cr CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients By scienceblogs.com Published On :: Thu, 06 Feb 2020 19:52:53 +0000 CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion. This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years. Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn. sb admin Thu, 02/06/2020 - 14:52 Categories Life Sciences Full Article
cr Appreciating van Leeuwenhoek: The Cloth Merchant Who Discovered Microbes By scienceblogs.com Published On :: Tue, 06 Apr 2021 14:49:13 +0000 Appreciating van Leeuwenhoek: The Cloth Merchant Who Discovered Microbes Imagine trying to cope with a pandemic like COVID-19 in a world where microscopic life was unknown. Prior to the 17th century, people were limited by what they could see with their own two eyes. But then a Dutch cloth merchant changed everything. His name was Antonie van Leeuwenhoek, and he lived from 1632 to 1723. Although untrained in science, Leeuwenhoek became the greatest lens-maker of his day, discovered microscopic life forms and is known today as the “father of microbiology.” Visualizing ‘animalcules’ with a ‘small see-er’ Leeuwenhoek opened the door to a vast, previously unseen world. J. Verolje/Wellcome Collection, CC BY Leeuwenhoek didn’t set out to identify microbes. Instead, he was trying to assess the quality of thread. He developed a method for making lenses by heating thin filaments of glass to make tiny spheres. His lenses were of such high quality he saw things no one else could. This enabled him to train his microscope – literally, “small see-er” – on a new and largely unexpected realm: objects, including organisms, far too small to be seen by the naked eye. He was the first to visualize red blood cells, blood flow in capillaries and sperm. Drawings from a Leeuwenhoek letter in 1683 illustrating human mouth bacteria. Huydang2910, CC BY-SA Leeuwenhoek was also the first human being to see a bacterium – and the importance of this discovery for microbiology and medicine can hardly be overstated. Yet he was reluctant to publish his findings, due to his lack of formal education. Eventually, friends prevailed upon him to do so. He wrote, “Whenever I found out anything remarkable, I thought it my duty to put down my discovery on paper, so that all ingenious people might be informed thereof.” He was guided by his curiosity and joy in discovery, asserting “I’ve taken no notice of those who have said why take so much trouble and what good is it?” When he reported visualizing “animalcules” (tiny animals) swimming in a drop of pond water, members of the scientific community questioned his reliability. After his findings were corroborated by reliable religious and scientific authorities, they were published, and in 1680 he was invited to join the Royal Society in London, then the world’s premier scientific body. Leeuwenhoek was not the world’s only microscopist. In England, his contemporary Robert Hooke coined the term “cell” to describe the basic unit of life and published his “Micrographia,” featuring incredibly detailed images of insects and the like, which became the first scientific best-seller. Hooke, however, did not identify bacteria. Despite Leuwenhoek’s prowess as a lens-maker, even he could not see viruses. They are about 1/100th the size of bacteria, much too small to be visualized by light microscopes, which because of the physics of light can magnify only thousands of times. Viruses weren’t visualized until 1931 with the invention of electron microscopes, which could magnify by the millions. An image of the hepatitis virus courtesy of the electron microscope. E.H. Cook, Jr./CDC via Associated Press A vast, previously unseen world Leeuwenhoek and his successors opened up, by far, the largest realm of life. For example, all the bacteria on Earth outweigh humans by more than 1,100 times and outnumber us by an unimaginable margin. There is fossil evidence that bacteria were among the first life forms on Earth, dating back over 3 billion years, and today it is thought the planet houses about 5 nonillion (1 followed by 30 zeroes) bacteria. Some species of bacteria cause diseases, such as cholera, syphilis and strep throat; while others, known as extremophiles, can survive at temperatures beyond the boiling and freezing points of water, from the upper reaches of the atmosphere to the deepest points of the oceans. Also, the number of harmless bacterial cells on and in our bodies likely outnumber the human ones. Viruses, which include the coronavirus SARS-CoV-2 that causes COVID-19, outnumber bacteria by a factor of 100, meaning there are more of them on Earth than stars in the universe. They, too, are found everywhere, from the upper atmosphere to the ocean depths. A visualization of the human rhinovirus 14, one of many viruses that cause the common cold. Protein spikes are colored white for clarity. Thomas Splettstoesser, CC BY-SA Strangely, viruses probably do not qualify as living organisms. They can replicate only by infecting other organisms’ cells, where they hijack cellular systems to make copies of themselves, sometimes causing the death of the infected cell. It is important to remember that microbes such as bacteria and viruses do far more than cause disease, and many are vital to life. For example, bacteria synthesize vitamin B12, without which most living organisms would not be able to make DNA. Likewise, viruses cause diseases such as the common cold, influenza and COVID-19, but they also play a vital role in transferring genes between species, which helps to increase genetic diversity and propel evolution. Today researchers use viruses to treat diseases such as cancer. Scientists’ understanding of microbes has progressed a long way since Leeuwenhoek, including the development of antibiotics against bacteria and vaccines against viruses including SARS-CoV-2. But it was Leeuwenhoek who first opened people’s eyes to life’s vast microscopic realm, a discovery that continues to transform the world. By Richard Gunderman, Chancellor's Professor of Medicine, Liberal Arts, and Philanthropy, Indiana University. This article is republished from The Conversation under a Creative Commons license. Read the original article. sb admin Tue, 04/06/2021 - 10:49 Categories Life Sciences Full Article
cr Home economics: The human cost of the affordability crisis By www.washingtonexaminer.com Published On :: Tue, 05 Dec 2023 11:00:37 GMT Soaring mortgage rates have combined with high housing prices to push homebuying out of reach for many people, causing major knock-on effects on their lives. Full Article
