The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Although gene-environment interactions have been implicated in the etiology of several disorders, the impact of paternal and/or maternal metabolic syndrome on the clinical phenotypes of offspring and the underlying genetic and epigenetic contributors of NAFLD have not been fully explored. To this end, we used the liver-specific insulin receptor knockout (LIRKO) mouse, a unique nondietary model manifesting 3 hallmarks that confer high risk for the development of NAFLD: hyperglycemia, insulin resistance, and dyslipidemia. We report that parental metabolic syndrome epigenetically reprograms members of the TGF-β family, including neuronal regeneration–related protein (NREP) and growth differentiation factor 15 (GDF15). NREP and GDF15 modulate the expression of several genes involved in the regulation of hepatic lipid metabolism. In particular, NREP downregulation increases the protein abundance of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and ATP-citrate lyase (ACLY) in a TGF-β receptor/PI3K/protein kinase B–dependent manner, to regulate hepatic acetyl-CoA and cholesterol synthesis. Reduced hepatic expression of NREP in patients with NAFLD and substantial correlations between low serum NREP levels and the presence of steatosis and nonalcoholic steatohepatitis highlight the clinical translational relevance of our findings in the context of recent preclinical trials implicating ACLY in NAFLD progression.

The mechanisms by which prostate cancer shifts from an indolent castration-sensitive phenotype to lethal castration-resistant prostate cancer (CRPC) are poorly understood. Identification of clinically relevant genetic alterations leading to CRPC may reveal potential vulnerabilities for cancer therapy. Here we find that CUB domain-containing protein 1 (CDCP1), a transmembrane protein that acts as a substrate for SRC family kinases (SFKs), is overexpressed in a subset of CRPC. Notably, CDCP1 cooperates with the loss of the tumor suppressor gene PTEN to promote the emergence of metastatic prostate cancer. Mechanistically, we find that androgens suppress CDCP1 expression and that androgen deprivation in combination with loss of PTEN promotes the upregulation of CDCP1 and the subsequent activation of the SRC/MAPK pathway. Moreover, we demonstrate that anti-CDCP1 immunoliposomes (anti–CDCP1 ILs) loaded with chemotherapy suppress prostate cancer growth when administered in combination with enzalutamide. Thus, our study identifies CDCP1 as a powerful driver of prostate cancer progression and uncovers different potential therapeutic strategies for the treatment of metastatic prostate tumors.

Facioscapulohumeral muscular dystrophy (FSHD) is caused by loss of repression of the DUX4 gene; however, the DUX4 protein is rare and difficult to detect in human muscle biopsies, and pathological mechanisms are obscure. FSHD is also a chronic disease that progresses slowly over decades. We used the sporadic, low-level, muscle-specific expression of DUX4 enabled by the iDUX4pA-HSA mouse to develop a chronic long-term muscle disease model. After 6 months of extremely low sporadic DUX4 expression, dystrophic muscle presented hallmarks of FSHD histopathology, including muscle degeneration, capillary loss, fibrosis, and atrophy. We investigated the transcriptional profile of whole muscle as well as endothelial cells and fibroadiopogenic progenitors (FAPs). Strikingly, differential gene expression profiles of both whole muscle and, to a lesser extent, FAPs, showed significant overlap with transcriptional profiles of MRI-guided human FSHD muscle biopsies. These results demonstrate a pathophysiological similarity between disease in muscles of iDUX4pA-HSA mice and humans with FSHD, solidifying the value of chronic rare DUX4 expression in mice for modeling pathological mechanisms in FSHD and highlighting the importance FAPs in this disease.

