A STING (stimulator of interferon genes) agonist GSK3996915 under investigation in early discovery for hepatitis B was orally dosed to a mouse model for understanding the parent drug distribution in liver, the target organ. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) was used to quantify the distribution of GSK3996915 in liver collected from mice administered a single oral dose at 90 mg/kg. GSK3996915 was detected with a zonal distribution localized in the portal triad and highly concentrated in the main bile ducts, indicating clearance through biliary excretion. High spatial resolution imaging showed the distribution of the parent drug localized to the cellular populations in the sinusoids, including the Kupffer cells. Additionally, a series of drug-related metabolites were observed to be localized in the central zones of the liver. These results exemplify the potential of utilizing MALDI IMS for measuring not only quantitative drug distribution and target exposure but also drug metabolism and elimination in a single suite of experiments.

ABSTRACTDespite global consensus on the importance of male involvement in family planning, disparities persist in low- and middle-income countries, where women continue to bear the responsibility for these initiatives. The Philippines, with a high fertility rate and unmet family planning needs, exemplifies this challenge. We present the experiences and lessons learned from implementing the no-scalpel vasectomy (NSV) program in Davao City, showcasing its potential for increasing male engagement in family planning decisions. Launched in 2008, the program aimed to address gender disparity by promoting NSV as a safe and effective contraceptive alternative to female-centric methods. Through the use of culturally sensitive information campaigns and couple-focused counseling, the program challenged traditional notions of masculinity and encouraged shared decision-making. Strong local government commitment and public-private partnerships played key roles in driving the program’s success. Results showed an average annual increase of 80% in NSV clients over the past 3 years compared to before the COVID-19 pandemic, underscoring its effectiveness. The program presents a compelling intervention model for similar initiatives, highlighting how overcoming cultural barriers, infrastructure limitations, and budgetary constraints through policy advocacy, strategic partnerships, and tailored approaches can significantly boost male involvement in family planning and improve reproductive health outcomes within communities.

Le texte complet de l’article est aussi disponible en français.

ABSTRACTTraining health workers is one of the biggest challenges and cost drivers when introducing a new contraceptive method or service delivery innovation. PATH developed a digital training curriculum for family planning providers who are learning to offer subcutaneous DMPA (DMPA-SC), including through self-injection, as an option among a range of contraceptive methods. The DMPA-SC eLearning course for health workers includes 10 lessons with an emphasis on informed choice counseling and training clients to self-inject. In partnership with Ministries of Health in Senegal and Uganda, the course was rolled out in select areas in 2019–2020, including during the COVID-19 pandemic when physical distancing requirements restricted in-person training. We conducted evaluations in both countries to assess the practical application of this digital training approach for contraceptive introduction. The evaluation consisted of a post-training survey, an observational assessment conducted during post-training supportive supervision, and an estimation of training costs.In both countries, a majority (88.6% in Uganda and 64.3% in Senegal) scored above 80% on a DMPA-SC knowledge test following the training. In Senegal, where there was a comparison group of providers trained in person, those providers scored similar on the post-test to eLearners. Providers in both groups and in both countries felt more prepared to administer DMPA-SC or offer self-injection to clients after receiving a supervision visit (93%–98% of eLearners felt very prepared after supervision as compared to 45%–72% prior). The evaluation results suggest that digital approaches offer a number of benefits, can be cost-effective, and are most optimal when blended with in-person training and/or supportive supervision.