cr Playoff combatants Shin, Creamer commit to Kingsmill By www.washingtonexaminer.com Published On :: Tue, 23 Apr 2013 04:00:00 GMT Last September in the Kingsmill Championship, winner Jiyai Shin and runner-up Paula Creamer engaged in a riveting, LPGA-record, nine-hole playoff. On Tuesday, the tournament announced both will be back for the event, which has been moved up on the LPGA calendar to May 2-5. Full Article
cr Winsome Sears says crime in DC was 'issue' in Capitals-Wizards arena move By www.washingtonexaminer.com Published On :: Thu, 14 Dec 2023 03:47:37 GMT Virginia Republican Lt. Gov. Winsome Sears cheered on the historic tentative move of the Washington Wizards and Washington Capitals teams to Potomac Yard in Alexandria, Virginia, while also lamenting that Washington, D.C.'s crime wave and safety concerns were a factor in the location change. Full Article
cr Climate warriors fighting some of the 'greatest crises humanity has ever seen' By www.latimes.com Published On :: Tue, 10 Sep 2024 10:00:31 GMT 'Something that Sunrise has taught me, and that I've learned from the world around me, is that hope comes through collective action but is also something that you need to practice.' Full Article
cr 'Grief into action.' Philanthropists give historic $150 million donation to City of Hope for pancreatic cancer research By www.latimes.com Published On :: Tue, 17 Sep 2024 09:30:06 GMT Entrepreneur Emmet Stephenson and his daughter are giving $150 million to City of Hope to fund an award for innovation research in pancreatic cancer. It's the largest single gift the center has received. Full Article
cr California hospitals scramble on earthquake retrofits as state limits extensions By www.latimes.com Published On :: Wed, 9 Oct 2024 10:00:05 GMT California legislators for years have granted extensions on a 1994 law requiring hospitals to retrofit their buildings to withstand earthquakes. Gov. Gavin Newsom in September vetoed an extension for all hospitals but signed a bill granting relief to rural and "distressed" hospitals and some others. Full Article
cr Microdosing Ozempic? Why some people are playing doctor with weight-loss drugs By www.latimes.com Published On :: Tue, 5 Nov 2024 11:00:12 GMT As demand for popular weight-loss drugs like Wegovy and Zepbound skyrockets, patients are taking dosage amounts into their own hands. Full Article
cr Jim Williams: Second-screen options draw U.S. Open to ESPN deal By www.washingtonexaminer.com Published On :: Sat, 18 May 2013 04:00:00 GMT On Thursday, the USTA announced a new 11-year multiplatform broadcast deal with ESPN. The deal will start in 2015 and will make the network the exclusive home of all U.S. Open tennis tournament coverage. Full Article
cr Schumer acknowledges Democrats must change the ‘things we did wrong’ By www.washingtonexaminer.com Published On :: Tue, 12 Nov 2024 23:02:44 +0000 Senate Majority Leader Chuck Schumer (D-NY) reflected on last week’s bruising electoral defeats in which Republicans flipped four seats, giving them a 53-seat majority in the Senate, emphasizing Democrats must do a thorough autopsy to understand “the things we did wrong.” “We have to understand the things we did wrong and we must change,” Schumer […] Full Article Senate Chuck Schumer Congress Leadership Mitch McConnell Republicans Washington D.C.
cr Randy Wittman on trading Jordan Crawford By www.washingtonexaminer.com Published On :: Fri, 22 Feb 2013 05:00:00 GMT I caught up with Wizards coach Randy Wittman prior to shootaround this morning ahead of facing the Denver Nuggets tonight. Here’s what he had to say about trading away Jordan Crawford: Full Article
cr Bradley Beal crisp in return after six-game absence By www.washingtonexaminer.com Published On :: Mon, 18 Mar 2013 04:00:00 GMT Bradley Beal looked like himself again in his first minutes back on the court in a 127-105 victory over Phoenix on Saturday following six missed games with a sprained left ankle. Full Article
cr Trump to host screening of Sound of Freedom at his New Jersey golf club By www.washingtonexaminer.com Published On :: Thu, 13 Jul 2023 20:40:15 GMT Former President and current GOP presidential front-runner Donald Trump has announced he will host a screening of the movie Sound of Freedom at his own golf course in New Jersey. Full Article
cr PGA Tour adds Tiger Woods to policy board after criticism by players over transparency By www.washingtonexaminer.com Published On :: Tue, 01 Aug 2023 17:53:48 GMT The PGA Tour announced it is adding Tiger Woods to its policy board and making changes to its governance after criticism from several players over the lack of transparency in the lead-up to the announced deal between the PGA Tour and the Saudi-backed LIV Golf in June. Full Article
cr TikTok creators sue U.S. government in a bid to stop potential ban By www.latimes.com Published On :: Wed, 15 May 2024 20:05:51 GMT TikTok creators sued the U.S. government on Tuesday, alleging a new law that could ban the app violates their free speech rights under the 1st Amendment. The legislation is meant to force Chinese owner ByteDance to sell the service. Full Article
cr Foundation honoring 'Star Trek' creator offers million-dollar prize to develop AI that's 'used for good' By www.latimes.com Published On :: Thu, 20 Jun 2024 12:00:35 GMT The Gene Roddenberry foundation will award $1 million to an early-stage venture focused on harnessing artificial intelligence in service of humanity. Full Article
cr Uber will add driverless Cruise vehicles to its fleet in 2025 By www.latimes.com Published On :: Fri, 23 Aug 2024 01:22:26 GMT The autonomous vehicle company Cruise, which lost its California operating license last year after one of its cars struck a pedestrian, announced a partnership this week with the ride-hail service Uber. Full Article
cr He's training the world's next microchip leaders. Here's why he worries By www.latimes.com Published On :: Fri, 13 Sep 2024 09:00:13 GMT Geopolitical tensions and technological constraints make the chip industry more complex to navigate. A groundbreaking engineer talks about it future. Full Article
cr Elon Musk's X says it's policing harmful content as scrutiny of the platform grows By www.latimes.com Published On :: Wed, 25 Sep 2024 11:00:51 GMT X, formerly Twitter, released a formal global transparency report Wednesday for the first time since Musk took over the social media platform. Full Article
cr FTC adopts 'click to cancel' rule to make it easier to end subscriptions, mirroring California law By www.latimes.com Published On :: Wed, 16 Oct 2024 22:00:58 GMT A divided FTC adopted a powerful rule that requires companies to make it just as easy to cancel a subscription as it is to sign up for one. Full Article
