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Selenium-mediated alleviation of skeletal muscle atrophy through enterotype modulation in mice

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03889D, Paper
Yixin Cheng, Xiaofan Liu, Yingao Hao, Shixu Wang, FangFang Wu, Lingzhuo Zhao, Du Peng, Du Yawen, Sun Sheng, Li Jianguo, Guangxu Ren
Selenium element improves dexamethasone-induced skeletal muscle atrophy by affecting enterotype.
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Impact of pH on the fabrication of egg white reinforced soy protein composite microgels for gastrointestinal delivery purposes

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03997A, Paper
Feng Liu, Yi Liu, Suyun Zhang, Gang Liu, Christos Ritzoulis, Yue Zhang
Protein molecules such as soy protein isolate (SPI) and egg white (EW) are highly promising materials for developing hydrogels (especially micro/nanogels) for the encapsulation, protection and controlled release of bioactive substances.
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Investigation of the hypoglycemic bioactive components of Phyllanthi Fructus through biological assessment combined with ultrafiltration affinity mass spectrometry

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04198D, Paper
Yifan Zhang, Qiang Yu, Peng Tan, Shimin Tian, Jun-zhi Lin, Mengqi Li, Li Han, Haozhou Huang, Ding-kun Zhang
Phyllanthi Fructus (PF) is a tropical fruit with the potential to effectively reduce postprandial blood glucose, making it highly promising for the development of functional foods. However, the lack of...
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Galacto-oligosaccharides regulates intestinal mucosal sialylation to counteract antibiotic-induced mucin dysbiosis

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04626A, Paper
Laipeng Xu, Xuan Li, Shuibing Han, Chunlong Mu, Wei-Yun Zhu
Intestinal mucin offers a physical barrier to maintain host-commensal homeostasis. Glycosylation is essential for appropriate function of mucin. Galacto-oligosaccharides (GOS) have been used as a prebiotic with proved intestinal benefits,...
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Protein-bound AGEs derived from methylglyoxal induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO00364K, Paper
Gang Yu, Jianxin He, Zhongshan Gao, Linglin Fu, Qiaozhi Zhang
Protein-bound advanced glycation end-products (AGEs) induce pro-inflammatory response and barrier integrity damage in epithelial cells by disrupting the retinol metabolism.
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Immunomodulatory properties of hempseed oligopeptides in an LRRK2-associated Parkinson's disease animal model

Food Funct., 2024, 15,11115-11128
DOI: 10.1039/D4FO03167A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Torrecillas-Lopez, Fernando Rivero-Pino, Paula Trigo, Rocio Toscano-Sanchez, Teresa Gonzalez-de la Rosa, Alvaro Villanueva, M. Carmen Millan-Linares, Sergio Montserrat-de la Paz, Carmen M. Claro-Cala
Hemp protein hydrolysate is capable of alleviating neuroinflammation by reducing the expression of pro-inflammatory cytokines, which could have promising effects in Parkinson's disease.
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Influence of dairy matrix on the prebiotic effects of inulin related to gut metabolic activity and bone health

Food Funct., 2024, 15,11129-11140
DOI: 10.1039/D4FO01635A, Paper
Xiaorui Zhao, Weiwei He, Louise M. A. Jakobsen, Farhad M. Panah, Banny Silva Barbosa Correia, Dennis Sandris Nielsen, Axel K. Hansen, Hanne Christine Bertram
This study investigated if the prebiotic efficacy of inulin depends on the dairy matrix used as vehicle.
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Lactobacillus plantarum 69-2 combined with α-lactalbumin hydrolysate alleviates DSS-induced ulcerative colitis through the TLR4/NF-κB inflammatory pathway and the gut microbiota in mice

Food Funct., 2024, 15,10987-11004
DOI: 10.1039/D4FO02975E, Paper
Yue Ma, Chuanbing Hu, Jing Zhang, Cong Xu, Lizhi Ma, Yunhe Chang, Muhammad Altaf Hussain, Jiage Ma, Juncai Hou, Zhanmei Jiang
Ulcerative colitis (UC), an inflammatory bowel disease, seriously affects people's quality of life.
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Aronia melanocarpa extract extends the lifespan and health-span of Caenorhabditis elegans via mitogen-activated protein kinase 1

