Wicket-keeper batsman KL Rahul on Sunday made sure to answer as many questions from fans as he did an 'Ask Rahul' session on Twitter.

Well, I was reminded of the song, "Catfish John," when I read Joseph Krumgold's Newbery Medal-winning Onion John:

Mama said: 'Don't go near that river
'Don't be hanging around old Catfish John'
Come the morning, I'd always be there
Walking in his footsteps in the sweet Delta dawn.
Catfish John was a river hobo who lived and died by the river bed

Thinking back, I still remember I was proud to be his friend. (Alison Krauss does it well, but I really like Jerry Garcia's version.)

"Onion John" is what the locals call the strange, sort of derelict man who hardly talks. "The way John spoke was his own secret. Most of the words he used were full of x's and z's and noises like ptchky and grvtch. It was a high speed language full of jokes, from the way he carried on. Every so often, talking away, he'd get too much for himself and bust out. There was no way of telling whether the jokes were that good or not. The only part of his conversation I ever understood was the end of it. He said, "Well, good day," each word separate and clear and then you knew he was finished with whatever he was telling you."

The story is narrated by Andy, a young teen. His folks don't forbid him to befriend Onion John, but they think Andy should focus on his studies, go to M.I.T., become an engineer, and/or be an astronaut.

I don't want to give away the plot, but will say this: The author won the Newbery Medal twice, which doesn't happen a lot. This one was good enough that I look forward to reading more Joseph Krumgold stories.

1. Zijn hitlijst was lang, zijn invloed op latere iconen zoals The Beatles en Prince immens: flamboyant rock-'n-rollpionier Little Richard (87) is niet meer  Het Nieuwsblad
2. Rock-n'-rollpionier Little 'Tutti Frutti' Richard (87) overleden  Het Laatste Nieuws
3. Rock 'n' roll-pionier Little Richard is overleden, herontdek zijn grootste hits  VRT NWS
4. Little Richard drukte zware stempel op de rock-'n-roll  De Tijd
5. Muzieklegendes over Little Richard: “Als ik zijn muziek beluisterde, kon ik God horen”  Het Laatste Nieuws
6. Hele verhaal bekijken via Google Nieuws

Samsonite plant ontslagronde in Oudenaarde  De TijdHele verhaal bekijken via Google Nieuws

Environmental News FOR IMMEDIATE RELEASE

SAN DIEGO – Hoy, la Agencia de Protección Ambiental de Estados Unidos (EPA, por sus siglas en inglés), en coordinación con el Banco de Desarrollo de América del Norte (BDAN), emitió una Solicitud de Propuestas (RFP, por sus siglas en inglés) a través del Programa Frontera 2020.

Magnitude   ML 2.9 Region   IONIAN SEA Date time   2020-05-10 02:50:18.0 UTC Location   37.28 N ; 20.60 E Depth   1 km

Magnitude   ML 3.4 Region   IONIAN SEA Date time   2020-05-10 02:52:15.1 UTC Location   37.27 N ; 20.59 E Depth   2 km

Magnitude   ML 3.3 Region   IONIAN SEA Date time   2020-05-10 02:57:42.0 UTC Location   37.23 N ; 20.48 E Depth   2 km

Magnitude   ML 3.2 Region   IONIAN SEA Date time   2020-05-10 02:59:12.2 UTC Location   37.23 N ; 20.47 E Depth   3 km

Magnitude   ML 3.4 Region   IONIAN SEA Date time   2020-05-10 03:06:00.5 UTC Location   37.25 N ; 20.46 E Depth   2 km

Magnitude   ML 2.8 Region   IONIAN SEA Date time   2020-05-10 03:08:49.5 UTC Location   37.74 N ; 19.51 E Depth   9 km

Magnitude   ML 3.1 Region   IONIAN SEA Date time   2020-05-10 03:22:11.4 UTC Location   37.24 N ; 20.45 E Depth   1 km

Magnitude   ML 3.0 Region   IONIAN SEA Date time   2020-05-10 03:59:08.4 UTC Location   37.27 N ; 20.50 E Depth   1 km

A classic rant, touchline despair and ultimate failure but mixed in with breathtaking attacking play - Kevin Keegan took Newcastle on a thrilling rollercoaster ride.

