When Scott Gann learned his son Dustin had dyslexia, he was shocked at the school's reaction. No one there wanted to use the word.

The Arkansas Department of Education will now provide on-site help for schools and districts in the state that are experiencing cybersecurity incidents.

An audit of the early-childhood education offerings in Minnesota finds complexity and fragmentation as well as a lack of data about program effectiveness.

The Montreal Canadiens are not the only team in the midst of a rebuild and it's not easy for anybody, especially not for Craig Conroy who's at the helm of the Calgary Flames and will be down a first-round pick at the next draft.

Longtime Red Wings GM and Hockey Hall of Famer Ken Holland joined the NHL in a new consulting role just months after parting with the Edmonton Oilers.

The former New Jersey Devils goalie finds themselves playing for a new Western Conference team.

The Winnipeg Jets will be without defenceman Logan Stanley for the short-term future.

With a need for youth in the system and for an urgent NHL course correction simultaneously, Pittsburgh will be a team to watch in the trade market

Washington sent a 2025 fifth-round pick and a 2027 third-round pick to Pittsburgh on Tuesday for Eller.

St. Louis led 2-0 after two periods, was outscored 3-0, allowed game-winner to Pastrnak with 1:47 remaining

There was some dramatic movement in the second College Football Playoff rankings. Here's who got slighted.

Penn State is on the verge of doing something that it hasn’t done in more than 40 years. The Nittany Lions can post three straight straight 10-win seasons for the first time since 1980-82 with its next two victories. It would be their sixth season with double-digit wins in nine years, the best such stretch since the program’s golden era from 1977-86. Yet some in the sellout crowd of 110,233 at ...

The U.S. Supreme Court took up the question of whether courts must find a juvenile offender permanently incorrigible before a sentence of life without parole.

Campaigns to get rid of police in schools catch a wave of momentum in some communities, but activists still face deep resistance from educators nationally.

FSU women's basketball improves to 2-1 after a dominating victory over FAMU on Monday.

Iowa isn't just replacing a generational scoring talent this season. The Hawkeyes also lost their coach and several other pieces from a team that made back-to-back national championship games.

Chance Gray scored 14 of her career-high 31 points in the third quarter and she tied a program-best with nine 3-pointers to help No. 12 Ohio State beat Charlotte 94-53 on Tuesday night. Gray finished 9 of 14 from 3-point range to top her previous best of six makes. Gray scored 11 points in the first half after making all three of her 3-pointers to help Ohio State build a 43-17 lead.

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease

Donna M. Wilcock
May 1, 2003; 23:3745-3751
Development Plasticity Repair

Laura Medlock
Apr 13, 2022; 42:3133-3149
Systems/Circuits

Prithviraj Rajebhosale
Oct 23, 2024; 44:e0063242024-e0063242024
Cellular

Nora D. Volkow
Dec 1, 2001; 21:9414-9418
Behavioral

Shiaoching Gong
Sep 12, 2007; 27:9817-9823
Toolbox

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease

Neuregulin1 (Nrg1) signaling is critical for neuronal development and function from fate specification to synaptic plasticity. Type III Nrg1 is a synaptic protein which engages in bidirectional signaling with its receptor ErbB4. Forward signaling engages ErbB4 phosphorylation, whereas back signaling engages two known mechanisms: (1) local axonal PI3K-AKT signaling and (2) cleavage by -secretase resulting in cytosolic release of the intracellular domain (ICD), which can traffic to the nucleus (Bao et al., 2003; Hancock et al., 2008). To dissect the contribution of these alternate signaling strategies to neuronal development, we generated a transgenic mouse with a missense mutation (V₃₂₁L) in the Nrg1 transmembrane domain that disrupts nuclear back signaling with minimal effects on forward signaling or local back signaling and was previously found to be associated with psychosis (Walss-Bass et al., 2006). We combined RNA sequencing, retroviral fate mapping of neural stem cells, behavioral analyses, and various network analyses of transcriptomic data to investigate the effect of disrupting Nrg1 nuclear back signaling in the dentate gyrus (DG) of male and female mice. The V₃₂₁L mutation impairs nuclear translocation of the Nrg1 ICD and alters gene expression in the DG. V₃₂₁L mice show reduced stem cell proliferation, altered cell cycle dynamics, fate specification defects, and dendritic dysmorphogenesis. Orthologs of known schizophrenia (SCZ)-susceptibility genes were dysregulated in the V₃₂₁L DG. These genes coordinated a larger network with other dysregulated genes. Weighted gene correlation network analysis and protein interaction network analyses revealed striking similarity between DG transcriptomes of V₃₂₁L mouse and humans with SCZ.

Low-intensity transcranial focused ultrasound stimulation (TUS) is a novel technique for noninvasive brain stimulation (NIBS). TUS delivered in a theta (5 Hz) burst pattern (tbTUS) induces plasticity in the human primary motor cortex (M1) for 30–60 min, showing promise for therapeutic development. Metaplasticity refers to activity-dependent changes in neural functions governing synaptic plasticity; depotentiation is the reversal of long-term potentiation (LTP) by a subsequent protocol with no effect alone. Metaplasticity can enhance plasticity induction and clinical efficacy of NIBS protocols. In our study, we compared four NIBS protocol combinations to investigate metaplasticity on tbTUS in humans of either sex. We delivered four interventions: (1) sham continuous theta burst stimulation with 150 pulses (cTBS150) followed by real tbTUS (tbTUS only), (2) real cTBS150 followed by sham tbTUS (cTBS only), (3) real cTBS150 followed by real tbTUS (metaplasticity), and (4) real tbTUS followed by real cTBS150 (depotentiation). We measured motor-evoked potential amplitude, short-interval intracortical inhibition, long-interval intracortical inhibition, intracortical facilitation (ICF), and short-interval intracortical facilitation before and up to 90 min after plasticity intervention. Plasticity effects lasted at least 60 min longer when tbTUS was primed with cTBS150 compared with tbTUS alone. Plasticity was abolished when cTBS150 was delivered after tbTUS. cTBS150 alone had no significant effect. No changes in M1 intracortical circuits were observed. Plasticity induction by tbTUS can be modified in manners consistent with homeostatic metaplasticity and depotentiation. This substantiates evidence that tbTUS induces LTP-like processes and suggests that metaplasticity can be harnessed in the therapeutic development of TUS.

