se Slack's secret sauce: how it became the fastest growing business app ever By www.smh.com.au Published On :: Thu, 31 Mar 2016 06:07:06 GMT Slack has launched its Asia-Pacific headquarters in Melbourne. We caught up with Ali Rayl, head of customer experience. Full Article
se Recruitment drive for cyber security specialists will bring challenges for government By www.smh.com.au Published On :: Mon, 02 May 2016 19:51:02 GMT Fear government's cyber security recruitment drive will lead to job cuts. Full Article
se Malcolm Turnbull promises $50 million reboot for troubled myGov By www.smh.com.au Published On :: Tue, 21 Jun 2016 22:06:13 GMT Takeover of troubled portal by Digital Transformation Office confirmed Full Article
se Governments should hack less, deliver better online services: Harvard IT expert By www.smh.com.au Published On :: Sat, 30 Jul 2016 13:30:00 GMT Western governments have established the international norm of online hacking and should not be surprised when foreign governments do the same. Full Article
se Digital public service means ditching control and embracing 'we' By www.smh.com.au Published On :: Mon, 01 Aug 2016 13:45:00 GMT Collaborating with the public is the key for a more engaging government experience. Full Article
se Call for a cyber security reserve corps to help fight major attacks By www.smh.com.au Published On :: Mon, 15 Aug 2016 14:15:00 GMT Experienced volunteers would help fight major online threats to governments, private industry and civil institutions. Full Article
se Centrelink apologises for new privacy breach By www.smh.com.au Published On :: Sat, 05 Nov 2016 06:37:10 GMT Rookie email error shares hundred of email addresses – twice. Full Article
se Is the Australian government agile and innovative? Not to those in the start-ups world By www.smh.com.au Published On :: Wed, 02 Nov 2016 04:25:22 GMT Public service departments "too nervous" to innovate, say start-ups. Full Article
se $212,000 per public service IT contractor, and we're hiring more of them By www.smh.com.au Published On :: Tue, 20 Dec 2016 08:47:58 GMT Contractors cost 80 grand more than public servants, Finance Departments says, and the public service hires more of them. Full Article
se Auditor-general exposes weaknesses in ACT government's IT systems By www.smh.com.au Published On :: Mon, 08 May 2017 02:35:19 GMT Electronic sexual health records and the births, deaths and marriages registry have been left exposed. Full Article
se Australia's Cyber Security Strategy: weaknesses, yes, but we're improving By www.smh.com.au Published On :: Fri, 02 Jun 2017 05:53:07 GMT The online world changes so fast it was always going to be tough to design a four-year strategy. Full Article
se Quirk's integrity questioned over failure to release "secret" IT report By www.smh.com.au Published On :: Tue, 08 Aug 2017 07:26:04 GMT Opposition councillors have called Brisbane's Lord Mayor Graham Quirk secretive and accused him of putting his integrity at stake over the failure to release an external review into the now terminated $122 million IT contact with Technology One. Full Article
se Labor to push for Senate inquiry into $10b government IT spend and tech wrecks By www.smh.com.au Published On :: Sun, 13 Aug 2017 14:01:00 GMT The probe would investigate a trail of blunders that have shredded the government's reputation. Full Article
se Cyber security threat: Is Australia's power grid safe from hackers? By www.smh.com.au Published On :: Fri, 10 Nov 2017 13:15:00 GMT Cyber attacks have labelled the number one threat to power and utility companies worldwide, a new EY report has found. Full Article
se Public service bosses to be schooled in digital following IT problems By www.smh.com.au Published On :: Wed, 10 Jan 2018 06:56:05 GMT Public service bosses will take lessons aiming to improve their leadership in all things digital. Full Article
se Medical records exposed by flaw in Telstra Health's Argus software By www.smh.com.au Published On :: Wed, 21 Mar 2018 21:21:02 GMT Default static password allowed medical practitioners' computers and servers to be accessed remotely by hackers. Full Article
