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The key entity of a DCAR agonist, phosphatidylinositol mannoside Ac1PIM1: its synthesis and immunomodulatory function

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/C9OB02724F, Communication
Yohei Arai, Shota Torigoe, Takanori Matsumaru, Sho Yamasaki, Yukari Fujimoto
We achieved the first synthesis of phosphatidylinositol mannoside Ac1PIM1, and a very potent agonist of an innate immune receptor DCAR is demonstrated.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of Glycosyl Sulfoximines by a Highly Chemo- and Stereoselective NH- and O-Transfer to Thioglycosides

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00647E, Paper
Arianna Tota, Claudia Carlucci, Luisa Pisano, Giuliano Cutolo, Guy James Clarkson, Giuseppe Romanazzi, Leonardo Degennaro, James A Bull, Patrick Rollin, Renzo Luisi
A synthesis of unprecedented and stable glycosyl sulfoximines is reported. The developed strategies represent the first examples of highly stereoselective sulfoximine formation directly from thioglycosides. X-ray analysis confirmed the structure...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Modular continuous flow synthesis of orthogonally protected 6-deoxy glucose glycals

Org. Biomol. Chem., 2020, 18,3254-3257
DOI: 10.1039/D0OB00522C, Communication
Subbarao Yalamanchili, Tu-Anh V. Nguyen, Nicola L. B. Pohl, Clay S. Bennett
The use of a continuous flow platform for the rapid and highly efficient construction of differentially protected glycals from commercial sources is described.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Base-promoted 1,6-conjugate addition of alkylazaarenes to para-quinone methides

Org. Biomol. Chem., 2020, 18,3354-3359
DOI: 10.1039/D0OB00419G, Paper
Amritha Rayaroth, Rajat Kumar Singh, Kalyanakrishnan A. V., Krishna Hari, Alagiri Kaliyamoorthy
1,1,2-Triarylethanes embedded with an azaarene unit were prepared in a single step at ambient temperature via the sodium hexamethyldisilazide mediated 1,6-conjugate addition of unactivated alkylazaarenes on para-quinone methides (p-QMs).
The content of this RSS Feed (c) The Royal Society of Chemistry




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Modular synthesis of oligoacetylacetones via site-selective silylation of acetylacetone derivatives

Org. Biomol. Chem., 2020, 18,3297-3302
DOI: 10.1039/D0OB00501K, Paper
Parantap Sarkar, Yuya Inaba, Hayato Shirakura, Tomoki Yoneda, Yasuhide Inokuma
Aliphatic oligoketones with tailored carbonyl and substituent sequences were modularly synthesized utilizing site-selective formation of enol silyl ethers. Their unique conformational preferences in solid-state were revealed by X-ray crystallography.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A base-promoted tandem approach to bicyclic 8-membered ring ketones

Org. Biomol. Chem., 2020, 18,3249-3253
DOI: 10.1039/D0OB00618A, Communication
Emerson E. F. dos Santos, Gabriela F. P. de Souza, Deborah A. Simoni, Airton G. Salles
A base-promoted tandem route toward unprecedented bicyclic furan/8-membered ring ketones is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry




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KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones

Org. Biomol. Chem., 2020, 18,3360-3366
DOI: 10.1039/D0OB00494D, Paper
Zhen Yang, Jing He, Yueting Wei, Weiwei Li, Ping Liu
A series of diverse fused [1,2,4]triazolo[3,4-c]quinoxalines was obtained by an efficient KI/TBHP-promoted [3 + 2] cycloaddition of pyrrolo[1,2-a]quinoxalines and N-arylsulfonylhydrazones.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Chemo- and regioselective click reactions through nickel-catalyzed azide–alkyne cycloaddition

Org. Biomol. Chem., 2020, 18,3374-3381
DOI: 10.1039/D0OB00579G, Paper
Woo Gyum Kim, Seung-yeol Baek, Seo Yeong Jeong, Dongsik Nam, Ji Hwan Jeon, Wonyoung Choe, Mu-Hyun Baik, Sung You Hong
Nickel-catalyzed [3 + 2] cycloaddition reactions of unsymmetrical alkynes and organic azides afford substituted 1,2,3-triazoles with high levels of chemo- and regioselectivity.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Chiral bifunctional sulfide-catalyzed asymmetric bromoaminocyclizations

