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Synergetic effect of mild hypothermia and antioxidant treatment on ROS-mediated neuron injury under oxygen-glucose deprivation investigated by scanning electrochemical microscopy

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05977H, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Junjie Zhang, Yulin Liu, Yuxiang Zhao, Siyu Zhang, Feng Xu, Fei Li
Ischemic stroke and reperfusion injury result in neuronal damage and dysfunction associated with oxidative stress, leading to overproduction of cellular reactive oxygen species (ROS) and reactive nitrogen species (RNS). In...
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Triple-Function Porphyrin in Glycopolymeric Photosensitizer: From PhotoATRP to Targeted PDT

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC06466F, Edge Article
Open Access
Jiahui Lin, Zhiyuan Ma, Weiwei Zuo, Meifang Zhu
Porphyrin derivatives serve as photocatalysts in reversible-deactivation radical polymerization and as photosensitizers in photodynamic therapy (PDT). Herein, a triple function porphyrin, ZnTPPC6Br, was synthesized as photocatalyst and initiator for photoATRP....
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Morphology of Lithium Halides in Tetrahydrofuran from Molecular Dynamics with Machine Learning Potentials

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC04957H, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marinella de Giovanetti, Sondre H. Hopen Eliasson, Sigbjørn L. Bore, Odile Eisenstein, Michele Cascella
The preferred structures of lithium halides (LiX, with X = Cl, Br, I) in organic solvents have been the subject of a wide scientific debate, and a large variety of...
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Rapid, Potent, and Persistent Covalent Chemical Probes to Deconvolute PI3Kα Signaling

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05459H, Edge Article
Open Access
Lukas Bissegger, Theodora Alexandra Alexandra Constantin, Erhan Keles, Luka Raguž, Isobel Barlow-Busch, Clara Orbegozo, Thorsten Schaefer, Valentina Borlandelli, Thomas Bohnacker, Rohitha SriRamaratnam, Alexander Schäfer, Matthias Gstaiger, John E. Burke, Chiara Borsari, Matthias Wymann
Chemical probes have gained importance in the elucidation of signal transduction in biology. Insufficient selectivity and potency, lack of cellular activity and inappropriate use of chemical probes has major consequences...
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Rare-earth metal complexes bearing electrophilic and nucleophilic carbon centres and their unique reactivity patterns towards pyridine derivatives

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC04197F, Edge Article
Open Access
weikang Wu, Thayalan Rajeshkumar, Shan Zhu, Fuxiang Chai, Dongjing Hong, ZeMing Huang, Qingbing Yuan, Laurent Maron, Shaowu Wang
The rare-earth metal dialkyl complexes (κ2-L1)RE(CH2SiMe3)2(THF)2 [RE = Lu(1a), Yb(1b), Er(1c), Y(1d), Dy(1e)] (L1 = 1-(2-N-C5H10NCH2CH2)-3-(2,6-iPr2C6H3N=CH)-C8H4N) and the rare-earth metal monoalkyl complexes (κ2-L1)2RE(CH2SiMe3)(THF)n [n = 0, RE = Lu(2a), Yb(2b);...
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Pronounced Electronic Modulation of Geometrically-Regulated Metalloenediyne Cyclization

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05396F, Edge Article
Open Access
Sarah E. Lindahl, Erin M. Metzger, Chun-Hsing Chen, Maren Pink, Jeff Zaleski
Using a diverse array of thermally robust phosphine enediyne ligands (dxpeb, X = Ph, Ph-pOCH3, Ph-pCF3, Ph-m2CH3, Ph-m2CF3, iPr, Cy, and tBu) a novel suite of cisplatin-like Pt(II) metalloenediynes (3,...
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Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer’s Disease