Cannabinoid and opioid receptor activities can be modulated by a variety of post-translational mechanisms including the formation of interacting complexes. This study examines the involvement of endogenous and exogenous chaperones in modulating the abundance and activity of cannabinoid CB₁ receptor (CB₁R), opioid receptor (DOR), and CB₁R-DOR interacting complexes. Focusing on endogenous protein chaperones, namely receptor transporter proteins (RTPs), we examined relative mRNA expression in the mouse spinal cord and found RTP4 to be expressed at higher levels compared with other RTPs. Next, we assessed the effect of RTP4 on receptor abundance by manipulating RTP4 expression in cell lines. Overexpression of RTP4 causes an increase and knock-down causes a decrease in the levels of CB₁R, DOR, and CB₁R-DOR interacting complexes; this is accompanied by parallel changes in signaling. The ability of small molecule lipophilic ligands to function as exogenous chaperones was examined using receptor-selective antagonists. Long-term treatment leads to increases in receptor abundance and activity with no changes in mRNA supporting a role as pharmacological chaperones. Finally, the effect of cannabidiol (CBD), a small molecule ligand and a major active component of cannabis, on receptor abundance and activity in mice was examined. We find that CBD administration leads to increases in receptor abundance and activity in mouse spinal cord. Together, these results highlight a role for chaperones (proteins and small molecules) in modulating levels and activity of CB₁R, DOR, and their interacting complexes potentially through mechanisms including receptor maturation and trafficking.

Identifying cancer therapy resistance is a key time-saving tool for physicians. Part of chemotherapy resistance includes senescence, a persistent state without cell division or cell death. Chemically inducing senescence with the combination of trametinib and palbociclib (TP) yields several tumorigenic and prometastatic factors in pancreatic cancer models with many potential antibody-based targets. In particular, urokinase plasminogen activator receptor (uPAR) has been shown to be a membrane-bound marker of senescence in addition to an oncology target. Methods: Here, 2 antibodies against murine uPAR and human uPAR were developed as immuno-PET agents to noninvasively track uPAR antigen abundance. Results: TP treatment increased cell uptake both in murine KPC cells and in human MiaPaCa2 cells. In vivo, subcutaneously implanted murine KPC tumors had high tumor uptake with the antimurine uPAR antibody independently of TP in young mice, yet uPAR uptake was maintained in aged mice on TP. Mice xenografted with human MiaPaCa2 tumors showed a significant increase in tumor uptake on TP therapy when imaged with the antihuman uPAR antibody. Imaging with either uPAR antibody was found to be more tumor-selective than imaging with [¹⁸F]FDG or [¹⁸F]F-DPA-714. Conclusion: The use of radiolabeled uPAR-targeting antibodies provides a new antibody-based PET imaging candidate for pancreatic cancer imaging as well as chemotherapy-induced senescence.

Both preclinical and clinical studies implicate functional impairments of several neuroactive metabolites of the kynurenine pathway (KP), the major degradative cascade of the essential amino acid tryptophan in mammals, in the pathophysiology of neurologic and psychiatric diseases. A number of KP enzymes, such as tryptophan 2,3-dioxygenase (TDO2), indoleamine 2,3-dioxygenases (IDO1 and IDO2), kynurenine aminotransferases (KATs), kynurenine 3-monooxygenase (KMO), 3-hydroxyanthranilic acid oxygenase (3-HAO), and quinolinic acid phosphoribosyltransferase (QPRT), control brain KP metabolism in health and disease and are therefore increasingly considered to be promising targets for the treatment of disorders of the nervous system. Understanding the distribution, cellular expression, and regulation of KP enzymes and KP metabolites in the brain is therefore critical for the conceptualization and implementation of successful therapeutic strategies.

