La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

La enseñanza bíblica en profundidad de John MacArthur lleva la verdad transformadora de la Palabra de Dios a millones de personas cada día.

[Capital FM] Nairobi -- The Politics surrounding the control of the Sh10.5 billion Road Maintenance Levy Fund between MPs and Governors has continued to stall talks to iron out the stalemate over the equitable revenue share to the devolved units.

Responsibility for the funding of cancer medication is set to be taken over by the Health Ministry from the Malta Community Chest Fund • Minister announces Paola Health Hub set to launch operations this week

Maltese producers raise alarm over ripple effect of late payments in funding and services to creatives from Malta Film Commission

The right to abortion is a human rights issue that no government agency, courts, local and state legislators, or anyone else has the right to violate or impede in any shape or form. It is a fundamental right that every woman must be free to exercise with impunity, in consultation with her doctor only, who […]

MANILA, Philippines — The excess campaign funds of then-president Rodrigo Duterte were used for the reward system of police officers during his administration’s brutal war on drugs.  Duterte himself admitted this to Santa Rosa City Rep. Dan Fernandez during the House of Representatives quad committee during its 11th probe on his controversial anti-drug campaign.  “I still remember that you mentioned na yung pera galing sa donation ng inyong campaign funds will be utilized for the reward system, that’s private money,” Fernandez said.  (I still remember you mentioned that the money from the donation for your campaign funds would be utilized […]...

Keep on reading: Excess campaign funds used for drug war reward system, Duterte admits

Education Cannot Wait (ECW) has delivered quality education to children in crisis “against all odds,” ECW Executive Director Yasmine Sherif said at the United Nations today. “And you can imagine the odds. We are seeing more armed conflict, a growth of climate-induced disasters and the biggest refugee movement since World War 2.”  Education Cannot Wait’s […]

The Head of Impact Assessment and Adaptation, Henry Neufeldt, UN Environment Programme Copenhagen Climate Centre, has called for increased climate adaptation funding, particularly for developing nations facing significant climate risks. UNEP’s latest report reveals an acute adaptation finance gap, with current international funding for developing countries at USD 30 billion—far below the USD 200 to 400 […]

“Cyprus has gone from zero to over 330 licensed investment entities managing €9 billion in assets in just a decade,” according to Maria Panayiotou, president of the Cyprus Investment Fund Association (CIFA). Speaking at the 5th Fund and Asset Management Conference in Athens, Panayiotou attributed this growth to “relentless effort and strategic vision.” She added […]

In the quantum realm, a particle’s properties can be separate from the particle itself, including its angular momentum – which could require a rethinking of fundamental laws

Descriptive statistics (DS) play a crucial role in establishing a solid foundation for study analysis and are important for understanding the results of a study or data set. If the data from DS is used incorrectly, the study may be misinterpreted. Descriptive statistics summarizes and organizes data, making analysis easier and providing an overview of the characteristics of sampled data. This analysis is comprised of measures of central tendency, which includes the mean, median, and mode of a particular data set. Understanding how to use each metric is essential for basic statistical analysis. The purpose of this short report is to review descriptive statistics and describe how to best utilize them during data analysis. The authors aim to provide this short report as an educational resource to assist the dental hygiene research community in understanding statistical analysis through descriptive statistics.

Country music star Darius Rucker paid the East Tennessee State University's NIL fund $10 for every minute he was on the field Saturday after what he called an "awkward" appearance.

As the philanthropic partner of IEEE, the IEEE Foundation expands the organization’s charitable body of work by inspiring philanthropic engagement that ignites a donor’s innermost interests and values.

One way the Foundation does so is by partnering with IEEE units to create memorial funds, which pay tribute to members, family, friends, teachers, professors, students, and others. This type of giving honors someone special while also supporting future generations of engineers and celebrating innovation.

Below are three recently created memorial funds that not only have made an impact on their beneficiaries and perpetuated the legacy of the namesake but also have a deep meaning for those who launched them.

