The following article, Witness Tampering? Asst. HHS Secretary Releases Threatening Text Messages From Dem Rep. Eric Swalwell: “In clear violation of House Ethics rules “, was first published on 100PercentFedUp.com.

Now that Michael Caputo, who was previously a target of the Mueller investigation, has been cleared, he has released some pretty damning text messages from the virulently anti-Trump lawmaker from California, Rep. Eric Swalwell (D). The text messages appear to prove that Swalwell, who has spent the last 3 1/2 years calling for Trump’s impeachment, […]

Continue reading: Witness Tampering? Asst. HHS Secretary Releases Threatening Text Messages From Dem Rep. Eric Swalwell: “In clear violation of House Ethics rules “ ...

Research Event

Event participants

Ambassador Zhong Jianhua, China’s Special Representative for African Affairs
Chair: Alex Vines OBE, Research Director, Area Studies and International Law; Head, Africa Programme, Chatham House

23 February 2015

Although a robust inflammatory response is needed to combat infection, this response must ultimately be terminated to prevent chronic inflammation. One mechanism that terminates inflammatory signaling is the production of alternative mRNA splice forms in the Toll-like receptor (TLR) signaling pathway. Whereas most genes in the TLR pathway encode positive mediators of inflammatory signaling, several, including that encoding the MyD88 signaling adaptor, also produce alternative spliced mRNA isoforms that encode dominant-negative inhibitors of the response. Production of these negatively acting alternatively spliced isoforms is induced by stimulation with the TLR4 agonist lipopolysaccharide (LPS); thus, this alternative pre-mRNA splicing represents a negative feedback loop that terminates TLR signaling and prevents chronic inflammation. In the current study, we investigated the mechanisms regulating the LPS-induced alternative pre-mRNA splicing of the MyD88 transcript in murine macrophages. We found that 1) the induction of the alternatively spliced MyD88 form is due to alternative pre-mRNA splicing and not caused by another RNA regulatory mechanism, 2) MyD88 splicing is regulated by both the MyD88- and TRIF-dependent arms of the TLR signaling pathway, 3) MyD88 splicing is regulated by the NF-κB transcription factor, and 4) NF-κB likely regulates MyD88 alternative pre-mRNA splicing per se rather than regulating splicing indirectly by altering MyD88 transcription. We conclude that alternative splicing of MyD88 may provide a sensitive mechanism that ensures robust termination of inflammation for tissue repair and restoration of normal tissue homeostasis once an infection is controlled.

Contact between inflammatory cells and endothelial cells (ECs) is a crucial step in vascular inflammation. Recently, we demonstrated that the cell-surface level of endomucin (EMCN), a heavily O-glycosylated single-transmembrane sialomucin, interferes with the interactions between inflammatory cells and ECs. We have also shown that, in response to an inflammatory stimulus, EMCN is cleared from the cell surface by an unknown mechanism. In this study, using adenovirus-mediated overexpression of a tagged EMCN in human umbilical vein ECs, we found that treatment with tumor necrosis factor α (TNF-α) or the strong oxidant pervanadate leads to loss of cell-surface EMCN and increases the levels of the C-terminal fragment of EMCN 3- to 4-fold. Furthermore, treatment with the broad-spectrum matrix metalloproteinase inhibitor batimastat (BB94) or inhibition of ADAM metallopeptidase domain 10 (ADAM10) and ADAM17 with two small-molecule inhibitors, GW280264X and GI254023X, or with siRNA significantly reduced basal and TNFα-induced cell-surface EMCN cleavage. Release of the C-terminal fragment of EMCN by TNF-α treatment was blocked by chemical inhibition of ADAM10 alone or in combination with ADAM17. These results indicate that cell-surface EMCN undergoes constitutive cleavage and that TNF-α treatment dramatically increases this cleavage, which is mediated predominantly by ADAM10 and ADAM17. As endothelial cell-surface EMCN attenuates leukocyte–EC interactions during inflammation, we propose that EMCN is a potential therapeutic target to manage vascular inflammation.