se Rethinking 'The Economic Consequences of the Peace' By feedproxy.google.com Published On :: Mon, 07 Oct 2019 15:10:01 +0000 Members Event 25 November 2019 - 1:00pm to 2:00pm Chatham House | 10 St James's Square | London | SW1Y 4LE Event participants Professor Michael Cox, Associate Fellow, US and the Americas Programme, Chatham House; Director, LSE IDEASProfessor Margaret MacMillan, Professor of History, University of Toronto; Emeritus Professor of International History, University of OxfordDr Geoff Tily, Senior Economist, TUC; Author, Keynes Betrayed: The General Theory, the Rate of Interest and 'Keynesian' EconomicsChair: Dr Jessica Reinisch, Reader in Modern European History, Birkbeck University of London John Maynard Keynes' The Economic Consequences of the Peace has long been a key reference point in discussions about the Treaty of Versailles and its impact on Germany and Europe’s rehabilitation. A century after its publication, the relevance of Keynes’ thinking – not least the influence it had on public perception of the treaty itself – offers an insight into the impact of expert analysis on how political decisions are received in public and academic spheres.This panel discusses the author, the book and the controversy they have generated up to the present day. How relevant is Keynes’ polemic and how applicable is his European economic recovery plan to our current period of global dislocation? What is the role of experts in the formation and scrutiny of international politics? And how can contemporary politicians use Keynes’ comprehensive assessment of the intersection between political, social and economic realities and national idealism to inform their approaches to international relations? Members Events Team Email Full Article
se Trade Tensions Set to Continue in 2020 By feedproxy.google.com Published On :: Tue, 14 Jan 2020 10:13:33 +0000 14 January 2020 Megan Greene Dame Deanne Senior Fellow in International Economics @economistmeg LinkedIn As the US faces off over trade with both China and the EU, expect another year of uncertainty. 2020-01-14-Zhangjiagang.jpg Unloading at a port in Zhangjiagang. Photo: Getty Images. Global trade policy is not going back to the consensus that prevailed over the past few decades. Even if the growing cycle of tariffs and trade threats is tamed in 2020, the economic consensus that underpinned broad support for open trade is breaking down, and escalation in trade tensions is likely.What next for the US and China?The US and China are currently at the centre of these tensions. The equity and bond markets started 2020 off euphorically as news of a ‘phase one’ trade deal between the two dominated headlines. Such a deal involves the US reducing some previously imposed tariffs and tabling another round of threatened ones, while China agrees to buy more US goods, including agriculture. This represents a détente of sorts, but don’t expect it to last; trade between the two countries is not actually at the heart of their trade war.The question instead is which country will have the biggest economy, based on excellence in industries such as artificial intelligence, machine learning and quantum computing. There is a national security component to this issue as well, given how much these high-tech industries feed into military and national security operations. This has increasingly become a concern for the United States as China has adopted a more aggressive regional stance, particularly in the South China Sea.Tariffs have been used as a tool by both countries to try to prevent the other from dominating the global economy, and while they have dented both economies, they aren’t a particularly effective tool. In particular, tariffs do nothing to address US concerns about intellectual property rights in China, forced technology transfers and state subsidies for high tech industries. The phase one deal, therefore, is a superficial one that fails to get at the heart of the matter.US–EU tensionsHowever, with a temporary US-China détente, the US may turn its attention to Europe. The EU and US are in the midst of negotiating a trade deal, but obstacles have been present from the start.Last July, France adopted a 3% digital tax that applies to firms with global revenues over €750 million per annum generated from digital activities, of which €25 million are made in its territory. A US investigation determined that the digital tax discriminates against US companies such as Google, Amazon, Apple and Facebook, and so the US has threatened France with 100% tariffs on luxury exports, including wine.The long-standing tensions between the US and EU over their aircraft manufacturing behemoths, Boeing and Airbus, make reaching a US–EU trade deal more complicated. They also risk undermining US–EU collaboration on some joint concerns regarding China’s trade policies and practices.The United States recently threatened to increase its punitive measures against European goods as retaliation for Airbus subsidies. The World Trade Organization (WTO) gave the US the green light to impose tariffs of up to 100% on $7.5 billion of EU exports last October, but the US had limited them to 10% on aircraft and 25% on industrial and agricultural products. Now, the US is threatening to escalate.Finally, the US has repeatedly threatened to impose tariffs on imported cars from