Assessing the cumulative human health risk caused by multiple toxic substances is a major challenge. New research has reported on developments in the US, where the Environmental Protection Agency (EPA) is creating a tool that will provide maps and other information to depict exposure data and risks at both a national and a local level.

New research has supported a more thorough integration of toxic mixture assessments into two major pieces of EU legislation: REACH and the Water Framework Directive. It recommended constructing a database of harmful chemicals in the environment which, among other uses, could assess mixture toxicity using a 'Concentration Addition' method.

A new tool that predicts the effects of complex mixtures in water has shown promising results. It correctly predicted the impacts of toxic mixtures on the model species Daphnia magna, or water fleas, in over 90 per cent of cases.

Ecological risk maps showing 'hotspots' of risk to wildlife from single or combined soil pollutants have been developed. These maps can be used to improve risk analysis and stakeholder communications.

The United Nation's Globally Harmonised System of Classification and Labelling of Chemicals (GHS) is an international initiative to standardise how chemicals are managed across the world. A recent study has proposed a suite of indicators which measure progress in implementing the GHS.

A recent study has investigated the effectiveness of the EU concentration limit for Plant Protection Products (i.e., agricultural pesticides) in protecting groundwater ecosystems. For the majority of pesticides, the standard of 0.1 micrograms per litre for each individual pesticide was found to be sufficient, but this may not be the case for some insecticides.

A recent report calls for an urgent, worldwide ban on the mining and use of asbestos. It argues that there is no safe use of asbestos that can prevent occupational and environmental exposure and urges all countries to use safer alternatives to asbestos in order to protect the health of their citizens.

A recent Bulgarian study has proposed a more environmentally friendly approach to manufacturing chemicals and biochemicals in multipurpose batch plants, which carefully considers how the production process is scheduled.

The recent oil spill in the Gulf of Mexico has highlighted the need to effectively evaluate possible response strategies. A new decision support tool can be used to consider the environmental, socio-economic and management effects of different responses to spills, translating them into monetary terms to provide a common currency for comparison.

Because natural conditions in the environment, such as temperature, can significantly affect the toxicity of pollutant chemicals on living organisms, the effects of pollutants can differ according to region. Ecological risk assessment should therefore include environmental characteristics relevant to each region, according to recent research.

A new index that condenses the overall environmental impact of pollutants at a particular site into a single value has been developed. This unique number captures the health status of the territory in terms of the risk of the pollutants to animals and plants in ecosystems, human health and the long-term fate of the pollutants in the environment.

To test the possible health impacts of human exposure to methylmercury through fish consumption, researchers fed mice a diet containing fish at levels that corresponded to a typical Western diet for humans. The mice suffered adverse health impacts after two months of being fed this diet, including reduced body growth rates and modified gene expression patterns.

Research into reuse of domestic 'greywater' (non-toilet wastewater) has found that typical treatment systems can significantly reduce overall water consumption. However, non-biodegradable micropollutants will continue to reach municipal wastewater treatment plants (WWTPs), unless a new disposal route is found for the greywater treatment sludge.

Pesticides and biocides can cause serious harm to aquatic ecosystems. A study by Swiss researchers has found that the levels of some common biocides entering wastewater and rivers from urban environments are similar to those of pesticides from agricultural land. Although smaller quantities are used in urban areas, similar total amounts escaped into surface waters.

Electronic waste (e-waste) contains a large variety of heavy metals which threaten the environment and human health. New research has assessed environmental and technological preferences for materials in products of individuals within the US electronics industry. Strict international legislation, such as the EU's RoHS Directive, was found to reduce the use of lead for companies that market their products abroad.

A new study suggests that the energy sources used in chemical production contribute significantly to environmental damage in developed countries. The researchers recommend increasing the efficient use of heat and electricity, in addition to reducing direct emissions of harmful pollutants, to dramatically improve the environmental impact of the chemical industry.

The official criteria used to assess how easily a chemical is taken up by biological organisms, known as the bioaccumulation potential, are considered reliable for most types of chemical. However, according to a new analysis, the criteria need updating to include uptake from contaminated sediment and food in order to reflect the realistic bioaccumulation risk for all chemicals.

