of Virtual Roundtable: Russia in Light of the COVID-19 Pandemic By feedproxy.google.com Published On :: Sun, 29 Mar 2020 21:25:01 +0000 Invitation Only Research Event 1 April 2020 - 1:00pm to 2:30pm Event participants Mathieu Boulegue, Research Fellow, Russia and Eurasia Programme, Chatham HouseNikolai Petrov, Senior Research Fellow, Russia and Eurasia Programme, Chatham HouseEkaterina Schulmann, Associate Fellow, Russia and Eurasia Programme, Chatham HouseChair: James Nixey, Programme Director, Russia and Eurasia, Chatham House Politically speaking, Russia has been isolating itself from the West for some years now, feeding its citizens a ‘besieged fortress’ mentality. Its uniqueness, however, means its approach to - and outcome from - the COVID-19 pandemic will also be distinctive. This webinar will explore how Russia is adapting its internal politics and its international relations to the ‘new normal’ of today. Department/project Russia and Eurasia Programme Anna Morgan Administrator, Ukraine Forum +44 (0)20 7389 3274 Email Full Article
of Virtual Roundtable: The Impact of COVID-19 on the Wider FSU Region By feedproxy.google.com Published On :: Thu, 16 Apr 2020 13:40:02 +0000 Invitation Only Research Event 21 April 2020 - 10:00am to 11:30am Event participants Christopher Davis, Professorial Fellow, Institute of Population Ageing, University of OxfordNino Evgenidze, Executive Director, EPRCKatya Gorchinskaya, Journalist, former CEO of Hromadske.uaKonstantin Sokulskiy, Head of Governance, UNDP, KazakhstanChair: James Nixey, Programme Director, Russia and Eurasia, Chatham House COVID-19 has put a serious strain on healthcare and economic systems around the world. This virtual roundtable will explore its impact on Russia, Ukraine, Georgia and Kazakhstan. Through a comparative examination of government and society responses, this event will show how COVID-19 has laid bare the region’s broader social, economic and political challenges. Department/project Russia and Eurasia Programme Anna Morgan Administrator, Ukraine Forum +44 (0)20 7389 3274 Email Full Article
of The Tyranny of doubt. By kolembo.wordpress.com Published On :: Thu, 19 Jun 2014 08:10:09 +0000 When you are born, You know that you are, Here to change the world, And it is good, And it’s alright, To do your best. Then, You’re checking the curtains, Just in case, You run out of sunshine. -evocative short poetry- Full Article Poetry aging dying hippie hope poetry time
of Officer in charge. By kolembo.wordpress.com Published On :: Fri, 27 Jun 2014 14:07:59 +0000 “There are no terrorists in this location” Reads the title, In classic bold type, On Foolscap paper, On a dusty desk, Inside a police outpost in Isiolo. “The drilling rigs will make no difference to, The cows or the goats or the lives of the people, Who do not live here.” “The construction does not […] Full Article Poetry Africa developing future oil poetry value
of Keep me out of this one By kolembo.wordpress.com Published On :: Sat, 28 Jun 2014 21:19:03 +0000 the lone yellow pebble bore witness to the abduction that took place at midnight. The man was bound and gagged and led away as women wept. Keep me out of this one. Did you know that a bear needs twenty seven, Square miles of forest, to live? Keep me out of this one. The woman […] Full Article Poetry poetry religion
of The tyranny of doubt By kolembo.wordpress.com Published On :: Tue, 23 Jun 2015 08:55:19 +0000 When you are born, You know that you are, Here to change the world, And it is good, And it’s alright, To do your best. Then, You’re checking the curtains, Just in case, You run out of sunshine. -evocative short poetry- Full Article Poetry Arab spring democracy doubt Eygpt poetry revolution uprising
of The sound of an African funeral By kolembo.wordpress.com Published On :: Sat, 22 Aug 2015 17:22:00 +0000 They sing for him, Swinging from heel to frail heel, Growing earth between the ground and, his casket, Bleeding love into the air Like orchids, Humming, They rise again And again their gently swaying busts, Move the air to and fro, To and fro, Intending that mother be comforted, Intending that her wet eyes, Smile […] Full Article Poetry Africa community family funerals hope Kenya poetry tragedy
of Office Lover By kolembo.wordpress.com Published On :: Tue, 24 Nov 2015 02:44:37 +0000 Dreaming of; Colorful balloons on an African plain, Hot air rising, with Rich people making eye contact, Heaving brandy glasses at the bar by the salt-lick lake, Making new friends with, Levitating boobs or Buoyant balls, Out on the reef, whilst; Putting out lurid spread-sheets, At the office photocopier, With Sam, And his dark […] Full Article Poetry
