evaluate our content. Because you can't fit everything on a small screen, you need to make decisions about what matters most.
  • Slash your architecture and shrink your content. Ask: "why do we need this?" Compare all your content to the goals you've established. Design should be intentional. Have purpose-driven design and purpose-driven content. If your design isn't going somewhere, it is going nowhere.
  • We can't always have meetings where everybody wins. We need to argue for the customer and that means not everyone in our meetings will get what they want. Purpose needs to drive our collaborations not individual agendas, which usually leak into our Web site designs.
  • It’s easy to give every stakeholder what they want. We've enabled this through Content Management Systems (CMS) that allow everyone to publish to the site. Don't take the easy way out. It’s harder to do the right thing. Harder for us, but better for the customer & bottom line.
  • Understanding the customer journey allows us to put the right content in the right place. Start with the most important interaction and build out from there. Focus on key interactions and build out from there. Sometimes the right place for your content isn't your Website -for video it could be YouTube or Vimeo.
  • Customers come to our sites with a purpose. Anything that gets in the way of that is a distraction. Constantly iterate on content to remove the cruft and surface what's needed. You can start with a content inventory to audit what is in your site, but most of this content is probably out of date and irrelevant. So being in a state of constant iteration works better.
  • When you want people to go deeper and engage, to slow down... scannability, which is good for transactions, can be bad for thoughtful content. Instead slow people down with bigger type, better typographic hierarchy, more whitespace.
  • Which sites should be slow? If the site is delivering content for the good of the general public, the presentation should enable slow, careful reading. If it’s designed to promote our business or help a customer get an answer to her question, it must be designed for speed of relevancy.




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Lost in exile: The forgotten Chagos Islanders of West Sussex

A group of Indian Ocean islanders, forcibly removed from their homes 50+ years ago and deported to England, are still fighting for recognition and basic rights. By Alexi Demetriadi.




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Can the migrants who make it convince others not to risk it?

How Senegal is trying to involve the diaspora to curb emigration. By Sofia Christensen




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Civil war, mental illness, poverty, gang violence: the many roots of homelessness

We talked to homeless in different countries and they revealed housing insecurity's different causes around the world.




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'Futures trading is not responsible for inflation'

The Indian government on Tuesday released the report from a Committee that studied the impact of futures trading on agricultural commodity prices. The Committee under chairmanship of Prof. Abhijit Sen, Member, Planning Commission was appointed on 2nd March, 2007.




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Another Green Revolution or people will starve

World food prices have been rising since 2000, but this sped up slightly in 2007, then sharply in early 2008. High prices have hit the urban poor especially hard, and led to food shortages, riots and demonstrations worldwide. IRRI is part of the Consultative Group on International Agricultural Research, a network of international agricultural research institutes started in the 1960s.




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'Wanna beat rice crisis, go for sweet potatoes'

In a recent call to Filipinos, president Arroyo said they should boil rice with sweet potatoes or they should go for cheaper cereals to avoid going hungry as rice prices soared to record levels. "This is a once-a-millennium global crisis. We have an action plan," Arroyo said, noting that residents of the central island of Cebu are already using cheap sweet potatoes to beat the crisis.




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Private Banks' Q4 nos may not reflect full extent of Covid-19 hit: Analysts

Among large banks, the brokerage sees ICICI Bank's PAT declining 49 per cent QoQ to Rs 2,100 crore in Q4FY20, followed by a 68 per cent sequential decline in Axis Bank's PAT at Rs 564.6 crore.




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Adani Green Q4 PBT at Rs 69 cr, firm says Covid-19 impact not significant

Lower expenses drive profit number; firm had incurred a loss in the same period a year ago




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Smooth Scrolling HTML Bookmarks using JavaScript

See how to use native JavaScript to create smooth scrolling HTML bookmark links inside the page, and for those that need legacy browser support, using jQuery instead.




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Community science: Not just a hobby

Community science brings a DIY sensibility to a range of research areas, providing a collegial atmosphere of collaboration and support.




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New lab, new adventure: Moving your lab to another country

Moving on with your career may entail moving to another country. Here’s a checklist to survive and thrive.




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Socially just pedagogies : posthumanist, feminist and materialist perspectives in higher education / edited by Vivienne Bozalek, Rosi Braidotti, Tamara Shefer and Michalinos Zembylas

London ; New York : Bloomsbury Academic, 2018




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Mothering from the field : the impact of motherhood on site-based research / edited by Bahiyyah Miallah Muhammad and Mélanie-Angela Neuilly.

New Brunswick : Rutgers University Press, [2019]




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Birth to three matters [electronic resource] : supporting the framework of effective practice / [edited by] Lesley Abbott and Ann Langston

Maidenhead ; New York : Open University Press, 2005




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Education in the era of globalization [electronic resource] / Klas Roth and Ilan Gur-Zeʼev (eds.)