the EU. This threat looms large for Germany in particular, which is a significant producer of automobiles and whose industry is still recovering from the diesel emissions scandal. Germany has for the past two decades been the powerhouse economy in the EU, but has more recently seen sclerotic growth.US election implicationsIt is an election year in the United States, and while it is too early to call the election (or even guess who the Democratic candidate might be), the ballot could bring about change on trade. Protectionism has historically been more of a Democrat policy than a Republican one, so there won’t be a complete reversal of Trump’s trade policy if a Democrat were to win. But there might be some changes.If a Democrat controlled the White House, the US would still want to pressure China, but it might adopt a more international approach in that effort. The US might also reverse the steel and aluminium tariffs that kicked off these heightened trade tensions.Most importantly, the US might stop hindering the WTO by appointing judges to the appellate body (without which the WTO cannot address rulings that are being appealed) and would likely work with other countries to reform the WTO. The focus would shift from confrontation to negotiation. This, of course, depends on which Democrat is in the White House.In the meantime, President Trump has a difficult balancing act. Being tough on China and bringing home American jobs were successful slogans in his first presidential bid. He will want to indicate he has delivered on both and will continue to do so. At the same time, tariffs have sparked dips in the markets that have caused the president to de-escalate trade tensions. As the 2020 election approaches, expect the administration to balance these two concerns.Looking beyond the vote, there may be some changes to the US approach to trade over the next decade, depending on which party is in government. The most pernicious aspect of the trade tensions on the global economy has been the uncertainty they have caused; businesses have deferred and delayed investment as they wait to see what the new rules of the global order are. They know the old consensus on trade won’t come back, but don’t yet know what the new consensus is.As long as the limbo persists, and it probably will for at least a few more years, trade issues will remain a risk for the global economy.This article is the first in a series of publications and roundtable discussions, part of the Chatham House Global Trade Policy Forum. Full Article
se Secrets and Spies: UK Intelligence Accountability After Iraq and Snowden By feedproxy.google.com Published On :: Wed, 15 Jan 2020 09:23:12 +0000 20 January 2020 How can democratic governments hold intelligence and security agencies to account when what they do is largely secret? Jamie Gaskarth explores how intelligence professionals view accountability in the context of 21st century politics. Jamie Gaskarth Senior Lecturer, University of Birmingham Secrets and Spies (cover image) Using the UK as a case study, this book provides the first systematic exploration of how accountability is understood inside the secret world. It is based on new interviews with current and former UK intelligence practitioners, as well as extensive research into the performance and scrutiny of the UK intelligence machinery.The result is the first detailed analysis of how intelligence professionals view their role, what they feel keeps them honest, and how far external overseers impact on their work.The UK gathers material that helps inform global decisions on such issues as nuclear proliferation, terrorism, transnational crime, and breaches of international humanitarian law. On the flip side, the UK was a major contributor to the intelligence failures leading to the Iraq war in 2003, and its agencies were complicit in the widely discredited U.S. practices of torture and 'rendition' of terrorism suspects. UK agencies have come under greater scrutiny since those actions, but it is clear that problems remain.Secrets and Spies is the result of a British Academy funded project (SG151249) on intelligence accountability.Open society is increasingly defended by secret means. For this reason, oversight has never been more important. This book offers a new exploration of the widening world of accountability for UK intelligence, encompassing informal as well as informal mechanisms. It substantiates its claims well, drawing on an impressive range of interviews with senior figures. This excellent book offers both new information and fresh interpretations. It will have a major impact.Richard Aldrich, Professor of International Security, University of Warwick, UKGaskarth’s novel approach, interpreting interviews with