of The smell of new curtains By kolembo.wordpress.com Published On :: Sun, 23 Oct 2016 20:12:31 +0000 It came from the right side like God, or a deer, a Migraine warning; Chemotherapy strikes at any time. Where am I going wrong? Under community skies and red roofed buildings, immaculate And unfinished, Holding on for next week’s rent, Even if you were alive, I’d not have listened, Missing a father to say […] Full Article Poetry cancer friendship hope internet relationships love
of The ladder of life By kolembo.wordpress.com Published On :: Fri, 28 Apr 2017 12:41:07 +0000 I don’t have friends, I do not think. Friends get married, and Drive bigger cars and, Have more intelligent things to talk about, better Places to go, are Becoming lawyers and doctors and ministers, Big people, and It sort of interrupts things. ♦photos♦ Jacob’s Ladder -short evocative poetry- Full Article Poetry capitalism poem poetry religion social psychology spirituality
of Still God of the night… By kolembo.wordpress.com Published On :: Thu, 26 Mar 2020 04:32:43 +0000 Life is easy, when you’re up on the mountain And you’ve got peace of mind, like you’ve never known But things change, when you’re down in the valley Don’t lose faith, for you’re never alone For the God on the mountain, is the God in the valley When things go wrong, He’ll make them right […] Full Article Poetry hope
of Champion Bakery of Phoenix, AZ By investing.96.lt Published On :: Thu, 05 Jul 2018 09:41:43 UTC People have started talking highly about the bakery shop that lies in the middle of the city of Phoneix, AZ. ABakeShop claims to bring the most delicious and unique flavors of cakes and desserts to its customers. People have expressed huge levels of satisfaction after availing their services. Full Article News
of CRM Software Development Company By investing.96.lt Published On :: Sun, 21 Apr 2019 02:12:55 UTC Sales Fundaa is a Dial N Search Pvt. Ltd. initiative, provides ERP software, CRM Software, Project Management Software, Manufacturing Software, AMC Software, Data Management Software, Real Estate CRM, Logistics Software and Human Resource Management Software. Full Article News
of CRM Software in Ahmedabad By investing.96.lt Published On :: Sun, 21 Apr 2019 02:14:09 UTC SalesFundaa provide a successful CRM software in Ahmedabad Gujarat, that is fit for any business deals based on customer enquiries. Get free quote now! Full Article News
of CRM Software in Pune By investing.96.lt Published On :: Sat, 03 Aug 2019 06:02:40 UTC Looking for best CRM solutions in Pune?. SalesFundaa is one of the best Custom CRM Development company in Pune, which provides new-age CRM software that helps to grow your business. Full Article News
of CRM Software in India By investing.96.lt Published On :: Sat, 03 Aug 2019 06:18:47 UTC SalesFundaa, top leading CRM Software Development Company in India. Our CRM Software Features is Activity Management, Alerts, Notifications, Analytics, Reporting, Billing, Invoicing, Calendar Management, Contact Management, Customer Information System, Social media management, Tasks and Deals. Full Article News
of CRM Software Blog By investing.96.lt Published On :: Sat, 03 Aug 2019 06:20:04 UTC Find here most important blogs for CRM Software. Here CRM Software related Information, guidelines, and helpful Blog. Full Article News
of CRM Software Blog SalesFundaa By investing.96.lt Published On :: Sat, 03 Aug 2019 06:21:17 UTC Find here most important blogs for CRM Software. Here CRM Software related Information, guidelines, and helpful Blog. Full Article News
of Customer Database Management Software in Mumbai, Pune, Ahmedabad By investing.96.lt Published On :: Sat, 03 Aug 2019 06:22:37 UTC Customer Database Management Software, Customer Management Software, Customer Database Software in Mumbai, Customer Database Management Software in Pune, Customer Database Management Software in Ahmedabad, India. Customer Database Management Software Full Article News
of Customer Relationship Management Software in Mumbai, Pune, Ahmedabad By investing.96.lt Published On :: Sat, 03 Aug 2019 06:23:49 UTC SalesFundaa is one of the Best Mumbai based Customer Relationship Management Software company in Mumbai, Pune, Ahmedabad. We provide CRM Software System, Build, Manage and Develop Business Relationships with your Customers. Full Article News
of Lead Management Software in India By investing.96.lt Published On :: Sat, 03 Aug 2019 06:25:00 UTC We provide CRM Lead Management Software Solution in Mumbai, Pune, Ahmedabad, Andheri, Borivali, Bandra, Goregaon, Juhu, Kandivali, Santacruz, Ghatkopar, Chembur, Dadar, Parel, India Full Article News