Approximately half of the world’s population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer. Bacterial virulence factors, such as the oncoprotein CagA, augment cancer risk. Yet despite high infection rates, only a fraction of H. pylori–infected individuals develop gastric cancer. This raises the question of defining the specific host and bacterial factors responsible for gastric tumorigenesis. To investigate the tumorigenic determinants, we analyzed gastric tissues from human subjects and animals infected with H. pylori bacteria harboring different CagA status. For laboratory studies, well-defined H. pylori strain B128 and its cancerogenic derivative strain 7.13, as well as various bacterial isogenic mutants were employed. We found that H. pylori compromises key tumor suppressor mechanisms: the host stress and apoptotic responses. Our studies showed that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and proteasomal degradation of the host proapoptotic factor Siva1. This process is mediated by the PI3K/Akt pathway. Inhibition of Siva1 by H. pylori increases survival of human cells with damaged DNA. It occurs in a strain-specific manner and is associated with the ability to induce gastric tumor.

Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer therapeutics. The most advanced of these are small molecules that target the HIF-2 isoform through binding the PAS-B domain of HIF-2α. These molecules are undergoing clinical trials with promising results in renal and other cancers where HIF-2 is considered to be driving growth. Nevertheless, a central question remains as to whether such inhibitors affect physiological responses to hypoxia at relevant doses. Here, we show that pharmacological HIF-2α inhibition with PT2385, at doses similar to those reported to inhibit tumor growth, rapidly impaired ventilatory responses to hypoxia, abrogating both ventilatory acclimatization and carotid body cell proliferative responses to sustained hypoxia. Mice carrying a HIF-2α PAS-B S305M mutation that disrupts PT2385 binding, but not dimerization with HIF-1β, did not respond to PT2385, indicating that these effects are on-target. Furthermore, the finding of a hypomorphic ventilatory phenotype in untreated HIF-2α S305M mutant mice suggests a function for the HIF-2α PAS-B domain beyond heterodimerization with HIF-1β. Although PT2385 was well tolerated, the findings indicate the need for caution in patients who are dependent on hypoxic ventilatory drive.

Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we report that vascular permeability–enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of neutrophil rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the bloodstream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed them to exhibit an activated phenotype and be capable of trafficking to the lungs where their presence was aligned with regions of vascular injury. Collectively, we demonstrate that increased microvascular leakage reverses the localization of directional cues across venular walls, thus causing neutrophils engaged in diapedesis to reenter the systemic circulation. This cascade of events offers a mechanism to explain how local tissue inflammation and vascular permeability can induce downstream pathological effects in remote organs, most notably in the lungs.