cr L.A. Times, Washington Post see subscription cancellations over not endorsing in presidential race By www.latimes.com Published On :: Tue, 29 Oct 2024 04:27:10 GMT The Washington Post has lost about 8% of its readers and the L.A. Times 1.8%. But some argue to stay with the newspapers for their roles in reality checking Donald Trump. Full Article
cr Creating Effective Scientific Posters By www.the-scientist.com Published On :: Wed, 30 Oct 2024 13:24:42 GMT Posters need to incorporate scientific communication and graphic design principles to reach their full potential. Full Article The Scientist University
cr Next-Generation PCR Instruments Boost Workflows By www.the-scientist.com Published On :: Fri, 01 Nov 2024 04:00:40 GMT Modern, intuitive, and reliable thermal cyclers excel at optimizing sequencing, cloning, and genotyping throughput. Full Article Magazine Issue
cr A Microbial Ally to Bring Science to the Masses By www.the-scientist.com Published On :: Fri, 01 Nov 2024 04:00:43 GMT By identifying Wolbachia in arthropods, science-enthusiast citizens can help researchers sample the bacteria’s hosts. Full Article Magazine Issue
cr DC's crime leads to more restaurants closing in 2023 than the previous year By www.washingtonexaminer.com Published On :: Tue, 26 Dec 2023 23:49:44 GMT Dozens of beloved Washington restaurants closed this year, more than in 2022, according to the Restaurant Association of Metropolitan Washington. Full Article
cr DC residents begin effort to recall Councilman Charles Allen over response to crime By www.washingtonexaminer.com Published On :: Wed, 03 Jan 2024 18:54:58 GMT Washington, D.C., Councilman Charles Allen is facing a recall effort led by a former government worker, who cited that the representative of Ward 6 should be more focused on curbing crime. Full Article
cr First-pitch strikes critical for Gonzalez By www.washingtonexaminer.com Published On :: Thu, 25 Apr 2013 04:00:00 GMT Gio Gonzalez threw strikes on Thursday night – 78 to be exact, on 112 pitches — keying his one-hit work over eight dominant innings in the Nats’ 8-1 victory over the Reds. Gonzalez (2-1), the Nats’ starter most susceptible to wildness, had walked 11 in 20 innings, lasting no more than six innings in any of his previous four starts. But with the lead from the third inning on, Gonzalez was able to attack. Full Article
cr Female tech jobseekers are furious that men claiming to be 'nonbinary' crashed their conference By www.washingtonexaminer.com Published On :: Thu, 05 Oct 2023 03:38:19 GMT A tech conference meant to be the largest gathering of female technologists faced backlash when biological men identifying as "nonbinary" were seen attending the event. Full Article
cr America’s commitment to technological innovation is at a crossroads By www.washingtonexaminer.com Published On :: Tue, 05 Dec 2023 11:00:20 GMT One of America’s enduring strengths has been its long embrace of technological innovation. From the widespread adoption of groundbreaking technologies such as the automobile and airplane, to the invention of common household appliances such as the dishwasher and microwave, America has never lost sight of technology’s critical role in driving economic development and societal progress. Full Article
cr Cancer Research Takes a Leap Thanks to Nobel-Winning MicroRNA Discovery By www.discovermagazine.com Published On :: Wed, 30 Oct 2024 13:00:00 GMT The Nobel Prize-winning discovery of microRNA has reshaped our understanding of gene regulation. Learn what these tiny molecules mean for cancer research. Full Article The Sciences
cr Human Skeletal Remains of the Mary Rose Shipwreck Give Insight to Health of the Crew By www.discovermagazine.com Published On :: Fri, 01 Nov 2024 18:15:00 GMT New application of Raman spectroscopy imaging allows scientists to probe the chemical composition of sailors lost at sea over 500 years ago. Full Article The Sciences
cr Fool's errand or heroic stand? GOP on Ted Cruz, Mike Lee By www.washingtonexaminer.com Published On :: Wed, 16 Oct 2013 23:17:53 GMT WASHINGTON (AP) — Fool's errand or heroic stand? Full Article
cr Microsoft Releases .NET 9 By www.thurrott.com Published On :: Tue, 12 Nov 2024 16:25:16 +0000 As promised, Microsoft today released .NET 9, the latest version of its free and open-source application platform. The post Microsoft Releases .NET 9 appeared first on Thurrott.com. Full Article Dev .NET .NET 9 WPF Windows Presentation Foundation
cr Microsoft Edge Has a New Trick to Get Data From Chrome Users on Windows By www.thurrott.com Published On :: Tue, 12 Nov 2024 17:19:38 +0000 Microsoft is once again trying to get Chrome users to share their browser data with its Edge browser on Windows. The post Microsoft Edge Has a New Trick to Get Data From Chrome Users on Windows appeared first on Thurrott.com. Full Article Cloud Microsoft Edge Google Chrome Microsoft Consumer Services Web browsers Windows Windows 11
cr Device Encryption (24H2) By www.thurrott.com Published On :: Tue, 12 Nov 2024 19:07:00 +0000 Windows 11 includes a full-disk encryption feature called Device encryption that protects the data on your system drive. Device encryption uses Microsoft BitLocker technologies, and it's enabled automatically the first time you sign in to Windows 11 using a Microsoft account (or Microsoft Work or school account). Technically speaking, Device encryption does not encrypt your entire system disk, which is divided into different logical volumes or partitions. Instead, it encrypts the C: drive, which is the volume that contains Windows and other system files. (This drive is often referred to as the system disk.) Any other volumes on this disk will not be encrypted (nor visible normally while using Windows 11). If you sign in to Windows 11 with a local account, Device encryption will be enabled automatically but not activated (or, fully enabled). If you are using Windows 11 Home, you can only activate Device encryption by signing in to Windows (at least once) with a Microsoft account. With Windows 11 Pro, you can use the BitLocker control panel, described later in this chapter, to activate Device encryption. For the most part, Device encryption is seamless and not something you will notice. But it is important to understand that any files that you copy or move to an encrypted disk are encrypted during the copy/move process. Likewise, any files that you copy or move from an encrypted disk are decrypted during that process as well. Decrypted files can be read or used by anyone, on any PC. When enabled, Device encryption also provides some additional functionality to the system disk on which Windows is installed. For example, when the PC boots, it will examine the integrity of the system to ensure that nothing suspicious has happened to the PC's firmware or startup