of Best Field Management Software By investing.96.lt Published On :: Fri, 27 Sep 2019 08:40:24 UTC Salesfundaa is India's Best CRM Order Management System and Field Management Software Company in Mumbai, Pune, and Ahmedabad India. We provide Automated Order and Field management software for retailers, wholesalers and multichannel brands. For more fisit on- https://www.salesfundaa.com/information/blogs/Field_Order_Management_Software Full Article News
of Order Management Software in Ahmedabad By investing.96.lt Published On :: Wed, 22 Jan 2020 08:05:38 UTC Salesfundaa is award-winning Order Management Software and Order Management Software company in Mumbai, Pune, Ahmedabad, India. We are providing cloud-based oredr management solution optimizes costs, dispatching, scheduling and reporting. Full Article News
of Graphic showing the role of satellite images in tracking environmental damage By feedproxy.google.com Published On :: Thu, 31 May 2012 16:35:16 +0000 1 June 2012 , Volume 68, Number 4 Eyes in the skies keeping watch on a planet under stress. Click on the PDF link to view the graphic Graphic EyesInTheSkies.jpg Full Article
of Why wealthy countries must not drop nuclear energy: coal power, climate change and the fate of the global poor By feedproxy.google.com Published On :: Thu, 12 Mar 2015 11:37:45 +0000 12 March 2015 , Volume 91, Number 2 Reinhard Wolf Full Article
of Implications of climate change for the UN Security Council: mapping the range of potential policy responses By feedproxy.google.com Published On :: Fri, 06 Nov 2015 14:06:18 +0000 6 November 2015 , Volume 91, Number 6 Shirley V. Scott Full Article
of UK Unplugged? The Impacts of Brexit on Energy and Climate Policy By feedproxy.google.com Published On :: Wed, 25 May 2016 10:43:26 +0000 26 May 2016 In the field of energy and climate change policy, remaining in the EU offers the best balance of policy options for Britain’s national interests. Download PDF Antony Froggatt Senior Research Fellow, Energy, Environment and Resources Programme LinkedIn Thomas Raines Director, Europe Programme @TomHRaines Google Scholar Shane TomlinsonSenior Associate, E3G; Former Senior Research Fellow, Chatham House 2016-05-26-uk-unplugged-brexit-energy.jpg A line of electricity pylons stretches beyond fields of rapeseed near Hutton Rudby, North Yorkshire, on 27 April 2015. Photo: Getty Images. SummaryOver the last 30 years the EU has played a central role in addressing the competitiveness, security and climate dimensions of energy policy among its member states. The UK has been critical in driving forward integration of the European energy market, and has been a strong advocate of liberalized energy markets and some climate change mitigation policies.If, at the June 2016 referendum, the UK does vote to leave the EU, energy and climate policy will be part of the overall package of issues to be negotiated, as it is unlikely that each sector will be treated separately. The model of relations for energy and climate may well be determined by political and public sentiment on higher-profile issues such as freedom of movement, rather than by what is best for the UK in these policy areas.The UK is increasingly reliant on imports, including from and through continental Europe, and its energy market is deeply integrated with that of its European neighbours. As a growing share of the UK’s electricity is exchanged with EU partners, it would be neither possible nor desirable to ‘unplug’ the UK from Europe’s energy networks. A degree of continued adherence to EU market, environmental and governance rules would be inevitable.This paper reviews the risks and trade-offs associated with five possible options for a post-exit relationship. Of these, the Norway or the Energy Community models would be the least disruptive, enabling continuity in energy market access, regulatory frameworks and investment; however, both would come at the cost of accepting the vast majority of legislation while relinquishing any say in its creation. The UK would thus have less, rather than more, sovereignty over energy policy.The Switzerland, the Canada and the WTO models offer the possibility of greater sovereignty in a number of areas, such as buildings and infrastructure standards as well as state aid. None the less, each would entail higher risks, with greater uncertainty over market access, investment and electricity prices. These models would reduce or even eliminate the UK’s contribution to the EU budget, but would also limit or cut off access to EU funding mechanisms.All five Brexit models would undermine the UK’s influence in international energy and climate diplomacy. The UK would no longer play any direct role in shaping the climate and energy policies of its EU neighbours, at a time when the EU’s proposed Energy Union initiatives offer the prospect of a more integrated and effective European energy sector. A decision to leave the EU would make it easier for a future UK government to change direction on climate policy, since only a change in domestic legislation would be required.