Cats. Cats are the best, and I can’t seem to settle down in any one place for too long, so my cats (possibly to their dismay) have had to move around with my silly butt. I don’t own a boat that can cross the Pacific Ocean, so that means taking them on a plane. BUT! While it’s no fun for anyone, it’s not really as hard as you think! Really really! My cats are my family, and if you’re here then you probably also have furry family members, and you are worried about flying with them. I’ve both taken my cats in the cabin and had to check them into the pet cargo hold (to my terror), but they not only survived, they are all flourishing wonderfully. While things do happen (and if something happens, raise a ruckus and make sure that whomever hurt your baby knows it), for the most part, flying is actually pretty safe for cats. Not that you want to take them. It’s just that sometimes you have to. So read on for my personal tips on how to make the flight go as smoothly as possible for all of you! Trust me, you’ll want it to be this way. My cats at the vet for their checkups and vaccinations. 1. Do Your Homework. This might seem obvious, but that being said, let’s put it out there anyway. Know your stuff! There are two things that you’re going to need to find out as soon as you decide to fly with your pets:      a) What paperwork does the airline require for me to bring my cat on the plane?      b) What does my arrival location require for me to bring my cat into the country/state? Usually, a) is the easiest part. It’s usually just a health certificate from your vet, issued less than a week before travel. Just book an appointment at your vet for less than a week before departure, and tell them that you’re flying to (wherever). All of my vets, even my one in Japan, either knew what they needed, or looked it up beforehand. Check your airline’s webpage (my absolute favorite for flying with pets is Alaska Air, btw. You can take two in the cabin by yourself, and it’s the only airline I know of that allows this!), and follow the instructions. I keep all of my paperwork with my passport while flying, so that I can show it to the ticketing agent or anyone else that asks (sometimes, nobody has, but at least I had it). In all of the cases where I’ve flown, my plane required a current health certificate to board, and when I left Japan, they required an inspection from the on-site team, which I just asked for when I arrived in Narita. b) can be easy, or it can be hard. In order to enter the US from Japan, I had to check the US Customs website for the country’s official regulations, and Washington State for its regulations.  The US didn’t have any regulations at the time, but Washington state required a health certificate (same as the plane), and current rabies vaccination, both of which I had done within the week before I left. Funny enough, nobody checked my paperwork after I landed, since it was the 4th of July and the Agricultural Inspections office was closed. When I went to Hawaii, it was another story. It was a long, long, long process (more than 6 months) to get all of my testing and paperwork done for Sansa to enter the state, but I did it, kept all of my paperwork in order, and was able to leave the airport in Hawaii with her in my arms without any fuss! There was a lot to do, but I just made sure that I knew what I needed, did it, and had the documentation, and things were pretty smooth sailing afterward! You should always check the official government pages to make sure that you have the correct information. In Hawaii’s case, it can be found here. All of my cats reacted differently to being examined. 2. Get your stuff in order! Once you have your list of things that you need (vaccinations, health checks, etc), then CALL the airline to make your reservations (you always need to call them in order to add pets to your tickets. They usually cost a little bit extra, and try to get them in the cabin if you can). Then, check your airline’s website to find out what kind of carrier you will need, and whether you will need anything else. When I flew to Washington the first time, and to Hawaii, I only had one cat, so I didn’t need any food (I brought some anyway, and a little bowl in my carryon just in case), and a soft-sided carrier that would fit in the dimensions they specified on their websites (it’s usually in the pet section or the carry-on section, and every airline is different). When I flew to Washington again, it was with three cats, so I needed two large hard carriers that met certain criteria for my babies flying underneath, and one soft-sided one for the baby going in the cabin. The website for the airline was very specific, but it was easy to find what I needed at Petco. Check, check, and check. I had my carriers, my paperwork, and I was ready! When your cat isn’t too happy about getting her shots. 3. Getting ready for the flight. A week or so before my flight (or days in my last case), I set all of my pet carriers out in the living room and set them up how I was going to have them for the flight — I lined the bottoms with puppy training pads (in case there was an accident in-flight), then a towel for absorbency (in the large hard carriers only), and finally, on top of that, a blanket that I had been using a lot (so that it had our scents on it, and would comfort the cats). I sprayed the interior of all of the carriers with Feliway, and left them out for the cats to get used to them. The carriers sitting out for the curious kitties to explore. They all took turns exploring the carriers, and after a few days, got comfortable with them and would lounge around inside, play with them, and rub up against the sides. This was all in order to reduce the stress of travel on them as much as possible. I continued to spray them with Feliway at least once a day until we left. There is no hard and fast rule on this, but I took away my cats’ food and water the morning of the trip, and waited until just before we left to toss out the litter boxes. There was some satisfaction in being able to stuff those nasty things in a giant garbage bag and haul them to the trash without scooping! Hey, take pleasure while you can– you’re about to undertake something pretty stressful! After I called my Uber, I rounded up the cats one by one and deposited them in their carriers. Nobody was particularly happy about this, but just be patient. Two of my babies at the airport waiting for inspection. All of them were champs! 4. The Flight Be calm, patient, and as rational as possible. I know that it’s pretty scary (terrifying, to me) to let your precious babies our of your sight, but once the porter had helped me to the ticket counters (I actually needed two the last time, and I tipped them very well), I just reminded myself that it would all be over soon, and that the calmer I was, the better the kitties would feel. In order to pass through security, you will need to remove the cats one-by-one from their carriers and hold them while the crew puts your carrier through the scanner, or manually scans by hand (two of mine were too large to fit). Sometimes, they will let you do all of this in a separate room so that the cats are calmer, but there isn’t always one available (it will say that you can do this on most websites, but I wasn’t allowed a separate room the last time and had to hold three wiggly cats in the middle of the airport). BRING A HARNESS FOR THIS. I can’t stress this enough. My cats don’t like harnesses, but I fastened one to them before I brought them out of the carrier, and removed it right after, and it brought me a lot of peace of mind. None of my cats tried to run, but I have heard that some cats do, and you don’t want to take that chance. Look for a harness like this one— thick and really hard to pull out of. Better safe than sorry. I only brought one harness for three cats, since I would only need to take out one cat at a time. By the next morning, everyone was already claiming “our” new bed as their own. And that’s it!  Once you’re on the flight, it’s mostly a waiting game. I honestly am not sure whether the cats or I were more stressed about the trip, and they were certainly shaken and scared when they arrived at our new home. However, within a few days, my cats were all behaving as if they’d never lived anywhere else. They rebound quickly as long as you shower them with love and affection. ???? Well, those are my tips for making the smoothest ride possible! It helps to have litter and litter pans, food, etc, sent to your new place before you arrive, as well, so that everything will be easy to set up for you. Make sure that your kitties are confined to one room for at least a few hours, and let them hide for as long as they need to. They’ll get curious and hungry and come out on their own. I hope this helps someone! If I did it, anyone can! Remember, I took three cats on a flight overseas BY MYSELF! Nobody to even drop my off at the airport but an UberXL driver! =^-^=