Food Funct., 2024, 15,11020-11035
DOI: 10.1039/D4FO02479F, Paper
Huan Zhang, Zhigang Zhu, Wenjing Wei, Zekun Liu, Huiji Zhou, Yueling Gong, Xinlei Yan, Jun Du, Houkai Li, Liang Chen, Lili Sheng
Aronia melanocarpa (AM) was shown to promote the lifespan and health-span of C. elegans via the PMK-1 pathway, highlighting the potential of AM as a dietary supplement for delaying aging.
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Lacticaseibacillus plantarum postbiotics prepared by the combined technique of pasteurization and ultrasound: effective measures to alleviate obesity based on the SCFAs-GPR41/GPR43 signaling pathway

Food Funct., 2024, 15,11005-11019
DOI: 10.1039/D4FO03591G, Paper
Chao Miao, Linge Wang, Huabing Wang, Yu Shen, Chaoxin Man, Wei Zhang, Yu Zhang, Qianyu Zhao, Yujun Jiang
Postbiotics prepared by ultrasound and pasteurization are used for the alleviation of obesity.
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Adherence to the Mediterranean diet is associated with reduced chronic pancreatitis risk: a longitudinal cohort study

Food Funct., 2024, 15,11072-11082
DOI: 10.1039/D4FO02588A, Paper
Open Access
Chunhua Zhou, Jiawei Geng, Hanyi Huang, Lintao Dan, Zhipeng Wu, Xixian Ruan, Yao Zhang, Jie Chen, Jing Sun, Duowu Zou
The role of diet on the risk of chronic pancreatitis (CP) is understudied.
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Dynamic changes in the gel properties, microbial community, and volatile flavor profile of Spanish mackerel (Scomberomorus niphonius) sausages inoculated with Lactiplantibacillus plantarum CY1-2

Food Funct., 2024, 15,11060-11071
DOI: 10.1039/D4FO03841J, Paper
Xinran Lv, Wenyu Wu, Shuilin Liu, Lili Ding, Anqi Ren, Le An, Fengling Bai, Jianrong Li, Xuepeng Li, Shumin Yi
This study aimed to examine the dynamic changes in the gel properties, microbial diversity, and volatile flavor compounds (VFCs) of Spanish mackerel sausages inoculated with Lactiplantibacillus plantarum CY1-2 during fermentation.
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Cardamonin protects against diabetic cardiomyopathy by activating macrophage NRF2 signaling through molecular interaction with KEAP1

Food Funct., 2024, 15,11083-11095
DOI: 10.1039/D4FO03543G, Paper
Wenshan Nan, Jialin Yin, Wenhao Hao, Huali Meng, Junduo Wu, Xiao Yin, Hao Wu
Cardamonin inhibited macrophage M1 polarization in diabetic cardiomyopathy by binding to KEAP1, leading to the dissociation of NRF2 from KEAP1. This promoted NRF2 nuclear translocation and antioxidant gene expression in M1 polarized macrophages.
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Solid-state fermentation of green lentils by Lactiplantibacillus plantarum leads to formation of distinct peptides that are absorbable and enhances DPP-IV inhibitory activity in an intestinal Caco-2 cell model

Food Funct., 2024, 15,11220-11235
DOI: 10.1039/D4FO03326D, Paper
Elisa Di Stefano, Nico Hüttmann, Pieter Dekker, Monic M. M. Tomassen, Teresa Oliviero, Vincenzo Fogliano, Chibuike C. Udenigwe
In vitro gastrointestinal digestion, brush border enzyme activity, and microbial fermentation with Lactiplantibacillus plantarum influenced the peptidome of green lentils and peptide transport across the intestinal Caco-2 cell monolayer.
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Dietary supplementation of pterostilbene, a major component in small berries, prevents alcohol-induced liver injury associated with lipid accumulation and inflammation

Food Funct., 2024, 15,11206-11219
DOI: 10.1039/D4FO03898C, Paper
Jia-Yi Dou, Sai-Hu Liu, Jia Guo, Chen-Yu Wang, Xu Dai, Li-Hua Lian, Zhen-Yu Cui, Ji-Xing Nan, Yan-Ling Wu
Pterostilbene (PTE), a natural stilbene found in small berries, exhibits multiple pharmacological activities, particularly antioxidant and anti-inflammatory activities.
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Regulation of redox enzymes by nutraceuticals: a review of the roles of antioxidant polyphenols and peptides

Food Funct., 2024, 15,10956-10980
DOI: 10.1039/D4FO03549F, Review Article
Joy I. Obeme-Nmom, Raliat O. Abioye, Samanta S. Reyes Flores, Chibuike C. Udenigwe
Several nutraceutical compounds, such as polyphenols and peptides, modulate the enzymatic antioxidant defence system, providing an avenue for the development of multifunctional functional foods.
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Up-regulation of myelin-associated glycoprotein is associated with the ameliorating effect of omega-3 polyunsaturated fatty acids on Alzheimer's disease progression in APP–PS1 transgenic mice