Electronic Arts Drops Prices on iOS and Android Games

Actinobacillus pleuropneumoniae (App) is the etiological agent of acute porcine pneumonia and responsible for severe economic losses worldwide. The capsule polymer of App serotype 1 (App1) consists of [4)-GlcNAc-β(1,6)-Gal-α-1-(PO4-] repeating units that are O-acetylated at O-6 of the GlcNAc. It is a major virulence factor and was used in previous studies in the successful generation of an experimental glycoconjugate vaccine. However, the application of glycoconjugate vaccines in the animal health sector is limited, presumably because of the high costs associated with harvesting the polymer from pathogen culture. Consequently, here we exploited the capsule polymerase Cps1B of App1 as an in vitro synthesis tool and an alternative for capsule polymer provision. Cps1B consists of two catalytic domains, as well as a domain rich in tetratricopeptide repeats (TPRs). We compared the elongation mechanism of Cps1B with that of a ΔTPR truncation (Cps1B-ΔTPR). Interestingly, the product profiles displayed by Cps1B suggested processive elongation of the nascent polymer, whereas Cps1B-ΔTPR appeared to work in a more distributive manner. The dispersity of the synthesized products could be reduced by generating single-action transferases and immobilizing them on individual columns, separating the two catalytic activities. Furthermore, we identified the O-acetyltransferase Cps1D of App1 and used it to modify the polymers produced by Cps1B. Two-dimensional NMR analyses of the products revealed O-acetylation levels identical to those of polymer harvested from App1 culture supernatants. In conclusion, we have established a protocol for the pathogen-free in vitro synthesis of tailored, nature-identical App1 capsule polymers.

Multidrug resistance (MDR) in cancer arises from cross-resistance to structurally- and functionally-divergent chemotherapeutic drugs. In particular, MDR is characterized by increased expression and activity of ATP-binding cassette (ABC) superfamily transporters. Sphingolipids are substrates of ABC proteins in cell signaling, membrane biosynthesis, and inflammation, for example, and their products can favor cancer progression. Glucosylceramide (GlcCer) is a ubiquitous glycosphingolipid (GSL) generated by glucosylceramide synthase, a key regulatory enzyme encoded by the UDP-glucose ceramide glucosyltransferase (UGCG) gene. Stressed cells increase de novo biosynthesis of ceramides, which return to sub-toxic levels after UGCG mediates incorporation into GlcCer. Given that cancer cells seem to mobilize UGCG and have increased GSL content for ceramide clearance, which ultimately contributes to chemotherapy failure, here we investigated how inhibition of GSL biosynthesis affects the MDR phenotype of chronic myeloid leukemias. We found that MDR is associated with higher UGCG expression and with a complex GSL profile. UGCG inhibition with the ceramide analog d-threo-1-(3,4,-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol (EtDO-P4) greatly reduced GSL and monosialotetrahexosylganglioside levels, and co-treatment with standard chemotherapeutics sensitized cells to mitochondrial membrane potential loss and apoptosis. ABC subfamily B member 1 (ABCB1) expression was reduced, and ABCC-mediated efflux activity was modulated by competition with nonglycosylated ceramides. Consistently, inhibition of ABCC-mediated transport reduced the efflux of exogenous C6-ceramide. Overall, UGCG inhibition impaired the malignant glycophenotype of MDR leukemias, which typically overcomes drug resistance through distinct mechanisms. This work sheds light on the involvement of GSL in chemotherapy failure, and its findings suggest that targeted GSL modulation could help manage MDR leukemias.

Chronic rejection of transplanted organs is the leading cause of transplant failure, and one that the field of organ transplantation has not overcome in almost six decades since the advent of immunosuppressive drugs enabled the field to flourish.

A woman from a least-reached group of people accepted Christ during Discipleship Centre student outreach.

some testimonies from Aussies who attended the 2010 OCZ and outreaches

Kelly Norman, an intern with OM Lifehope in the UK, shares her personal insights about why she reaches out to the homeless in Birmingham.