The work of Diné artist DY Begay, now on view at the National Museum of the American Indian, blends tradition and modernity

Written by the former chief historian of NASA, the book examines the evolution of our cosmic understanding—from early civilizations to the present day

The [...]

New York- FAO Director-General José Graziano da Silva and the President of the UN Security Council (UNSC), Ambassador Ismael Gaspar Martins, have concurred upon the importance of using FAO’s regular [...]

The Director-General addressed the members of the UN Security Council (UNSC) on Tuesday in what was FAO’s first appearance before the principal UN body on global peace and security affairs.

Organized [...]

Q: Ambassador, how did the Programme Committee in its recent session judge FAO's contribution to the eradication of hunger, food insecurity and malnutrition?

Ambassador Hoogeveen: [...]

Today, FAO launched two new reports in time for the 160^th session of the Council:

-          FAO + Belgium: Inclusive approaches to end hunger and promote [...]

Information Note.

The food security situation in Gaza is catastrophic. Famine is imminent in the Northern Governorates and there is a risk of famine across the rest of the Gaza Strip, according [...]

The firebrand politician once quipped that she would like to be remembered as a woman who ‘had guts’

Chris Mah, researcher at the Smithsonian Institution's National Museum of Natural History in the invertebrate zoology department, describes the characteristics of different sea star species observed on the final dive of the Laulima O Ka Moana expedition. (Credit: Video courtesy of the NOAA Office of Ocean Exploration and Research, 2017 Laulima O Ka Moana)

Chef Darin Nesbit demonstrates how to cook cricket-crusted redfish. (Still Image: Natthanan Chumphookaew/iStock)

E.O. Wilson discusses his new book, "Half-Earth," and his recent and thought-provoking proposal to devote half the surface of the Earth to nature. The livestream video features E.O. Wilson and Kirk Johnson, Sant Director of the National Museum of Natural History.

In this time-lapse video, watch how workers built a visitor’s center in South Africa using ancient Roman techniques such as the arched ceiling, or vault

What makes human and orangutan brains different? Researchers at the National Zoo hope to find out by playing customized computer games with the savvy primates.

Aziz Ansari | Smithsonian Magazine’s 2016 American Ingenuity Award Winner for Performing Arts The actor, comedian and author is being honored for his starring role as Dev Shah in “Master of None,” the Netflix series that he created with Alan Yang. Like the character he plays, Ansari is the son of Indian immigrant parents, and his smart, surprising take on life, love, technology and cultural identity in the United States has helped make the show “the year’s best comedy straight out of the gate,” as the New York Times put it. Among Ansari’s other accomplishments are his unforgettable portrayal of the loopy Tom Haverford on NBC’s “Parks and Recreation,” his best-selling book about dating in the internet age, Modern Romance (co-authored with Eric Klinenberg), and his blockbuster stand-up act that sold out Madison Square Garden. Read more about Ansari’s work: http://smithmag.co/jvdAaL | #IngenuityAwards And more about the American Ingenuity Awards: http://smithmag.co/77xPqy

The Director of the Smithsonian's Hirshhorn Museum predicts what the museum's collections will hold in the next 40 years Read more at http://www.smithsonianmag.com/specialsections/40th-anniversary/Arts-Bold-New-Direction.html

Filmed by the famous photographer during the Spanish Civil War, this clip debuted at the 2010 Orphan Film Symposium

Despite being just one minute long, this Ask Smithsonian video hosted by Eric Schulze is crammed full of strange things you never knew – but should – about Saturn’s rings. Prepare to be amazed.

What fueled the frenzy that sent so many to their deaths in colonial America? And how did Americans reckon with the aftermath of the panic? --- For more videos from Smithsonian Magazine: https://www.smithsonianmag.com/videos/ Digital Editorial Director: Brian Wolly Supervising Producer & Scriptwriter: Michelle Mehrtens Video Editor: Sierra Theobald

Smithsonian magazine commissioned Drew Gardner for a project that connects Black Americans today to their lost ancestry. Read about Gardner’s project and process, as well as more details about the subjects of this incredible series here: https://www.smithsonianmag.com/history/descendants-black-civil-war-heroes-wear-heritage-pride-180983397/ Video produced by Sierra Theobald. Special thanks to Drew Gardner Additional credits: Emma MacBeath, WikiTree US Black Heritage project; Ottawa Goodman, research and coordinator; Sam Dole, Penumbra Foundation; Elizabeth Zuck, set design; Calvin Osbourne, props and costume; Angela Huff, hair and make up; Diego Huerta, Lexia Krebs, behind-the-scenes filming; background prints by Fujifilm USA

From the kitchen of his new restaurant in Brooklyn, the chef talks about what it takes to fuse Asian cuisine with an American twist