BackgroundIncident benzodiazepine prescriptions in primary care for anxiety decreased between 2003 and 2018. However, from 2008, incident prescribing of benzodiazepines for anxiety increased among those aged 18–34 years. There are increasing concerns around prescribing of benzodiazepines. Further, although guidelines state benzodiazepines should only be prescribed short term, in 2017, 44% of incident prescriptions were prescribed for longer than the recommended duration of 2–4 weeks.AimTo understand when and why GPs prescribe benzodiazepines for anxiety in young adults.Design and settingA qualitative study was undertaken using in-depth interviews with 17 GPs from 10 general practices in South West England.MethodInterviews were conducted by telephone or videocall. A topic guide was used to ensure consistency across interviews. Interviews were audio-recorded, transcribed verbatim, and data analysed using reflexive thematic analysis.ResultsGPs described caution in prescribing benzodiazepines for anxiety in young adults, but thought they had an important role in acute situations. GPs described caution in prescribing duration, but some thought longer-term prescriptions could be appropriate. In light of these views, some GPs questioned whether primary care needs to revisit how clinicians are using benzodiazepines. GPs perceived that some young adults requested benzodiazepines and suggested this might be because they wanted quick symptom relief. GPs noted that refusing to prescribe felt uncomfortable and that the number of young adults presenting to general practice, already dependent on benzodiazepines, had increased.ConclusionPatient-driven factors for prescribing benzodiazepines suggest there are current unmet treatment needs among young adults with anxiety. Given increases in prescribing in this age group, it may be timely to revisit the role of benzodiazepines in the management of people with anxiety in primary care.

The usual challenges of conducting primary care research, including randomized trials, have been exacerbated, and new ones identified, during the COVID-19 pandemic. HOMER (Home versus Office for Medication Enhanced Recovery; subsequently, Comparing Home, Office, and Telehealth Induction for Medication Enhanced Recovery) is a pragmatic, comparative-effectiveness research trial that aims to answer a key question from patients and clinicians: What is the best setting in which to start treatment with buprenorphine for opioid use disorder for this patient at this time? In this article, we describe the difficult journey to find the answer. The HOMER study began as a randomized trial comparing treatment outcomes in patients starting treatment with buprenorphine via induction at home (unobserved) vs in the office (observed, synchronous). The study aimed to enroll 1,000 participants from 100 diverse primary care practices associated with the State Networks of Colorado Ambulatory Practices and Partners and the American Academy of Family Physicians National Research Network. The research team faced unexpected challenges related to the COVID-19 pandemic and dramatic changes in the opioid epidemic. These challenges required changes to the study design, protocol, recruitment intensity, and funding conversations, as well as patience. As this is a participatory research study, we sought, documented, and responded to practice and patient requests for adaptations. Changes included adding a third study arm using telehealth induction (observed via telephone or video, synchronous) and switching to a comprehensive cohort design to answer meaningful patient-centered research questions. Using a narrative approach based on the Greek myth of Homer, we describe here the challenges and adaptations that have provided the opportunity for HOMER to thrive and find the way home. These clinical trial strategies may apply to other studies faced with similar cultural and extreme circumstances.

Vision is initiated by capturing photons in highly specialized sensory cilia known as the photoreceptor outer segment. Because of its lipid and protein composition, the outer segments are prone to photo-oxidation, requiring photoreceptors to have robust antioxidant defenses and high metabolic synthesis rates to regenerate the outer segments every 10 days. Both processes required high levels of glucose uptake and utilization. Retinitis pigmentosa is a prevalent form of inherited retinal degeneration characterized by initial loss of low-light vision caused by the death of rod photoreceptors. In this disease, rods die as a direct effect of an inherited mutation. Following the loss of rods, cones eventually degenerate, resulting in complete blindness. The progression of vision loss in retinitis pigmentosa suggested that rod photoreceptors were necessary to maintain healthy cones. We identified a protein secreted by rods that functions to promote cone survival, and we named it rod-derived cone viability factor (RdCVF). RdCVF is encoded by an alternative splice product of the nucleoredoxin-like 1 (NXNL1) gene, and RdCVF was found to accelerate the uptake of glucose by cones. Without RdCVF, cones eventually die because of compromised glucose uptake and utilization. The NXNL1 gene also encodes for the thioredoxin RdCVFL, which reduces cysteines in photoreceptor proteins that are oxidized, providing a defense against radical oxygen species. We will review here the main steps of discovering this novel intercellular signaling currently under translation as a broad-spectrum treatment for retinitis pigmentosa.

RADIO shock jock fan Alan Jones unleashed on both sides of politics on Q&A last night — and came out in defence of Brexit.

