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Georgia President calls for fresh election after contested vote

By www.thehindu.com
Published On :: Mon, 11 Nov 2024 22:57:55 +0530

Georgian President Salome Zurabishvili calls for fresh elections amid allegations of electoral fraud, sparking crisis and international concern


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Trump expected to pick Marco Rubio for U.S. Secretary of State

By www.thehindu.com
Published On :: Tue, 12 Nov 2024 09:37:03 +0530

Top role for Rubio could bolster Republicans' Latino gains; Rubio opposed $95 billion military aid to Ukraine


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Bangladesh asks Interpol for help in arresting ousted Prime Minister Sheikh Hasina

By www.thehindu.com
Published On :: Tue, 12 Nov 2024 21:10:54 +0530

A special tribunal in Bangladesh has asked the international police organization Interpol to issue a red notice for the arrest of ousted Prime Minister Sheikh Hasina in connection with the deaths of hundreds of protesters


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Requested ₹130 crore from Centre for the development of Vijayawada GGH: Vijayawada MP Chinni

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 20:18:42 +0530

All Anganwadi centres in NTR district will get a building of their own with clean kitchens, says Chinni


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Construction of one lakh houses under PMAY 1.0 scheme to be completed by December: Kolusu Parthasarathy

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 21:04:54 +0530

During a review of the Housing Department in Chittoor and Tirupati districts, he says that construction work was not completed in certain places due to lack of sand supply or heavy rains


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State, Society and Mobilization in Europe during the First World War [electronic resource] / edited by John Horne.

By darius.uleth.ca
Published On ::

Cambridge : Cambridge University Press , 1997.


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P3MOT-decorated metal-porphyrin-based zirconium-MOF for the efficient electrochemical detection of 4-nitrobenzaldehyde

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2093-2100
DOI: 10.1039/D4AY00152D, Paper
Wen-yi Chen, Xin-yu Huang, Qian Sun, En-qing Gao
Developed a novel hybrid P3MOT@PCN-222(Fe) via in situ polymerization for 4-NBA detection. Showcased broad detection range, high sensitivity, selectivity and stability, laying groundwork for environmental monitoring.
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Sodium alginate hydrogelation mediated paper-based POCT sensor for visual distance reading and smartphone-assisted colorimetric dual-signal determination of L-lactate

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2077-2084
DOI: 10.1039/D4AY00041B, Paper
Wenjuan Wang, Danrong Chen, Yujiao Cai, Zijing Liu, Hongfen Yang, Hongbin Xie, Jinquan Liu, Shengyuan Yang
Here, we show a paper-based POCT sensor based on lactate dehydrogenase-mediated alginate gelation combined with visual distance reading and smartphone-assisted colorimetric dual-signal analysis to determine the concentration of L-lactate in yogurt samples.
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Electrochemical aptasensor based on silver-thiolated graphene for high-sensitive detection of Pb2+

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00322E, Paper
Jie Zhou, Changchun Hu, Shuo Li, Chuanxiang Zhang, Yuan Liu, Zhu Chen, Song Li, Hui Chen, Yan Deng
The presence of lead ions (Pb2+) not only leads to environmental contamination but also poses a significant risk to public health through their migration into food and drinking water. Therefore,...
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Nanocubic cobalt-containing Prussian blue analogue-derived carbon-coated CoFe alloy nanoparticles for noninvasive uric acid sensing

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00121D, Paper
Yunting Qin, Dan Xiao, Xilan Gao, Xicui Zhang, Yanxue Xu
This work describes an electrochemical sensor for the fast noninvasive detection of uric acid (UA) in saliva.
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Subtle adjustment of the cyclic potential on electro-activated glassy carbon electrodes for sensitive sensing of methyl parathion

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00079J, Paper
Yunyin Yang, Sian Chen, Changqiu Zhang, Yanqing Li, Xinrong Zong, Yitao Lv, Min Zhang
Upon experiencing a negligible change of 0.5 V which only takes 5 more seconds, the signal value of an e-GCE was efficiently enhanced from 2-fold to 30-fold compared with a bare GCE.
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A lateral flow strip for on-site detection of homocysteine based on a truncated aptamer

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00274A, Paper
Yunqing Wu, Tianyu Huang, Xin Chen, Mingyuan Wang, Xiaoli Wang, Yuting Zhang, Nandi Zhou
A lateral flow strip based on a truncated aptamer for on-site detection of homocysteine in human serum.
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One-step electrodeposited hybrid nanofilms in amperometric biosensor development

By pubs.rsc.org
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Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00290C, Tutorial Review
Yuliya E. Silina
This review summarizes developments in amperometric biosensors with electrodeposited sensing films. It was shown how the analytical merit of one-step designed biosensors can be controlled by the change of chemical factors within the same engineering platform.
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Correction: An impedimetric sensor based on molecularly imprinted nanoparticles for the determination of trypsin in artificial matrices – towards point-of-care diagnostics