I’ve been to Forks and La Push, where the Twilight book series takes place, but I’ve never been to the actual filming locations from the movies! That’s because while the director wanted to film in Forks, when he came to scout the town he realized there was just not enough infrastructure to support an entire film crew– there were literally not enough places to house and feed all of the people who would be working on the movie, and there was no other large town within driving distance! (Yeah, Forks is really far out there) Enter Halloweento— I mean, St. Helens, Oregon! St. Helens stands in for most of Forks in the movies, and a few places in nearby Portland, Oregon make up most of the rest. I ended up nearby by complete accident, as it was only when I picked up a brochure at Halloweentown that I learned that Bella’s house was just on the other side of town! LUCKY!!!  So, we took a short break to drive over to the locations that were still standing, and made a special detour to Portland because how could we leave the Cullen house behind?! I WANTED TO GO INSIDE SO BADLY! It is a real house with real people that live there, and although they encouraged taking photos from outside (according both to a brochure from City Hall and a sign in front of the house), the inside was off-limits. Honestly, it’s not Bella that I particularly love. I didn’t care for her portrayal by Kristen Stewart (sorry!), or her melancholy, passive attitude in the book. Actually, I didn’t care for Edward, either. It was the idea of a love so strong that forces of  nature were pulling you together. It’s the idea of fitting together so perfectly that you can’t do anything without the other that I am a complete sucker for! I said it on my old Livejournal years ago, but Twilight is just a big Mary Sue anyway, so I like to imagine myself as Bella, with a gorgeous (female) Edward out there waiting for me. ???? Like I said, it’s the love, not the characters themselves. I’ll fight you on this (just kidding). ???? Here is where Edward rescued Bella from some catcallers, complete with the mural that the movie crew painted (!) on the building. And the theater that they drove past, that you can’t really see well in the movie but hey, it was on the map!! This is Jilly’s, which supplied all of the dresses in the shop when Bella went to pick out something with her friends for prom. Oddly enough, they had this sign outside but no actual merchandise inside. Go figure. ???? This place, which is a private house now, was the bookstore where Bella went to find out more information about the Quileute myths. And then, though we only had a little bit of time, we drove over to Portland and checked out Edward’s house. I have to say…. THIS HOUSE WAS GORGEOUS. Whew! I would LOVE to live there. LOVE LOVE LOVE! I would also have loved a tour, but it is a private residence, and therefore we kept our distance. Mmm, but it sure is gorgeous! Twilight brings back a lot of memories for me, and it’s special because I grew up (mostly) in Washington. It’s also not the only book series to claim that there are werewolves living amongst the local residents. The town that I spent most of my childhood in also has a series revolving around it! I’m planning to take a trip over there to see my old friends and photograph all of the wolfy places of interest, so I’ll post about it then! Love ya, and see ya tomorrow!

