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Lebanon media claims Israeli strike hit apartment south of Beirut

Israeli warplanes launched a strike at dawn targeting a residential apartment in a building in the Dawhet




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Chemical synthetic approaches to mimic the TRAIL: promising cancer therapeutics

RSC Med. Chem., 2024, 15,3639-3651
DOI: 10.1039/D4MD00183D, Review Article
Abdullah-Al Masum, Shin Aoki, Md. Mahbubur Rahman, Yosuke Hisamatsu
TRAIL induced apoptosis signalling by death receptors (DR4/DR5).
The content of this RSS Feed (c) The Royal Society of Chemistry




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In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP

RSC Med. Chem., 2024, 15,3674-3694
DOI: 10.1039/D4MD00580E, Research Article
Jinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin Jin
Oridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.
The content of this RSS Feed (c) The Royal Society of Chemistry




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New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation

RSC Med. Chem., 2024, 15,3759-3777
DOI: 10.1039/D4MD00498A, Research Article
Lucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. Enriz
A diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction

RSC Med. Chem., 2024, 15,3652-3673
DOI: 10.1039/D4MD00425F, Review Article
Semim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra Borah
Metabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway

RSC Med. Chem., 2024, 15,3817-3836
DOI: 10.1039/D4MD00477A, Research Article
Maha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa Matboli
ZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy

RSC Med. Chem., 2024, 15,3912-3912
DOI: 10.1039/D4MD90040E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex Joseph
The content of this RSS Feed (c) The Royal Society of Chemistry




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T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers

It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students




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Delhi AQI drops to 361 in ‘very poor’ category as smog engulfs national capital

Delhi recorded its first dense fog of the season on Wednesday as visibility dropped to 0 metres at 8 a.m.




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All set for Urus festival at Pedda Dargah in Kadapa

Thousands of devotees from across Andhra Pradesh, Tamil Nadu, Karnataka and Maharashtra expected to converge at the famous Sufi shrine for the week-long event starting on November 16




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117 applications received at Kuppam’s first ‘Praja Darbar’




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Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam




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Peddapalli goods train derailment: Several trains cancelled or diverted

Three railway lines were affected in the derailment. Some trains skipped stoppages.




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Karnataka bypolls: Channapatna, Shiggaon and Sandur constituencies witness overall turnout of 76.9% till 5 p.m.

A total of 45 candidates are in the fray in these byelections




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Death of woman after delivery at private hospital in Dharmapuri sparks row; RDO holds inquiry




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Sindhu movers to pre-quarters, Lakshya bows out of Kumamoto Masters Japan




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Migrants return to Channapatna in droves to cast their vote

Many voters across the constituency spoke freely about ‘high amounts’ paid by two parties both sides, besides transport charges, in this intensely fought electoral battle




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Congress demands white paper on government recruitments in Goa since 2019

The Congress attack came a day after a woman member of BJP’s mahila morcha was arrested in connection with the jobs scam




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Village Administrative Officer arrested in DVAC trap in Tiruppur




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Tambaram Corporation begins population survey and area mapping for improved coverage of UPHCs




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Photographer from Gaza Strip among winners at top photography award in UAE

The Hamdan bin Mohammed bin Rashid Al Maktoum International Photography Award (HIPA) is the richest photography competition in the world.




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No roadmap yet for better traffic signage system in Kozhikode city

Emergency signboards and lane markings near roundabouts have not yet been introduced to streamline the traffic management




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64.98% cast votes in Malappuram in Wayanad bypoll

While Eranad and Wandoor registered 69.42% and 64.43% polling respectively, voting percentage in Nilambur stood at 61.91%




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U-shaped flyover on IT corridor nearing completion




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L-G approves proposal to deploy former bus marshals on anti-pollution duties




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BJP councillor nominated presiding officer for mayoral polls, AAP raises objections

Mayoral elections today; ruling party says L-G should have considered either incumbent Mayor or most senior councillor for role to ensure fairness; AAP in habit of casting aspersions, says BJP




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Trump taps former Democrat Tulsi Gabbard as US intel chief; Senator Marco Rubio as Secretary of State

Tulsi Gabbard demanded U.S. military withdrawal from Iraq and Syria during her 2020 Presidential run; Marco Rubio would be the first Hispanic as the top U.S. diplomat




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Karnataka rolls out APAAR ID for schoolchildren

Critics questioned the need for a new ID, given that students in the State are already assigned Student Achievement Tracking System IDs




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Action initiated against apartment for connecting sanitary line to Cauvery pipeline




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If 23andMe goes bust, what happens to its DNA database?

Millions of people have used 23andMe’s simple genetic testing service, which involves ordering a saliva test, spitting into a tube, and sending it back to the company for a detailed DNA analysis




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Visakhapatnam-Gunupur express to be cancelled on some days from November 13 owing to traffic blocks

The cancellation is owing to traffic blocks in the Naupada-Gunupur section of Waltair Division




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Sri Kanaka Mahalakshmi temple hundi collection crosses ₹39 lakh in 63 days in Visakhapatnam




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Centre approves widening of Rajahmundry-Anakapalli and Rayachoti-Kadapa national highways to six lanes, says MP




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Waltair Divisional Railway Manager inspects Koraput-Jagdalpur section




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10 hostel students hospitalised after falling sick in Visakhapatnam district




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There is an urgent need to build metro rail project in Visakhapatnam, say local MLAs in the State Assembly

People have been facing severe traffic problems in the and there is a need for rapid transport system like metro rail, says Gajuwaka MLA




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Ganababu, Chiranjeevi Rao appointed Whips in Legislative Assembly and Council respectively




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Complete laying of roads and repair works in Zone II, GVMC Commissioner directs officials in Visakhapatnam




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Continuous rendition of Guru Granth Sahib till November 15 in Visakhapatnam




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VSEA expresses concern over iron ore supply to VSP due to proposed ArcelorMittal & Nippon Steel plant in Anakapalli

We have appealed to the governments to take a note of RINL’s iron ore issue before finalising anything on Mittal’s steel plant in Anakapalli, says association general secretary




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Water level in Papanasam dam stands at 85.60 feet




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Water level in Mullaperiyar dam stands at 123.95 feet




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NTPC Green Energy to incur ₹1 lakh crore capex over next 3 years

NTPC Green currently has a portfolio of 16,896 MW, of which 3320 MW are operational and 13,576 MW are contracted and awarded, with an additional pipeline of 9.2 GW




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Green Frontier Capital launches ₹1,500 cr fund for climate tech start-ups

The fund will focus on accelerating India’s low-carbon transition through investments in transformative climate technologies




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AptarGroup expands manufacturing footprint in India

The facility will help the company meet the growing demands of the domestic pharmaceutical industry




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How are Indian investors shaping the real estate boom at Expo City Dubai?

Indian investors are among the top three buyers of residential and commercial real estate in Expo City, says Ahmed Al Khatib, Chief Development and Delivery Officer Expo City Dubai.




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Today’s top tech news: Elon Musk to co-lead government department; Apple’s new AI wall tablet; Netflix grows on ad-supported tier




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Ramco Systems maintains leadership position in APAC payroll solutions 

Ramco Systems’ recently launched Payce platform was noted for its technology-first approach and ability to minimise manual intervention in payroll processing




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Taapsee Would Like A Rose, Har Roz!

Taapsee Pannu's off-screen style too reflects her eye for detail, making her a fashionista worth following.




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Meet richest family of Bollywood, once sold fruits, has net worth of Rs 10000 crore, not Kapoors, Khans, it is...

Meet rihest family of Bollywood surpassing the net worth of the Khans, Kapoor,