files. If an issue is found, you'll be prompted to provide the recovery key, which was saved to your Microsoft account (or Work and school account) in the form of a very lengthy text-based password. (This is discussed below.) Manage device encryption Device encryption doesn't offer much in the way of management: This feature is enabled for you automatically when you sign in to Windows 11 using a Microsoft account. However, you can ensure that device encryption is enabled and even disable this feature--which we do not recommend--using the Settings app. To do so, open Settings (WINKEY + I) and navigate to Privacy & security > Device encryption. If you just signed in to Windows 11 for the first time, you may see an "Encryption is in progress" message at the top of this Settings page. That message will disappear when Windows 11 finishes encrypting the system disk. Here, you will find a toggle for device encryption and links to "BitLocker drive encryption" and "Find your BitLocker recovery key," the latter of which launches your default web browser and displays an informational website. If you are using Windows 11 Pro, the "BitLocker drive encryption" link will open the Bi... The post Device Encryption (24H2) appeared first on Thurrott.com. Full Article Windows 11 Field Guide Files Premium
cr Microsoft Releases November 2024 Patch Tuesday Updates By www.thurrott.com Published On :: Tue, 12 Nov 2024 19:10:45 +0000 The November 2024 Patch Tuesday updates for Windows 11 versions 24H2 and 23H2 make it possible to use the Copilot key on PCs that have one to open other apps. The post Microsoft Releases November 2024 Patch Tuesday Updates appeared first on Thurrott.com. Full Article Windows Windows 10 Windows 11 Patch Tuesday
cr Former The Onion Writer Takes On La La Land in Micro Budget By www.thestranger.com Published On :: Mon, 04 Nov 2024 11:22:00 -0800 The 2024 Bainbridge Island Film Festival runs from November 7-10. by Charles Mudede If catastrophe strikes on Tuesday, and all you can see is four years of gloom and more gloom, then it might be the right time to take a ferry to Bainbridge for two reasons. One, the November-colored waters of Elliott Bay will match and maybe even soothe your mood. (One thing you can always depend on is the love misery has for company.) Two, there is a festival, Bainbridge Film Festival, which features a superb distraction, the comedy Micro Budget. Directed by Morgan Evans, who has worked for The Onion, the film cannot be praised for originality but for getting the most out of a concept that really should have no gas left in it: The mockumentary. The plot: An Iowan, Terry (Patrick Noth), decides to relocate to LA to make a movie that can only be, when completed, unspeakably bad. His wife is very pregnant, he doesn't have enough money, and the sun has never shined on his imagination. He hires actors who have many rungs to climb before they come anywhere close to the D List, and the production moves from one absurdity to the next. During the filming process, the pregnant wife suffers, the actors suffer, and the members of the production team work without disguising their contempt. All, including the cousin shooting the documentary, are caught in the fantasy of a madman who should have kept his desires in the lowest drawer of his office desk. We have been there and seen all of that. And yet, Micro Budget, is actually funny and, once in a while, reaches a region that can be called brilliant (particularly in the moments when the director attempts to meet what he imagines to be the woke standards of Hollywood). The film also has a priceless cameo. One you will never expect in a million years. It's worth watching even if a catastrophe is averted on November 6. The 2024 Bainbridge Island Film Festival runs from November 7-10. Full Article Film/TV Arts
cr Stop Doom-Scrolling and Look at These Photos from Seattle’s Largest Cat Convention By www.thestranger.com Published On :: Tue, 05 Nov 2024 10:59:00 -0800 Mute Steve Kornacki, unclench your jaw, and scroll through these sweet scenes from Sea-Meow. by Megan Seling Photos by Madison Kirkman Sea-Meow, which bills itself as Washington’s largest cat convention, invaded Seattle Center’s Exhibition Hall over the weekend and brought with it appearances from the Two Crazy Cat Ladies, Moshow the Cat Rapper, and Christopher Watson aka the Catluminati, as well as a cat costume contest, a cat-calling contest, cat bingo, and dozens of vendors slinging everything from cat beds to catnip to cat coffee. (That is, cat-themed coffee that benefits cat rescues and not, like, coffee for cats.) But most importantly, there were cats. So many cats. Old cats, young cats, kitten cats. Cats available for adoption, cats available for snuggles, and cats being pushed, carried, and cradled in backpacks and strollers and those bags with little clear bubble cutouts that make them look like grumpy-faced astronauts. Election results won’t be in for several hours, and even then, it may take days to know who won. So close Twitter (what are you still doing on that hell site anyway???), mute Steve Kornacki, unclench your jaw, and scroll through these sweet scenes from Sea-Meow. Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Madison Kirkman Full Article Cats Arts
cr Slog AM: SIFF's Egyptian Theater Floods, CDC Cracks Down on Bird Flu, and Who the Fuck Is Sending These Racist Texts? By www.thestranger.com Published On :: Fri, 08 Nov 2024 07:52:00 -0800 The Stranger's morning news round-up. by Nathalie Graham One more for the blue: After a neck-in-neck race, Rep. Marie Gluesenkamp Perez officially won re-election to the House in the 3rd Congressional District, beating out far-right challenger Joe Kent. Her win is another step forward for Democrats as they try to take back the House and retain a shred of power in the coming administration from hell. About two dozen races nation-wide still need to be decided. Please spare us, H5N1: The Centers for Disease Control want more testing done for bird flu after blood tests on 115 of dairy workers showed 7% had bird flu antibodies, meaning they'd already contracted the disease at some point. Previously, we only confirmed 46 cases of bird flu jumping from cows to farmworkers. This new study suggests that bird flu has infected many more people than the confirmed cases. Experts say this indicates the H5N1 viruses are a greater threat than we realized. Great! Another flu just in time for the vaccine-doubters to take office. Wet weekend—and then week—ahead: Friday will likely be our last dry day for a while. Get your galoshes ready. The rain starts Saturday and it'll continue at least throughout the week. I hope you like rain this weekend! ????