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY90029D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Sabrina Di Masi, Marco Costa, Francesco Canfarotta, Antonio Guerreiro, Alicia Hartley, Sergey A. Piletsky, Cosimino Malitesta
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Analysis of O-acetylated sialic acids by 3-nitrophenylhydrazine derivatization combined with LC-MS/MS

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00330F, Paper
Chenhao Zhao, Xingdan Wang, Jing Wu, Yeli Hu, Qiwei Zhang, Qi Zheng
The 3-NPH-labeled sialic acids produce a high abundance of reporter ions, which can improve the accuracy of quantitative analysis of O-acetylated species.
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Discrimination of Diptera order insects based on their saturated cuticular hydrocarbon content using a new microextraction procedure and chromatographic analysis

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00214H, Paper
Open Access
Lixy Olinda León-Morán, Marta Pastor-Belda, Pilar Viñas, Natalia Arroyo-Manzanares, María Dolores García, María Isabel Arnaldos, Natalia Campillo
The nature and proportions of hydrocarbons in the cuticle of insects is characteristic of the species and age. Chemical analysis of cuticular hydrocarbons allows species discrimination, which is of great...
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A novel ratiometric sensor for fluorimetric and visual dual-mode detection of Al3+ in environmental water based on the target-regulated formation of Eu MOFs

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00324A, Paper
Tao-Li Chen, Xiang-Juan Kong, Xin-Xin Dong, Zhi-Jie Mao, Fang-Fang Kong, Qiang Xiao
The illustration of the ratiometric sensor for fluorimetric (A) and visual detection (B) of Al3+.
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Field method for preservation of total mercury in waters, including those associated with artisanal scale gold mining

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02216A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
David C. P. King, Michael J. Watts, Elliott M. Hamilton, Robert J. G. Mortimer, Mike Coffey, Odipo Osano, Maureene Auma Ondayo, Marcello Di Bonito
A method was developed for sampling and preserving total Hg from water samples, recovering >75% Hg over 4 weeks of storage. The method was assessed using water samples at artisanal gold mining sites in Kenya.
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Rapid detection of monkeypox virus and differentiation of West African and Congo Basin strains using endonuclease restriction-mediated real-time PCR-based testing

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00492B, Paper
Juan Zhou, Fei Xiao, Xiaolan Huang, Jin Fu, Nan Jia, Chunrong Sun, Min Chen, Zheng Xu, Hui Huang, Yi Wang
A novel multiplex ET-PCR assay that integrates PCR amplification, restriction endonuclease cleavage and real-time fluorescence detection was devised to diagnose MPXV infection and distinguish the Congo Basin and West Africa MPXV strains.
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Ag-coated tetrapod gold nanostars (Au@AgNSs) for acetamiprid determination in tea using SERS combined with microfluidics

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00297K, Paper
Qian Ke, Limei Yin, Heera Jayan, Hesham R. El-Seedi, Xiaobo Zou, Zhiming Guo
The combination of highly sensitive SERS substrate core–shell Au@AgNSs and microfluidic chip featuring four circular split hybrid structures were used for quantitative detection of acetamiprid in tea. The LOD of acetamiprid was 0.048 ng mL−1.
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A novel electrophoretic assisted hydrophobic microdevice for enhancing blood cell sorting: design and numerical simulation

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2368-2377
DOI: 10.1039/D4AY00196F, Paper
Xinkun Chen, Xueye Chen
Microfluidic technology has great advantages in the precise manipulation of micro–nano particles, and the hybrid microfluidic separation technology has attracted much attention due to the advantages of both active and passive separation technology at the same time.
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Polymeric membrane potentiometric sensors based on template-removal-free imprinted receptors for determination of antibiotics

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00263F, Paper
Xinyao Wang, Guohua Cui, Rongning Liang, Wei Qin
Currently, Nernstian-response-based polymeric membrane potentiometric sensors using the molecularly imprinted polymers (MIPs) as the receptors have been successfully developed for determination of organic ionic species. However, the preparation of these...
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Design and fabrication of La-based perovskites incorporated with functionalized carbon nanofibers for the electrochemical detection of roxarsone in water and food samples

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00264D, Paper
Mariya Antony John Felix, Santhiyagu Sahayaraj Rex Shanlee, Shen-Ming Chen, Sundaresan Ruspika, Ramachandran Balaji, Narendhar Chandrasekar, Periyanayagam Arockia Doss
Fabrication of potent electrocatalyst, La-based perovskites coupled with functionalized carbon nanofibers (LMO/f-CNF) for ultrasensitive electrochemical detection of roxarsone in edible and water samples.
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The preparation of a boronate affinity-based controlled oriented imprinting coating on a silica nanoparticle surface for the separation and purification of shikimic acid in herbal medicine

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00219A, Paper
Yumin Yang, Daojin Li, Bingqian Liu
Shikimic acid (SA) is one of the most effective drugs against the A (H1N1) virus and has high medicinal value.
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Three-dimensional hotspot structures constructed from nanoporous gold with a V-cavity and gold nanoparticles for surface-enhanced Raman scattering

