Put pictures of 1975-era Aerosmith and 1995-era Guided By Voices next to each other and you probably wouldn’t think the bands have anything in common.…

The Buzz Bin HERE'S THE BEEF…

Sewing is my new coping mechanism.…

You might not know it from the fancy attire they wear on stage at the Fox Theater, but for the musicians in the Spokane Symphony, it's a part-time gig. It's a prestigious gig, to be sure, but like most artists, for the musicians, it's just one piece of a puzzle full of hustle they have to solve to make a living.…

Gonzaga Athletic Director Mike Roth took to the Zoom online meeting app Wednesday for a lengthy chat with members of the school community, fans and media to answer questions about college sports in the era of COVID-19. Like so many things regarding the coronavirus, there are a lot of hopes for a rapid return to normalcy — all of them couched in the reality that none of us really know how the pandemic is going to affect our lives three months from now, or six months down the line.…

THE SHOW WILL GO ON…

Noting that safety of its fans and vendors is always a priority, the folks behind Lilac City Comicon announced Friday that this year's event would move from its original June dates to Oct. 11-12 at the Spokane Convention Center. Anyone who bought tickets for the original June 6-7 comicon will be able to use those tickets at the rescheduled event, or refunds will be available from the businesses where tickets were bought, once those businesses are able to reopen.…

By The New York Times The New York Times Company As President Donald Trump presses for states to reopen their economies, his administration is privately projecting a steady rise in the number of cases and deaths from the coronavirus over the next several weeks, reaching about 3,000 daily deaths June 1, according to an internal document obtained by The New York Times, nearly double from the current level of about 1,750.…

ON INLANDER.COM NATION: Even as U.S. President Donald Trump urges states to reopen their economies, his own administration projects that the death toll from COVID-19 will spike to 3,000 people per day.…

ON INLANDER.COM NATION: As meatpacking plants nationwide shutdown due to COVID-19 outbreaks, certain meat products are becoming harder to find at grocery stores and fast-food drive-thrus.…

The latest issue of the Inlander is hitting newsstands today. Find it at your local grocery store and hundreds of other locations; use this map to find a pickup point near you.…

This is what it feels like to live during an historic event.…

Cops are hackers now, too.…

In times of trouble, escaping into the art that calms you is key to keeping your sanity.…

At every level of America's food system, mandated closures and outbreaks of COVID-19 have interrupted the finely tuned network that normally gets food from farmers and food processors to restaurants, grocery stores and food banks.…

ON INLANDER.COM COVER: While Washington state forges alliances, Idaho battles coronavirus its own way.…

The puppet's felt hair bounces as she stage-whispers to the other puppets, almost conspiratorially, about their plans.…

A coalition of immigrant-focused organizations has created the Spokane Relief Fund for Undocumented Immigrants, in order to help families who are unable to access federal aid during the coronavirus shutdowns. The partners sponsoring the work include the Spokane Immigrant Rights Coalition (SIRC), the Hispanic Business and Professional Association, Latinos en Spokane, Mujeres in Action and Raiz.…

What do Arabian horses, women veterans, ceramics and the food industry have in common?…

Loved, or loathed, depending on who you ask, mushrooms come in many forms, including those readily available in the grocery store, and others — like morels — that require more determined sourcing.…

Growing up, Luke Parker played sports.…

The Inlander is a community newspaper covering news, politics, events, happy hour, everything that's happening today, things to do on the weekend, in Spokane, Coeur d'Alene, the greater Inland Northwest and beyond.

[IMAGE-1] Crystal Bertholic has been a leader in the region's craft cocktail revival since the beginning. Before she got her start shaking, stirring and straining mixed drinks, Bertholic was steaming milk and roasting coffee; then pouring craft beers.…

Best Touring Broadway Musical of 2019-20 LES MISERABLES After being nominated for multiple Tony Awards, the 2014 Broadway revival of Les Mis hit the road three years later, allowing audiences far beyond New York City to get swept up in its gripping, tragic tale of romance and revolution.…

Mosey on up to the bar at Lil Sumthin' Saloon for a sip of Southern hospitality by way of Texas, and a samplin' of some old-fashioned country vibes.…

Don't be caught empty-handed (or empty-hearted) this Valentine's Day, coming up Friday, Feb. 14.…

A little more than a year ago, local French-inspired bakery miFlavour moved into a building on East Sprague Avenue after two years in a shared commercial kitchen.…

ProPublica’s health reporter Caroline Chen explains what the conversation around asymptomatic coronavirus carriers is missing, and what we need to understand if we’re going to beat this nefarious virus together. By Caroline Chen, ProPublica In the early days of the coronavirus outbreak in the U.S., around the last week of February, I joked to a colleague that maybe now, finally, people would learn how to wash their hands properly.…

By Michael D. Shear and Sarah Mervosh WASHINGTON — President Donald Trump on Friday openly encouraged right-wing protests of social distancing restrictions in states with stay-at-home orders, a day after announcing guidelines for how the nation’s governors should carry out an orderly reopening of their communities on their own timetables.…

