ap Lebanon media claims Israeli strike hit apartment south of Beirut By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:10:43 +0530 Israeli warplanes launched a strike at dawn targeting a residential apartment in a building in the Dawhet Full Article World
ap Chemical synthetic approaches to mimic the TRAIL: promising cancer therapeutics By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3639-3651DOI: 10.1039/D4MD00183D, Review ArticleAbdullah-Al Masum, Shin Aoki, Md. Mahbubur Rahman, Yosuke HisamatsuTRAIL induced apoptosis signalling by death receptors (DR4/DR5).The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ap In vitro identification of oridonin hybrids as potential anti-TNBC agents inducing cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3674-3694DOI: 10.1039/D4MD00580E, Research ArticleJinhua Ning, Nini Zhan, Zhanpan Wu, Yuzhe Li, Die Zhang, Yadian Shi, Yingxun Zhou, Chuan-Huizi Chen, Wenbin JinOridonin analogue 11a showed significant antitumor efficacy in vitro via cell cycle arrest and apoptosis by regulation of p21, γH2AX and cleaved PARP accumulation, meanwhile, displayed much more stable than oridonin in human plasma.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ap New ATP-competitive inhibitors of E. coli GyrB obtained from the mapping of the hydrophobic floor at the binding site: synthesis and biological evaluation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3759-3777DOI: 10.1039/D4MD00498A, Research ArticleLucas Gutierrez, Peter Peršolja, Rodrigo Tosso, Nace Zidar, Danijel Kikelj, Ricardo D. EnrizA diagram of the active site of E. coli gyrase B, highlighting the hydrophobic subsite, including key residues relevant to ligand binding.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ap Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3652-3673DOI: 10.1039/D4MD00425F, Review ArticleSemim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra BorahMetabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ap Evaluating the therapeutic potential of genetically engineered probiotic Zbiotics (ZB183) for non-alcoholic steatohepatitis (NASH) management via modulation of the cGAS-STING pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3817-3836DOI: 10.1039/D4MD00477A, Research ArticleMaha Saad, Walaa Ibrahim, Amany Helmy Hasanin, Aya Magdy Elyamany, Marwa MatboliZBiotics administration in the NASH model downregulated the RNA panel (MAPK3, EDN1, TNF, miR-6888-5p, lncRNA RABGAP1L-DT-206), restored intestinal barrier integrity, reduced hepatic inflammation, and improved lipid profiles and liver enzymes.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ap Correction: computational design, synthesis, and assessment of 3-(4-(4-(1,3,4-oxadiazol-2-yl)-1H-imidazol-2-yl)phenyl)-1,2,4-oxadiazole derivatives as effective epidermal growth factor receptor inhibitors: a prospective strategy for anticancer therapy By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3912-3912DOI: 10.1039/D4MD90040E, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Nilesh Raghunath Khedkar, Milind Sindkhedkar, Alex JosephThe content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ap T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:15:58 +0530 It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students Full Article Tamil Nadu
ap Delhi AQI drops to 361 in ‘very poor’ category as smog engulfs national capital By www.thehindu.com Published On :: Wed, 13 Nov 2024 09:14:04 +0530 Delhi recorded its first dense fog of the season on Wednesday as visibility dropped to 0 metres at 8 a.m. Full Article Delhi
ap All set for Urus festival at Pedda Dargah in Kadapa By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:44:11 +0530 Thousands of devotees from across Andhra Pradesh, Tamil Nadu, Karnataka and Maharashtra expected to converge at the famous Sufi shrine for the week-long event starting on November 16 Full Article Andhra Pradesh
ap 117 applications received at Kuppam’s first ‘Praja Darbar’ By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:37:24 +0530 Full Article Andhra Pradesh
ap Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:28:31 +0530 Full Article Andhra Pradesh
ap Peddapalli goods train derailment: Several trains cancelled or diverted By www.thehindu.com Published On :: Wed, 13 Nov 2024 13:43:36 +0530 Three railway lines were affected in the derailment. Some trains skipped stoppages. Full Article Telangana
