w For a fair probe: On the Kejriwal bail order and CBI conduct By www.thehindu.com Published On :: Mon, 16 Sep 2024 00:47:00 +0530 Kejriwal bail order is a reminder to CBI to dispel perception of bias Full Article Editorial
w Down to the wire: On the run-up to the U.S. presidential election By www.thehindu.com Published On :: Tue, 17 Sep 2024 00:30:00 +0530 The U.S. presidential race is poised on a knife’s edge Full Article Editorial
w Third front: On the expanding nature of the conflict in West Asia By www.thehindu.com Published On :: Wed, 18 Sep 2024 00:10:00 +0530 Israel’s fighting three enemy militias at once highlights the pressing need for a ceasefire Full Article Editorial
w A way out: On the government and doctor-led protests in West Bengal By www.thehindu.com Published On :: Wed, 18 Sep 2024 00:20:00 +0530 The West Bengal government must enable the changes doctors want to see Full Article Editorial
w Wrong notion: On simultaneous elections By www.thehindu.com Published On :: Fri, 20 Sep 2024 00:10:00 +0530 The idea of simultaneous elections is inherently anti-federal Full Article Editorial
w Pivot to watch: On the U.S. Fed’s rate reduction, its impact By www.thehindu.com Published On :: Sat, 21 Sep 2024 00:10:00 +0530 Full Article Editorial
w Staunch the breach: On India, Pakistan and the Indus Waters Treaty By www.thehindu.com Published On :: Sat, 21 Sep 2024 00:20:00 +0530 India and Pakistan need to drop their hard line stances on the Indus Waters Treaty Full Article Editorial
w Unwarranted curbs: On the Centre’s move on a ‘fact-checking unit’ By www.thehindu.com Published On :: Mon, 23 Sep 2024 00:20:00 +0530 Fact-checking cannot be an excuse to impose censorship Full Article Editorial
w Triumph squared: On India’s chess double win in Budapest By www.thehindu.com Published On :: Tue, 24 Sep 2024 00:16:00 +0530 India’s chess double win was fashioned by its young generation of players Full Article Editorial
w Visit wrap-up: On PM Modi’s U.S. visit, announcements By www.thehindu.com Published On :: Wed, 25 Sep 2024 00:20:00 +0530 The Modi U.S. visit announcements will see New Delhi being put to the test Full Article Editorial
w Rogue state: On Israel’s conflict with Hezbollah By www.thehindu.com Published On :: Thu, 26 Sep 2024 00:10:00 +0530 Israel is choosing war over peace, escalation over compromise Full Article Editorial
w Demand flux: On growth dynamics By www.thehindu.com Published On :: Mon, 30 Sep 2024 00:20:00 +0530 Growth dynamics may falter with waning urban consumption Full Article Editorial
w Steady but slow: On the VIPER mission, lessons for India By www.thehindu.com Published On :: Tue, 01 Oct 2024 00:30:00 +0530 India’s space programme needs more resources to realise its full potential Full Article Editorial
w The edge of war: On the West Asia situation By www.thehindu.com Published On :: Tue, 01 Oct 2024 00:57:00 +0530 Iran should not give Israel an excuse to widen the war Full Article Editorial
w Inflection point: On the escalation in the multi-party West Asia conflict By www.thehindu.com Published On :: Thu, 03 Oct 2024 00:20:00 +0530 West Asia needs the intervention of major world powers for peace Full Article Editorial
w Desert storm: On the T20 Women’s World Cup By www.thehindu.com Published On :: Fri, 04 Oct 2024 00:15:00 +0530 Women’s cricket gets the spotlight as the T20 World Cup gets underway Full Article Editorial
w Split decision: On the rivalry between the two NCP factions By www.thehindu.com Published On :: Fri, 04 Oct 2024 00:25:00 +0530 The ECI and the office of the Speaker have not played fair in cases of defection Full Article Editorial
w Marina mayhem: On the IAF’s Chennai air show By www.thehindu.com Published On :: Tue, 08 Oct 2024 00:23:00 +0530 The deaths at the air show in Chennai could have been prevented with better arrangements Full Article Editorial
w Sweet and sour: On the laddu ‘adulteration’ case By www.thehindu.com Published On :: Thu, 10 Oct 2024 00:10:00 +0530 The inquiry into laddu adulteration must not be communalised Full Article Editorial
w Take the gauntlet: On safety and the Indian Railways By www.thehindu.com Published On :: Mon, 14 Oct 2024 00:38:00 +0530 ‘Kavach’ implementation is a priority but will not be a silver bullet Full Article Editorial
w A Korean win: On the 2024 Nobel Prize in Literature By www.thehindu.com Published On :: Tue, 15 Oct 2024 00:20:00 +0530 A Nobel raises Korean prose to success levels of its drama and music Full Article Editorial
w Taking guard: On the RBI and growth concerns By www.thehindu.com Published On :: Tue, 15 Oct 2024 00:26:00 +0530 The central bank’s price worries may be warranted but growth concerns are emerging Full Article Editorial
w Deeper role: On the U.S. and West Asia conflicts By www.thehindu.com Published On :: Wed, 16 Oct 2024 00:10:00 +0530 The escalating conflict cycle in West Asia could have disastrous consequences Full Article Editorial
w Sufferers, awarded: On the 2024 Nobel Peace Prize By www.thehindu.com Published On :: Wed, 16 Oct 2024 00:20:00 +0530 The Nobel Peace for the selfless Nihon Hidankyo should help stir debates on nuclear disarmament Full Article Editorial
w Canadian frostbite: On the India-Canada diplomatic war By www.thehindu.com Published On :: Thu, 17 Oct 2024 00:20:00 +0530 India must consider the impact of its next steps on its diplomacy and image Full Article Editorial
w Battle of wits: On the Maharashtra and Jharkhand elections By www.thehindu.com Published On :: Fri, 18 Oct 2024 00:20:00 +0530 The Maharashtra and Jharkhand polls will witness intense political battles Full Article Editorial
w Allow for deliberation: On the legitimate demands of Ladakh By www.thehindu.com Published On :: Tue, 22 Oct 2024 00:15:00 +0530 The lack of a legislature and regional autonomy in Ladakh has led to the current protests Full Article Editorial