️It could be wet for the State H.S. football tournament games across the Puget Sound region. #pnw pic.twitter.com/JAvPx7hegV — Jake Whittenberg (@jwhittenbergK5) November 8, 2024 That's nice: Boeing said it will pay the employees the money they lost while being furloughed during the machinists' strike that started in September. Egyptian flooding: A pipe leak at the historic Egyptian Cinema on Capitol Hill shut down the 108-year-old theater for the "foreseeable future." Repairs will be expensive and take months. The universe does not want me or my people (progressives, art house movie lovers) to be happy this week. INBOX: The SIFF Cinema Egyptian is going to be closed for "the foreseeable future and the Fine Arts building leadership expect that it will take multiple months of building closure to assess, repair and reopen." Sad news especially during what is a big time of the year for film. pic.twitter.com/v2ItPx5Lpi — Chase 'Hutch' Hutchinson (@EclecticHutch) November 7, 2024 Another hit while we're down: Don't forget, five light rail stops will close this weekend. Starting at 10 pm on Friday through 5 am Monday, Westlake, Symphony, Pioneer Square, International District/Chinatown, and Stadium stations will all be closed and inaccessible. Trains will run between Lynnwood and Capitol Hill and between Sodo and Angle Lake. Shuttle buses will be available to bridge gaps between open and closed stations. It’s all part of the crawling effort to connect Line 1 to the Eastside line. Sign of the times: Margaret Atwood's The Handmaid's Tale rocketed to the top of Amazon's bestsellers list this week. Racist texts: In the days after the election, Black and Brown people across the country received spammy, racist texts telling them they had "been selected to pick cotton at the nearest plantation" and that the senders' "executive slave catchers" would pick them up. State attorney generals say they will root out who sent these texts. A second Donald Trump term means the masks covering the depravity in America are well and truly off. Racists are emboldened. Nobody panic: Forty-three monkeys escaped from a medical lab in South Carolina. "There is almost no danger to the public," a local police chief said. No danger? Isn't this how Planet of the Apes started? Israeli soccer fans attacked in Amsterdam: Israel’s Maccabi Tel Aviv and Dutch's Ajax faced off in a Europa League soccer game Thursday. After the game, people attacked Israelis in hit-and-run scooter attacks. Five Israeli fans went to the hospital, but have since been released. Around 20 to 30 other Israelis sustained light injuries. Police arrested 63 people, and ten are still in custody. Context, as always, is important. In the days leading up to the match, social media videos showed Maccabi fans "chanting anti-Arab slurs, praising Israeli military attacks in Gaza, and yelling 'fuck the Arabs,'" according to CNN. Ajax won the game 5-0. And now, something from Ashley about the cops: Fill’er up: The King County Jail officially lifted misdemeanor booking restrictions for the Seattle Police Department (SPD) allowing officers to finally lock up all those pesky Target shoplifters and people who tried to use the bathroom at PCC one too many times and ended up trespassed. I wrote about how SPD Deputy Chief Eric Barden told officers in a department wide email Tuesday that they should book people into jail whenever a public safety interest existed and only show additional discretion when the department neared their misdemeanor bed limit of 135 people per day. Most people charged with misdemeanors spend less than a week in jail, so could be a lot of people cycling through, which King County Department of Public Defense Interim Director Matt Sanders said will ultimately make it harder for people to hold down jobs, maintain housing, and secure behavioral health treatment, ultimately undermining public safety in the city. Did you hear about San Francisco's new mayor? He's a centrist Democrat and he's the heir to the Levi's fortune. Daniel Lurie won the ranked-choice voting election with 56.2% of the vote. Incumbent London Breed only received 43.8%. San Franciscans made clear they are sick of seeing poverty and being confronted with crimes of desperation. Unfortunately, as we know very well in Seattle, electing a centrist may hide the problems for a bit, but it will do nothing to fix them. A porn gorge: North Korean soldiers deployed in Russia have unrestricted internet access for the first time in their lives and they're using it to watch mountains of porn and jerk themselves silly. Boys will be boys! Need something to do tonight? The world is bleak. Why not laugh a little at an improv show? The improv theater I wrote about for my column is having a battle of the star signs show tonight followed by an open-to-all improv jam. I'll be performing on the Scorpio team even though I'm not a Scorpio (don't tell anyone). A song for your Friday: This just feels like the sound of my psyche right now. Full Article Slog AM Slog AM/PM
cr Slog AM: City Budget Hearing Tonight, Rob Saka Seeks End of South Lake Union Streetcar, Trump Set on Senator Marco Rubio for Secretary of State By www.thestranger.com Published On :: Tue, 12 Nov 2024 08:25:00 -0800 The Stranger's morning news round-up. by Ashley Nerbovig Goooooood morning: The National Weather Service predicts a 50% chance of rain today, with a breezy evening ahead. Meteorologists expect wind speeds to possibly top 29 miles per hour, so batten down your rotting porch pumpkins people! Time to talk dollars: Want to tell the City Council how to spend your tax dollars? Go to public comment tonight at 5 pm at City Hall. Or you can participate remotely. You can go to tell them to support a capital gains tax, or oppose cuts to tenant services. Or tell the Council to respect the Jumpstart spend plan and actually use the payroll tax to pay for affordable housing, as it was intended. Check back on the blog for more coverage of the budget from Hannah. ICYMI: With the blowout loss for former Council Member Tanya Woo, Hannah tells City Council Member Sara Nelson to count her days. Local politicos plan to mount a serious challenge to the conservative Council President Nelson next year in the hopes of ousting her and her pro-cop, pro-business agenda out of office. Rob Saka Seeks Street Car phase-out: Saka proposed phasing out the South Lake Union streetcar and redirecting the funding to bus service in the City. The budget for the street car is about $4.4 million, which isn't a whole lot of money when you consider Saka wants $2 million to remove the Delridge median so he can take a left turn. Last week, the Office of Police Accountability (OPA) completed its investigation into