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Coumarin–azasugar–benzyl conjugates as non-neurotoxic dual inhibitors of butyrylcholinesterase and cancer cell growth

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00312H, Paper
I. Caroline Vaaland Holmgard, Aday González-Bakker, Eleonora Poeta, Adrián Puerta, Miguel X. Fernandes, Barbara Monti, José G. Fernández-Bolaños, José M. Padrón, Óscar López, Emil Lindbäck
Coumarin–azasugar–benzyl conjugates were obtained through the CuAAC reaction, displaying dual anti-Alzheimer and anti-cancer activity in vitro and no neurotoxicity.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Unusual immunosuppressive pyridine-containing bisnor- (c23), tetranor- (c21) and pentanor- (c20) sesterterpenoids from Tibetan Leucosceptrum canum

Org. Biomol. Chem., 2024, 22,3019-3024
DOI: 10.1039/D4OB00334A, Paper
Man Li, Ling Feng, Han Zhang, Yan-Chun Liu, Ting-Ting Zhou, Yu Zheng, Kai Guo, Yan Liu, Sheng-Hong Li
Six unusual pyridine-containing bisnor- (C23), tetranor- (C21) and pentanor- (C20) sesterterpenoids were obtained from the medicinal plant Leucosceptrum canum of Tibetan origin. The immunosuppressive activities of these sesterterpenoids were observed.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Robust flight plans can keep airlines afloat




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Air India’s roadmap can be tricky to pull off

The airline has to work hard to drastically grow its network and fleet while improving reliability as well




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Zomato users can now schedule order 2 days in advance

Zomato’s order scheduling is available at more than 35,000 restaurants across 30 cities




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For type 2 diabetes, focusing on when you eat – not what – can help control blood sugar

Time-restricted eating, also known as the 16:8 diet, became popular for weight loss around 2015. Studies have since shown it is also an effective way for people with type 2 diabetes to manage blood glucose




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What is stereotactic radiation therapy for prostate cancer? How does it compare to other treatments?

Stereotactic radiotherapy uses high doses of radiation to target and kill cancer cells; it uses newer machines that can deliver very focused radiation beams




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Ayushman Bharat: All seniors above 70 can avail health coverage except those in Delhi, West Bengal

Senior citizens eligible for PM-JAY regardless of income; Ayushman Vaya Vandana card will help cut out-of-pocket health spends; on Ayurveda Day, PM launches initiatives to validate traditional herbal medicine, promote Indian medical systems




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National Pharmaceutical Pricing Authority directs firms to cut prices of three anti-cancer drugs

Govt. had earlier scrapped customs duty on Trastuzumab, Osimertinib and Durvalumab and also reduced GST rates on them




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As breast cancer incidence rises, doctors raise importance of early detection, need for women to be breast aware

Chennai accounts for highest crude incidence rate of breast cancer in T.N., data shows; a number of factors have led to this, say doctors




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What is breast density and how is it associated with cancer? Explained

Breast density matters because of two main reasons: it may make it harder to detect signs of cancer on a mammogram, and it is linked with an increased risk of breast cancer




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Glioblastoma: why immunotherapy may offer hope for brain cancer patients

Recent trials have shown that immunotherapy can safely be delivered through injections into the cerebrospinal fluid; scientists are now exploring how to adapt these methods to penetrate the tumour more effectively




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Osteoporosis can shorten your life − here’s how to prevent fractures and keep bones healthy

The key to having healthy bones for a lifetime is to take some simple preventive measures – and the earlier, the better




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Can mid-level healthcare providers compensate for physician shortages in rural India?

To make up for doctor shortages, several countries around the world have introduced a cadre of MLHPs into their health systems; however, in India, mainstreaming of MLHPs has time and again been met with resistance from organised medicine 




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What's This American Doing In Bollywood?

'In India, I'm able to work with the biggest stars on creating a scene, creating that emotion, without being too hung up on their persona.'




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'I can feel Irrfan's presence'

'My respect for Irrfan has grown 100 times now when he is no longer with us.'




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'You Can Be Ice Cold Evil'

'You don't have to be screaming and making faces to be evil.'




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An Indian Film Makes Waves At Cannes

'I have nostalgia for Ladakhi culture, which is common to both Muslims and Buddhists.''It is kind of a Buddhist way of life. You are compassionate and nice to each other.''You are good human beings.'




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'Can't Say Bigg Boss Promoting Polygamy'

'Ranvir will run out of steam pretty soon.''The way he is reacting or rather, overreacting to things, I am sure he will be exhausted soon.''You need to chill at times to play a game like Bigg Boss.'





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'How Can You Body-Shame Someone For Fun?'

'If a senior person like Ranvir Shorey, who has worked in the industry for so many years, cannot take a stand for me, what should I expect from the others?'




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'The Audience Can't Be Tricked'

'In the audience's mind there is no urgency to go see a film in the theatre.''If you pay for social media buzz it does not convert into bums on seats.'




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'Nothing Can Keep Akshay Down'

'Mohanlal and Akshay are two actors who trust me implicitly.'