senior figures from the intelligence world, brings fresh insight on a significant yet contested topic. He offers an impressively holistic account of intelligence accountability—both formal and informal—and, most interestingly of all, of how those involved understand it. This is essential reading for those wanting to know what accountability means and how it is enacted.Rory Cormac, Professor of International Relations, University of NottinghamAbout the authorJamie Gaskarth is senior lecturer at the University of Birmingham, where he teaches strategy and decision-making. His research looks at the ethical dilemmas of leadership and accountability in intelligence, foreign policy, and defence. He is author/editor or co-editor of six books and served on the Academic Advisory panel for the 2015 UK National Security Strategy and Strategic Defence and Security Review.Available now: Buying optionsInsights: Critical Thinking on International Affairs Department/project Russia and Eurasia Programme Full Article
se Hiroki Sekine By feedproxy.google.com Published On :: Thu, 23 Jan 2020 13:30:55 +0000 Visiting Fellow, Asia-Pacific Programme Biography Hiroki Sekine is visiting fellow with the Asia-Pacific Programme at Chatham House.He was director of the policy and strategy office for financial operations at JBIC from July 2016 until June 2019 and, most recently, senior advisor to the corporate planning department at the Japan Bank for International Cooperation (JBIC).During this time, Hiroki led an internal taskforce to facilitate a trilateral partnership between the US, Australia and Japan, aiming to enhance infrastructure development under the Free and Open Indo-Pacific Strategy.He has led project finance deals for power and petrochemical projects in Asia, the Middle East and South America. In 2018, Hiroki was appointed as adjunct professor at Kyoto University.Hiroki Sekine is based at Chatham House until June 2021, hosted by the Asia-Pacific programme. During his fellowship, Hiroki is undertaking research on infrastructure development in the Asia-Pacific. Areas of expertise Infrastructure development policy in the Asia-Pacific regionFinance (incl. green finance, project finance, and sovereign finance)Public finance policy (incl. multilateral finance agencies, development finance agencies) Past experience 2019 - presentSenior advisor, Corporate Planning Department, Japan Bank for International Cooperation2016-19 Director, Policy and Strategy Office for Financial Operations, Japan Bank for International Cooperation2015-16 Advisor, Credit Analysis Department, Japan Bank for International Cooperation2013-15Director, Division 2, Corporate Finance Department2011-13Director, Power and Water Finance Department, Japan Bank for International Cooperation2010-11Advisor, Asia and Oceania Finance Department, Japan Bank for International Cooperation2008-10Deputy Director, Division2, Asia and Oceania Finance Department, Japan Bank for International Cooperation2005MSc in Finance, London Business School, University of London1995B.A. in Economics, University of Tokyo +44 (0)20 7314 3626 Email Full Article
se The great Chinese surprise: the rupture with the United States is real and is happening By feedproxy.google.com Published On :: Wed, 04 Mar 2020 13:25:56 +0000 4 March 2020 , Volume 96, Number 2 Xiangfeng Yang Read Online Ample evidence exists that China was caught off guard by the Trump administration's onslaught of punishing acts—the trade war being a prime, but far from the only, example. This article, in addition to contextualizing their earlier optimism about the relations with the United States under President Trump, examines why Chinese leaders and analysts were surprised by the turn of events. It argues that three main factors contributed to the lapse of judgment. First, Chinese officials and analysts grossly misunderstood Donald Trump the individual. By overemphasizing his pragmatism while downplaying his unpredictability, they ended up underprepared for the policies he unleashed. Second, some ingrained Chinese beliefs, manifested in the analogies of the pendulum swing and the ‘bickering couple’, as well as the narrative of the ‘ballast’, lulled officials and scholars into undue optimism about the stability of the broader relationship. Third, analytical and methodological problems as well as political considerations prevented them from fully grasping the strategic shift against China in the US. Full Article