Time for a break is here - the new Weekday Escape arrived! This week we get typical escape games only - four rooms with firmly closed door. The first comes Amajeto who locked you in their nice living room and... Tagged as: amajeto, blog, browser, escape, free, gotmail, japanese, pixelkobo, pointandclick, puzzle, rating-g, smartcode, spiceapp, weekday-escape

Hi, it's escaping time! With Amajeto's light and fresh room we move closer to spring and all the cute tiny birds support that feeling. TomoLaSiDo reached us a bit late for Valentine, but never mind it's fun - actually, it's... Tagged as: amajeto, blog, browser, escape, free, japanese, pixelkobo, pointandclick, puzzle, rating-g, rinnogogo, tomolasido, weekday-escape

Another escape Wednesday is here! Very retro Ariyoshi's game is quite short but fun, with refreshing approach to the genre. TomoLaSiDo locked you in their room on the day with special calendar date and you need to gather several outlets... Tagged as: ariyoshi, blog, browser, escape, free, japanese, nicolet, pixelkobo, pointandclick, puzzle, rating-g, tomolasido, weekday-escape

Welcome, this week it's retro time again! Vitamin Hana wants you to escape from an unusual place - from an oceanarium. Then you get locked in Yomino Kagura's prettily decorated room, and then it's time for No1game 's short adventure... Tagged as: blog, browser, escape, escapemen, free, fuwayura, japanese, no1game, pointandclick, puzzle, rating-g, vitaminhana, weekday-escape, yominokagura

Hi! The week is over and the brand new Weekday Escape here! Amajeto helps you to enjoy your stay at home and suggests some activities like looking for lost remote controller in coded drawers and finding ways how to open... Tagged as: amajeto, blog, browser, escape, free, japanese, masa, pixelkobo, pointandclick, puzzle, rating-g, rinnogogo, weekday-escape

Hi, it's time for a break, it's escaping time! Selfdefiant wants you to escape a desert temple which is, very conveniently, placed next to a stream so no worries of dehydration in case you stay here longer than expected. TomoLaSiDo... Tagged as:

Hello - the new WE is here! Wishing you beautiful spring and happy playing during this quarantine time! Amajeto is definitely back and has changed remarkably, the latest game is bigger and feels more like their older escapes. Very nice.... Tagged as: blog, browser, escape, free, gotmail, japanese, nicolet, pointandclick, puzzle, rating-g, selfdefiant, spiceapp, tomolasido, weekday-escape

Hi, it's time to have some fun from the past! This Weekday Escape is retro! Vitamin Hana wants you to escape a room - no surprise - but also to redecorate it. Yomino Kagura isn't so demanding, their escape is... Tagged as: blog, browser, esc-forest, escape, escapemen, free, japanese, no1game, pointandclick, puzzle, rating-g, vitaminhana, weekday-escape, yominokagura

It's Wednesday, it's escape time! Amajeto locked you in their room and wants you to escape, and TomoLaSiDo as well. Puzzles aren't hard so it doesn't take long to leave to enjoy the lovely weather outside. In Spiceapp's escape you... Tagged as: amajeto, blog, browser, escape, free, gotmail, japanese, masa, pointandclick, puzzle, rating-g, spiceapp, tomolasido, weekday-escape

Hi, hope your week is fine so far - now even better with new Weekday Escape! From Amajeto's room you'll escape easily with all the practice you have. Then you get locked in Akatsuki no Yado's one, a bit complicated... Tagged as: akatsukinoyado, amajeto, blog, browser, escape, free, gotmail, japanese, nicolet, pointandclick, puzzle, rating-g, spiceapp, weekday-escape

We're still waiting to hear news about Apple Card's performance relative to the major card issuers, but that hasn't stopped Samsung from announcing plans to launch an "innovative" debit card as part of a new mobile-first money management platform the company has been developing over the last year.


Announced on Thursday in a blog post by Samsung Pay vice-president Sang Ahn, the forthcoming debit card is in partnership with finance company SoFi and will be backed by a cash management account.