ap Karnataka bypolls: Channapatna, Shiggaon and Sandur constituencies witness overall turnout of 76.9% till 5 p.m. By www.thehindu.com Published On :: Wed, 13 Nov 2024 10:37:35 +0530 A total of 45 candidates are in the fray in these byelections Full Article Karnataka
ap Death of woman after delivery at private hospital in Dharmapuri sparks row; RDO holds inquiry By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:12:49 +0530 Full Article Coimbatore
ap Sindhu movers to pre-quarters, Lakshya bows out of Kumamoto Masters Japan By www.thehindu.com Published On :: Thu, 14 Nov 2024 06:10:19 +0530 Full Article Sport
ap Migrants return to Channapatna in droves to cast their vote By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:05:41 +0530 Many voters across the constituency spoke freely about ‘high amounts’ paid by two parties both sides, besides transport charges, in this intensely fought electoral battle Full Article Karnataka
ap Congress demands white paper on government recruitments in Goa since 2019 By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:39:40 +0530 The Congress attack came a day after a woman member of BJP’s mahila morcha was arrested in connection with the jobs scam Full Article India
ap Village Administrative Officer arrested in DVAC trap in Tiruppur By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:56:15 +0530 Full Article Coimbatore
ap Tambaram Corporation begins population survey and area mapping for improved coverage of UPHCs By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:18:44 +0530 Full Article Chennai
ap Photographer from Gaza Strip among winners at top photography award in UAE By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:19:09 +0530 The Hamdan bin Mohammed bin Rashid Al Maktoum International Photography Award (HIPA) is the richest photography competition in the world. Full Article World
ap No roadmap yet for better traffic signage system in Kozhikode city By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:33:12 +0530 Emergency signboards and lane markings near roundabouts have not yet been introduced to streamline the traffic management Full Article Kerala
ap 64.98% cast votes in Malappuram in Wayanad bypoll By www.thehindu.com Published On :: Wed, 13 Nov 2024 23:39:14 +0530 While Eranad and Wandoor registered 69.42% and 64.43% polling respectively, voting percentage in Nilambur stood at 61.91% Full Article Kerala
ap U-shaped flyover on IT corridor nearing completion By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:01:19 +0530 Full Article Tamil Nadu
ap L-G approves proposal to deploy former bus marshals on anti-pollution duties By www.thehindu.com Published On :: Thu, 14 Nov 2024 01:08:11 +0530 Full Article Delhi
ap BJP councillor nominated presiding officer for mayoral polls, AAP raises objections By www.thehindu.com Published On :: Thu, 14 Nov 2024 01:08:46 +0530 Mayoral elections today; ruling party says L-G should have considered either incumbent Mayor or most senior councillor for role to ensure fairness; AAP in habit of casting aspersions, says BJP Full Article Delhi
ap Trump taps former Democrat Tulsi Gabbard as US intel chief; Senator Marco Rubio as Secretary of State By www.thehindu.com Published On :: Thu, 14 Nov 2024 03:23:10 +0530 Tulsi Gabbard demanded U.S. military withdrawal from Iraq and Syria during her 2020 Presidential run; Marco Rubio would be the first Hispanic as the top U.S. diplomat Full Article World
ap Karnataka rolls out APAAR ID for schoolchildren By www.thehindu.com Published On :: Thu, 14 Nov 2024 06:20:00 +0530 Critics questioned the need for a new ID, given that students in the State are already assigned Student Achievement Tracking System IDs Full Article Karnataka
ap Action initiated against apartment for connecting sanitary line to Cauvery pipeline By www.thehindu.com Published On :: Thu, 14 Nov 2024 06:35:00 +0530 Full Article Bengaluru
ap If 23andMe goes bust, what happens to its DNA database? By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:54:51 +0530 Millions of people have used 23andMe’s simple genetic testing service, which involves ordering a saliva test, spitting into a tube, and sending it back to the company for a detailed DNA analysis Full Article Science
ap Visakhapatnam-Gunupur express to be cancelled on some days from November 13 owing to traffic blocks By www.thehindu.com Published On :: Wed, 13 Nov 2024 15:53:57 +0530 The cancellation is owing to traffic blocks in the Naupada-Gunupur section of Waltair Division Full Article Visakhapatnam
