me Pomegranate Coconut Fish By www.abc.net.au Published On :: Tue, 05 Apr 2016 14:38:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Damo and Zoe Gaeau. Their new book is "That Sugar Guide". Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
me Flourless Chocolate Cake (almond meal) By www.abc.net.au Published On :: Tue, 03 May 2016 15:44:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Tad Lombardo Director & Head Chocolatier at Cioccolato Lombardo. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Cakes Lifestyle and Leisure:Recipes:Dessert Australia:VIC:Melbourne 3000
me Caramel slice By www.abc.net.au Published On :: Thu, 05 May 2016 10:37:00 +0800 Base 1 cup (150g) plain flour 1 cup (150g) plain flour 1/2 cup (40g) desiccated coconut 1/2 cup (90g) brown sugar 125g unsalted butter, melted Filling 1/3 cup (115g) golden syrup 125g unsalted butter 2 x 395g sweetened condensed milk Pinch salt Topping 200g dark chocolate 1 tbs vegetable oil Full Article ABC Local wheatbelt Lifestyle and Leisure:Recipes:Biscuits and Slices Australia:WA:Geraldton 6530
me Buckwheat polenta with roasted vegetables, blue cheese, pine nuts and thyme By www.abc.net.au Published On :: Mon, 09 May 2016 13:18:00 +0800 As the cold weather sets in, this nourishing winter dish is perfect to warm hands, feet and heart. The addition of buckwheat flour to polenta gives it a delicious smoky earth flavour and adds to the nutrition level of this dish. Rich in fibre and silica, gluten free buckwheat contain rutin, a bioflavonoid that is know to increase blood circulation and reduce high blood pressure. Perfect for winter! Full Article ABC Local southwestwa Lifestyle and Leisure:Recipes:Main Lifestyle and Leisure:Recipes:Mostly Vegetarian Health:Diet and Nutrition:Healthy recipes Australia:WA:Pemberton 6260
me Mocha-Cappuccino Caramel Biscuit Cheesecake By www.abc.net.au Published On :: Mon, 23 May 2016 11:39:00 +1000 This indulgent cheesecake is as light as air, with all the ingredients of an afternoon tea rolled into one - coffee, chocolate and caramel biscuits. Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Dessert Australia:QLD:Bundaberg 4670
me Betel leaf with seared scallops, lime and sticky tamarind sauce By www.abc.net.au Published On :: Fri, 03 Jun 2016 12:26:00 +1000 Seafood in a different way by the Golden Pig. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:All Australia:QLD:Brisbane 4000
me Zucchini and Parmesan Savoury Pancakes By www.abc.net.au Published On :: Mon, 06 Jun 2016 10:11:00 +1000 A vegetarian dish with a tasty side salad Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
me Sesame, honey, ginger and soy grilled salmon with lime By www.abc.net.au Published On :: Tue, 07 Jun 2016 10:50:00 +0800 Atlantic Salmon is Australia's most popular farmed fish and is a healthy weekly staple for many people. This recipe offers a marinade more commonly thought of for chicken however is simply delicious with salmon. Enjoy with a fresh local limes, which are in season from early April to mid September. Full Article ABC Local southwestwa Lifestyle and Leisure:Recipes:Main Science and Technology:Animals:Fish Health:Diet and Nutrition:Healthy recipes Australia:WA:Pemberton 6260
me Greek sesame crusted feta wih honey By www.abc.net.au Published On :: Fri, 17 Jun 2016 11:20:00 +1000 250g Greek feta cheese 2 eggs 1 tsp. of smoked paprika 1 tsp. of freshly ground pepper 1/2 cup plain flour, enough to coat the feta 60g sesame seeds Sunflower oil for frying 4 tbsps. of local honey Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
me Mushroom and pearl barley soup with parmesan By www.abc.net.au Published On :: Tue, 21 Jun 2016 10:27:00 +0800 Cold damp weather prompts all manner of mushrooms and fungi to emerge from the forest floor. Having neighbours willing to share their regular harvest of field mushrooms is one of the many great privileges of living in the Southern Forests. However, this hearty winter soup can be equally delicious when made with cultivated mushrooms easily purchased from supermarkets and independent grocers. Full Article ABC Local southwestwa Lifestyle and Leisure:Recipes:Soups Australia:WA:Pemberton 6260
me Local Pecan & Carrot Cake with cheats Caramelised Fig Vanilla Ice Cream By www.abc.net.au Published On :: Thu, 30 Jun 2016 11:46:00 +1000 I love a carrot cake . Usually walnuts are used however who doesn't want to take advantage of the local new season pecans at our local markets . Happy baking! Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