Org. Biomol. Chem., 2020, 18,3367-3373
DOI: 10.1039/D0OB00459F, Paper
Takumi Nakamura, Ken Okuno, Kazuma Kaneko, Masahiro Yamanaka, Seiji Shirakawa
A chiral bifunctional sulfide catalyst bearing a urea moiety promotes the enantioselective bromoaminocyclization of 2-allylanilines to produce optically active 2-substituted indolines.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Controlling the liberation rate of the in situ release of a chemical fuel for the operationally autonomous motions of molecular machines

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00669F, Paper
Chiara Biagini, Giorgio Capocasa, Daniele Del Giudice, Valerio Cataldi, Luigi Mandolini, Stefano Di Stefano
Aminolysis of the anhydride of 2-cyano-2-phenylpropanoic acid can be employed to conveniently regulate the liberation rate of the related acid which, in turn, can be used as a fuel for acid–base operated molecular machines.
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A Selectfluor-promoted oxidative reaction of disulfides and amines: access to sulfinamides

Org. Biomol. Chem., 2020, Advance Article
DOI: 10.1039/D0OB00720J, Paper
Haibo Mei, Jiang Liu, Romana Pajkert, Gerd-Volker Röschenthaler, Jianlin Han
An unprecedented metal-free oxidative reaction of disulfides and amines with Selectfluor as a mild oxidant under aerobic conditions was developed.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Highly modified steroids from Inonotus obliquus

Org. Biomol. Chem., 2020, Accepted Manuscript
DOI: 10.1039/D0OB00474J, Paper
Chun-Xin Zou, Zilin Hou, Ming Bai, Rui Guo, Bin Lin, Xiaobo Wang, Xiaoxiao Huang, Shaojiang Song
Six undescribed steroids were isolated from the fungus Inonotus obliquus. Notably, compounds 1 and 2 represented the first example of 8, 14-seco-4-methylpregnane. By spectroscopic data analyses, quantum chemical calculations and...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Man arrested for molesting Finnish woman in Jaipur

A person has been arrested in Jaipur for allegedly robbing and molesting a Finnish woman at a bar cum restaurant, police said.




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Urban Ministry questions Delhi govt's move to set up SEZs

The Centre has questioned the legality of SEZs in absence of any provision for the same in the Master Plan Delhi (MPD) 2021.




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Aspiring actor-cum-model arrested for killing IT professional

A 20-year-old aspiring actor- cum-model was arrested in the national capital for allegedly murdering a young woman IT professional a week ago after she refused to heed to his demand for money.




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Cos use foreign money for political funding. Isn’t that influencing polls?

A recent Intelligence Bureau (IB) report has claimed that some well-known NGOs are working to stall economic development at the behest of their foreign donors. Activists and rights groups have been up in arms ever since the report was leaked.




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Women suffer sanitation absence most — also impacts economy: Bindeshwar Pathak

One month after the horrific Badaun gang rape exposed how gravely at risk women and minors lacking domestic toilets are.




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India needn't follow West's energy model — have a new path: ​Sam Tranum

There's a fundamental mismatch between India's energy resources and the needs of its people and companies for energy.




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Swiss accounts are a diversion. Bulk of black money is right here in India

The scent of 'black money' is in the air again. At the Supreme Court's order, Modi sarkar has set up a Special Investigation Team to look into cases of illegal outflow of money to foreign havens.




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Hindu guru convicted of molesting girls in US

An octogenarian Hindu religious leader, head of a Hindu ashram, one of the largest temples in the US, has been convicted of molesting two young girls.




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Hindu guru gets 14 years prison for sexual molestation in US

Absconding Indian godman Prakashanand Saraswati, also known as Shree Swamiji, has been sentenced to 14 years in prison and fined USD 10,000.