Chris embraces our cyberpunk subscription overlords. Josh kills the innkeeper (accidentally). Meanwhile Robert plunges down the .Hack hole.

The post RPG Cast – Episode 610: “No One Should Learn Japanese from Super Robot Wars” appeared first on RPGamer.

Chris is on the dice web. Kelley's cat will break her foot with a metal d20. Johnathan fights his "bad me" supervillain self.

The post RPG Cast – Episode 658: “Space Marines Were in the Bible” appeared first on RPGamer.

Chris believes rabites are full of juice. Kelley's furry tank game bias is exposed. Robert gets to be the Snivey he always was inside. Rock flautist.

The post RPG Cast – Episode 702: “He Plays Flute Like Your Mom Plays SNES” appeared first on RPGamer.

Josh increases his charisma with Sega BASS fishing. Chris plays something other than Path of Exile. Kelley thinks the world sucks and goes to pet a cat. Cook my toast.

The post RPG Cast – Episode 709: “2004 Jankiness in 2024” appeared first on RPGamer.

More than a billion passengers flew with budget airlines last year, helping lift total passengers to 3.7 billion.

Super Mario Party Jamboree (NS) has remained in first place on the retail charts in Japan with sales of 57,522 units, according to Famitsu for the week ending October 27, 2024. 

Farmagia (NS) debuted in eighth place with sales of 4,296 units.

Romancing SaGa 2: Revenge of the Seven (NS) remained in second place with sales of 14,646 units. The PS5 version fell from third to seventh place with sales of 5,097 units.

Call of Duty: Black Ops 6 (PS5) is up one spot to third place with sales of 8,620 units and Mario Kart 8 Deluxe (NS) re-entered the top 10 in fourth place with sales of 5,782 units.

Professional Baseball Spirits 2024-2025 (PS5) is up two spots to fifth with sales of 5,729, and The Legend of Zelda: Echoes of Wisdom (NS) is up two spots to sixth place with sales of 5,492 units.

The Nintendo Switch was the best-selling platform with 60,096 units sold. The PlayStation 5 sold 13,965 units, the Xbox Series X|S sold 2,610 units, and the PlayStation 4 sold 53 units.

Here are the best-selling games in Japan:

1. [NSW] Super Mario Party Jamboree (Nintendo, 10/17/24) – 57,522 (364,484)
2. [NSW] Romancing SaGa 2: Revenge of the Seven (Square Enix, 10/24/24) – 14,646 (85,013)
3. [PS5] Call of Duty: Black Ops 6 (Activision, 10/25/24) – 8,620 (35,567)
4. [NSW] Mario Kart 8 Deluxe (Nintendo, 04/28/17) – 5,782 (6,044,039)
5. [PS5] Professional Baseball Spirits 2024-2025 (Konami, 10/17/24) – 5,729 (84,989)
6. [NSW] The Legend of Zelda: Echoes of Wisdom (Nintendo, 09/26/24) – 5,492 (294,371)
7. [PS5] Romancing SaGa 2: Revenge of the Seven (Square Enix, 10/24/24) – 5,097 (37,254)
8. [NSW] Farmagia (Marvelous, 11/01/24) – 4,296 (New)
9. [NSW] Animal Crossing: New Horizons (Nintendo, 03/20/20) – 4,253 (7,943,533)
10. [NSW] Minecraft (Microsoft, 06/21/18) – 4,242 (3,666,338)

Here is the hardware breakdown (followed by lifetime sales):

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463007/super-mario-party-jamboree-tops-the-japanese-charts/

ublisher Bethesda Softworks and developer MachineGames have released a gameplay deep dive video for Indiana Jones and the Great Circle that is nearly 15 minutes in length.

"From locations and puzzles to gear and combat, MachineGames Audio Director, Pete Ward, takes us on a whirlwind journey through the world of The Great Circle," reads the description to the video. "Get ready for launch with this look at Indy’s grand adventure."

