There are many uses for antibodies labeled with metal ions. Most of these methods involve first attaching a metal chelator to the antibody molecule. This is achieved using standard cross-linking chemistry and then adding the desired metal at appropriate concentration and pH. The method described here outlines a basic procedure for creating a lanthanide conjugate. Lanthanide conjugates are used for proximity assays, as MRI contrast agents, or for mass cytometry experiments. Different metals and chelators can be substituted, but the basic procedures are similar.

We assess the dynamics of volatility spillovers among global systemically important banks (G-SIBs). We measure spillovers using vector-autoregressive models of range volatility of the equity prices of G-SIBs, together with machine learning methods. We then compare the size of these spillovers with the degree of systemic importance measured by the Basel Committee on Banking Supervision's G-SIB bucket designations.

FSI Briefs No 1, April 2020. Regulatory policy responses should seek to support economic activity while preserving the financial system's soundness and ensuring transparency. The recommendation for banks to make full use of capital and liquidity buffers should go hand in hand with restrictions on dividends and bonuses and clarity concerning the process for rebuilding them. Flexibility in loan classification criteria for prudential and accounting purposes should be complemented with sufficient disclosure on the criteria banks use to assess creditworthiness. The publication of detailed guidance on the application of expected loss provisioning rules, combined with sensible transitional arrangements, may constitute a balanced approach to mitigating the unintended effects of the new accounting standards.

BIS Bulletin No 8, April 2020. Information on local labour markets and Google searches can be used to construct a measure of the vulnerability of employment in different regions of the United States to the Covid-19 shock. Regional exposure to Covid-19 varies significantly, ranging from a low of 2% to a high of 98% of total local employment. We test for the usefulness of the Covid-19 exposure measure by showing that areas with higher exposure report more Google search queries related to the pandemic and unemployment benefits.

FSI Briefs No 4, April 2020. Currently, insurers are more likely to experience losses from financial market volatility than from higher insurance claims arising from Covid-19. Few insurance supervisors have seen a need to strengthen or adjust prudential requirements to insulate insurers from current financial market uncertainties. So far, authorities have responded mainly by taking measures to provide operational relief to insurers from regulatory and supervisory requirements so that they can continue providing insurance services. These measures will also help insurers to enhance risk monitoring of their Covid-19 financial exposures. Some authorities have set out expectations for insurers to conserve capital through prudent exercise of dividend and variable remuneration policies. The aim is to enhance their resilience against huge uncertainties from potential Covid-19 fallout. Other capital-related measures should relieve supervisory pressures and reduce the tendency of insurers to manage their investments in a procyclical manner. These measures include: extending the supervisory intervention ladder, triggering the countercyclical lever and recalibrating capital requirements. The far-reaching impact of Covid-19 calls for sustained vigilance by both supervisors and insurers. In the post-pandemic phase, the extraordinary measures currently warranted will need to be unwound through a carefully crafted exit strategy that preserves sound risk management practices and protects policyholders' interests.

This paper reviews post-crisis financial regulatory reforms, examines how they fit together and identifies open issues. Specifically, it takes stock of the salient new features of bank and CCP international standards within a unified analytical framework.

Recent literature has highlighted that international trade is mostly priced in a few key vehicle currencies, and is increasingly dominated by intermediate goods and global value chains (GVCs). Taking these features into account, this paper reexamines the business cycle dynamics of international trade and its relationship with monetary policy and exchange rates.

Our ongoing celebration of the Library of Congress National Book Festival continues with crime and mystery writer Karin Slaughter discussing "Broken," part of her Will Trent series, on the Fiction & Mystery stage at the 2010 Festival.

British product designer Lucy Hughes has invented a biodegradable plastic made from fish offcuts

Press release about the Basel Committee launching the consolidated Basel Framework, 16 December 2019.

The BIS Board of Directors has decided to invite the central banks of Kuwait, Morocco and Vietnam to become members of the BIS. This is the first such expansion since 2011 and will take the number of members to 63.

The Bank for International Settlements (BIS) today announced two key appointments to the BIS Innovation Hub, a new initiative designed to support central bank collaboration on new financial technology. (Press release, 19 February 2020)

Press release about Basel Committee assesses members' implementation of the Net Stable Funding Ratio and large exposures framework, 19 March 2020

Press release "Saudi G20 Presidency and the Bank for International Settlements (BIS) Innovation Hub invite global innovators to solve RegTech and SupTech challenges", 27 April 2020

It works like a very fine "molecular knob" able to modulate the electrical activity of the neurons of our cerebral cortex, crucial to the functioning of our brain.