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00348A, Paper
Yang Xu, Yan Wu, Jianjun Wei, Yuanyu Zhao, Peili Xue
A nanoporous gold V-shaped resonant cavity (NPGVRC) structure constructed with plasmonic resonance coupling effect. The NPGVRC has excellent SERS performance and 3D hotspot properties.
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Pictures from the dear departed

By www.thehindubusinessline.com
Published On :: Thu, 19 Sep 2013 16:09:14 +0530


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Unwarranted curbs: On the Centre’s move on a ‘fact-checking unit’

By www.thehindu.com
Published On :: Mon, 23 Sep 2024 00:20:00 +0530

Fact-checking cannot be an excuse to impose censorship


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Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
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Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

By pubs.rsc.org
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RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
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A novel, glutathione-activated prodrug of pimasertib loaded in liposomes for targeted cancer therapy

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00517A, Research Article
Open Access
Arianna Amenta, Susanna Comi, Marcelo Kravicz, Silvia Sesana, Antonia Antoniou, Daniele Passarella, Pierfausto Seneci, Sara Pellegrino, Francesca Re
A novel, glutathione-activated prodrug of pimasertib (PROPIMA) has been developed. PROPIMA showed ability to inhibit tumour cell migration and proliferation controlled over time, while also achieving a high incorporation rate into liposomes.
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Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00608A, Research Article
Sunil Kumar, Bishnu Prasad Pandey, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rania B. Bakr, Hoon Kim, Bijo Mathew
A total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.
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Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00297K, Research Article
Branislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea Nikolić
In this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.
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Modulating polybasic character of galactose-based glycosylated antitumor ether lipids for enhanced cytotoxic response

By pubs.rsc.org
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RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00662C, Research Article
Rajat Arora, Ayan Mukherjee, Gilbert Arthur, Mark W. Nachtigal, Frank Schweizer
We describe the multi-step synthesis of different dibasic and tribasic galactosamine-based glycosylated antitumor ether lipids (GAELs) and their cytotoxic response in comparison to doxorubicin and cisplatin.
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Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
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Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00626G, Research Article
Aleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan Veerappan
Lipidation modulates the Gram-selective antibacterial activity of QPyNATh.
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meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
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Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00553H, Research Article
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro Cosconati
Non-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.
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3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00597J, Research Article
Albert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken Witt
Somatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...
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Adjuvant strategies to tackle mcr-mediated polymyxin resistance

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00654B, Review Article
Madison R. Nuske, Junlang Zhong, Renjie Huang, Vijayalekshmi Sarojini, Jack L. Y. Chen, Christopher J. Squire, Mark A. T. Blaskovich, Ivanhoe K. H. Leung
The emergence of the mobile colistin resistance (mcr) gene is a significant threat contributing to the worldwide antibiotic resistance crisis. This review discusses adjuvant strategies to restore polymyxin sensitivity in these resistant bacteria.
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Doctor assaulted inside Tiruchi ESI Hospital

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 18:29:04 +0530


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Duo arrested for possession of banned tobacco products worth ₹3 lakh in Tiruchi

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 18:23:30 +0530


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Three arrested for assaulting doctor in ESI hospital

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 19:23:47 +0530


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Bids invited for setting up International Dugong Conservation Centre at Manora

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 19:03:19 +0530

The proposed centre, to be set up at an estimate of ₹41 crore, is being established to conserve endangered Dugong species and its habitat in the Palk Bay


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Railways using treated water from its STP for maintaining green spaces

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 20:46:00 +0530

The treated water is stored in an overhead tank and used in gardens at the two railway rest houses meant for officers at Kallukuzhi near Tiruchi Railway Junction


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Consultant to be appointed soon to design Kalaignar grand library in Tiruchi

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 18:41:18 +0530

The centre will offer translation, services for persons with disabilities and children, training and mentorship programmes, besides hosting monthly literary events


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Two doctors posted at Uppiliyapuram UPHC

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 20:29:46 +0530


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607: Astro Launches an Integrated Database

By shoptalkshow.com
Published On :: Mon, 18 Mar 2024 08:39:41 +0000

Fred K. Schott stops by to talk about Astro announcement of Astro DB, the pluses and minuses of it, whether you have to always use the database with Astro DB, how to migrate data, seeding your database, upgrading the database, and what about Astro DB pricing?


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Water, unlimited

By www.thehindu.com
Published On :: Fri, 26 Dec 2014 16:00:55 +0530

Anamika Mukherjee writes on what went into creating the water supply system in her home


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October decisions on ‘assisted dying’ for terminally ill

By www.thehindubusinessline.com
Published On :: Sun, 06 Oct 2024 21:38:00 +0530

India, UK to legislate on allowing patients this choice


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Aggregated customer power

By www.thehindubusinessline.com
Published On :: Sun, 13 Oct 2024 20:00:00 +0530

User-friendly financial services are a click away with account aggregators


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