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QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism




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WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2




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LncRNA <i>SNORD3A</i> specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression




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MicroRNA let-7c (MIRLET7C; let-7c), miR-99a and miR-125b as prognostic markers of luminal breast cancer

Studies in patient samples and cell culture suggest let-7c, miR-99a and miR-125b could serve as prognostic markers in patients with estrogen receptor–positive luminal breast cancers.




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Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor

Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives.




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Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest inhibiting PGF could help treat hypertension.




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Topoisomerase II binding protein 1 (TOPBP1)

Mouse and cell culture studies suggest inhibiting TOPBP1 could help treat cancer.




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Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity




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In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states




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Bridging naïve and primed pluripotency




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FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome




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TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials




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Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy




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Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism




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Head-to-head trials in inflammatory bowel disease: past, present and future




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Author Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities




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Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear




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Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression




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Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity




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Probing nanoscale fluctuation of ferromagnetic meta-atoms with a stochastic photonic spin Hall effect




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Wheelchair propulsion fatigue thresholds in electromyographic and ventilatory testing




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Impact of COVID-19 outbreak on spinal pathology: single center first impression




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Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus




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Associations of interruptions to leisure-time sedentary behaviour with symptoms of depression and anxiety




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Author Correction: “Dysfunctions” induced by Roux-en-Y gastric bypass surgery are concomitant with metabolic improvement independent of weight loss




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Efficient generation of mouse models with the prime editing system




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Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing




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Activation and targeting of ATG8 protein lipidation




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Peter Ward: 'Membership organisations can thrive and prosper'




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Special products for specialist cleaning




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Fixed orthodontic appliances: a practical guide




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Mechanistic insight into the spread of tau pathology




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NLRP3 inflammasome activity as biomarker for primary progressive multiple sclerosis




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Does the presenting phenotype predict survival in ALS–FTD?




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Predicting brain-disorder risk genes




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The Folly and Vanity of The Project to Redesign New Delhi, The Wire

Six years ago, the then editor of the Hindustan Times invited me to write a fortnightly column. I agreed, on condition that there would be no censorship. While occasionally some changes to my text were made without my consent, there was no attempt to get me to rewrite my column or change its arguments. Until [...]




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Surgeon’s protection during ophthalmic surgery in the Covid-19 era: a novel fitted drape for ophthalmic operating microscopes




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Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea




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Design, implementation, and evaluation of a nurse-led intravitreal injection programme for retinal diseases in Singapore




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Modeling shield immunity to reduce COVID-19 epidemic spread




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Protect against market exclusivity in the fight against COVID-19




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Protecting the population with immune individuals




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This Virus Is Tough, but History Provides Perspective: The 1968 Pandemic and the Vietnam War

Nathaniel L. Moir recounts the events of 1968: The war in Vietnam and extensive civil unrest in the United States — and yet another big problem that made life harder. In 1968, the H3N2 pandemic killed more individuals in the United States than the combined total number of American fatalities during both the Vietnam and Korean Wars.




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To Pressure Iran, Pompeo Turns to the Deal Trump Renounced

The secretary of state is preparing an argument that the U.S. remains a participant in the Obama-era nuclear deal, with the goal of extending an arms embargo or destroying the accord.




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Cutoff point estimation for serum vitamin D concentrations to predict cardiometabolic risk in Brazilian children




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Promoting healthy lifestyle in Chinese college students: evaluation of a social media-based intervention applying the RE-AIM framework




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Central catheter removal timing and growth patterns in preterm infants




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Placental expression of leptin: fetal sex-independent relation with human placental growth




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The U.S.-Russia Initiative to Prevent Nuclear Terrorism Newsletter: November 2018 - November 2019

  • Russians View Terrorists as Third Most Probable Source of Nuclear Attack
  • U.S. Adopts New Strategy for Countering of WMD Terrorism
  • Elbe Group Calls for U.S.-Russian Cooperation against Terrorism
  • Belfer Center Experts on Combatting Complacency about Nuclear Terrorism
  • Can Threat Emanating from Jihadists of Central Asia Have a WMD Dimension?
  • NTI and CENESS on Radiological Risks in Central Asia
  • Hecker Assesses Probability of Radiological and Nuclear Terrorism
  • Luxembourg Forum: It’s Vital for US and Russia to Intensify Cooperation to Combat Nuclear Terrorism




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Project on Managing the Atom Seeking Full-Time Research Associate

The Managing the Atom (MTA) project at the Harvard Kennedy School is seeking a full-time Research Associate to support research projects directed by Professor Matthew Bunn on a range of nuclear policy topics including strategic stability and the future of nuclear arms control, reducing the risks of nuclear theft and terrorism worldwide, stemming the spread of nuclear weapons, and addressing key constraints on and risks of nuclear energy. Reporting to the MTA co-principal investigator Prof. Matthew Bunn, the Research Associate will play a major role in researching and writing papers and reports in these areas.