EPICS in IEEE Fischer Mertel Community of Projects

The EPICS in IEEE Fischer Mertel Community of Projects was established to support projects “designed to inspire multidisciplinary teams of engineering students to collaborate and engineer solutions to address local community needs.”

The fund was created by the children of Joe Fischer and Herb Mertel to honor their fathers’ passion for mentoring students. Longtime IEEE members, Fischer and Mertel were active with the IEEE Electromagnetic Compatibility Society. Fischer was the society’s 1972 president and served on its board of directors for six years. Mertel served on the society’s board from 1979 to 1983 and again from 1989 to 1993.

“The EPICS in IEEE Fischer Mertel Community of Projects was established to inspire and support outstanding engineering ideas and efforts that help communities worldwide,” says Tina Mertel, Herb’s daughter. “Joe Fischer and my father had a lifelong friendship and excelled as engineering leaders and founders of their respective companies [Fischer Custom Communications and EMACO]. I think that my father would have been proud to know that their friendship and work are being honored in this way.”

The nine projects supported thus far have the potential to impact more than 104,000 people because of the work and collaboration of 190 students worldwide. The projects funded are intended to represent at least two of the EPICS in IEEE’s focus categories: education and outreach; human services; environmental; and access and abilities.

Here are a few of the projects:

• The Engineering Outreach at San Diego K–12 Schools project aims to bridge the city’s STEM education gap by sending IEEE members to schools to teach project-based lessons in mechanical, aerospace, electrical and computer engineering, as well as computer science. The project is led by the IEEE–Eta Kappa Nu honor society’s Kappa Psi chapter at the University of California San Diego and the San Diego Unified School District.
• Students from the Sahrdaya College of Engineering and Technology student branch in Kodakara, India, are developing an exoskeleton for nurses to support their lumbar spine region.
• Volunteers from the IEEE Uganda Section and local engineering students are designing and fabricating a stationary bicycle to act as a generator, providing power to families living in underserved communities. The goal of the project is to reduce air pollution caused by generators and supply reliable, affordable power to people in need.
• The IEEE Colombian Caribbean Section’s Increasing Inclusion of Visually Impaired People with a Mobile Application for English Learning project aims to ensure visually impaired students can learn to read, write, and speak English alongside their peers. The section’s members are developing a mobile app to help accomplish their goal.

IEEE AESS Michael C. Wicks Radar Student Travel Grant

The IEEE Michael C. Wicks Radar Student Travel Grant was established by IEEE Fellow Michael Wicks prior to his death in 2022. The grant provides travel support for graduate students who are the primary authors on a paper being presented at the annual IEEE Radar Conference. Wicks was an electronics engineer and a radio industry leader who was known for developing knowledge-based space-time adaptive processing. He believed in investing in the next generation and he wanted to provide an opportunity for that to happen.Ten graduate students have been awarded the Wicks grant to date. This year two students from Region 8 (Africa, Europe, Middle East) and two students from Region 10 (Asia and Pacific) were able to travel to Denver to attend the IEEE Radar Conference and present their research. The papers they presented are “Target Shape Reconstruction From Multi-Perspective Shadows in Drone-Borne SAR Systems” and “Design of Convolutional Neural Networks for Classification of Ships from ISAR Images.”

Life Fellow Fumio Koyama and IEEE Fellow Constance J. Chang-Hasnain proudly display their IEEE Nick Holonyak, Jr. Medal for Semiconductor Optoelectronic Technologies at this year’s IEEE Honors Ceremony. They are accompanied by IEEE President-Elect Kathleen Kramer and IEEE President Tom Coughlin.Robb Cohen

IEEE Nick Holonyak Jr. Medal for Semiconductor Optoelectronic Technologies

The IEEE Nick Holonyak Jr. Medal for Semiconductor Optoelectronic Technologies was created with a memorial fund supported by some of Holonyak’s former graduate students to honor his work as a professor and mentor. Presented on behalf of the IEEE Board of Directors, the medal recognizes outstanding contributions to semiconductor optoelectronic devices and systems including high-energy-efficiency semiconductor devices and electronics.