The exponential growth of international travel since the 1960s has left border management systems worldwide struggling to keep up and has exposed weaknesses in states’ abilities to effectively manage their borders, especially regarding terrorist attacks, human trafficking, and illegal migration.

This report describes the range of policies available to improve immigrants’ economic integration through language acquisition, especially those focused on getting immigrants into jobs or moving into higher-paying jobs. It assesses promising models and practices from Europe and North America.

Civil society provides a crucial link between governments and the communities they represent—infusing policy processes with grassroots knowledge to which governments may not otherwise have access. Looking at the European Union’s efforts to engage with civil society in its “neighborhood,” this report examines the benefits, challenges, and mechanisms to building dialogue and cooperation on migration and development.

European dominance in U.S. immigration flows has decreased significantly since World War II, a result of economic, demographic, and policy trends on both sides of the Atlantic. Today, migration from European Union Member States to the United States, while small, is characterized by a substantial numbers of European scientists, professionals, and businesspeople.

On this Teachers’ Day, I fondly remember Fraulein Daphne Adams, my first German teacher who influenced my love for languages and who transitioned recently in Jamaica. Miss Adams was first and foremost an excellent, no-nonsense teacher of modern...

Declaring it has been “pained” by the Jodian Fearon situation, the embattled Andrews Memorial Hospital (AMH) is speaking out, saying it has never been approached for or rejected efforts at registration or certification since it began operating 76...

ADVISORY COLUMN: SMALL BUSINESS On Thursday, May 7, the RJR/GLEANER Communications group staged a virtual town hall meeting on Television Jamaica titled “COVID-19...

Lady Allen – wife of Jamaica’s Governor General Sir Patrick Allen – says Jamaican women are among the strongest and most resilient in the world, and despite many bearing the full brunt of the coronavirus pandemic as breadwinners for their families...

This volume, by a former senior counsel to the 9/11 Commission, argues that the U.S. approach to immigration and border security is off-kilter and not keeping pace with the scope and complexity of people’s movement around the world, nor with expectations regarding freedom of movement.

Ce manuel pratique et simple d’utilisation à l’usage des décideurs et des praticiens fait le point des mesures les plus récentes prises par les pouvoirs publics en direction des diasporas. La question qui se pose aux responsables politiques n’est pas tant de savoir si les diasporas peuvent être utiles à leur pays d’origine, mais comment elles le sont et quels types de politiques et de programmes publics sont à même de favoriser ces relations.

Across the Atlantic, large-scale migration has brought about unprecedented levels of diversity, transforming communities in fundamental ways — with a resulting immigration backlash and criticism of "multiculturalism." This volume delivers recommendations on what policymakers must do to build and reinforce inclusiveness given the realities on each side of the Atlantic.

This edited volume develops a pragmatic approach to the engagement of highly skilled members of the diaspora for the benefit of their countries of origin. The book, edited by a World Bank senior economist, is based on empirical work in middle-income and high-income economies.

The enactment of President Clinton’s Limited English Proficiency (LEP) Executive Order, issued in 2000, triggered a proliferation of efforts to provide services to individuals who cannot speak, understand, read, or write English fluently. With increased service provision, state and local government agencies have expressed a strong and growing interest in assuring the quality and cost-effectiveness of language access services. This paper attempts to catalog and describe some of those tools and practices.

This interactive language access webinar, one in a series offered by the Migration Policy Institute's National Center on Immigrant Integration Policy, examines how New York and Illinois have broken down some of these barriers to proactively engage LEP communities to obtain workforce services.

This webinar examines how New York and Illinois have proactively engaged Limited English Proficient (LEP) communities to obtain workforce services.

This is the latest in NCIIP’s language access webinar series exploring the policy and program implementation imperatives for government and community agencies serving Limited English Proficient (LEP) populations.

This webinar from the MPI’s National Center on Immigrant Integration Policy and the U.S. Conference of Catholic Bishops’ Bridging Refugee Youth & Children’s Services program explores federal requirements for providing interpretation and translation in schools and how select school districts in Minnesota and Colorado have managed these requirements.