View the gameplay deep dive below:

Indiana Jones and the Great Circle will launch for the Xbox Series X|S, PC via Steam and Microsoft Store, and Xbox Game Pass on December 9.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463033/indiana-jones-and-the-great-circle-gets-gameplay-deep-dive/

Fox News host Bret Baier recapped his Wednesday night interview with Vice President Kamala Harris, telling his colleagues that he got a sense early on that Harris “was going to be tough to redirect without me trying to interrupt.”

The interview, Harris’ first on the right-wing network since becoming the Democratic nominee, was broadcast on Special Report after being filmed in the previous hour. According to Baier, the interview had been scheduled for 5 p.m., but Harris showed up 15 minutes late. This, he complained, was like “icing the kicker” in football.

“We were supposed to start at 5 p.m. This was the time they gave us. Originally, we were going to do 25 or 30 minutes. They came in and said, ‘Well, maybe 20.’ So, it’s already getting whittled down. And then the vice president showed up at about 5:15 p.m. We were pushing the envelope to be able to turn it around for the top of the 6 p.m.. So that’s how it started,” Baier said.

Read more at The Daily Beast.

Disaster was averted at a Kentucky hospital when an ostensibly deceased organ donor began “thrashing” around in the operating theater, a preservationist tells NPR.

“He was moving around,” Natasha Miller recalled of the patient, whom NPR identified as Anthony Thomas “TJ” Hoover II. “He was crying visibly.”

The two surgeons assigned to the transplant naturally refused to go through with the procedure, which was reportedly scheduled to take place at Baptist Health Richmond Hospital in October 2021. But when her colleague called Kentucky Organ Donor Affiliates, which coordinated the harvest, Miller said the supervisor told them they “were going to do the case” and needed to “find another doctor.”

Read more at The Daily Beast.

Ogres, Orcs, and Khorne are all on the way in the upcoming expansion for strategy game Total War: Warhammer 3, and Creative Assembly have just released their latest dev vlog with a few more details on what to expect. There’s still no word on the exact title, although given the established naming convention (Shadows Of Change, Thrones Of Decay), I’m tentatively calling it “Sniffers Of Glue” in honour of the No Think, Only Krump faction selection.

You’ll find the vlog in its full glory below. What’s interesting about this one is that vlog mainstay director Rich Alridge has brought along some new faces: battle designer Josh King and audio director Chris Goldsmith. And, yes, so no-one can accuse me of burying the lede: that audio design involved the enthusiastic, deeply disgusting slurping of porridge and yoghurt, and the jangling of real bones. The source of the bones is not revealed.

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We’re still a week away from Blizzard’s Warcraft 30th Anniversary Direct next Wednesday the 13th of November, but art from an apparent remaster of 1995 real time strategy game Warcraft II: Tides Of Darkness has leaked online, via Xibbly user Stiven. It’s a thin one, as far as leaks go, but does show what looks to be cover, logo art, and a Battle.net icon. Thanks for the spot, Percy Coswald Gamer.

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Foxhole is one of my favourite games to read about, even if I don't play it. It's a massively multiplayer World War 2 game, viewed from above, where battlefield logistics matters as much as aiming and flanking. Its developers have just announced a major new update coming next summer, Foxhole: Airborne, which adds planes to the game for the first time.

Planes, in a topdown MMO? It makes a little more sense if you watch the trailer.

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Take-Two Interactive have sold their publishing label Private Division to an unnamed party, along with five of Private Division's "live and unreleased titles". The GTA 6 publisher have also finally confirmed that they have shut down OlliOlli World and Rollerdrome devs Roll7 together with Kerbal Space Program 2 creators Intercept Games, months after performing mass layoffs at both studios.

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JUDY WOODRUFF: Firefighters say they are making some progress battling the wildfires in Northern California. In all, the fires have consumed more than 220,000 acres, an area larger than New York City.

More than 5,700 structures have been destroyed. And at least 41 people have died, making it the deadliest wildfire in the state’s history.