A new study has developed a set of indicators to evaluate how well companies voluntarily manage dangerous chemicals. These indicators can be used to check progress towards the World Summit on Sustainable Development goal of effectively managing chemicals.

In line with EU legislative requirements, new research has developed models to assess the toxicity of chemicals in terms of their effects on human development. One of the models has been made freely accessible online, so that it is easy to use for industry and regulators.

Many agricultural pesticides used in Europe could disrupt male hormones and lead to infertility problems, according to laboratory tests. ‘Biomonitoring’ studies to investigate the actual behaviour of pesticides in the human body are now urgently needed to clarify the link between pesticide exposure and male reproductive health.

Improving air quality in offices, public buildings and in cars is likely to have a significant impact on human health, even more so than reducing exposure to outdoor air pollutants or pesticides, according to a new study. Researchers also revealed that the estimation of risk of exposure to a mixture of chemicals increased when they accounted for interactions between the chemicals, although more data are needed to improve the scientific certainty of these predictions.

By ranking the ‘hazard potential’ of a wide range of chemicals used to make common plastics, Swedish researchers have highlighted which plastic polymers are made from the most hazardous chemicals. These should be prioritised for assessing the risk of causing human or environmental harm.

Research in four German rivers indicates that several organic compounds pose a risk of acute toxic effects on invertebrates. Some of these compounds are already priority substances under the EU Water Framework Directive1 (WFD); others could warrant designation at least as river basin specific pollutants in the German River Basin Management Plans.

A new study examines different methods for assessing the health impacts of chemicals that people are exposed to at work. Combining two different approaches may help reduce the effect of the shortcomings of each approach and provide greater assurance that the most damaging chemicals are prioritised for regulatory action.

The Deepwater Horizon Oil Spill saw the first ever use of chemical dispersants to reduce the impacts of an oil spill at a deepwater level. A new study has investigated the fate of these dispersants in deepwater and concluded that they do not biodegrade well.

A new review of the anti-microbial substance triclosan argues that past risk assessments have underestimated its toxicity to aquatic organisms. New data from Germany suggest that aquatic organisms are frequently overexposed to damaging levels of triclosan in waterways, and the researchers suggest it could be restricted under EU legislation.

A recent study has considered the levels at which active pharmaceutical ingredient (API) residues are safe when released into water bodies from drug manufacturing plants. It proposes that environmental reference concentrations and maximum tolerable concentrations are adopted for each API.

There are differences in the assessment and restriction of chemicals exempt from the EU’s regulatory instrument REACH. A new study has analysed the differences between several regulatory frameworks that govern these chemicals and recommended greater harmonisation in assessment criteria and regulatory follow-up.

According to new research, there was no substantial change from 2000 to 2009 in the global use of the insecticide DDT to control diseases such as malaria. Pyrethroids, another type of insecticide, are also widely used, but there are concerns that insects are developing resistance and insecticidal nets containing pyrethroids are becoming less effective.

Comparative toxic assessments across regions and countries are needed to minimise human exposure to harmful chemicals associated with consumer products. A new study has developed a US version of the EU Toxic Potential Indicator (TPI) and compared the two models for over 500 chemicals. Differences in results exist, indicating a need for more harmonisation between regulatory thresholds and guidelines.

Evidence to indicate that early exposure to environmental contaminants may result in a greater risk of serious disease later on in life has been presented by researchers in a new White Paper. Measures to prevent non-contagious illnesses, such as diabetes, asthma and cancer should therefore focus on the early stages in life, including the time spent in the womb, they suggest.

A new study has examined contamination of fully grown soybean plants by two nanomaterials – nano-cerium oxide and nano-zinc oxide. The results could be concerning, as they indicate that the nanomaterials are absorbed by plants, possibly affecting growth, yield, and the fixation of nitrogen in soil, an important ecosytem service.

Populations of otters, grey seals and sea eagles are slowly recovering in Sweden, which is likely to be thanks in part to a ban on organochlorine chemicals, such as PCBs and DDT, in the 1970s, according to a new study. However, the research shows that negative effects of these chemicals on the reproductive health of female animals persisted for more than 15 years after the ban was introduced.

A new study has evaluated disinfection by-products (DBPs) formed during the treatment of ballast water. As some of the DBPs produced are hazardous, the study concludes that more information is needed to ensure DBPs from treatment methods do not harm human health or aquatic environments.