This MPI webinar features U.S. Department of Justice (DOJ) officials discussing the department’s efforts to improve communications with Limited English Proficient (LEP) communities in federal and federally-funded programs and activities.

This MPI webinar features U.S. Department of Justice (DOJ) officials discussing the department’s efforts to improve communications with Limited English Proficient (LEP) communities in federal and federally-funded programs and activities.

A webinar on language access contracting for federal, state, and local officials, agency administrators, and community stakeholders concerned with the oversight and implementation of language access provision.

A webinar on language access contracting for federal, state, and local officials, agency administrators, and community stakeholders concerned with the oversight and implementation of language access provision.

This report highlights gaps and anomalies in labor protection, while recognizing that U.S. law sets significant standards for minimum wage, overtime pay, child labor, safe and healthy workplaces, antidiscrimination, labor organizing, and collective bargaining.

This Migration Policy Institute webinar discusses labor enforcement laws during the Clinton, Bush and Obama administrations and chronicles gaps in labor protection.

This webinar discusses labor enforcement laws during the Clinton, Bush, and Obama administrations and chronicles gaps in labor protection, while also discussing the elements necessary for an effective labor standards enforcement system and why labor standards enforcement should become a pillar of immigration policymaking.

I'm a Japanese,struggling to catch English. Exa: V/B, we don't have the similar sound of V. so both sounds B. Can native English speakers always hear the difference of B/V even in France,Spanish or other Europe language?

The Army is requesting bids for a $25 million contract for wearable sensors to detect early symptoms of COVID-19.

Part of a series exploring issues likely to be addressed by the new National Integration Plan, this webinar, with perspectives from the cities of New York and Seattle and others delves into possible recommendations on federal coordination of local government immigrant integration initiatives, including language access. 

Part of a series exploring issues likely to be addressed by the new National Integration Plan, this webinar, with perspectives from the cities of New York and Seattle and others examines possible recommendations on federal coordination of local government immigrant integration initiatives, including language access. 

Whether driven by pragmatism, local laws, or federal civil-rights provisions, state and local governments and agencies across the United States increasingly have designed and implemented language access services (i.e. translation and interpretation) in response to growing Limited English Proficient populations. This commentary argues it is time for the federal government to follow suit.

Testimony of Donald Kerwin, former MPI Vice President for Programs, before the House Homeland Security Committee's Subcommittee on Border, Maritime, and Global Counterterrorism at its hearing: "Moving Toward More Effective Immigration Detention Management." 

The Halifax & Region Military Family Resource Centre assembled boxes filled with goodies and keepsakes from Nova Scotia this week to send to each crew member. The gesture comes after six crew members were killed in a helicopter crash in late April.

Today, we came across an interesting video where Govinda can be seen shaking his leg with actress Kriti Sanon on his hit song 'Main Toh Raste Se Ja Raha Tha'.

Personal Agenda with Ricky Kej: “Best thing about lockdown? My dog is really happy!”  Hindustan Times

An OMer learning Turkish was encouraged when she shared the message of the gospel with a taxi driver in a city in Western Turkey.

Norwegian Bible school students on mission trip to South Africa, shares the Gospel at the garbage dump outside Pretoria

On 24 December, OM Philippines-Cebu witnessed the overflowing joy of about 135 families during Christmas parties they hosted in two typhoon-affected areas.

Christina reflects on lessons learned about valuing people the way Christ did, while cleaning trash and volunteering in a refugee camp in Šid, Serbia.

OM Norway Field Leader Willy Andre Meberg expresses condolences and prayer for the people of Norway.

A Roma man’s cry to God for mercy to spare his son’s life transforms his future and the future of his small town.

A recap of Bus4Life's ministry in Romania during the summer of 2018.

After struggling to connect with an immigrant woman in Zurich, one worker listens to the woman’s story and thus learns the language of her heart.

Two lifelong friends from the US bring a message of hope, friendship and a future to marginalised locals during OM Zambia’s first-ever wheelchair camp.