se Coronavirus: Global Response Urgently Needed By feedproxy.google.com Published On :: Sun, 15 Mar 2020 14:33:11 +0000 15 March 2020 Jim O'Neill Chair, Chatham House Robin Niblett Director and Chief Executive, Chatham House @RobinNiblett Creon Butler Research Director, Trade, Investment & New Governance Models: Director, Global Economy and Finance Programme LinkedIn There have been warnings for several years that world leaders would find it hard to manage a new global crisis in today’s more confrontational, protectionist and nativist political environment. 2020-03-15-Korea-Stock-Exchange.jpg A currency dealer wearing a face mask monitors exchange rates in front of a screen showing South Korea's benchmark stock index in Seoul on March 13, 2020. Photo by JUNG YEON-JE/AFP via Getty Images. An infectious disease outbreak has long been a top national security risk in several countries, but the speed and extent of COVID-19’s spread and the scale of its social and economic impact has come as an enormous and deeply worrying shock.This pandemic is not just a global medical and economic emergency. It could also prove a decisive make-or-break point for today’s system of global political and economic cooperation.This system was built up painstakingly after 1945 as a response to the beggar-thy-neighbour economic policies of the 1930s which led to the Second World War. But it has been seriously weakened recently as the US and China have entered a more overt phase of strategic competition, and as they and a number of the other most important global and regional players have pursued their narrowly defined self-interest.Now, the disjointed global economic response to COVID-19, with its enormous ramifications for global prosperity and economic stability, has blown into the open the urgent need for an immediate reaffirmation of international political and economic cooperation.What is needed is a clear, coordinated and public statement from the leaders of the world’s major countries affirming the many things on which they do already agree, and some on which they should be able to agree.In particular that:they will give the strongest possible support for the WHO in leading the medical response internationally;they will be transparent and tell the truth to their peoples about the progress of the disease and the threat that it represents;they will work together and with the international financial institutions to provide businesses, particularly SMEs, and individuals whatever support they need to get through the immediate crisis and avoid long-term damage to the global economy; they will ensure the financial facilities for crisis support to countries - whether at global or regional level - have whatever resources they need to support countries in difficulty;they will avoid new protectionist policies - whether in trade or finance;they commit not to forget the poor and vulnerable in society and those least able to look after themselves.Such a statement could be made by G20 leaders, reflecting the group’s role since 2010 as the premier forum for international economic cooperation.But it could be even more appropriate coming from the UN Security Council, recognising that COVID-19 is much more than an economic challenge; and also reflecting the practical fact, in a time when international travel is restricted, the UNSC has an existing mechanism in New York to negotiate and quickly agree such a statement.A public statement by leading countries could do a great deal to help arrest a growing sense of powerlessness among citizens and loss of confidence among businesses worldwide as the virus spreads.It could also set a new course for international political and economic cooperation, not just in relation to the virus, but also other global threats with potentially devastating consequences for economic growth and political stability in the coming years. Full Article
se Chinese Overseas Direct Investment and the Economic Crisis: Reaching Out By feedproxy.google.com Published On :: Tue, 24 Mar 2020 09:54:24 +0000 1 January 2009 , Number 5 Decisions taken today will determine the course of events for a generation. Nowhere is this truer than over the question of China’s investment abroad. This issue lies at the heart of what part the country will play in the global finance and trade system, and how it will work with the rest of the world in laying the foundations for longer term growth and stability after the current crisis is over. Professor Kerry Brown Associate Fellow, Asia-Pacific Programme @Bkerrychina LinkedIn Google Scholar Peter Wood Independent China strategist based in Hong Kong HaierFlickr.jpg Chinese companies establish a presence abroad. Full Article