"In 2020, Samsung Pay will be expanding our service from being a rewarding way to shop and pay, to also being a rewarding way to manage money," writes Ahn. "Over the past year we have been busy developing a mobile-first money management platform. Our vision is to help consumers better manage their money so that they can achieve their dreams and goals. Now more than ever, mobile financial services and money management tools will play an even bigger role in our daily lives while also opening up new possibilities."

The debit card is scheduled to launch this summer. Other than that, Samsung hasn't offered any details on how it will work, but expect it to integrate with Samsung's existing mobile payment system.

Launched in August 2019, ‌Apple Card‌ is a credit card linked to Apple Pay and built into the Wallet app on iPhone. Apple partnered with Goldman Sachs to launch the card, and in October the investment bank hailed it as "the most successful credit-card launch ever." Nine months later, neither Apple nor Goldman Sachs has offered any concrete details on its performance.

During the global health crisis, Apple has introduced an ‌Apple Card‌ Assistance Program that allows ‌‌Apple Card‌‌ holders to skip their March and April payments without incurring interest charges for that billing cycle. For more details on how the card works, check out our comprehensive Apple Card guide.
This article, "Samsung Announces 'Innovative' Debit Card Launching this Summer" first appeared on MacRumors.com

Discuss this article in our forums

The Label's "The_Otherside" is this week's addition to Apple Arcade on the iPhone, iPad, and Apple TV. The game is described as both a turn-based RPG and a strategy board game:

Otherside is a turn based RPG and strategy board game where you will control four survivors who hope to push back the shadowy threat. Make your way through each level solving puzzles, fighting monsters, and destroying the spirit anchors that threaten our dimension.

Do you have what it takes to restore the town back to normal and save the day?

"The_Otherside" is available on the App Store with an Apple Arcade subscription. The service provides iPhone, iPad, Apple TV, and Mac users with access to over 100 games with no in-app purchases or ads for $4.99 per month.
This article, "Apple Arcade's Latest Game Combines Turn-Based RPG With Strategy Board Game" first appeared on MacRumors.com

Discuss this article in our forums

A new NFC specification announced this week by the NFC Froum will allow future NFC enabled devices to offer wireless charging capabilities, which means a smartphone could be used to charge a small accessory like headphones.


According to the NFC Forum, the Wireless Charging Specification (WLC) will allow smartphones or other NFC charging devices to wirelessly charge small, battery-powered consumer and IoT devices at a power transfer rate of up to one watt.

The 1W rating is much slower than the Qi-based standard used by iPhones and other smartphones. Qi-based wireless charging on the iPhone maxes out at 7.5W, but is even faster on some Android devices.

Charging over NFC would require new hardware, and it's not a feature that can be added to existing devices. The NFC Forum believes the WLC specification could be used to complement Qi-based wireless charging.

It works using a single antenna to manage communications and charging, which is convenient for low-power devices like smart watches, fitness trackers, and earbuds that already use NFC for connectivity because there's no need to build in Qi support.

"The NFC Forum's Wireless Charging Technical Specification allows for wireless charging of small battery-powered devices like those found in many of the estimated 36 billion IoT devices in use today," said Koichi Tagawa, chair, NFC Forum. "NFC wireless charging is truly transformative because it changes the way we design and interact with small, battery-powered devices as the elimination of plugs and cords enables the creation of smaller, hermetically-sealed devices."

Apple in 2015 joined the NFC Forum and participates in the approval of new NFC specifications and developments.

Rumors in 2019 suggested that Apple was working on bilateral wireless charging that would allow its iPhones to charge the AirPods and the Apple Watch, but the feature was ultimately nixed. At the time, Apple analyst Ming-Chi Kuo said that the two-way wireless charging feature Apple was exploring did not meet Apple's requirements.