w West versus the rest: On western conduct and India By www.thehindu.com Published On :: Wed, 23 Oct 2024 00:10:00 +0530 The West must not tolerate terror threats in the name of free speech Full Article Editorial
w Growth prescription: On the latest World Economic Outlook By www.thehindu.com Published On :: Thu, 24 Oct 2024 00:20:00 +0530 The IMF’s ‘mediocre’ medium-term outlook merits policy attention Full Article Editorial
w Cost of Games: On the 2026 Commonwealth Games By www.thehindu.com Published On :: Fri, 25 Oct 2024 00:10:00 +0530 Taking out popular sports from the CWG is a short-term solution Full Article Editorial
w At a loss: On the New Zealand-India three-match series By www.thehindu.com Published On :: Mon, 28 Oct 2024 00:10:00 +0530 India batters frittered away the home advantage against New Zealand Full Article Editorial
w Escalation ladder: On conflict between Israel and Iran By www.thehindu.com Published On :: Tue, 29 Oct 2024 00:15:00 +0530 Iran should show strategic restraint; and the world should rein in Israel Full Article Editorial
w Western front: On the parties and their prospects in the Maharashtra polls By www.thehindu.com Published On :: Tue, 29 Oct 2024 00:30:00 +0530 Granular factors can determine the outcome in Maharashtra Full Article Editorial
w Towards Europe: On the India visits by the leaders of Germany, Spain By www.thehindu.com Published On :: Thu, 31 Oct 2024 00:20:00 +0530 India used visits by leaders of Germany and Spain to balance ties in Europe Full Article Editorial
w Watch: When Jimmy Sheirgill Got Violent By www.rediff.com Published On :: 'As a storyteller, one always looks to create something for the audience which is thrilling, engaging and entertaining and that is exactly what we have endeavoured with Sikandar Ka Muqaddar.' Full Article
w What Makes <I>Andaz Apna Apna</I> Such Fun Even Today By www.rediff.com Published On :: Andaz Apna Apna is practically the most quoted film since Sholay, observes Sukanya Verma, as she celebrates 30 years of this cult classic movie. Full Article
w Why Kriti Is So Grateful By www.rediff.com Published On :: Kriti Kharbanda took a trip down memory lane when her rom-com Shaadi Mein Zaroor Aana clocked seven years since its release. Full Article
w Why Abhishek Missed Aishwarya's Birthday By www.rediff.com Published On :: When Aishwarya celebrated her birthday in Dubai on November 1, the speculation regarding the Abhishek-Aishwarya marital rift ran even higher. Full Article
w The Woman Who Lost Everything By www.rediff.com Published On :: When the landslide hit, Sruthi's house was washed away, along with its inhabitants. Full Article
w Look Who Just Met Tom Cruise! By www.rediff.com Published On :: Kartik wants to savour Litti Chokha in Patna... Amyra holidays in Phuket... Karishma in Italy... Full Article
w The role of silicon in drug discovery: a review By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3286-3344DOI: 10.1039/D4MD00169A, Review Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Jenny-Lee Panayides, Darren Lyall Riley, Felix Hasenmaile, Willem A. L. van OtterloThis review aims to highlight the role of silicon in drug discovery.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
w The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3576-3596DOI: 10.1039/D4MD00438H, Research ArticleRuolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang ChenRho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
w A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3444-3459DOI: 10.1039/D4MD00318G, Research ArticleAnuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar MaitiNiloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
w Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3433-3443DOI: 10.1039/D4MD00468J, Research ArticleMeijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing LiA synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
w Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3529-3557DOI: 10.1039/D4MD00481G, Research ArticleMohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai AdelDiscovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
w SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3460-3468DOI: 10.1039/D4MD00405A, Research ArticleXiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli BiSchematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
w Rationally modified SNX-class Hsp90 inhibitors disrupt extracellular fibronectin assembly without intracellular Hsp90 activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3609-3615DOI: 10.1039/D4MD00501E, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Gciniwe S. Mathenjwa, Abir Chakraborty, Abantika Chakraborty, Ronel Muller, Mathew P. Akerman, Moira L. Bode, Adrienne L. Edkins, Clinton G. L. VealeRationally modified Hsp90 inhibitors which retained of on-target activity but showed no engagement of intracellular Hsp90, or stimulation of the heat shock response, were found to significantly alter the extracellular fibronectin network.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
w Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3597-3608DOI: 10.1039/D4MD00378K, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. JenkinsIn silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
w Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00471J, Research ArticlePoorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar ShrivastavaScreening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
w Therapeutic upregulation of DNA repair pathways: strategies and small molecule activators By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00673A, Review ArticleJuhyung Song, Cheoljun Park, Francis E. B. Cabanting, Yong Woong JunPotential therapeutic target proteins for upregulating DNA repair system are reviewed, along with reported small-molecule activators.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