se Webinar: European Democracy in the Last 100 Years: Economic Crises and Political Upheaval By feedproxy.google.com Published On :: Thu, 23 Apr 2020 10:25:01 +0000 Members Event Webinar 6 May 2020 - 1:00pm to 2:00pm Event participants Pepijn Bergsen, Research Fellow, Europe Programme, Chatham HouseDr Sheri Berman, Professor of Political Science, Barnard CollegeChair: Hans Kundnani, Senior Research Fellow, Europe Programme, Chatham House In the last 100 years, global economic crises from the Great Depression of the 1930s to the 2008 financial crash have contributed to significant political changes in Europe, often leading to a rise in popularity for extremist parties and politics. As Europe contends with a perceived crisis of democracy - now compounded by the varied responses to the coronavirus outbreak - how should we understand the relationship between externally-driven economic crises, political upheaval and democracy?The panellists will consider the parallels between the political responses to some of the greatest economic crises Europe has experienced in the last century. Given that economic crises often transcend borders, why does political disruption vary between democracies? What can history tell us about the potential political impact of the unfolding COVID-19-related economic crisis? And will the unprecedented financial interventions by governments across Europe fundamentally change the expectations citizens have of the role government should play in their lives?This event is based on a recent article in The World Today by Hans Kundnani and Pepijn Bergsen who are both researchers in Chatham House's Europe Programme. 'Crawling from the Wreckage' is the first in a series of articles that look at key themes in European political discourse from the last century. You can read the article here. This event is open to Chatham House Members. Not a member? Find out more. Full Article
se Catalytic residues, substrate specificity, and role in carbon starvation of the 2-hydroxy FA dioxygenase Mpo1 in yeast By feedproxy.google.com Published On :: 2020-04-29 Keisuke MoriApr 29, 2020; 0:jlr.RA120000803v1-jlr.RA120000803Research Articles Full Article
se Development of a sensitive and quantitative method for the identification of two major furan fatty acids in human plasma By feedproxy.google.com Published On :: 2020-04-01 Long XuApr 1, 2020; 61:560-569Methods Full Article
se A Direct Fluorometric Activity Assay for Lipid Kinases and Phosphatases By feedproxy.google.com Published On :: 2020-04-27 Jiachen SunApr 27, 2020; 0:jlr.D120000794v1-jlr.D120000794Methods Full Article
se Lithium ion adduction enables UPLC-MS/MS-based analysis of multi-class 3-hydroxyl group-containing keto-steroids By feedproxy.google.com Published On :: 2020-04-01 Qiuyi WangApr 1, 2020; 61:570-579Methods Full Article
se Heritability of 596 lipid species and genetic correlation with cardiovascular traits in the Busselton Family Heart Study By feedproxy.google.com Published On :: 2020-04-01 Gemma CadbyApr 1, 2020; 61:537-545Patient-Oriented and Epidemiological Research Full Article
se Phosphatidylinositol Metabolism, Phospholipases, Lipidomics, and Cancer:In Memoriam of Michael J. O. Wakelam (1955-2020) By feedproxy.google.com Published On :: 2020-04-28 Edward A DennisApr 28, 2020; 0:jlr.T120000868v1-jlr.T120000868Tribute Full Article
se Dynamics of sphingolipids and the serine palmitoyltransferase complex in rat oligodendrocytes during myelination By feedproxy.google.com Published On :: 2020-04-01 Deanna L. DavisApr 1, 2020; 61:505-522Research Articles Full Article
se Hexacosenoyl-CoA is the most abundant very long-chain acyl-CoA in ATP binding cassette transporter D1-deficient cells By feedproxy.google.com Published On :: 2020-04-01 Kotaro HamaApr 1, 2020; 61:523-536Patient-Oriented and Epidemiological Research Full Article
se ANGPTL4 inactivates lipoprotein lipase by catalyzing the irreversible unfolding of LPLs hydrolase domain By feedproxy.google.com Published On :: 2020-04-23 Kristian K KristensenApr 23, 2020; 0:jlr.ILR120000780v1-jlr.ILR120000780Images in Lipid Research Full Article
se Circulating oxidized LDL increased in patients with acute myocardial infarction is accompanied by heavily modified HDL. By feedproxy.google.com Published On :: 2020-04-14 Naoko SawadaApr 14, 2020; 0:jlr.RA119000312v1-jlr.RA119000312Research Articles Full Article
se The grease trap: uncovering the mechanism of the hydrophobic lid in Cutibacterium acnes lipase By feedproxy.google.com Published On :: 2020-05-01 Hyo Jung KimMay 1, 2020; 61:722-733Research Articles Full Article
se Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice By feedproxy.google.com Published On :: 2020-05-01 Yipeng SuiMay 1, 2020; 61:696-706Research Articles Full Article
se An LC/MS/MS method for analyzing the steroid metabolome with high accuracy and from small serum samples By feedproxy.google.com Published On :: 2020-04-01 Teng-Fei YuanApr 1, 2020; 61:580-586Methods Full Article