ap Sri Kanaka Mahalakshmi temple hundi collection crosses ₹39 lakh in 63 days in Visakhapatnam By www.thehindu.com Published On :: Wed, 13 Nov 2024 18:35:50 +0530 Full Article Visakhapatnam
ap Centre approves widening of Rajahmundry-Anakapalli and Rayachoti-Kadapa national highways to six lanes, says MP By www.thehindu.com Published On :: Wed, 13 Nov 2024 19:40:27 +0530 Full Article Visakhapatnam
ap Waltair Divisional Railway Manager inspects Koraput-Jagdalpur section By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:10:15 +0530 Full Article Visakhapatnam
ap 10 hostel students hospitalised after falling sick in Visakhapatnam district By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:28:02 +0530 Full Article Visakhapatnam
ap There is an urgent need to build metro rail project in Visakhapatnam, say local MLAs in the State Assembly By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:53:57 +0530 People have been facing severe traffic problems in the and there is a need for rapid transport system like metro rail, says Gajuwaka MLA Full Article Visakhapatnam
ap Ganababu, Chiranjeevi Rao appointed Whips in Legislative Assembly and Council respectively By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:08:49 +0530 Full Article Visakhapatnam
ap Complete laying of roads and repair works in Zone II, GVMC Commissioner directs officials in Visakhapatnam By www.thehindu.com Published On :: Wed, 13 Nov 2024 21:38:50 +0530 Full Article Visakhapatnam
ap Continuous rendition of Guru Granth Sahib till November 15 in Visakhapatnam By www.thehindu.com Published On :: Wed, 13 Nov 2024 22:29:06 +0530 Full Article Visakhapatnam
ap VSEA expresses concern over iron ore supply to VSP due to proposed ArcelorMittal & Nippon Steel plant in Anakapalli By www.thehindu.com Published On :: Thu, 14 Nov 2024 00:51:25 +0530 We have appealed to the governments to take a note of RINL’s iron ore issue before finalising anything on Mittal’s steel plant in Anakapalli, says association general secretary Full Article Visakhapatnam
ap Water level in Papanasam dam stands at 85.60 feet By www.thehindu.com Published On :: Wed, 13 Nov 2024 17:41:46 +0530 Full Article Madurai
ap Water level in Mullaperiyar dam stands at 123.95 feet By www.thehindu.com Published On :: Wed, 13 Nov 2024 20:20:34 +0530 Full Article Madurai
ap NTPC Green Energy to incur ₹1 lakh crore capex over next 3 years By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 16:54:13 +0530 NTPC Green currently has a portfolio of 16,896 MW, of which 3320 MW are operational and 13,576 MW are contracted and awarded, with an additional pipeline of 9.2 GW Full Article Companies
ap Green Frontier Capital launches ₹1,500 cr fund for climate tech start-ups By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 20:18:58 +0530 The fund will focus on accelerating India’s low-carbon transition through investments in transformative climate technologies Full Article Companies
ap AptarGroup expands manufacturing footprint in India By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 20:57:14 +0530 The facility will help the company meet the growing demands of the domestic pharmaceutical industry Full Article Companies
ap How are Indian investors shaping the real estate boom at Expo City Dubai? By www.thehindubusinessline.com Published On :: Thu, 14 Nov 2024 06:00:00 +0530 Indian investors are among the top three buyers of residential and commercial real estate in Expo City, says Ahmed Al Khatib, Chief Development and Delivery Officer Expo City Dubai. Full Article Podcast
ap Today’s top tech news: Elon Musk to co-lead government department; Apple’s new AI wall tablet; Netflix grows on ad-supported tier By www.thehindu.com Published On :: Wed, 13 Nov 2024 11:08:56 +0530 Full Article Technology
ap Ramco Systems maintains leadership position in APAC payroll solutions By www.thehindubusinessline.com Published On :: Wed, 13 Nov 2024 12:26:47 +0530 Ramco Systems’ recently launched Payce platform was noted for its technology-first approach and ability to minimise manual intervention in payroll processing Full Article Stocks
ap Taapsee Would Like A Rose, Har Roz! By www.rediff.com Published On :: Wed, 13 Nov 2024 10:25:27 +0530 Taapsee Pannu's off-screen style too reflects her eye for detail, making her a fashionista worth following. Full Article
ap Meet richest family of Bollywood, once sold fruits, has net worth of Rs 10000 crore, not Kapoors, Khans, it is... By www.dnaindia.com Published On :: Thu, 14 Nov 2024 00:38:31 GMT Meet rihest family of Bollywood surpassing the net worth of the Khans, Kapoor, Full Article Entertainment