Endocrine disrupting chemicals (EDCs) can interfere with the hormonal systems of both humans and wildlife. New research quantifying EDCs in marine environments in Greece found concentrations which present significant risks to sediment-dwelling organisms.

To date, it has been difficult to collect data that are robust enough to demonstrate specific effects of chemical pollution in rivers on aquatic wildlife. However, a recent study combining detailed chemical, toxicological and ecological data in three European river basins now provides evidence linking cause and effect by revealing significant differences in the effects of differently polluted sediments on the organisms living in the river basins and the riverbed biodiversity.

Applying a low voltage to polluted river sediment can boost microbes’ natural ability to degrade harmful polychlorinated biphenyl (PCB) contaminants, according to a new study. The approach could be a cost-effective, sustainable strategy to bioremediate polluted sites.

A recent study compared the decentralised treatment of pharmaceutical contaminants in wastewater at hospitals with centralised treatment at conventional and upgraded wastewater plants. The results suggest that additional (post) treatments may not always provide significant benefits.

A recent study has described a simple method to screen the toxicity of materials used in consumer products. Using utility meter products as examples, the study found, for example, that stainless steel and polyvinyl chloride (PVC) had high toxicity potentials and suggests less toxic, but equally effective and priced, alternatives that could be used instead.

Research into mercury has identified two genes in bacteria that appear to be required for turning the metal into its most toxic form, methylmercury. The study adds to a growing body of research that helps us to understand the transformations that mercury undergoes in the environment and the microbes involved in these transformations.

A new tool has been developed which highlights ‘hot spots’ of pharmaceutical pollution in Europe, where human health and aquatic environments could potentially be affected. The results suggest that the substances and locations posing the greatest risk are not the same for the aquatic environment as for human health.

Methylmercury may accumulate more quickly in fish as the climate grows warmer, new research suggests. Researchers in the US have found that levels of the toxin were higher in fish exposed to higher temperatures; global warming could therefore lead to increased human exposure to methylmercury through seafood consumption.

Combinations of antibiotics have been found in high enough concentrations to pose a serious threat to aquatic ecosystems, in a recent Spanish study. Antibiotics can have toxic effects on the bacteria and algae that form the basis of aquatic ecosystems.

Mercury, in the form of monomethylmercury, can accumulate in fish to high concentrations, presenting the greatest concern for human exposure to this potent neurotoxin. New long-term research of fish in a natural setting has shown that removal rates of the toxin from body tissues are likely to be even slower than thought.

A new study assessing the levels, and potential health risk, of toxic heavy metals in market-bought fish and shellfish in Spain has found that they are generally below European Commission regulatory limits, and that these products are therefore safe to eat for the average consumer in Spain. However, for high level consumers of specific fish species, toxic element levels could pose a risk to health.

Exposure to polluted soil can affect human health, but the risk may vary depending on the soil type. A recent study has shown that the differing amounts of cadmium and lead that can be dissolved in the human digestive system can be predicted for contaminated agricultural, urban and woody habitat soils using a model. Its authors suggest this is a useful method for assessing the risks of contaminated land.

A new study of clean-up workers seven years after the 2002 Prestige oil tanker spillage has found potential evidence for long-term impacts on their hormonal and immune systems as a result of exposure to the oil. The results suggest new health surveillance measures may be appropriate for workers involved in future oil clean-up operations.

Human activities, including industrial development along coastal areas, risk polluting the marine environment with heavy metals which can harm human health and aquatic life. A recent study has found elevated levels of metal pollution in the Jade area of the German Wadden Sea, but concludes that metal contamination of the sediments would not be expected to have harmful effects on the marine environment and living organisms here.

Changes in complex microbial communities known as ‘biofilms’ at the bottom of rivers can reveal the effects of pesticide and pharmaceutical pollution of river water, according to a recent study. Painkillers and anti-inflammatory drugs were found to have a significant effect on the structure and functioning of the biofilms.

The European ban on atrazine has effectively reduced concentrations of the herbicide in coastal waters, a new study has found. However, the researchers also warn that, in some areas, atrazine levels remain relatively high as some countries have not yet restricted use of the chemical.