Seattle Police Department (SPD) Officer Kevin Dave, who hit and killed 23-year-old Jaahnavi Kandula as she crossed through a crosswalk in January 2023. The OPA found Dave violated the department's driving policies as well as its policies requiring officers to follow the law. The City must hold a Loudermill hearing for Dave, which allows him to tell his side of the story before deciding on his discipline, so it may be a couple months before we know the final outcome. In the meantime, Dave continues to fight the traffic ticket Republican City Attorney Ann Davison issued him for his killing of Kandula. Seattle Municipal Court shows Dave's next hearing is scheduled for 8:30 am on December 18 in courtroom 301. BREAKING: OPA concluded its investigation into SPD Officer Kevin Dave on Friday and sustained policy violations for breaking the law and vehicle operation. Next step will be deciding discipline for him. — Ashley Nerbovig (@AshleyNerbovig) November 11, 2024 What's your plan for this week anyway? Maybe you're checking out Christmas Dive Bar? Or maybe it's too soon? Maybe you're trying to enjoy something with more Thanksgiving vibes? Well, as always, our sister publication EverOut has you covered with the top 41 things to do this week in Seattle. Republicans likely to control the US House: As it stands, Republicans have won 214 seats in the House, with Democrats at 205, and 16 races yet to be called. To control the House, Republicans need only to pick up another four seats, which they seem highly likely to do. Congress returned to Washington this week, ready to start setting Trump's right-wing agenda into motion. Trump plans to pick Senator Marco Rubio for Secretary of State: The worst people in American continue to jockey for a position in Trump's new administration, with Florida Republican Rubio possibly securing the role of America's top diplomat, according to Politico. We're sure to hear more names in the coming days, including people such as Tiffany Justice, co-founder of Moms for Liberty, who Trump may consider for Secretary of Education. The nightmare continues. Israel kills 14 in Gaza: Two Israeli strikes killed 14 people in an area Israel had mostly declared to be a humanitarian zone. The deaths included at least two children, according to the Associated Press. Migos’ “Bad And Boujee” (Feat. Lil Uzi Vert): Been a minute since I checked out Tom Breihan's the Number Ones column, and I'm glad I plumbed it for a song today because I normally wouldn't think about Migos around holiday season, but that's when "Bad and Boujee" climbed to the number one spot on the charts, so I suppose that makes it a holiday classic. Full Article Slog AM Slog AM/PM
cr Screaming With Meaning: The Definitive Blood Brothers Lyrics Q&A By www.thestranger.com Published On :: Tue, 12 Nov 2024 15:34:00 -0800 "These pigs locked me up to see what color I'd rot into!" by Suzette Smith Like any fan of Seattle hardcore band the Blood Brothers, I have found myself at a show, pressed up against a wall of people, shouting the wrong lyrics to their songs. For instance, on their hit "USA NAILS" there's a hook where you think you're singing a cheer-style "one, one, and two!" but the lyrics are actually: "These pigs locked me up to see what color I'd rot into!" The energetic screamo group was active from 1997-2007, during which time they released five critically-acclaimed albums, completed several European tours, and even played a set on Jimmy Kimmel Live, overcoming the reservations of the show's freaked-out producers. Perhaps the best indicator of their success is the fact that their US reunion tour—which hits Seattle on November 14 and 15—is selling out in several cities. Ever ones to cut the bullshit, Blood Brothers don't have a new record; they're playing the fucking hits. Still, the tour is timed with Epitaph's anniversary reissue of one of their biggest albums Crimes (2004) on vinyl. When we sat down to talk to Johnny Whitney, who fronts the band with fellow singer/screamer/guttural whisperer Jordan Blilie, he noted that plenty of lyrics websites list incorrect verses for Blood Brothers songs. "It's hilarious how wrong some of them are," Whitney said. "The lyrics on Spotify are not even close to what I'm actually saying. Just buy the fucking CD, and look it up. Come on, people." We spoke with Whitney and Blilie separately, over sprawling phone calls that we have organized into this piece. For clarity, we're listing their responses together, as we seek to get into the nitty gritty of this group's danceable, screaming-nightmare material. Foremost, Whitney and Blilie both began by gushing about the other three members of their band: frenetic drummer Mark Gajadhar, vigorous guitarist Cody Votolato, and ultra-versatile bassist Morgan Henderson, who is currently best known as a member of Fleet Foxes. "I cannot fucking believe that I got to work with these guys," Whitney says. "I just took all those things for granted at the time. Everybody was, and still is, coming from totally different places [musically], but there was always something really special about all of us together that was there from the moment that we started." THE STRANGER: Johnny, I've always gotten the impression that you're the major force behind the lyrics. JOHNNY WHITNEY: I came up with the majority of the lyrics, but it certainly was collaborative between Jordan and I. I would freewrite as much as I could, to have material to draw from, and going back to those notebooks kept things as free and fresh and not contrived as possible. The drawback of that approach is the lyrics are very abstract and hard to parse direct meaning from, but that's also kind of the point. I found myself writing about the absence of answers, or the absence of concrete truths that you can hold onto. A lot of times, my process would center around coming up with a cool idea: a song name or some common refrain that we would want to work into a song, like "Burn Piano Island, Burn." Something that has a hook or conveys an image or feeling. Then we would reverse engineer the lyrics from that. JORDAN BLILIE: I would absolutely say that I felt like Johnny was the driver, and for good reason. He's really good. When you see someone who is in a flow state, you do your best to accentuate and collaborate, to help mold and shape and add your pieces. It was always stuff that I was really excited to dig into. It was just that rich and that vibrant. The challenge for me was what can I add to it, you know? It always pushed me to try and come up with the most creatively-inspired stuff that I could. You two have such an engaging stage style. People would call it sassy, but that has always felt like a description from people