Extraction was supposedly the most-watched new movie on Netflix last week, and yet it feels suspiciously like one you've already seen, possibly late at night on some obscure cable channel back in the '90s.…

At around 5:30 pm on Thursday, there were two camps of people set up in Coeur d'Alene Park in Browne's Addition.…

Yesterday, Spokane Mayor Nadine Woodward and other local leaders urged Gov. Jay Inslee to allow Spokane County to open on a different schedule than the rest of the state.  Inslee, however, wouldn't budge.…

A nonmetallic compound having an ionic bond with a halide ion is used as a catalyst for living radical polymerization. Even if a radical initiator is not used, a monomer can be subjected to a radical polymerization to obtain a polymer having narrow molecular weight distribution. The cost of the living radical polymerization can be remarkably reduced, and it is made possible to prevent adverse effects of using a radical initiator (such as side reactions). The present invention is significantly more environmentally friendly and economically excellent than conventional living radical polymerization methods, due to advantages such as low toxicity of the catalyst, low amount of the catalyst necessary, high solubility of the catalyst, mild reaction conditions, and no coloration/no odor, etc. The catalyst can be applied to various monomers and enables synthesis of high molecular weight polymers.

A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond;where part (B) is a bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond;where part (C) is a bivalent radical, a —(CH2)t— bivalent radical, or a covalent bond; andwhere part (T) is a —Y-L-Z— radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.

The present invention relates to a process for preparing a compound of formula wherein: R2 is cycloalkyl or alkyl, each of which may be optionally substituted; Y is —CONR3R4, —CN or CO2R5; R3, R4 and R5 are each independently H or alkyl; n is 1 to 6; wherein said process comprising the steps of: (i) treating a compound of formula (IV), where R1 is alkyl, with a compound of formula (V) and forming a compound of formula (IIIb); (ii) treating said compound of formula (IIIb) with a compound of formula (I1) to form a compound of formula (I).

The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating 5-HT2C and/or RSK disorders, including diseases and disorders mediated by GPCRs and/or RSKs.

A process for reductive amination of aliphatic cyanoaldehydes to aliphatic diamines comprising (1) providing a mixture of 1,3-cyanocyclohexane carboxaldehyde and/or 1,4-cyanocyclohexane carboxaldehyde; (2) contacting said mixture with a metal carbonate based solid bed or a weak base anion exchange resin bed at a temperature from 15 to 40 ° C. for a period of at least 1 minute; (3) thereby treating said mixture, wherein said treated mixture has a pH in the range of 6 to 9; (4) feeding said treated mixture, hydrogen, and ammonia into a continuous reductive amination reactor system; (6) contacting said treated mixture, hydrogen, and ammonia with each other in the presence of one or more heterogeneous metal based catalyst systems at a temperature from 80 ° C. to 160 ° C. and a pressure from 700 to 3500 psig; (7) thereby producing one or more cycloaliphatic diamines is provided.

A compound represented by Formula 1 below and an organic light-emitting device including an organic layer containing the compound of Formula 1: wherein R1 to R4, X and Y, a and b, and m and n are defined as in the specification.

Provided are an anti-static and anti-microbial surface treatment agent including a quaternary ammonium salt compound as an active ingredient and a method of preventing a polymer fiber from developing static electricity by using the surface treatment agent. The quaternary ammonium salt compound has excellent anti-static and anti-microbial effects for the prevention or improvement of static electricity in a polymer fiber. Accordingly, the quaternary ammonium salt compound is suitable for use as a fabric softener, or an anti-static agent, and also, provides anti-microbial effects to a polymer fiber.

A process for conversion of aliphatic bicyclic amines to aliphatic diamines including contacting one or more bicyclic amines selected from the group consisting of 3-azabicyclo[3.3.1]nonane and azabicyclo[3.3.1]non-2-ene with ammonia and hydrogen, and alcohols in the presence of heterogeneous metal based catalyst systems, a metal selected from the group consisting of Co, Ni, Ru, Fe, Cu, Re, Pd, and their oxides at a temperature from 140° C. to 200° C. and a pressure from 1540 to 1735 psig for at least one hour reactor systems; forming a product mixture comprising aliphatic diamine(s), bicyclic amine(s), ammonia, hydrogen, and alcohol(s); removing said product mixture from the reactor system; removing at least some of the ammonia, hydrogen, water, alcohols, bicyclic amines from said product mixture; thereby separating the aliphatic diamines from said product mixture.

Techniques for evaluation and/or retraining of a classification model built using labeled training data. In some aspects, a classification model having a first set of weights is retrained by using unlabeled input to reweight the labeled training data to have a second set of weights, and by retraining the classification model using the labeled training data weighted according to the second set of weights. In some aspects, a classification model is evaluated by building a similarity model that represents similarities between unlabeled input and the labeled training data and using the similarity model to evaluate the labeled training data to identify a subset of the plurality of items of labeled training data that is more similar to the unlabeled input than a remainder of the labeled training data.