Food Funct., 2024, 15,11236-11251
DOI: 10.1039/D4FO03355H, Paper
Yan Shao, Fei Li, Bo Zou, Yanling Jin, Xiaoyang Wang, Liting Wang, Youying Huang, Yu Xie, Wei Sun, Jing X. Kang, Kai Liu, Yi Huang, Wei Huang, Bin Wang
Our study showed that MAG upregulation might be the new regulatory mechanism for omega-3 PUFAs to exert AD protective effects, which is helpful for expanding our understanding of the health-promoting effects of omega-3 PUFAs.
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Human milk oligosaccharides and milk fat globule membrane reduce allergic reactions in mice through the modulation of gut microbiota and metabolic functions

Food Funct., 2024, 15,11252-11265
DOI: 10.1039/D4FO03851G, Paper
Xinzhang Chen, Shengjun Yang, Zhengtao Guo, Bailiang Li, Zhongjiang Wang, Lianzhou Jiang
Human milk oligosaccharides (HMOs) and the milk fat globule membrane (MFGM) represent novel treatments for cow's milk allergy (CMA).
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Techno-functional, antioxidant, and amino acid characterization of hydrolyzed bioactive peptides from coconut (Cocos nucifera L.) meal protein

Food Funct., 2024, 15,11266-11279
DOI: 10.1039/D4FO02741H, Paper
Roshanak Zolqadri, Zahra Akbarbaglu, Khashayar Sarabandi, Seyed Hadi Peighambardoust, Seid Mahdi Jafari, Amin Mousavi Khaneghah
In this study, the techno-functional characteristics and nutritional value of coconut meal protein (CMP) and the obtained polypeptides by alcalase (H-Alc), trypsin (H-Try), pancreatin (H-Pan), and pepsin (H-pep) were investigated.
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Allergenicity evaluation of an extensively hydrolyzed infant formula based on cow milk protein

Food Funct., 2024, 15,11036-11046
DOI: 10.1039/D4FO03582H, Paper
Hongbo Li, Lin Yang, Jiayi Li, Quan Gao, Tiantian Liu, Yang Zou, Xiaohong Chen, Hongjuan Li, Jinghua Yu
We developed an extensively hydrolyzed infant formula (EHF) with a protein composition similar to breast milk (whey protein-to-casein ratio of 6 : 4) and evaluated its sensitization in vitro and in vivo.
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Effects of vegetarian diets on blood lipids, blood glucose, and blood pressure: a systematic review and meta-analysis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03449J, Review Article
Xin Xia, Jinkai Zhang, Xinfang Wang, Ke Xiong, Zhaobao Pan, Jinyu Wang
Our systematic review and meta-analyses showed that vegetarian diets significantly reduced blood lipids and blood glucose and had null effects on blood pressure.
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Development of Pickering water-in-oil emulsions using a dual stabilization of candelilla wax and acylated EGCG derivatives to enhance the survival of probiotics (Lactobacillus plantarum) powder

Food Funct., 2024, 15,11141-11157
DOI: 10.1039/D4FO01342E, Paper
Zhaojuan Shi, Jun Wu, Xingting Wang, Tongqiao Nie, Qingmei Zeng, Chuanxun Yuan, Risheng Jin
Candelilla wax reinforced the stability of Pickering W/O emulsions with a three-dimensional crystal network. The oil phase volume fraction of the emulsions showed dramatic differences in protecting probiotic viability from environmental stresses.
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Maternal n-3 fatty acid supplementation has an immediate impact on the human milk fatty acid composition

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02548B, Paper
Yannan He, Lin Chen, Miao Miao, Yongmei Dai, Li Qin, Jing Lin, Yumei Qi, Huijuan Xiao, Yajun Qiu, Xiaohong Zhang, Hailan Sun, Jianing Wang, Meng-yan Xu, Ping Tan, Bo Yang, Guiju Sun, Feng Zhao, Duo Li
Fatty acids are essential components in breast milk with mutable characteristics.
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Alleviating effect of whey protein supplementation on oxidative stress in hypothyroidism