se A novel NanoBiT-based assay monitors the interaction between lipoprotein lipase and GPIHBP1 in real time By feedproxy.google.com Published On :: 2020-04-01 Shwetha K. ShettyApr 1, 2020; 61:546-559Methods Full Article
se Roles of endogenous ether lipids and associated PUFA in the regulation of ion channels and their relevance for disease By feedproxy.google.com Published On :: 2020-04-07 Delphine FontaineApr 7, 2020; 0:jlr.RA120000634v1-jlr.RA120000634Research Articles Full Article
se Serum non-esterified fatty acids have utility as dietary biomarkers of fat intake from fish, fish oil and dairy in women By feedproxy.google.com Published On :: 2020-03-31 Sandi M. AzabMar 31, 2020; 0:jlr.D120000630v1-jlr.D120000630Methods Full Article
se LDL subclass lipidomics in atherogenic dyslipidemia:Effect of statin therapy on bioactive lipids and dense LDL By feedproxy.google.com Published On :: 2020-04-15 M John ChapmanApr 15, 2020; 0:jlr.P119000543v1-jlr.P119000543Patient-Oriented and Epidemiological Research Full Article
se Dietary plant stanol ester supplementation reduces peripheral symptoms in a mouse model of Niemann-Pick type C1 disease. By feedproxy.google.com Published On :: 2020-04-14 Inês Magro dos ReisApr 14, 2020; 0:jlr.RA120000632v1-jlr.RA120000632Research Articles Full Article
se Metabolic phospholipid labeling of intact bacteria enables a fluorescence assay that detects compromised outer membranes By feedproxy.google.com Published On :: 2020-03-10 Inga NilssonMar 10, 2020; 0:jlr.RA120000654v1-jlr.RA120000654Research Articles Full Article
se Skin barrier lipid enzyme activity in Netherton patients is associated with protease activity and ceramide abnormalities By feedproxy.google.com Published On :: 2020-04-07 Jeroen van SmedenApr 7, 2020; 0:jlr.RA120000639v1-jlr.RA120000639Research Articles Full Article
se Characterization of the small molecule ARC39, a direct and specific inhibitor of acid sphingomyelinase in vitro By feedproxy.google.com Published On :: 2020-03-10 Eyad NaserMar 10, 2020; 0:jlr.RA120000682v1-jlr.RA120000682Research Articles Full Article
se Dispersed lipid droplets: an intermediate site for lipid transport and metabolism in primary human adipocytes. By feedproxy.google.com Published On :: 2020-04-15 Björn MorénApr 15, 2020; 0:jlr.ILR120000808v1-jlr.ILR120000808Images in Lipid Research Full Article
se GPIHBP1, a partner protein for lipoprotein lipase, is expressed only in capillary endothelial cells By feedproxy.google.com Published On :: 2020-05-01 Xia MengMay 1, 2020; 61:591-591Images in Lipid Research Full Article
se Images in Lipid Research By feedproxy.google.com Published On :: 2020-05-01 Stephen G. YoungMay 1, 2020; 61:589-590Editorials Full Article
se Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2016-12-30T00:06:37-08:00 Zinc is a critical element for insulin storage in the secretory granules of pancreatic beta cells. The islet-specific zinc transporter ZnT8 mediates granular sequestration of zinc ions. A genetic variant of human ZnT8 arising from a single nonsynonymous nucleotide change contributes to increased susceptibility to type-2 diabetes (T2D), but it remains unclear how the high risk variant (Arg-325), which is also a higher frequency (>50%) allele, is correlated with zinc transport activity. Here, we compared the activity of Arg-325 with that of a low risk ZnT8 variant (Trp-325). The Arg-325 variant was found to be more active than the Trp-325 form following induced expression in HEK293 cells. We further examined the functional consequences of changing lipid conditions to mimic the impact of lipid remodeling on ZnT8 activity during insulin granule biogenesis. Purified ZnT8 variants in proteoliposomes exhibited more than 4-fold functional tunability by the anionic phospholipids, lysophosphatidylcholine and cholesterol. Over a broad range of permissive lipid compositions, the Arg-325 variant consistently exhibited accelerated zinc transport kinetics versus the Trp-form. In agreement with the human genetic finding that rare loss-of-function mutations in ZnT8 are associated with reduced T2D risk, our results suggested that the common high risk Arg-325 variant is hyperactive, and thus may be targeted for inhibition to reduce T2D risk in the general populations. Full Article
se UK Tech Weekly Podcast - Episode Three: The Internet of Sex Robots - Facebook likes, AI and Trump By play.acast.com Published On :: Fri, 26 Feb 2016 17:02:04 GMT In this week's UK Tech Weekly Podcast host Matt Egan is joined by PC Advisor staff writer Chris Minasians chats about Facebook's new like buttons, the team has contracted smartphone fever from the Mobile World Conference in Barcelona and finally, acting editor of Macworld UK David Price, discusses Donald Trump boycotting Apple. See acast.com/privacy for privacy and opt-out information. Full Article