The wine industry and the tourism business connected with it are trying to take stock. More than $50 billion in California’s economy comes from the wine business. And nearly 24 million people visit the region for that reason every year.

Special correspondent Joanne Jennings reports from Napa County.

JOANNE JENNINGS, Special Correspondent: The Mayacamas mountain range creates a natural barrier between Sonoma and Napa Counties. And it is here where the massive Nuns fire is posing a tough challenge for some 11,000 firefighters who are taming the blaze with aircraft and units on the ground.

CAPT. MARK BRENNERMAN, Viejas fire Department: We’re going around and making sure none of these fires that are still smoldering and smoking, we’re not going to get another big fire out of them.

JOANNE JENNINGS: Even as firefighters are battling shifting winds, owners and workers in Wine Country are trying to determine just how much damage has been done.

The tony Highlands gated community was among the first to be consumed by flames when the Atlas fire raced through this canyon, leaving several mansions in rubble. Down the hill, at the Silverado resort, charred remnants of the Safeway PGA Tour remain. The major golf event had just wrapped up last Sunday afternoon, a few hours before flames engulfed tents and grandstands, forcing spectators and athletes to evacuate.

MAN: Do you see how it burned right up to the retaining wall here?

JOANNE JENNINGS: Silverado resident Steve Messina stayed behind and shot video of fire crews containing the flames, which consumed some condos. Within minutes, flames raced three miles down Silverado Trail, home to several storied hillside vineyards.

Most wineries in the region have been spared the worst. But hundreds suffered some damage. And at least eight vineyards have been significantly damaged or destroyed.

Pierre Birebent, who has been making wines for the family-owned Signorello estate for 20 years, rushed to his winery as quickly as he could.

PIERRE BIREBENT, Signorello Estate Vineyards: I jumped right in my truck, came down, and then when I was riding down, I saw the hill all flaming.

JOANNE JENNINGS: Two vineyard workers joined him to help save the estate’s tasting room.

PIERRE BIREBENT: But the smoke was getting very thick, and the wind was very strong. And after an hour, we couldn’t breathe anymore. At the moment, I was so upset. It was rage to see that I couldn’t do anything. But it was like fighting a giant.

JOANNE JENNINGS: The tasting room, which also housed the winery’s office and a dining room, burned to the ground. But Birebent says he wants to focused on what survived.

Fortunately, he said, the fire stopped short of reaching the vineyard, the crush pad, or any of the barrels of wine stored on site; 95 percent of this year’s grapes were already picked.

But, to be on the safe side, Birebent is taking these samples to a lab to make sure the juice is not too acidic for winemaking. If the crops are OK, a staff of 25 employees will have jobs to return to.

As the fires begin to recede and the smoke clears, people here are beginning to wonder when the tourists, who fuel much of the economy, will return.

It’s a serious concern for Andrew and Jeni (ph) Schluter, who are self-employed and are raising a young family.

ANDREW SCHLUTER, Andrew’s Tours and Transportation: I do wine tours and transportation for people. And my business started to do really, really well. I was on track to have the best month ever.

JOANNE JENNINGS: Andrew just bought this new SUV, which has been idle in his driveway collecting ash. Jeni is a personal trainer and has family who lost their homes in the fires. She’s just not sure how they’re going to make ends meet.

WOMAN: I think we’re just overwhelmed, you know? And uncertainty is kind of scary.

ANDREW SCHLUTER: We will hopefully get by for awhile, but we might make — have to make some hard decisions shortly.

JOANNE JENNINGS: While fires burn nearby, some vineyards are already open to tourists. At the Raymond Vineyard, workers are crushing grapes at a feverish pitch. The tasting room is open for the first time since the fires started.

Jeremy and Erika Moore arrived from Tennessee yesterday. They considered canceling their trip, but decided the best way they could help people here is to give them their business.