Food Funct., 2024, 15,11158-11168
DOI: 10.1039/D4FO03186E, Paper
Ann Liya Sajan, Jenat Pazheparambil Jerom, Bhagyasree Rajasekharan Nair, Devanandana Dileep Kumar Sajitha, Reshma Soman, Ajmal Jalal, Raveendran Harikumaran Nair
Supplementation with whey protein is effective for treating hypothyroidism-associated oxidative stress by enhancing the antioxidant system, reducing lipid peroxidation and maintaining cellular ionic balance.
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Mechanistic insights into EGCG's preventive effects on obesity-induced precocious puberty through multi-omics analyses

Food Funct., 2024, 15,11169-11185
DOI: 10.1039/D4FO03844D, Paper
Qiuyun Gu, Qiujv Du, Lina Xia, Xiaoting Lu, Xiaoqing Wan, Ying Shao, Jieyi He, Peiying Wu
Epigallocatechin gallate (EGCG) has demonstrated potential effects on obesity-induced precocious puberty, but the underlying mechanisms remain unclear.
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Functional yogurt: a comprehensive review of its nutritional composition and health benefits

Food Funct., 2024, 15,10927-10955
DOI: 10.1039/D4FO03671A, Review Article
Sangkaran Pannerchelvan, Leonardo Rios-Solis, Helmi Wasoh, Mohamad Zulfazli Mohd Sobri, Fadzlie Wong Faizal Wong, Mohd Shamzi Mohamed, Rosfarizan Mohamad, Murni Halim
Functional yogurt contains a variety of nutritional components that offer numerous health benefits, with limitations that can potentially be overcome.
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Ellagic acid ameliorates alcohol-induced cognitive and social dysfunction through the gut microbiota-mediated CCL21-CCR7 axis

Food Funct., 2024, 15,11186-11205
DOI: 10.1039/D4FO03985H, Paper
Hongbo Zhang, Min Luo, Yinuo Li, Lu Liu, Ji Bian, Lan Gong, Caian He, Lin Han, Min Wang
EA enhanced the abundance of beneficial bacteria as well as their derived metabolites, thereby inhibiting chronic alcohol-induced neuroinflammation via regulation of the gut microbiota-mediated CCL21-CCR7 axis, ultimately ameliorating AICSD.
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The co-fermentation of whole-grain black barley and quinoa improves murine cognitive impairment induced by a high-fat diet via altering gut microbial ecology and suppressing neuroinflammation

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02704C, Paper
Fenfen Wei, Huibin Jiang, Chuang Zhu, Lingyue Zhong, Zihan Lin, Yan Wu, Lihua Song
A high-fat diet (HFD) is associated with various adverse health outcomes, including cognitive impairment and an elevated risk of neurodegenerative conditions.
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Advances in plant-derived extracellular vesicles: isolation, composition, and biological functions

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04321A, Review Article
Yao-Bo Zeng, Xun Deng, Li-Sha Shen, Yong Yang, Xing Zhou, Lianbao Ye, Sibao Chen, Da-Jian Yang, Guo-Qing Chen
Plant-derived extracellular vesicles (PDEVs) are nanoscale vesicles released from plant cells into the extracellular space.
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In vitro gastrointestinal digestion of marine oil emulsions and liposomal solutions: fate of LC-PUFAs upon lipolysis

Food Funct., 2024, 15,11291-11304
DOI: 10.1039/D4FO03161J, Paper
Open Access
Sawsan Amara, Maureen Gerlei, Carole Jeandel, Moulay Sahaka, Frédéric Carrière, Michel Linder
Marine liposomes are more resistant than triacylglycerol emulsion to lipolysis under gastric condition. They can protect LC-PUFA (EPA and DHA) and are a better gastric-stable delivery system for their intestinal absorption than TAG.
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Association between olive oil consumption and all-cause, cardiovascular and cancer mortality in adult subjects: a systematic review and meta-analysis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO04161E, Paper
Andrea del Saz-Lara, Alicia Saz-Lara, Iván Cavero-Redondo, Carlos Pascual-Morena, Carmen Mazarío-Gárgoles, Francesco Visioli, María-Carmen López de las Hazas, Alberto Dávalos
Fourteen studies were systematically reviewed and seven were included in the meta-analysis. Consumption of OO is associated with a reduction of cardiovascular mortality (16%), all-cause mortality (15%) and cancer mortality (11%) in adult population.
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Human Milk Metals and Metalloids Shape Infant Microbiota

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO01929F, Paper
Open Access
Eduard Flores Ventura, Manuel Bernabeu, Belén Callejón Leblic, Raúl Cabrera-Rubio, Laxmi Yeruva, Javier Estañ-Capell, Cecilia Martínez-Costa, Tamara García-Barrera, Maria Carmen Collado
Background: The profile of metal (loid)s in human milk is essential for infant growth and development, yet its impact on the development of the infant microbiota remains unclear. Elements such...
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Lacticaseibacillus paracasei JM053 alleviates osteoporosis in rats by increasing the content of soy isoflavone aglycones in fermented soymilk