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05469E, Edge Article
Open Access
Jennifer Shyong, Jinliang Wang, Tran Quoc Dung Huynh, Marina Fayzullina, Bo Yuan, Ching-Kuo Lee, Thomas Minehan, Paul M. Seidler, Clay Wang
Alzheimer’s Disease (AD) is a neurodegenerative disorder proven to be caused by the aggregation of protein tau into fibrils, resulting in neuronal death. The irreparable neuronal damage leads to irreversible...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sequence-dependent Conformational Transitions of Disordered Proteins During Condensation

Chem. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4SC05004E, Edge Article
Open Access
Jiahui Wang, Dinesh Devarajan, Keerthivasan Muthukumar, Youngchan Kim, Arash Nikoubashman, Jeetain Mittal
Intrinsically disordered proteins (IDPs) can form biomolecular condensates through phase separation. It is recognized that the conformation of IDPs in the dense and dilute phases, as well as at the...
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13/09:44 EST Flood Warning Summary for Queensland




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The seven qualities of successful male playback singers




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When a drummer sits down to write music

Rijul Victor’s experiments with EDM led him to start a solo project, which is now releasing his debut album as an electronic music producer




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Following a seven-day cinema diet

The Mumbai Film Festival this year had themes of suffocation, alienation, personal struggle, politics, rape, morality, gender, family…and a few characters we fell in love with, says Namrata Joshi




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An auteur of diverse genres

Cary Fukunaga on his favourite version ofTrue Detective, the challenges of working onBeast of Nations, and why he’s a student of history




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When imagination and real life collide

Nidhi Dalmia’sHarpbrings to the fore the real-life conflicts faced by people in ’60s India




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Incongruent to their motive

Deepa and Dilip Mehta’s latest films are well-intentioned but ineffective attempts to look at sexual crimes and the adult film industry respectively to analyse the increase in rape in the country




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Entertainment with a finesse

Filmmaker Mansoor Khanon the cinema of his illustrious father and his comeback plans




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Who’s Afraid of Roger Ballen?

The South African photographer whose strange and extreme works are difficult to turn away from, is displaying his work in India for only the second time




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A highly recommended underdog

Thrilling gameplay and beautiful visuals make Titanfall2 a worthy purchase





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Want to work with directors who enrich my acting: Ranveer

The 31-year-old actor said after megastar Amitabh Bachchan and superstar Shah Rukh Khan, he is the only actor to be directed by Bhansali and Chopra.




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Dabbling in different mediums

Beyond sharing her experience of working with the powerhouse combination of Alia Bhatt, Shah Rukh Khan and Gauri Shinde in the upcomingDear Zindagi, Ira Dubey talks about her undying love for theatre and more




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A new twist in the military shooter genre

Without celebrating war and patriotism, Battlefield 1 manages to be fresh despite its dated milieu




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Abhishek Bachchan has ten million followers on Twitter




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Accepting queer children

A new anthology of stories, translated from Marathi, is about ordinary folks coming to terms with the queer sexuality of their children and siblings




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I never do anything that I don’t enjoy: Ruskin Bond

The celebrated author chats about his latest work, how everything inspires him and why his books always have such a visual element to them




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Of memory and violence

Iffat Fatima’s films capture the trauma of the families of the disappeared.




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Counter culture queen

In an exclusive interview, Anushka Sharma opens up about shunning parties, her production company and her goals for the year




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From text to speech : the MITalk system / Jonathan Allen, M. Sharon Hunnicutt, Dennis Klatt, with Robert C. Armstrong and David Pisoni

Cambridge [Cambridgeshire] ; New York : Cambridge University Press, 1987




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Share Market Highlights 18 April 2024: Sensex falls 330 pts, Nifty at 22,000; media, metal stocks shine, FMCG, healthcare drag

Sensex, Nifty updates on 18th April 2024: Equity benchmarks BSE Sensex and NSE Nifty extended losses on Thursday. As per provisional figures, BSE Sensex fell 332.23 pts or 0.46 per cent to trade at 72,611.45 as of 3.35 pm and Nifty 50 declined 103.70 pts or 0.47 per cent to trade at 22,044.20., Bharti Airtel, Power Grid Corp, M&M, BPCL, and Tata Steel were the top gainers, while Nestle, Apollo Hospitals, Axis Bank, HCL Technologies, and ONGC were the major laggards. The stocks that hit a 52-week high on the NSE include AAA Tech (19.33 per cent), Just Dial (12.95 per cent), Indo Tech (10 per cent) and Hi-Tech Gear (10 per cent).