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How can AI, ML skills help sharpen problem-solving abilities in children?

As the world is rapidly moving towards the evolving digital space, skills like problem-solving have become more important than ever. The entire market size of AI is projected to grow from USD 214.6 billion in 2024 to 1,339.1 billion in 2030 with a CAGR of 35.7%. In Today's scenario, skills like problem-solving are not just limited to professionals, it becomes crucial to teach kids how to think critically and creatively to steer through the complexities of modern life. This not only sharpens their abilities but also boosts innovation and helps develop young minds to use tools needed to solve real-world problems.




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What artistes can do to save the planet

‘Detritus’, a multiform performance, highlights the urgent need to switch to sustainable art practices




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Apprenticeships can make India’s youth matter

With a target of skilling 500 million people by 2022, apprenticeship will be the key to increasing the employability of youth




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Selecting the right candidate

Building a team or an institution requires both courtesy and common sense




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‘Before you can create, you must forget’

Unlearning is an indispensable part of innovation-led growth, says best-selling author Vijay Govindarajan




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Campco releases Ayush and Poushtik manures under its brand for arecanut farmers

The multi-state cooperative has so far earned Rs. 22 crore profit from April during the current financial year




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‘MSP guarantee can nudge farmers to diversify beyond paddy and wheat, bolster incomes and consumption’




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Centre increases Fair and Remunerative Price of sugarcane; will be in force from October 1

Minister Anurag Thakur says the decision will benefit 5 crore farmers, including family members, and lakhs of other persons involved in the sugar sector




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India’s rising water stress can dent its sovereign credit profile: Moody’s Ratings

The country is among those most vulnerable to water management risks, and has the poorest access to basic services, including water, among G-20 economies, the rating major flagged




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Can the migrants who make it convince others not to risk it?

How Senegal is trying to involve the diaspora to curb emigration. By Sofia Christensen




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The great American outdoors

A trek through one of the more memorable national parks of the US




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Helsinki: The Scandinavian design capital

If you love great design and architecture, Finland’s capital is right up your alley




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Lamborghini Huracan Evo: A car that speaks to you

The 2020 Lamborghini Huracan Evo is a smart car that really gets to know your driving style




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Improving education policy together [electronic resource] : how it's made, implemented, and can be done better / Nansi Ellis and Gareth Conyard.

Abingdon, Oxon ; New York, NY : Routledge , 2024.




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Journal of Southeast Asian American education & advancement [electronic resource] : JSAAEA

Dorchester, Mass. : National Association for the Education and Advancement of Cambodian, Laotian, and Vietnamese Americans




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In Frames | India at Cannes 2023

India made its presence felt at the 76th Cannes Festival through four movie screenings, accompanied by Indian celebrities, social media influencers, and even entrepreneurs representing the country




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Watch | Directors’ Take: How director Sashi Kiran Tikka approached ‘Goodachari’ and ‘Major’ like an American indie

Sashi Kiran Tikka, director of ‘Goodachari’ and ‘Major’, looks back at the indie approach to filmmaking, collaborative work atmosphere and his days at the New York Film Academy




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The worst accident in the world : Chernobyl, the end of the nuclear dream / Nigel Hawkes [and others] ; illustrations by Duncan Mil.

London : Pan Books Ltd : William Heinemann Ltd, 1986.




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Mark Twain and the American West / Joseph L. Coulombe.

Columbia : University of Missouri Press, c2003.




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La guerra dei vulcani (2012) / directed by Francesco Patierno [DVD].

[Rome] : Luce Cinecittà, [2012]




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Reservation reelism : redfacing, visual sovereignty, and representations of Native Americans in film / Michelle H. Raheja.

Lincoln : University of Nebraska Press, [2010]




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La fuerza del destino : la historia de Iván y Lucía (2011) / created by María Zarattini ; written by Claudia Velazco, María Zarattini ; directed by Benjamín Cann, José Ángel García [DVD].

Universal City, CA : Vivendi Entertainment, [2011]




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Sir Henry Raeburn, 1756-1823 / by Duncan Thomson.

[Edinburgh] : National Galleries of Scotland, [1994]




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The land carries our ancestors : contemporary art by Native Americans / Jaune Quick-to-See Smith ; Joy Harjo, heather ahtone, Shana Bushyhead Condill.

Washington, DC : National Gallery of Art ; Princeton ; Oxford : In association with Princeton University Press, [2023]




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Surrealism and us : Caribbean and African diasporic artists since 1940 / edited by María Elena Ortiz ; with contributions by María Elena Ortiz, Annette K. Joseph-Gabriel, Negarra A. Kudumu, Lindsey Reynolds, and Ashley Stull Meyers.

Fort Worth, TX : Modern Art Museum of Fort Worth ; New York, NY : DelMonico Books, [2024]




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Psychocandy / Paula Mejia.

New York : Bloomsbury, Bloomsbury Academic, An Imprint of Bloomsbury Publishing Plc, 2016.