Holonyak was a prolific inventor and longtime professor of electrical engineering and physics. In 1962, while working as a scientist at General Electric’s Advanced Semiconductor Laboratory in Syracuse, N.Y., he invented the first practical visible-spectrum LED and laser diode. His innovations are the basis of the devices now used in high-efficiency light bulbs and laser diodes. He left GE in 1963 to join the University of Illinois Urbana-Champaign as a professor of electrical engineering and physics at the invitation of John Bardeen, his Ph.D. advisor and a two-time Nobel Prize winner in physics. Holonyak retired from UIUC in 2013 but continued research collaborations at the university with young faculty members.

“In addition to his remarkable technical contributions, he was an excellent teacher and mentor to graduate students and young electrical engineers,” says Russell Dupuis, one of his doctoral students. “The impact of his innovations has improved the lives of most people on the earth, and this impact will only increase with time. It was my great honor to be one of his students and to help create this important IEEE medal to ensure that his work will be remembered in the future.”

The award was presented for the first time at this year’s IEEE Honors Ceremony, in Boston, to IEEE Fellow Constance Chang-Hasnain and Life Fellow Fumio Koyama for “pioneering contributions to vertical cavity surface-emitting laser (VCSEL) and VCSEL-based photonics for optical communications and sensing.”

Establishing a memorial fund through the IEEE Foundation is a gratifying way to recognize someone who has touched your life while also advancing technology for humanity. If you are interested in learning more about memorial and tribute funds, reach out to the IEEE Foundation team: donate@ieee.org.

Diesel equipment will be replaced with hydrogen- or electric-power gear.

Officials in New York City have quietly told hundreds of migrants that the city will stop funding hotels in upstate Albany in December.

The post NYC Warns Migrants Funding for Upstate Hotel Rooms Is Ending appeared first on Breitbart.

One of the leading contenders to be Donald Trump's Treasury Secretary cut his teeth in the belly of the beast: George Soros's hedge fund.

The post How Scott Bessent Fought The Left While Working in George Soros’s Hedge Fund appeared first on Breitbart.

The province says the move comes "after years of AIMCo consistently failing to meet its mandated benchmark returns." For now, Finance Minister Nate Horner has been appointed the AIMCo board's sole director and chair. Senior public servant Ray Gilmour has been appointed interim CEO.

THE Coalition’s pet fund for regional development projects will be rebranded and criteria changed to exclude outer metropolitan suburbs.

FDA’s mission is “at risk” because of inadequate funding. So says Alliance for a Stronger FDA President Diane Dorman, testifying before the FDA Science Board. Her remarks come 5 years after the Science Board made a similar declaration, concluding that decades of underfunding had left FDA without the resources to fulfill its mandate and make science-based decisions. Congress responded with more monies for the agency, but since then the FDA’s workload has increased even faster. The current threat to FDA comes from two sources: four major new laws to implement since 2009; and changes in the environment in which FDA operates, notably acceleration of globalization and increasing scientific complexity. Ms. Dorman’s remarks are reprinted below. If you care about FDA, FDA Matters urges you to read her testimony, go to the Alliance’s site (www.StrengthenFDA.org) and join.

At a time when FDA’s responsibilities continue to grow rapidly, the agency has been caught in an across-the-board reduction (sequester) in federal discretionary spending, effective March 2, 2013. Although Congress may yet reverse course and restore money to affected federal agencies, this is not considered a high probability. Altogether, FDA will lose about $209 million between now and September 30, 2013. This will reduce inspections, slow drug and device approvals, and restrict implementation of the Food Safety Modernization Act and other recent legislation. Because of the many questions about the process and outcome, this is FDA Matters’ primer on the sequester of FDA funds.

By Mike Cloonan, CEO of Sionna Therapeutics, as part of the From The Trenches feature of LifeSciVC An insightful piece on this blog following the JPM healthcare conference noted the “refreshing burst of enthusiasm” in the biotech sector. It’s true

The post Lessons From A Private Funding Round: Science, Relationships, And Experience appeared first on LifeSciVC.