A system and method that facilitates urban traffic state detection based on support vector machine (SVM) and multilayer perceptron (MLP) classifiers is provided. Moreover, the SVM and MLP classifiers are fused into a cascaded two-tier classifier that improves the accuracy of the traffic state classification. To further improve the accuracy, the cascaded two-tier classifier (e.g., MLP-SVM), a single SVM classifier and a single MLP classifier are fused to determine a final decision for a traffic state. In addition, fusion strategies are employed during training and implementation phases to compensate for data acquisition and classification errors caused by noise and/or outliers.

A computer-implemented method is provided for statistical data learning under privacy constraints. The method includes: receiving, by a processor, a plurality of pieces of statistical information relating to a statistical object and aggregating, by the processor, the plurality of pieces of statistical information so as to provide an estimation of the statistical object. Each piece of statistical information includes an uncertainty variable, the uncertainty variable being a value determined from a function having a predetermined mean. The number of pieces of statistical information aggregated is proportional to the reliability of the estimation of the statistical object.

A modeling framework for evaluating the impact of weather conditions on farming and harvest operations applies real-time, field-level weather data and forecasts of meteorological and climatological conditions together with user-provided and/or observed feedback of a present state of a harvest-related condition to agronomic models and to generate a plurality of harvest advisory outputs for precision agriculture. A harvest advisory model simulates and predicts the impacts of this weather information and user-provided and/or observed feedback in one or more physical, empirical, or artificial intelligence models of precision agriculture to analyze crops, plants, soils, and resulting agricultural commodities, and provides harvest advisory outputs to a diagnostic support tool for users to enhance farming and harvest decision-making, whether by providing pre-, post-, or in situ-harvest operations and crop analyzes.

A spiking neuron-based working memory device is provided. The spiking neuron-based working memory device includes an input interface configured to convert input spike signals into respective burst signals having predetermined forms, and output a sequence of the burst signals, the burst signals corresponding to the input spike signals in a burst structure, and two or more memory elements (MEs) configured to sequentially store features respectively corresponding to the outputted sequence of the burst signals, each of the MEs continuously outputting spike signals respectively corresponding to the stored features.

An apparatus for selecting a motion signifying artificial feeling is provided. The apparatus includes: an feeling expression setting unit configured to set probabilities of each feeling expression behavior performed for each expression element of a robot for each predetermined feeling; a behavior combination generation unit configured to generate at least one behavior combination combined by randomly extracting the feeling expression behaviors in each expression element one by one; and a behavior combination selection unit configured to calculate an average for the probabilities of the feeling expression behaviors included in each behavior combination for each feeling of a robot and select behavior combinations in which the average of the probabilities of the feeling expression behaviors most approximates the predetermined feeling value of a robot from each behavior combination.

Methods, apparatuses and articles of manufacture for use in a mobile device to determine whether a dynamic user profile is to transition from a first state to a second state based, at least in part, on one or more sensed indicators. The dynamic user profile may be indicative of one or more current inferable user behavior contexts for a user co-located with the mobile device. The mobile device may transition a dynamic user profile from a first state to a second state, in response to a determination that the dynamic user profile is to transition from the first state to the second state, and operatively affect one or more functions performed, at least in part, by the mobile device based, at least in part, on the transition of the dynamic user profile to the second state.

A method for performing relational analysis of parsed input is employed to create a visual map of knowledge information. A title, header or subject line for an input item of information is parsed into syntactical components of at least a subject component and any predicate component(s) relationally linked as topic and subtopics. A search of topics and subtopics is carried out for each parsed component. If a match is found, then the parsed component is taken as a chosen topic/subtopic label. If no match is found, then the parsed component is formatted as a new entry in the knowledge map. A translation function for translating topics and subtopics from an original language into one or more target languages is enabled by user request or indicated user preference for display on a generated visual map of knowledge information.

A method of identifying one or more particular images from an image collection, includes indexing the image collection to provide image descriptors for each image in the image collection such that each image is described by one or more of the image descriptors; receiving a query from a user specifying at least one keyword for an image search; and using the keyword(s) to search a second collection of tagged images to identify co-occurrence keywords. The method further includes using the identified co-occurrence keywords to provide an expanded list of keywords; using the expanded list of keywords to search the image descriptors to identify a set of candidate images satisfying the keywords; grouping the set of candidate images according to at least one of the image descriptors, and selecting one or more representative images from each grouping; and displaying the representative images to the user.

A method, system and computer program product for generating answers to questions. In one embodiment, the method comprises receiving an input query, decomposing the input query into a plurality of different subqueries, and conducting a search in one or more data sources to identify at least one candidate answer to each of the subqueries. A ranking function is applied to each of the candidate answers to determine a ranking for each of these candidate answers; and for each of the subqueries, one of the candidate answers to the subquery is selected based on this ranking. A logical synthesis component is applied to synthesize a candidate answer for the input query from the selected the candidate answers to the subqueries. In one embodiment, the procedure applied by the logical synthesis component to synthesize the candidate answer for the input query is determined from the input query.