who have never been to a play and can't recognize theater. Do either of you have a background in theater arts? WHITNEY: I wanted to be a child actor—I actually auditioned for that movie Blank Check (1994). Actually, a year after Jordan and I met, we were both in a Jr. High production of Alice in Wonderland. He was the Mad Hatter, and I was the Mock Turtle. BLILIE: Why would you say that? [Laughs] Jordan Blilie (left) and Johnny Whitney (right) Suzette Smith Jordan Blilie screams on the tour's first night in San Francisco. Suzette Smith "USA NAILS" was such a hit, and it involved a phone number everyone could scream. How did that come to be? WHITNEY: The name and the "1-900-USA-NAILS" comes from the chain nail salon, but we reverse-engineered it into a song about somebody using their one phone call from the county jail to call a phone sex line. It's the idea of loneliness, disaffection, and parasocial relationships with things that exist solely for their own profit or gain. And yet it's also danceable. There are these moments live where you have an audience of people shaking their asses and shouting "to see what color I'd rot into!" Did you start with that idea and work backwards, or just jam it into that moment of the song? WHITNEY: At that time, the band would all sit together in a room and have a kind of song tribunal about how each part should go. Then, at some point, we'd have a semi -finished version and [Jordan and I] would just try to fit lyrics to the songs. Especially on Burn, Piano Island, Burn. Some of those songs needed an editor so bad, right? I wouldn't change a thing about it, but looking back, there are parts where it sounds like everybody's playing a different song at the same time, but it kind of works, right? And for the lyrics, sometimes we just had to make it work. That wasn't the first time Jordan whispered his lyrics in a guttural tone, but it's one of the more emblematic, right? How did that start? BLILIE: By necessity—I don't have much of a range, you know? I have this weird baritone. Very early on we were drawing from crust punk, where you just have two voices screaming. And we didn't put a whole lot of thought into even what the other person was doing. But then, as we continued to develop, the stuff became more complex, and there was more room for different sorts of shadings of what we could do vocally. So it was just finding out: What is it I can do other than scream at the top of my lungs? WHITNEY: Jordan's part at the end just works right? He was very inspired by Jarvis Cocker. BLILIE: Yeah, you can trace that right back to Pulp. If you listen to any Pulp song, there's gonna be some whispery storytelling, with the compression cranked up so you can kind of hear every lick of the lips. <a href="https://thebloodbrothersofficial.bandcamp.com/album/burn-piano-island-burn">Burn, Piano Island, Burn by The Blood Brothers</a> BLILIE: Some of my favorite moments of writing with Johnny are the ones that we would where we would crack each other up. Can you give an example? BLILIE: Every lyric of "Guitarmy." We really got a kick out of the idea of opening our major label debut with the words, "do you remember us?" Because of the audacity, the absurdity of it. So you guys all started this band when you were in your teens. BLILIE: Yeah, we started when we were like, 15-16. Are there any lyrics that have not aged well, in your opinion? BLILIE: I'm sure they're the ones that we're not playing. [Laughs.] This question reminds me of something one of my professors said. It was my first class at UCLA, Queer Lit from Walt Whitman to Stonewall. In class discussions my fellow classmates would critique writing from the 1800s for not satisfying certain criteria, and our professor would say: You cannot look at the text backwards. You have to look at it forwards. You can't apply current day criteria to something that was written when that criteria didn't even exist. You have to engage with it in the context of when it was written. I don't think anything we wrote is in a canon warranting that level of examination, but it's useful nonetheless. It's a way for me to remind myself that I was 20, and I had the tools of a 20-year-old. It helps me to not beat myself up too much about it. WHITNEY: There's a story behind this. When we were doing the song "Camouflage, Camouflage" on Young Machetes, Jordan and I were going back and forth on the lyrics. He was like, "Yeah, I'm great with all this." But he put a line through one verse, where I say: "All the girls in Montreal are smashing skateboards in the street." And I was just like: Fuck you, dude. I'm gonna keep this in. But he was right, because it sounds stupid, and it's like, really horny and makes me want to light my skin on fire. So I'm changing it to something else, probably something different every night. Johnny Whitney (left) holds a crowd member's hand for support. Suzette Smith The crowd supports Johnny Whitney while he sings. Suzette Smith I wonder about imagery in Blood Brothers' songs that seems to be responding to beauty standards at the time. Like, in "Ambulance, Ambulance" you've got this blistering segue to the chorus: "What is love? / What is scam? / What is sun? / What is tan?" WHITNEY: That's a double meaning. Because it's like tan—like suntan—but also tan is a blah color, right? It's like the color of a dentist's office wall. If you think of the idea of love being something that could feel on-fire, passionate, the color of a dentist's office wall is the opposite. Although, tanning does come into play in a lot of our lyrics. I've noticed as well. Or on "Beautiful Horses" the lyrics are "gallop into your romance novels / dance atop heavy pectorals." BLILIE: I think we were seeing an increasingly vapid culture, and we were trying to dig into that—dig into: What does it do to someone when they're bombarded by these sorts of images and messages? There was a lot of that in that writing; I can't say specifically with "Beautiful Horses," but I think "Trash Flavored Trash," would probably fit under that umbrella. <a href="https://thebloodbrothersofficial.bandcamp.com/album/crimes-bonus-track-version">Crimes (Bonus Track Version) by The Blood Brothers</a> In "Rats and Rats and Rats for Candy" there's an ongoing narrative of rats living inside a woman. It's like a play. There are characters. And the rats eventually chew out of her and try to find a new body to live in. I wondered if that was also about beauty standards or body dysmorphia? WHITNEY: That song, it's about that, but it's also about manipulation, right? Not to get too personal, but I grew up with somebody who weaponized being sick—faked being sick—for their entire life in order to manipulate people