This new 10-minute TEDMED talk is getting quite a bit of attention:


 (if embedded video does not work, try the TED site itself.)

In it, Roger Stein claims to have created an approach to advancing drugs through clinical trials that will "fundamentally change the way research for cancer and lots of other things gets done".

Because the costs of bringing a drug to market are so high, time from discovery to marketing is so long, and the chances of success of any individual drug are so grim, betting on any individual drug is foolish, according to Stein. Instead, risks for a large number of potential assets should be pooled, with the eventual winners paying for the losers.

To do this, Stein proposes what he calls a "megafund" - a large collection of assets (candidate therapies). Through some modeling and simulations, Stein suggests some of the qualities of an ideal megafund: it would need in the neighborhood of $3-15 billion to acquire and manage 80-150 drugs. A fund of this size and with these assets would be able to provide an equity yield of about 12%, which would be "right in the investment sweet spot of pension funds and 401(k) plans".

Here's what I find striking about those numbers: let's compare Stein's Megafund to everyone's favorite Megalosaurus, the old-fashioned Big Pharma dinosaur sometimes known as Pfizer:

	Megafund (Stein)	Megalosaurus (Pfizer)
Funding	$3-15 billion	$9 billion estimated 2013 R&D spend
Assets	80-150	81 (in pipeline, plus many more in preclinical)
Return on Equity	12% (estimated)	9.2% (last 10 years) to 13.2% (last 5)

Since Pfizer's a dinosaur, it can't possibly compete with the sleek, modern Megafund, right? Right?

These numbers look remarkably similar. Pfizer - and a number of its peers - are spending Megafund-sized budget each year to shepherd through a Megafund-sized number of compounds. (Note many of Pfizer's peers have substantially fewer drugs in their published pipelines, but they own many times more compounds - the pipeline is just the drugs what they've elected to file an IND on.)

What am I missing here? I understand that a fund is not a company, and there may be some benefits to decoupling asset management decisions from actual operations, but this won't be a tremendous gain, and would presumably be at least partially offset by increased transaction costs (Megafund has to source, contract, manage, and audit vendors to design and run all its trials, after all, and I don't know why I'd think it could do that any more cheaply than Big Pharma can). And having a giant drug pipeline's go/no go decisions made by "financial engineers" rather than pharma industry folks would seem like a scenario that's only really seen as an upgrade by the financial engineers themselves.
A tweet from V.S. Schulz pointed me to a post on Derek Lowe's In the Pipeline blog. which lead to a link to this paper by Stein and 2 others in Nature Biotechnology from a year and a half ago. The authors spend most of their time differentiating themselves from other structures in the technical, financial details rather than explaining why megafund would work better at finding new drugs. However, they definitely think this is qualitatively different from existing pharma companies, and offer a couple reasons. First,

[D]ebt financing can be structured to be more “patient” than private or public equity by specifying longer maturities; 10- to 20-year maturities are not atypical for corporate bonds. ... Such long horizons contrast sharply with the considerably shorter horizons of venture capitalists, and the even shorter quarterly earnings cycle and intra-daily price fluctuations faced by public companies.

I'm not sure where this line of though is coming from. Certainly all big pharma companies' plans extend decades into the future - there may be quarterly earnings reports to file, but that's a force exerted far more on sales and marketing teams than on drug development. The financing of pharmaceutical development is already extremely long term.

Even in the venture-backed world, Stein and team are wrong if they believe there is pervasive pressure to magically deliver drugs in record time. Investors and biotech management are both keenly aware of the tradeoffs between speed and regulatory success. Even this week's came-from-nowhere Cinderella story, Intercept Pharmaceuticals, was founded with venture money over a decade ago - these "longer maturities" are standard issue in biotech. We aren't making iPhone apps here, guys.