Samsung has implemented bilateral wireless charging in its smartphones, but the Wireless PowerShare option does not use NFC and is powered by the Qi-based charging coils in the device. Samsung's smartphones can charge other smartphones or accessories like headphones that support Qi wireless chargers.
This article, "New NFC Specification Will Let Smartphones Charge Small Devices" first appeared on MacRumors.com

Discuss this article in our forums

Apple's next-generation Apple Watch and watchOS 7 will focus on new mental health capabilities, according to leaker Jon Prosser who recently spoke on the Geared Up podcast. The mention of new ‌Apple Watch‌ features comes towards the end of the podcast.


The next-generation version of the ‌Apple Watch‌, the ‌Apple Watch‌ Series 6, has been rumored to include a blood oxygen sensor, which Prosser says Apple will take advantage of to implement new mental health-related features, such as detecting panic attacks.

What their biggest focus on is right now and I hope it comes this year, it might come next year, but I hope it's coming to WWDC is mental health capabilities. Where they can take the oxygen levels in your blood with your heart rate and determine if you're hyperventilating.

They can identify a panic attack before it happens and warn you on your watch. Especially if you're driving, they'll ask you to pull over and they'll offer breathing exercises once you get pulled over.

Prosser says that while he hopes the feature is released this year, "it might come next year." He also says he hopes for a WWDC unveiling, but if the new feature relies on a blood oxygen sensor in an unreleased version of the ‌Apple Watch‌, it's not likely Apple will unveil the capability until the fall when new ‌Apple Watch‌ models that support it are released.

There is, however, a possibility that it will be revealed at WWDC if older ‌Apple Watch‌ models have a latent ability to detect blood oxygen level, which is not clear at this time, or if the feature does not involve blood oxygen monitoring.

The panic attack detecting rumor was first shared by EverythingApplePro and leaker Max Weinbach back in April, who said that the ‌Apple Watch‌ will also be able to determine when a user is experiencing high levels of stress. Weinbach and EverythingApplePro did not suggest the feature would rely on blood oxygen monitoring, however, and said that it would be available on the ‌Apple Watch‌ Series 4 or later.

Hints that blood oxygen tracking capabilities are coming to a future version of the ‌Apple Watch‌ were found in a leaked version of iOS 14. Blood oxygen monitoring is an important feature because a drop in blood oxygen levels can suggest a serious respiratory or cardiac problem that requires immediate medical attention.

Multiple prior rumors from Bloomberg and other sources have also indicated that the next-generation ‌Apple Watch‌ and watchOS 7 will include sleep tracking features, allowing the ‌Apple Watch‌ to measure sleep quality, length, and other metrics.
This article, "Rumor Claims watchOS 7 Will Have 'Mental Health Capabilities' to Detect Panic Attacks" first appeared on MacRumors.com

Discuss this article in our forums

Apple's rumored high-end over-ear headphones may be called "AirPods Studio" and retail for $349, according to Jon Prosser of YouTube channel Front Page Tech.


In keeping with the successful ‌AirPods‌ brand, the rumored "Studio" over-ear headphones would significantly diversify Apple's ‌AirPods‌ lineup, which last added the in-ear AirPods Pro in October 2019. The supposed price of $349 would place "‌AirPods‌ Studio" as a direct competitor to high-end noise-canceling over-ear headphones from Bose and Sony.

Looks like Apple is sticking with the “‌AirPods‌” branding for their new over-ear headphones.

‌AirPods‌ Studio
Codename: B515
$349

— Jon Prosser (@jon_prosser) May 9, 2020

Prosser has previously accurately leaked the April 15 launch date of the new iPhone SE and, most recently, the May 4 launch date of the refreshed 13-inch MacBook Pro.

Apple analyst Ming-Chi Kuo expects Apple's over-hear headphones to enter mass production in mid-2020, which may suggest a fall 2020 launch.
This article, "Apple's Over-Ear Headphones May Be Called 'AirPods Studio' and Cost $349" first appeared on MacRumors.com

Discuss this article in our forums

The Ursa Majors are ready for votes and the nominees have been revealed. Voting can be found at their website and is open throughout the month of March. Two categories, however, received no nominees due to being an insufficient number of nominations and will not be put up to vote for a winner. Those two categories being Fursuits and Non-Fiction.