and extract something they needed out of them. The character in that song is kind of a victim, but like a siren at the same time. They're trying to lure somebody in. Is that person the rats, or are they Candy? WHITNEY: The rats are in Candy. I mean, it's both. What about "The Shame?" Your group resonates so much with "everything is gonna be just awful / when we're around" that you're putting it on t-shirts 20 years later. What does it mean? WHITNEY: The whole premise of that song is having to sell yourself—how to commoditize yourself. It's about how you function in a capitalist society. You sink or swim by your ability to market yourself, make yourself desirable—whether it be in relationships, job market, blah blah blah. I've always been repulsed by that and was especially at the time we wrote it, which was in Venice Beach, while we were recording Burn, Piano Island, Burn. It was the longest time I'd ever been in LA, and that's the epicenter of being a self-salesman. That line encapsulates the feeling of being sold something. And you're in a position where, in order to survive, you have to be your own salesman. Salesmen show up in other songs, like "The Salesman, Denver Max." That's another one that almost feels like a short story. WHITNEY: I initially cribbed the idea for that song's lyrics from the Joyce Carol Oates short story, "Where Are You Going? Where Have You Been?" It follows a narrative of a very dangerous, predatory man in the process of stalking and kidnapping somebody. “Denver Max” was a huge, uncomfortable gamble for me, because I wrote the entire song on my acoustic guitar, recorded it to a 4-track, and then played it for the guys—totally expecting them to hate it. It was really daunting to try to contribute as a songwriter; Cody, Morgan, and Mark are such talented musicians. I think they may have hated it; I don't really remember how we ended up recording it. It was nobody's favorite thing, but we just tracked it, and it sounded great and worked. Have you read anything by playwright Caryl Churchill? WHITNEY: Never heard of her. "Live at the Apocalypse Cabaret" has a lyric in it that reminds me of her play Far Away, which has a scene of milliners making hats for people to wear at a public execution, so I always felt a symmetry there, because of the lyrics "the cross-eyed map of the afterlife is knitting tiny neck ties." WHITNEY: I'm going to be super honest, the songs that I'm the most familiar with the lyrics of, at this very moment, are songs that were going to be playing, because I've been rehearsing them. But I do remember, with that song, we were trying to be funny without being silly. Like, a cross-eyed map is a map that makes no sense, where you don't know where you're going. Knitting tiny neckties are noose ties. It's like dressing yourself up for death, right? It's trying to dress up something that's really heinous and horrible and incomprehensible, and also trying to navigate that, through a map that makes no sense. At this moment you have cracked my understanding of a play you haven't even read. But I digress, I've read that "Celebrator" was a direct response to Toby Keith's "Courtesy of the Red, White and Blue." BLILIE: That pumped up patriotism felt gross when taken in context with the images and much of the information that we were seeing come out of Iraq and Afghanistan. Is that why there are so many mentions of amputated limbs on Crimes? BLILIE: The bulk of Crimes was trying to engage with war so that's where you get a lot of that grizzly imagery. Well, personally, it's so nice that you're touring right now. Blood Brothers are great for when you need to scream, but you can't. You can scream along to the Blood Brothers in your head, or out loud at a show. BLILIE: I'm glad that we could be of service, in that regard. It's hard for me not to go into a really bleak mindset when I look at our current political landscape. I find myself equal parts enraged and terrified. And there are times when I have to just close all news down. I guess it is a good time to get up and scream. The Blood Brothers play the Showbox Thurs, Nov 14 and Fri, Nov 15. Thursday's show is all ages, and Friday's is 21+. This story was originally published in our sister paper, Portland Mercury. Full Article Music Arts
cr Democratic mistakes By scripting.com Published On :: Fri, 08 Nov 2024 12:30:49 GMT I've actually written a lot, but haven't wanted to publish most of it. So many reasons why the Dems lost. Maybe I should just list them. Biden shouldn't have run again. There would have been a primary. Given the result of the election this week, we should have found out what support each candidate had with voters. We didn't get to choose the candidate. That said Harris ran a fantastic campaign. Biden should not have shut down his campaign website. Rather than using it to raise money to feed to the media industry, they should have organized and listened, to develop new channels of communication with voters that were not dependent on journalism. Every time the Dems run a campaign, win or lose, they shut down their connection to the electorate. The voters' only role in the party was when they needed our money and our vote. We were not part of governing. Huge mistake. And I'm not just saying that now, I've said that about every Democratic campaign since Obama. This is probably the biggest single mistake the Dems keep making. We needed a prosecutor at the top of Justice. I don't know what Garland actually did, but I'm sure it will all be swept out by whoever is Trump's AG. Men's votes need to be sought and welcomed, specifically. So much has been done to alienate male voters, which is why so many voted for Trump. We could have had a bunch of them this year, if we had only spoken to them with respect. I don't know if we can reboot the Democrats as an opposition party given all these problems. Whatever comes next is going to perform very differently from the party that lost this election. If we try to do it again the same old way, it will fail even worse. I think everyone knows this by now. Full Article
cr 8 Ways To Help Increase The Shareability Of Your Content By www.rssfeedsgenerator.com Published On :: Mon, 13 Apr 2015 13:09:49 +0000 Creating shareable content is key for spreading brand awareness and is a very important aspect for online marketing success. Not only is great content one of the most important foundations of your website, it is the driving force for online engagement and has been known to improve relationships with existing readers/clients as well as gain […] Full Article eBusiness Tips content management tips content sharing technologies content syndication
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