Second,

Although big pharma companies are central to the later stages of drug development and the marketing and distributing of approved drugs, they do not currently play as active a role at the riskier preclinical and early stages of development

Again, I'm unsure why this is supposed to be so. Of Pfizer's 81 pipeline compounds, 55 are in Phase 1 or 2 - a ratio that's pretty heavy on early, risky project, and that's not too different from industry as a whole. Pfizer does not publish data on the number of compounds it currently has undergoing preclinical testing, but there's no clear reason I can think of to assume it's a small number.

So, is Megafund truly a revolutionary idea, or is it basically a mathematical deck-chair-rearrangement for the "efficiencies of scale" behemoths we've already got?

[Image: the world's first known dino, Megalosaurus, via Wikipedia.]

Pending post verification are claims that total $279 million for the March-May 2007 period. The areas of greatest concern to us include costs for helicopter operations ($83 million annually), radar maintenance ($65 million annually) and Joint Staff operations ($5 million annually).

Tarin requested that an additional $500 million of U.S. assistance flow through the GOP - in addition to the $174 million already committed - to bolster GOP credibility and allow the GOP to more adequately support its priorities.

Between August 2006 and July 2007, we received a claim for 26 million USD in barbed wire and pickets. While these items are no doubt helpful in protecting outposts, the claim figures are highly suspect.

The AIADMK spent the highest share in spreading the party’s propaganda (99.5%) and relied only on media and advertisements

Total income for the selected regional parties in FY20 amounted to ₹803.24 crore, of which 55% was from unknown sources

Jan 24, 2024

In this Q&A, Joseph S. Nye talks about his advice for the interim and future president of Harvard in the wake of Claudine Gay's resignation, which countries should be highest on our radar to prevent the threat of nuclear war, what role the U.S. should play in the Russia-Ukraine war, the significance of U.S. alliances in the Middle East, and more.

Mar 18, 2024

Harvard Kennedy School hosted Jahi Wise, Senior Adviser to the Administrator of the U.S. Environmental Protection Agency, to discuss the design and implementation of the Greenhouse Gas Reduction Fund, a historic investment in American clean energy technology finance.

EY�s Natalie Deak on how hedge fund managers are pursuing growth

Nuelle� Chief Commercial Officer Lesa Musatto briefly shares why Fiera� was created, its benefits and how it works.

Broll footage and soundbites from a Recreational Boating & Fishing Foundation (RBFF) event at the George Bush Presidential Library on Thursday, April 14, 2016, in College Station, Texas. RBFF is a nonprofit organization whose mission is to increase participation in recreational angling and boating, thereby protecting and restoring the nation�s aquatic natural resources.

Learn more about the 2016 PetSafe� Bark for Your Park� grant-giving program in this video.

The Leukemia & Lymphoma Society exists to find cures and ensure access to treatments for blood cancer patients. We are saving lives not someday, but today.

Eva Longoria :30 English

Qantas Wallabies player Nick Cummins promotes the #pass4prostate challenge and USA vs. Australia match coming up on Sept. 5 in Chicago. #pass4prostate and the match are presented by Astellas Pharma

St. Baldrick�s Foundation grants reach the best research far and wide, funding both individual doctors and groups of institutions focused on childhood cancers and their cures. Every cent benefits children everywhere.

AACR Survey and Cancer Progress Report 2015 Video

Purple Purse PSA

Dr. David Weinstock of Dana-Farber Cancer Institute discusses his LLS grant

The Journey Home :60 TV PSA

whether it is compulsory to submit CA Certificate for refund claim exceeding Rs 200000 /- in case of GST refund due to inverted duty structure ??

The Income Tax Department has intensified scrutiny on dubious tax refund claims for the assessment years 2021-22 and 2022-23, issuing notices to multiple taxpayers across the country. ...

New figures show university graduates could be eligible for refunds worth nearly £200m.

The funding of British Olympians makes it impossible for emerging sports to develop, says the chief executive of British Handball.

Nicky Hunt expects to challenge for a medal at Rio 2016 after learning she will receive full Olympic funding from Archery GB.