Source: www.androidcentral.com - Saturday, May 09, 2020
After being delayed back in April due to the coronavirus, UFC 249 is back on and we have all the details on how you can watch the highly anticipated event online or on TV in the U.S., Canada, UK and Australia. UFC 249 was originally scheduled to take place in Brooklyn, New York but the UFC had to relocate the event to the VyStar Veterans Memorial Arena in Jacksonville, Florida. However, while the event is back on, there won't be any fans in attendance for Saturday's fights for safety reasons. The venue may have changed and fans won't be crowded around the octagon but many of the fights originally scheduled for UFC 249 will be included on the new card. The biggest change though is that Tony Ferguson will now be taking on Justin Gaethje in the Interim UFC Lightweight Championship as Khabib Nurmagomedov is unable to leave his home country of Russia due to its coronavirus travel restrictions. Ferguson is known for his incredible cardio and pressure while Gaethje's kill or be killed mentality sets himself apart from the pack. Ferguson also hasn't lost a match since May 2012 and in that time, he's won 12 fights and defeated Kevin Lee, Anthony Pettis, Donald Cerrone and more. Gaethje on the other hand is on a three fight winning streak following back-to-back losses. In addition to the interim lightweight championship, Henry Cejudo will go up against Dominick Cruz for the UFC bantamweight championship. Elsewhere on the card, Francis Nga

MS Dhoni and his love affair with motorcycles need no introduction. Here we shed some light on Mahi's Yamaha RX135 that was one of his first bikes!

2019 Ducati Diavel 1260S Review | When the Italians thought of building a cruiser, you knew there'd be a lot of power but then they didn't stop there. The Diavel 1260 is a fusion of a superbike and a cruiser, creating a class of its own.

Suvarna Jagtap, chairperson, Lasalgaon Agriculture Produce Market Committee (APMC), told FE that three cases of coronavirus were reported at Lasalgaon at a distance of 3 km from the main market yard.

The Japanese electronics firm has bagged city surveillance projects in Bhopal and Ludhiana. It is now eyeing projects under Smart Cities mission in Guwahati and Jabalpur.

Digital allows to work from anywhere as long as there is a computer and a good internet connection -- half the battle is won

However, the High Court rejected this invocation of Rule 165, ruling that the it specified only the payability conditions of fees, and not the chargeability of it.

Even now, a state like West Bengal’s data looks dodgy; others like Gujarat and UP also pose challenges

With wage-flow stoppered, and unable to get ration in the cities, most migrant workers have had to rely on food distribution by government and NGOs.

Your digital assets are the building blocks for brand voice. Use them wisely

In a statement, GSTN said this new functionality on the GST portal is aimed at providing a major relief to taxpayers, especially at the time of the COVID-19 crisis when there is limited access to cash resources.

A new DAA initiative to increase ad transparency offers instant access "to information and control over interest-based advertising"

1 Ugandan Shilling = 0.015 Macedonian Denar

1 Ugandan Shilling = 0.0038 Estonian Kroon

1 Salvadoran Colon = 6.4933 Macedonian Denar

1 Salvadoran Colon = 1.6297 Estonian Kroon

1 Romanian Leu = 12.7603 Macedonian Denar

1 Romanian Leu = 3.2026 Estonian Kroon

1 Ukrainian Hryvnia = 2.1174 Macedonian Denar

1 Ukrainian Hryvnia = 0.5314 Estonian Kroon

1 Tanzanian Shilling = 0.0246 Macedonian Denar

1 Tanzanian Shilling = 0.0062 Estonian Kroon

1 Venezuelan Bolivar Fuerte = 5.6898 Macedonian Denar

1 Venezuelan Bolivar Fuerte = 1.428 Estonian Kroon

1 Yemeni Rial = 0.227 Macedonian Denar

1 Yemeni Rial = 0.057 Estonian Kroon

1 Paraguayan Guarani = 0.0087 Macedonian Denar