Food Funct., 2024, Accepted Manuscript
DOI: 10.1039/D4FO04381B, Paper
Yaping Zheng, Shasha Cheng, Hongxuan Li, Yilin Sun, Ling Guo, Chaoxin Man, Yu Zhang, Wei Zhang, Yujun Jiang
Lacticaseibacillus paracasei JM053 has a high ability to convert soy isoflavones and can be used as a fermentation strain to ferment soymilk, thereby increasing the content of free aglycones in...
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Ergothioneine improves cognitive function by ameliorating mitochondrial damage and decreasing neuroinflammation in a D-galactose-induced aging model

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02321H, Paper
Fangyang Chen, Botao Wang, Xin Sun, Yage Wang, Ruiyan Wang, Kaikai Li
EGT intervention significantly improved D-galactose induced oxidative stress, neuroinflammation, and mitochondrial function, resulting in the alleviation of memory injury.
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A novel method for exploration and prediction of the bioactive target of rice bran-derived peptide (KF-8) by integrating computational methods and experiments

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO02493A, Paper
Rui Liang, Fangliang Song, Ying Liang, Yanpeng Fang, Jianqiang Wang, Yajuan Chen, Zhongxu Chen, Xiaorong Tan, Jie Dong
The diagram of the strategy to explore peptide targets based on model predictions and experiments.
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Correction: Using integrated transcriptomics and metabolomics to explore the effects of infant formula on the growth and development of small intestinal organoids

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO90094D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Xianli Wang, Yuxin Jing, Chengdong Zheng, Chenxuan Huang, Haiyang Yao, Zimo Guo, Yilun Wu, Zening Wang, Zhengyang Wu, Ruihong Ge, Wei Cheng, Yuanyuan Yan, Shilong Jiang, Jianguo Sun, Jingquan Li, Qinggang Xie, Xiaoguang Li, Hui Wang
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Oral administration of cranberry-derived exosomes attenuates murine premature ovarian failure in association with changes in the specific gut microbiota and diminution in ovarian granulosa cell PANoptosis

Food Funct., 2024, Advance Article
DOI: 10.1039/D4FO03468F, Paper
Open Access
Zeyu Cui, Te Liu, Yichao Wen, Weihao Li, Jianghong Xu, Yingjuan Chen, Danping Chen, Ying Zhu
We confirmed that oral administration of cranberry-derived exosomes attenuated murine POF by modulating the gut microbiota and decreasing ovarian granulosa cell PANoptosis.
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Promote millets for nutritional security

Several studies show that consumption of millets reduce the risk of heart disease and have a positive impact on anaemia apart from controlling blood pressure




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Facing up to the result and realities of Nov 5

A lot of back-room games could unfold after the November elections. The Trump camp is already laying the ground




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Editorial. India needs a stable population, not more children

Southern States’ concerns need to be addressed by the Finance panel




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New Zealand makes history, and how

Notching up a Test series win in India for the first time, the Kiwis were dominant, thanks largely to the contributions of Rachin Ravindra and Mitchell Santner




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Editorial. India needs to focus on being a global AI power

The country’s vast pool of skilled professionals in engineering, data science and software development puts it in a position to become a global AI hub




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Holistic healthcare

Govt has focussed on a citizen-centric approach




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Editorial. BRICS’ financial ambitions cannot be wished away

BRICS countries have expressed the need for developing a platform where central bank digital currencies can be linked. This will reduce intermediation costs




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Editorial. FMCG firms should look within for falling performance

FMCG multinationals seem to be hurt more by sector-specific disruptions that they have failed to foresee, than any economy-wide distress




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Diwali, amidst a choking Delhi

Green crackers are a step in the right solution. But they are not a complete solution




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Editorial. German Chancellor’s visit can boost multi-level engagement

Germany’s overtures to India are significant on various counts — geo-politics, technology sharing, immigration and trade talks




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Editorial. Structural issues leading to DAP shortage need fixing

With the government holding the selling price of DAP at a fraction of production costs, producers depend on subsidies to make ends meet.




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Librarians’ vital role in the world of academics

Their part in fostering knowledge is invaluable




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Pitfalls of Congress playing the caste card

The Congress’ caste politics will only help the BJP, particularly at the national level