Dordrecht : Springer, [2007]




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[ASAP] Exposure to Trichloroethylene Metabolite <italic toggle="yes">S</italic>-(1,2-Dichlorovinyl)-L-cysteine Causes Compensatory Changes to Macronutrient Utilization and Energy Metabolism in Placental HTR-8/SVneo Cells

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00356




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[ASAP] Carbon Nanotubes Modulate Activity of Cytotoxic Compounds via a Trojan Horse Mechanism

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00370




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[ASAP] Low Concentrations of Tetrabromobisphenol A Disrupt Notch Signaling and Intestinal Development in <italic toggle="yes">in Vitro</italic> and <italic toggle="yes">in Vivo</italic> Models

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00528




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[ASAP] Identifying Cysteine, <italic toggle="yes">N</italic>-Acetylcysteine, and Glutathione Conjugates as Novel Metabolites of Aristolochic Acid I: Emergence of a New Detoxification Pathway

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00488




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[ASAP] Biotransformation Mechanism of Pesticides by Cytochrome P450: A DFT Study on Dieldrin

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00013




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[ASAP] Analysis of the Different Metabolic Phenotypes of Metalaxyl Enantiomers in Adolescent Rat by Using <sup>1</sup>H NMR Based Urinary Metabolomics

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00011




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[ASAP] The Role of Cyclooxygenases-2 in Benzo(<italic toggle="yes">a</italic>)pyrene-Induced Neurotoxicity of Cortical Neurons

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00451




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[ASAP] Surface Functionalization of Pegylated Gold Nanoparticles with Antioxidants Suppresses Nanoparticle-Induced Oxidative Stress and Neurotoxicity

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00368




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[ASAP] <italic toggle="yes">In Vitro</italic> Metabolism of Isopropylated and <italic toggle="yes">tert</italic>-Butylated Triarylphosphate Esters Using Human Liver Subcellular Fractions

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00002




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[ASAP] Systems Toxicology Approaches Reveal the Mechanisms of Hepatotoxicity Induced by Diosbulbin B in Male Mice

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00503




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[ASAP] Comprehensive <italic toggle="yes">In Vitro</italic> Metabolism Study of Bisphenol A Using Liquid Chromatography-High Resolution Tandem Mass Spectrometry

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00042




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[ASAP] Triiodothyronine Attenuates Silica-Induced Oxidative Stress, Inflammation, and Apoptosis via Thyroid Hormone Receptor a in Differentiated THP-1 Macrophages

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00018




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[ASAP] Synergy between Experiments and Computations: A Green Channel for Revealing Metabolic Mechanism of Xenobiotics in Chemical Toxicology

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00448




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[ASAP] <italic toggle="yes">In Vitro</italic> Toxicity and Chemical Characterization of Aerosol Derived from Electronic Cigarette Humectants Using a Newly Developed Exposure System

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00490




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[ASAP] Cellular Metabolism in High-Throughput <italic toggle="yes">In Vitro</italic> Reporter Gene Assays and Implications for the Quantitative <italic toggle="yes">In Vitro</italic>–<italic toggle="yes&

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00037




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[ASAP] Neurotoxicology of Nanomaterials

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00050




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[ASAP] Therapeutic Potential of Carnosine and Its Derivatives in the Treatment of Human Diseases

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00010




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[ASAP] The Urine Proteome in Toxicology

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00126




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[ASAP] Thioproline Serves as an Efficient Antioxidant Protecting Human Cells from Oxidative Stress and Improves Cell Viability

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00055




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[ASAP] Arsenite Binds to ZNF598 to Perturb Ribosome-Associated Protein Quality Control

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00412




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[ASAP] Comparison of the Base Excision and Direct Reversal Repair Pathways for Correcting 1,<italic toggle="yes">N</italic><sup>6</sup>-Ethenoadenine in Strongly Positioned Nucleosome Core Particles

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00089




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[ASAP] Unexpected Observations: Probiotic Administration Greatly Aggravates the Reproductive Toxicity of Perfluorobutanesulfonate in Zebrafish

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00139




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[ASAP] Most Influential Physicochemical and In Vitro Assay Descriptors for Hepatotoxicity and Nephrotoxicity Prediction

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00040




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[ASAP] Advanced <italic toggle="yes">In Vitro</italic> Testing Strategies and Models of the Intestine for Nanosafety Research

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.0c00079




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[ASAP] Functionalized Surface-Charged SiO<sub>2</sub> Nanoparticles Induce Pro-Inflammatory Responses, but Are Not Lethal to Caco-2 Cells

Chemical Research in Toxicology
DOI: 10.1021/acs.chemrestox.9b00478




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Teaching made easy : a manual for health professionals / Kay Mohanna, Elizabeth Cottrell, David Wall and Ruth Chambers.

Abingdon, Oxon : Radcliffe Publishing Ltd, [2011]




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CUDA by example : An introduction to general-purpose GPU programming / Jason Sanders, Edward Kandrot.

Upper Saddle River, NJ : Addison-Wesley, [2011]




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Inventing the mathematician : gender, race, and our cultural understanding of mathematics / Sara N. Hottinger.

Albany : State University of New York Press, [2016]




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Terraferma : & other stories / Jonathan Falla.

Fife : Stupor Mundi, 2017.




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Prometheus (2012) / directed by Ridley Scott [DVD].

[U.K.] : 20th Century Fox, [2012]




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Poéthique : une autothéorie / Jean-Claude Pinson.

Seyssel : Champ Vallon, [2013]




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The idea of the Gothic cathedral : interdisciplinary perspectives on the meanings of the medieval edifice in the modern period / edited by Stephanie A. Glaser.

Turnhout, Belgium : Brepols, [2018]




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He Got High and Broke into a Church. Later, He Was Baptized There