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Why this conservative hybrid fund makes sense amidst market volatility

Aditya Birla Sun Life Regular Savings has been a consistent outperformer while keeping risks at bay




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Should you invest in ICICI Prudential Credit Risk Fund?

Credit risk funds, which invest at least 65 per cent of their portfolio in corporate bonds rated AA or below, offer a shot at high accrual returns




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Baroda BNP Paribas Retirement fund: Should you invest in the NFO?

The hybrid fund offering would take a flexicap approach to stocks and duration management for bonds




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MF shareholding trends

Prime Mutual Funds Database has recently released its monthly tracker of mutual funds for April




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Markets correlate with economic performance, not political dispensation: Ashish Somaiyaa, CEO, WhiteOak Capital AMC

Ashish Somaiyaa, CEO, WhiteOak Capital AMC, on the impact of elections on the market and more




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Why this dividend yield fund may suit investors seeking lower volatility

Since its inception in December 2020, HDFC Dividend Yield fund has outperformed the broader markets convincingly




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Three key MF inflow trends in May 2024

Monthly investments via SIPs crossed the ₹20,000-crore mark for the second successive month.




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Why this consumption thematic fund is an attractive investment now

Nippon India Consumption fund has been a consistent outperformer across market cycles




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Should you subscribe to the Motilal Oswal Nifty India Defence Index fund NFO?

Exposure to indigenised defence spending through a passive fund




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Mutual Funds and NRIs: If you are a non-resident Indian, here is how you can partake in the India growth story

If you’re a Non-Resident Indian eyeing India’s growth story, here are the basics that matter




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Why this consistent ultra short-term fund is a worthy debt investment

ICICI Prudential Ultra Short-Term fund can make the most of persistently high short-term interest rates




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Not devoid of stock ideas, though markets aren’t cheap: Neelesh Surana, CIO, Mirae Asset Mutual Fund

Open to spinning off passive fund business under MF Lite, says Swarup Mohanty, Vice-Chairman and CEO, Mirae Asset Investment Managers




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43% of equity MF schemes fail to beat benchmark indices

Multi-cap and Focused funds were the best performers with 75 per cent and 64 per cent or 18 each of the 24 and 28 schemes beat their respective benchmark




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SBI Contra fund: Why this long-term outperformer is a worthy investment

A multi-cap and contrarian approach helps the fund figure among the best across equity categories




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Prudent crosses ₹1 lakh crore in MF Assets Under Management

Prudent became the second non-banking mutual fund distributor to achieve this milestone last Friday




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ICICI Prudential Flexicap Fund: A steady outperformer for the long term

ICICI Prudential Flexicap’s performance over the past three years places it in the top-quartile of its category




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Why this value fund may be a good investment for the long term

Nippon India Value has consistently outperformed its benchmark and delivered optimal risk-adjusted returns




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Baroda BNP Paribas Dividend Yield NFO: Should you invest?

The new fund will invest in companies with healthy cashflows and look to avoid dividend traps




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Why this focused fund can be a worthy investment in heated markets

Mahindra Manulife Focused fund is large-cap heavy and takes moderate risks in its portfolio




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Missed market turning points in our mid-cap fund: DSP MF’s Kalpen Parekh

Kalpen Parekh of DSP Mutual Fund on his fund house’s investment philosophy, the markets, valuation metrics and more




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Amid volatile markets, this dividend yield fund is a smart investment

With geopolitical tensions, US elections and crude prices weighing on sentiments, it may be a good time to take the safer option of dividend yield investing