‘Brexit’ could affect the balance of energy policy among the remaining member states. In its absence, the centre of gravity for EU energy policy might shift away from market mechanisms and result in weaker collective action on greenhouse gas reduction targets.In the field of energy and climate change policy, remaining in the EU offers the best balance of policy options for Britain’s national interests: the UK would continue to benefit from the integrated energy market, while maintaining influence over its direction and minimizing uncertainty for crucial investment. Department/project Europe Programme, UK-EU27 Energy Cooperation, Energy, Environment and Resources Programme Full Article
of Security and Climate Change: Are we Living in 'The Age of Consequences'? By feedproxy.google.com Published On :: Fri, 11 Nov 2016 14:23:00 +0000 Research Event 1 December 2016 - 7:00pm to 9:00pm Chatham House, London Event participants Brigadier General Stephen A. Cheney, CEO, American Security Project; Member, Foreign Affairs Policy Board, US Department of StateMajor General Munir Muniruzzaman, President and CEO, Bangladesh Institute of Peace and Security Studies; Former Military Advisor to the President of Bangladesh Rear Admiral Neil Morisetti, Director of Strategy, UK Department of Science, Technology, Engineering and Public Policy; University College London; Former UK Government Climate and Energy Security EnvoyDr Patricia Lewis, Research Director, International Security, Chatham HouseChair: Rt Hon Sir Oliver Letwin MP, Former UK Cabinet Office Minister The US Department of Defense regards climate change as an ‘accelerant of instability and conflict’. A former head of the US Pacific Command described it as the most significant long-term security threat in his region. US federal agencies have recently been mandated to fully consider the impacts of climate change in the development of national security policy. This step-change in the US approach reflects the Pentagon’s conclusion that climate impacts are a ‘threat multiplier’ for security concerns – not just for the future – but which pose ‘an immediate risk to national security’.A new documentary from the US, The Age of Consequences, explores the links between climate change and security, including in current events in Syria, Egypt, the Sahel and Bangladesh. Our high-level panel will reflect on key sections from the documentary, which will be screened during the event, and explore whether security strategists, militaries and policy-makers in nations other than the US are fully cognisant of the risks posed by a changing climate, and whether they are ready to anticipate and respond to its potentially destabilizing effects.The panel discussion will be followed by a Q&A.THIS EVENT IS NOW FULL AND REGISTRATION HAS CLOSED. Department/project Energy, Environment and Resources Programme Full Article
of The Impacts of the Demand for Woody Biomass for Power and Heat on Climate and Forests By feedproxy.google.com Published On :: Mon, 30 Jan 2017 10:52:15 +0000 23 February 2017 Although most renewable energy policy frameworks treat biomass as carbon-neutral at the point of combustion, biomass emits more carbon per unit of energy than most fossil fuels. Download PDF Duncan Brack Associate Fellow, Energy, Environment and Resources Programme @DuncanBrack Google Scholar 2017-02-15-woody-biomass-climate-forests-brack.jpg Fuel composed of wood chips to be used for the UEM (Usine d’Electricité de Metz) biomass plant in Metz, eastern France. Photo: Getty Images. SummaryThe use of wood for electricity generation and heat in modern (non-traditional) technologies has grown rapidly in recent years, and has the potential to continue to do so.The EU has been, and remains, the main global source of demand, as a result of its targets for renewable energy. This demand is largely met by its own forest resources and supplemented by imports from the US, Canada and Russia.Countries outside the EU, including the US, China, Japan and South Korea, have the potential to