If you enjoy film, fiction, art, or any other of the many items that are up for selection as the best of the best for the year of 2019 be sure to vote this month. If you like non-fiction or fursuits, well, you can always be sure to nominate next year.

The nominees are:

read more

After the bumper here, the review will get into spoiler territory. I will say that if you are a Sonic fan this movie will give you a sense of pride as it is far better than it should have had any right in being. Taking the franchise’s lore and resetting it to tell its own story, but retaining the strong characterization and quip heavy personalities of Sonic and Robotnik that makes their rivalry such a strong one. It also keeps the first entry simple with the hedgehog and doctor being the only two characters from the universe being in the film. This makes the story stronger since it can develop those two far more and not have to worry about any other kind of side character fan service for now.

Hey, at least now Sonic fans can brag to Mario ones that Mario may still be the king of games, but Sonic blew the plumber’s cinematic pieces out of the water. Not that that was a high bar I suppose. Then again, having better quality games than Sonic these days isn’t one either (the author quips while using a quote from Sonic Forces for his review’s headline).

In the video game Sonic the Hedgehog, timing is everything. While at the heart of the game is a fast paced platformer, its foundation has always been learning the layout of a level and timing your actions appropriately. In a twist, the timing of this film and its release had quite a bit of impact on my view of it.

read more

As governments restrict gatherings of people, furry conventions are being postponed or canceled. Here's a quick run down of events in April, May, and June and their status as of May 5 17:28 EDT (UTC-4) in response to the COVID-19 pandemic - updates to come.

A new section has been added for past events impacted for historical purposes.

Links go to statements if available, or to their Twitter feed or site. See also: Furry Fandom and the Internet forced back to roots by viral outbreak

read more

Erowid Exp113948

Erowid Exp114340

Erowid Exp101191

On the Young Turks, Cenk Uygur quotes passages from Bob Woodward's book, "The Price of Politics", quoting statements made by President Obama proving that he intends to cut entitlements like social security, medicare, and medicaid. Continue reading →

Linda McMahon is running for the US Senate in Connecticut. For twenty (20) years, she ran World Wrestling Entertainment (WWE) with her husband, Vince McMahon. A few years ago, a documentary film examined the WWE's celebration of violence against women. Her campaign doesn't want Connecticut voters to see that film. Watch these excerpts from the film to see why. Continue reading →

After being elected in 2008 on "hope and change", "change you can believe in", and "change the way Washington works", President Obama now says that he cannot change Washington from the inside? Then why should we re-elect him in 2012? Continue reading →

Cornel West and Tavis Smiley criticize President Barack Obama for being to the right of even President Richard Nixon. Continue reading →

I am still holding on a call to the Internal Revenue Service, even though I called (800) 829-0115 two hours ago. This telephone number is the one often included in notices from the Internal Revenue Service for overdue business taxes. … Continue reading →

Have you ever noticed that the Internal Revenue Service's regulations often are illogical? Does anyone at the IRS think through its regulations? Continue reading →

Vermont Sen. Bernie Sanders talks about the need for a "serious debate about serious issues," and whether he plans to challenge Hillary Clinton for the Democratic nomination. Sanders also adds that America needs to hear Hillary Clinton's opinions on the TPP, middle class struggles, and the Keystone XL pipeline. Continue reading →

Hillary Faces Questions About Cash Donations to Clinton Foundation. Continue reading →

Accountants CPA Hartford Connecticut LLC:  This is a rush transcript for April 26, 2015. It may contain errors. GEORGE STEPHANOPOULOS, HOST: And the author of “Clinton Clash,” Peter Schweizer, joins us now. Thank you for joining us this morning, Peter. … Continue reading →

Clinton Cash - do you trust Bill and Hillary Clinton in positions of power Continue reading →

Democratic presidential candidate Sen. Bernie Sanders explains why he thinks he thinks his record of “strong and bold leadership” could help him best candidate Hillary Clinton in the Democratic primary. Continue reading →

Senator Bernie Sanders does not think that Hillary Clinton can stand up and fight for the middle class. Continue reading →