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Indian-origin model accuses Aus modelling agency of racism

According to a report in the local daily, Kema Rajandran was told by a Parth-based modelling agency that her work chances were "limited" in the country because she was not Caucasian.




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Indians in Singapore produce movie

A group of Indian professionals in Singapore has produced a film, 'Mausams', which captures the tensed personal moments and challenges of working a city.




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Lucknow zoo animals are more active in lockdown




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Two more areas turn hotspots after 3 test +ve




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Delhi Covid-19 cases mount to 6,318; toll 68

The total number of coronavirus cases in the national capital climbed to 6,318, with 338 new cases and two fresh deaths being reported on Friday, according to the Delhi government authorities.




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Woman kills self at AIIMS after her mother dies

A 23-year-old woman allegedly committed suicide at the AIIMS here after her mother died of cancer at the hospital, police said on Saturday. She was reported missing after her mother passed away on Wednesday and her body was found near the new private ward block of the hospital on Saturday, they said, adding that she fell to her death from a building.




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3 more Delhi pvt hosps to treat corona patients




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Motorola Edge, Motorola Edge+ launched: Here are the specifications, price, availability

Motorola is back in the flagship game with premium Edge series.




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USGS releases first comprehensive geological map of moon using Apollo data

The new map explains the 4.5-billion-year-old history of our neighbour in space.




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NASA's Hubble captures breakup of comet ATLAS into more than two dozen pieces

Hubble identified about 30 fragments on April 20, and 25 pieces on April 23.




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PUBG Mobile India Series 2020: Prize money, date of tournament and registration details

The tournament has a Rs 50 lakh prize pool.




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The BEST MOMENTS of Aahana Kumra's Life

"From a very early age, I imagined myself playing powerful characters," she says, and she proves it with her filmography.





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'I don't do films that just want to make money'

Nithya Menen's fiery interview.




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'Fatherhood makes you more vulnerable'

'I have been dropped from films, I have been replaced after workshops. I did not play cricket for India. If I have to sit and think who Angad Bedi is, the end of that thought is that I am human. Life has taught me a lot.'






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Meet Moosa from The Family Man

'Raj and DK have taken the effort to look at Moosa as a person.''Like, what happened to him?''What made him become a terrorist?''The emotional trauma that he might have had... that clicked for me.'




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'Self-love is the most important thing'

'You can be fat, you can be thin, you can be fair, or not, you are whatever you are.''It is about being happy about yourself.'




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'Most of my films are ahead of their time'

'Everyone thought I was a good-looking boy with chocolate hero looks, and was offered such roles only. I was so depressed when people said that a singer's son cannot be an actor; that he should be a singer. I needed a film to showcase my talent.'




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Why Stree/Bala director makes movies in a jiffy

'I am making movies in a jiffy because I want to work with everyone.'




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'I was lucky to meet Karan Johar; most people don't'

'Access is such a big step.''But once you enter those rooms, it's up to what you do in those rooms.''Film-making is a very expensive business and they will not put money into people they don't believe in.''So talent speaks at the end of the day.'





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'Tiger does action as if it is poetry in motion'

'I think Baaghi 3 is the biggest action film that we have witnessed in recent times.'




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Ranveer's mom to spy: Amruta Subhash's amazing journey

'After Gully Boy, many interesting projects started coming my way.''But things really changed with the Filmfare. Now, people notice me.''It's a good space, where you don't have to tell people who you are.'





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[ASAP] Modifying the Electrocatalyst–Ionomer Interface via Sulfonated Poly(ionic liquid) Block Copolymers to Enable High-Performance Polymer Electrolyte Fuel Cells

ACS Energy Letters
DOI: 10.1021/acsenergylett.0c00532




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[ASAP] Detecting the Onset of Lithium Plating and Monitoring Fast Charging Performance with Voltage Relaxation

ACS Energy Letters
DOI: 10.1021/acsenergylett.0c00831




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Blog: If Modi loses in 2019, we’re back to old, unsettled politics