increase the use of biomass (including agricultural residues as well as wood), but so far this has not taken place at scale, partly because of the falling costs of competing renewables such as solar PV and wind. However, the role of biomass as a system balancer, and its supposed ability, in combination with carbon capture and storage technology, to generate negative emissions, seem likely to keep it in contention in the future.Although most renewable energy policy frameworks treat biomass as though it is carbon-neutral at the point of combustion, in reality this cannot be assumed, as biomass emits more carbon per unit of energy than most fossil fuels. Only residues that would otherwise have been burnt as waste or would have been left in the forest and decayed rapidly can be considered to be carbon-neutral over the short to medium term.One reason for the perception of biomass as carbon-neutral is the fact that, under IPCC greenhouse gas accounting rules, its associated emissions are recorded in the land use rather than the energy sector. However, the different ways in which land use emissions are accounted for means that a proportion of the emissions from biomass may never be accounted for.In principle, sustainability criteria can ensure that only biomass with the lowest impact on the climate are used; the current criteria in use in some EU member states and under development in the EU, however, do not achieve this as they do not account for changes in forest carbon stock.Also see Woody Biomass for Power and Heat: Impacts on the Global Climate, which assesses the impact of the use of biomass for energy on greenhouse gas emissions, how these are accounted for under international climate accounting rules, and analyses the sustainability criteria currently in use and under development to minimise negative impacts. Department/project Energy, Environment and Resources Programme, The Environmental Impact of the Use of Biomass for Power and Heat Full Article
of Marvia Providence ‘Anointed’ for ministry - Offers ‘Bible pull up and come again’ entertainment to gospel audiences By jamaica-gleaner.com Published On :: Sun, 03 May 2020 00:23:57 -0500 Just the mention of the name Marvia Providence sends a tingle to the toes and, immediately, feet start tapping and bodies begin swaying. Before you know it, all the ‘warriors’ – prayer and otherwise – are in full flight. That’s the effect of the... Full Article
of Isha Blender opens up about loss of her son - Shares the heartbreaking tale in latest track ‘I Wish’ By jamaica-gleaner.com Published On :: Mon, 04 May 2020 00:17:11 -0500 REGGAE ARTISTE Isha Blender is still coming to terms with the loss of her son, Josiah, on January 5, a mere two days after she celebrated her birthday. The daughter of legendary crooner Everton Blender said the death of a child can be one of the... Full Article
of Inner Circle to create song from winning poem - Close to 100 entries for Circle of Light contest By jamaica-gleaner.com Published On :: Tue, 05 May 2020 00:07:04 -0500 IT IS said that every cloud has a silver lining, and that could still hold true, even in the midst of a terrifying global pandemic. Despite COVID-19, the cycle of life continues, and out of it has sprung forth an inspiring poetry competition,... Full Article
of Kingston meets MoBay for Mother’s Day concert - ‘Enchanting Evening of Music’ planned By jamaica-gleaner.com Published On :: Sat, 09 May 2020 00:06:41 -0500 Despite its best efforts, COVID-19 will not be allowed to steal the joy of Mother’s Day this year. An array of the island’s top singers and musicians have pledged to infuse the accustomed specialness into the day dedicated to mothers with a concert... Full Article
of Nicole Plummer | Reading for life; a life of reading By jamaica-gleaner.com Published On :: Sun, 29 Mar 2020 00:20:48 -0500 When I tell people that I do not remember learning how to read, they laugh. But I really do not recall learning to read. Reading was an activity that excited my family, and so it was no surprise that I would love reading. The love of books and... Full Article
of Mark Ricketts | Time to rethink economic implications - Jamaica engages IMF but the cost of the pandemic remains high By jamaica-gleaner.com Published On :: Sun, 19 Apr 2020 00:15:32 -0500 On Tuesday, April 14, the International Monetary Fund downgraded Jamaica’s growth prospects to -5.6 per cent. This is a severe contraction warranting substantial Government intervention. However, at times, the Government waits too late to respond... Full Article