Tissue engineering has a unique set of tools and technologies for developing preventive strategies, diagnostics, and treatments that can play an important role during the ongoing COVID-19 pandemic.

A protein shredder that occurs in cell membranes of brain cells apparently also indirectly regulates the fat metabolism.

A randomized, controlled clinical trial evaluating the safety and efficacy of a treatment regimen of the investigational antiviral remdesivir plus the anti-inflammatory drug baricitinib for coronavirus disease 2019 (COVID-19) has begun.

A number of fishing zones in the Gulf of St. Lawrence have been closed after North Atlantic right whales were sighted earlier this week.

Nova Scotia students and teachers will not be returning to the classroom this year. At-home learning will continue until June 5, when the province's school year will end.

A 9-year-old girl was found safe in the Lanaudière region, after she had gone missing Thursday evening in the woods behind her family's second home. 

The provincially appointed trustee of the English Montreal School Board says the Quebec government made the “right decision” when it postponed the reopening of Montreal-area elementary schools to May 25.

A young boy is recovering in hospital after being hit by a car in Montreal's LaSalle borough Friday afternoon, police say.

Here’s some culinary inspiration as you wait out a global pandemic

Derek Jeter, Larry Walker and the rest of this year's Baseball Hall of Fame class will have to wait another year for their big moment at Cooperstown.

Cleveland Indians reliever Emmanuel Clase was suspended 80 games by Major League Baseball on Friday for testing positive for a banned performance-enhancing drug.

Tampa Bay Rays' Blake Snell claimed champion status after defeating Lucas Giolito of the Chicago White Sox in the inaugural MLB The Show player league on Sunday.

The Cleveland Indians held a video conference with players and other team officials to lay out the provisional plan for returning to organized workouts with designs on being ready for a potential 2020 opening day of July 1, according to The Athletic.

The University of Manitoba is laying off dozens of employees as it tries to find savings at a time when post-secondary schools have largely been closed since COVID-19 emerged on the Prairies, a union says.

About one in 12 Manitoba jobs disappeared during the first two months of the COVID-19 pandemic, according to Statistics Canada's latest monthly survey of Canadian employment.

A dead body was found along the CP Rail line near Molson, Manioba, RCMP say.

A group of Winnipeg-born hockey players connected with a sexist group chat are being either let go from their teams or investigated, after screenshots from the private chat were made public earlier this week.

The union that represents thousands of Manitoba workers is asking what safety protocols were in place when a construction worker was killed after a trench wall collapsed on him earlier this week.

We can expect to see more seasonable temperatures by next weekend, says a meteorologist from Environment Canada.

Winnipeg will soon test "small cell" technology to improve cellular reception in parts of Winnipeg, ahead of a possible future transition to 5G service. 

They're not necessarily treating sick patients in hospitals, but a number of Manitoba-based scientists are working long hours and facing incredible pressure to battle the novel coronavirus from their labs and research facilities.

Solar Opposites (date: 5/9/2020 - Rank: 4)

Laurie Garrett (date: 5/9/2020 - Rank: 3)

As a result of the pandemic, USPS, which has run at a loss for years, is even more cash-strapped. It expects to lose $2 billion each month during the pandemic. That prompted Postmaster General Megan Brennan to ask Congress for $50 billion in funds -- $25 billion to offset lost revenue from declining mail volume due to the pandemic, and another $25 billion for modernization.

Officials with Maritime Pride Eggs say their Summerside, P.E.I., egg facility will cease processing operations on June 5.

Health PEI plans to create a COVID-19 unit within the Prince Edward Home to be used for any long-term care resident — living in any long-term care facility on the Island — who is diagnosed with the virus.

With time on their hands, many Islanders have tapped into their creative sides. Some people who are artistic had more time to create and try new things, while others discovered untapped potential as makers. 

Former Michigan Gov. Rick Snyder says he won’t continue with a fellowship at Harvard University following backlash over his role in Flint’s water crisis.

Inflation pressure could be weak even after consumer demand for non-discretionary goods and services begins to grow as the economy gets back on its feet.

Equities are likely to keep trading in volatile ranges until the many conflicting narratives in the market give way to a singular message for investors.

Information technology, health care, and consumer discretionary stocks that outperformed in the last decade have done well in the first four months of 2020.

A look at support and regenerative policy initiatives by the Federal Reserve and the Government as more than 20 million jobs were lost in April 2020.

If he fouls this up, we’re doomed.

The virus is a test. We have the freedom to respond.

Interview with Mr Luis de Guindos, Vice-President of the European Central Bank, and La Vanguardia, conducted by Mr Manel Pérez and published on 12 April 2020.