JEREMY MOORE, Tourist: On the one hand, a few hundred yards from here, you can see them shuttling up with the helicopters fighting fires, but then here it’s beautiful. They are doing some great tastings, and they are working outside on the crops. So, it’s a weird combination of tragedy, but then at the same time business must go on, too.

JOANNE JENNINGS: Proprietor Jean-Charles Boisset owns several wineries in California, France and Canada, but like many other people here, he and his family had to evacuate their home when the flames came dangerously close.

Still, he is bullish about the future of the wine industry in this region.

JEAN-CHARLES BOISSET, Boisset Collection: Napa has been one of the most amazing agricultural places in California for a long time, so it will survive those fires. What I love, as a Frenchman here in California, is that amazing American positive attitude.

We will recover. We will walk again, run again, and we will welcome all our guests and give them the dreams of fine wine.

JOANNE JENNINGS: For the PBS NewsHour, I’m Joanne Jennings in Napa Valley, California.

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A newly spotted asteroid named 2024 RW1 burned up in the atmosphere over the South Pacific, creating a spectacular bright flash in the sky over the Philippines just hours after first being detected

Data collected by the Zhurong rover and orbiting satellites suggests the existence of an ancient shoreline in the Utopia Planitia region of Mars

The first ever full-scale demonstration of a nuclear reactor designed to passively cool itself in an emergency was a success, showing that it should be possible to build nuclear plants without the risk of dangerous meltdown

Devices that let people with paralysis walk and talk are rapidly improving. Some see a future in which we alter memories and download skills – but major challenges remain

Information on faces recognised, voice commands and internet searches can be extracted from an Amazon Echo smart assistant without help from the user or manufacturer

Google, Microsoft and others have taken big steps towards error-free devices, hinting that quantum computers that solve real problems aren’t far away

Smartphones have indeed created an "anxious generation", but it isn't young people, it is their parents, argues neuroscientist Dean Burnett

Gears just a few micrometres wide can be carved from silicon using a beam of electrons, enabling tiny robots or machines that could interact with human cells

A simulator for the process of scientific discovery shows that AI models still fall short of human scientists and engineers in coming up with hypotheses and carrying out experiments on their own

There has been another shock at the Grand Slam of Darts.

The Pokemon Company is teaming up with content creators to stage a 24-hour unboxing live stream for its new Scarlet & Violet - Surging Sparks card set as you Gotta Catch 'Em All

Unidentified Anomalous Phenomena -- that's UAPs for short -- are the centerpiece of a hearing Wednesday co-conducted by the two subcommittees of the House Oversight and Accountability Committee. The joint hearing is titled "Unidentified Anomalous Phenomena: Exposing the Truth."

A company announced the launch of two new advanced drones designed to improve military operations with the use of cutting-edge technology.

In an interview with IT World Canada, consulting giant Deloitte highlighted the importance of an ecosystem-based approach to tackle issues around digital equity in Canada and service delivery challenges in the public sector. “Our strong view is that the people of Canada benefit when there’s effective collaboration between public and private organizations, including on critical […]

The sun blasted a coronal mass at Earth earlier this week, and after back-to-back major hurricanes, some are concerned it could impact the power grid.

Police were in pursuit for half an hour down narrow country lanes

After years trapped in licensing hell, the classic action-RPG is back. But does it still hold up in the days of Dark Souls?

Around 25 per cent of the world’s population has intestinal parasite infections – these could hinder the effectiveness of covid-19 vaccines, according to research in mice

Climate change is extending mosquito season and helping to drive outbreaks of dengue fever, Oropouche virus and eastern equine encephalitis

Loneliness was long thought to cause health conditions ranging from diabetes to cardiovascular disease, but new research paints a more nuanced picture

Our immune cells change a lot as the decades progress, which could explain why we become more susceptible to certain conditions

How well do we look after people who are seriously sick? Astonishingly, research is scant – which makes Neil Vickers and Derek Bolton's ambitious new book, Being Ill, very welcome