of G. Anthony Hylton | A glimpse of a post-COVID-19 world By jamaica-gleaner.com Published On :: Sun, 26 Apr 2020 00:13:49 -0500 The lessons of COVID-19 are yet to crystallise, but the evidence so far has yielded some early insights of developments that are likely to shape the national and global agenda for the immediate future. The speed and scale of the spread of the... Full Article
of Mark Wignall | Party politics not for softies By jamaica-gleaner.com Published On :: Sun, 03 May 2020 00:12:06 -0500 I cannot quite remember the exact day he called me, but I know that it was sometime in the early 1990s. Six weeks before that, he was selected as constituency caretaker for a rough garrison seat that was going through some changes, slowly but... Full Article
of Pure and profound love – The Timolls’ story By jamaica-gleaner.com Published On :: Mon, 30 Mar 2020 00:10:07 -0500 “As the large wooden doors of the chapel opened and I saw my bride for the first time, our minds and hearts communicated in a way only love could evoke.” This sincere sentiment, echoed by the proud groom, only expresses a drop in the ocean of... Full Article
of Web Hosting coupons - offersget.com By investing.96.lt Published On :: Sat, 07 Jul 2018 10:08:57 UTC Web Hosting coupons, coupon codes. 50% off 100% working Web Hosting discount codes, offers. Offersget promo codes on Shared, Reseller, VPS, Dedicated server hosting. Domains promo codes, Web Hosting offers, Web Hosting promo codes and discounts more on other services. Full Article Online Shopping
of PRMT1 Is Required for the Maintenance of Mature {beta}-Cell Identity By diabetes.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 Loss of functional β-cell mass is an essential feature of type 2 diabetes, and maintaining mature β-cell identity is important for preserving a functional β-cell mass. However, it is unclear how β-cells achieve and maintain their mature identity. Here we demonstrate a novel function of protein arginine methyltransferase 1 (PRMT1) in maintaining mature β-cell identity. Prmt1 knockout in fetal and adult β-cells induced diabetes, which was aggravated by high-fat diet–induced metabolic stress. Deletion of Prmt1 in adult β-cells resulted in the immediate loss of histone H4 arginine 3 asymmetric dimethylation (H4R3me2a) and the subsequent loss of β-cell identity. The expression levels of genes involved in mature β-cell function and identity were robustly downregulated as soon as Prmt1 deletion was induced in adult β-cells. Chromatin immunoprecipitation sequencing and assay for transposase-accessible chromatin sequencing analyses revealed that PRMT1-dependent H4R3me2a increases chromatin accessibility at the binding sites for CCCTC-binding factor (CTCF) and β-cell transcription factors. In addition, PRMT1-dependent open chromatin regions may show an association with the risk of diabetes in humans. Together, our results indicate that PRMT1 plays an essential role in maintaining β-cell identity by regulating chromatin accessibility. Full Article
of Insulin-Deficient Diabetic Condition Upregulates the Insulin-Secreting Capacity of Human Induced Pluripotent Stem Cell-Derived Pancreatic Endocrine Progenitor Cells After Implantation in Mice By diabetes.diabetesjournals.org Published On :: 2020-03-20T11:50:28-07:00 The host environment is a crucial factor for considering the transplant of stem cell–derived immature pancreatic cells in patients with type 1 diabetes. Here, we investigated the effect of insulin (INS)-deficient diabetes on the fate of immature pancreatic endocrine cell grafts and the underlying mechanisms. Human induced pluripotent stem cell–derived pancreatic endocrine progenitor cells (EPCs), which contained a high proportion of chromogranin A+ NK6 homeobox 1+ cells and very few INS+ cells, were used. When the EPCs were implanted under the kidney capsule in immunodeficient mice, INS-deficient diabetes accelerated increase in plasma human C-peptide, a marker of graft-derived INS secretion. The acceleration was suppressed by INS infusion but not affected by partial attenuation of hyperglycemia by dapagliflozin, an INS-independent glucose-lowering agent. Immunohistochemical analyses indicated that the grafts from diabetic mice contained more endocrine cells including proliferative INS-producing cells compared with that from nondiabetic mice, despite no difference in whole graft mass between the two groups. These data suggest that INS-deficient diabetes upregulates the INS-secreting capacity of EPC grafts by increasing the number of endocrine cells including INS-producing cells without changing the graft mass. These findings provide useful insights into postoperative diabetic care for cell therapy using stem cell–derived pancreatic cells. Full Article
of Pancreas Pathology of Latent Autoimmune Diabetes in Adults (LADA) in Patients and in a LADA Rat Model Compared With Type 1 Diabetes By diabetes.diabetesjournals.org Published On :: 2020-03-20T11:50:28-07:00 Approximately 10% of patients with type 2 diabetes suffer from latent autoimmune diabetes in adults (LADA). This study provides a systematic assessment of the pathology of the endocrine pancreas of patients with LADA and for comparison in a first rat model mimicking the characteristics of patients with LADA. Islets in human and rat pancreases were analyzed by immunohistochemistry for immune cell infiltrate composition, by in situ RT-PCR and quantitative real-time PCR of laser microdissected islets for gene expression of proinflammatory cytokines, the proliferation marker proliferating cell nuclear antigen (PCNA), the anti-inflammatory cytokine interleukin (IL) 10, and the apoptosis markers caspase 3 and TUNEL as well as insulin. Human and rat LADA pancreases showed differences in areas of the pancreas with respect to immune cell infiltration and a changed ratio between the number of macrophages and CD8 T cells toward macrophages in the islet infiltrate. Gene expression analyses revealed a changed ratio due to an increase of IL-1β and a decrease of tumor necrosis factor-α. IL-10, PCNA, and insulin expression were increased in the LADA situation, whereas caspase 3 gene expression was reduced. The analyses into the underlying pathology in human as well as rat LADA pancreases provided identical results, allowing the conclusion that LADA is a milder form of autoimmune diabetes in patients of an advanced age. Full Article
of Aaron's 85th birthday a celebration of a great life By mlb.mlb.com Published On :: Tue, 5 Feb 2019 19:48:00 EDT Henry "Hank" Aaron was born in Alabama three years after Willie Mays, 85 years ago Tuesday. Now, all this time later, Aaron is as much the conscience and the soul of baseball as any man alive. But we don't just celebrate a great baseball life today. We celebrate a great American life. Full Article
of Quiet offseason shouldn't nix Braves' potential By mlb.mlb.com Published On :: Thu, 7 Feb 2019 13:49:07 EDT As the Mets, Nationals and Phillies have made multiple upgrades, Braves GM Alex Anthopoulos has thus far limited his offseason activity to giving Josh Donaldson a record one-year deal and bringing to fruition the desires of Brian McCann and Nick Markakis to play for the Braves. Full Article
of Inbox: How to judge Braves' offseason? By mlb.mlb.com Published On :: Fri, 8 Feb 2019 15:32:36 EDT Reporter Mark Bowman addresses the Braves' offseason as a whole, as well as identifying a Minor League who has a chance at making the club out of Spring Training. Full Article
of 30 low-key acquisitions who could pay off big By mlb.mlb.com Published On :: Tue, 12 Feb 2019 13:57:13 EDT Fans and analysts spend the entire offseason speculating where the top free agents could go, but sometimes an under-the-radar pickup can end up making a world of difference. As positional competitions begin to heat up at Spring Training camps this month, MLB.com's beat writers were asked to identify one potentially overlooked acquisition for each of the 30 clubs. Here's who they came up with. Full Article
of Uniform patch to mark 150 years of pro baseball By mlb.mlb.com Published On :: Tue, 12 Feb 2019 10:09:05 EDT All 30 Major League teams will wear special "MLB 150" patches on their uniforms for the entire 2019 season in honor of the 150th anniversary of the 1869 Cincinnati Red Stockings, the first openly all-salaried professional baseball team. Full Article
of Braves can still win the offseason By mlb.mlb.com Published On :: Thu, 14 Feb 2019 23:00:00 EDT We're reluctant to finalize our list of offseason winners because, as you may have heard, there are some prominent unsigned free agents. Not just Bryce Harper and Manny Machado, either. Full Article
of Brown is proud of Braves' rich history By mlb.mlb.com Published On :: Thu, 14 Feb 2019 21:18:29 EDT It didn't come as a surprise to anyone when Dana Brown left the Blue Jays as a special assistant to general manager Ross Atkins to join the Braves as vice president of scouting. Full Article
of Freeman pleased with Braves' offseason deals By mlb.mlb.com Published On :: Sat, 16 Feb 2019 14:17:17 EDT Freddie Freeman spent the offseason sharing excitement about the possibility that Josh Donaldson would not end up being the Braves' only significant offseason addition. Full Article