me Swedish meatballs By www.abc.net.au Published On :: Fri, 22 Jul 2016 10:47:00 +1000 400g pork/beef mince 1 egg 1 onion, grated 1/4 cups fresh breadcrumbs 1/2 tsp. allspice 1/4 tsp. ground cloves Pinch of nutmeg 1 tbsp. olive oil 20g butter 150ml beef stock 2 tbsp. brown sugar Lingonberry sauce, sour cream, dill and parsley potatoes, baby cos leaves and cucumber wedges to serve Full Article ABC Local widebay Lifestyle and Leisure:All:All Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
me Wholemeal buttermilk soda bread By www.abc.net.au Published On :: Fri, 02 Sep 2016 12:04:00 +1000 170g/6oz self-raising wholemeal flour 170g/6oz plain flour 1/2 tsp salt 1/2 tsp bicarbonate of soda 290ml/1/2 pint buttermilk Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
me Eucalyptus smoked Marburg emu fillet, beets, macadamia plus Lilly Pilly and finger lime spritzer By www.abc.net.au Published On :: Mon, 19 Sep 2016 10:34:00 +1000 Delicious Australian dish with fresh Lilly Pilly and finger lime spritzer. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
me Calamari and fermented celeriac, barbecued peas and beef fat By www.abc.net.au Published On :: Tue, 20 Sep 2016 12:17:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Dan Hunter, chef and owner of Otways' restaurant Brae. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
me Medallions of Beef, with pan juice sauce, wilted cherry tomatoes, wine and basil By www.abc.net.au Published On :: Thu, 06 Oct 2016 10:07:00 +1100 Medallions of Beef, with pan juice sauce, wilted cherry tomatoes, any old wine and basil. Really nice with a potato salad, with fresh spring peas and crispy bacon pieces. Something I do very often is knock up quick tasty dinner utilising your favourite heavy-based frying pan. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
me Creme Chantilly By www.abc.net.au Published On :: Thu, 27 Oct 2016 15:31:00 +1100 Sweetened whipped cream with vanilla Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690
me Creme Patisserie (Pastry cream) By www.abc.net.au Published On :: Thu, 27 Oct 2016 15:38:00 +1100 100g Flour 250g Sugar 8 Egg yolks 1lt Milk Vanilla or other preferred flavouring Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690
me Corn Fritters with Fresh Turmeric Yoghurt By www.abc.net.au Published On :: Thu, 10 Nov 2016 10:59:00 +1000 Quick easy fresh summer dish. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
me Bbq salmon, prawns, Jamon, radish, cucumber and melon salad By www.abc.net.au Published On :: Mon, 14 Nov 2016 10:12:00 +1000 Fresh, summer BBQ staple. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
me Lemon Meringue Pie By www.abc.net.au Published On :: Wed, 23 Nov 2016 14:54:00 +1100 For the pastry casing: 200g plain flour 100g butter 50g sugar zest of half a lemon 1g vanilla seed 1/2 egg (beat egg, then halve it - should be about 25g) For the curd: 450ml water 180g sugar 75g cornflour 3ea lemons 45g butter 4 eggs For the Italian meringue: 4 x egg whites 270g caster sugar 1 x drop lemon juice 100ml water Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:All:All Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690
me Szechuan Tuna, pear and eschallot salsa, mango gel, parmesan crisp, rocket oil By www.abc.net.au Published On :: Tue, 13 Dec 2016 11:39:00 +1000 Delicious summer tuna dish. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
me Loukanika Homemade Sausages with leek and fennel By www.abc.net.au Published On :: Tue, 10 Jan 2017 12:25:00 +1100 Kathy Tsaples, author of Sweet Greek Life, shared this recipe on Foodie Tuesday, a weekly segment on ABC Radio Melbourne's Drive program at 3.30pm. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
me Loukanika Homemade Sausages with orange By www.abc.net.au Published On :: Tue, 10 Jan 2017 12:28:00 +1100 Kathy Tsaple, author of Sweet Greek Life, shared this recipe on Foodie Tuesday, a weekly segment on ABC Radio Melbourne's Drive program at 3.30pm. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
me Turmeric King Prawn Curry By www.abc.net.au Published On :: Thu, 23 Feb 2017 13:09:00 +1100 Turmeric is a wonderful spice, it's loud in colour (and stains big-time) but it's mild in flavour; exquisite complex and peppery. Make sure you use fresh turmeric - powdered turmeric is the equivalent of canned asparagus! Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
me Parmesan and Herby Crumbed Pork Loin with raw cabbage salad and lemon By www.abc.net.au Published On :: Thu, 02 Mar 2017 07:55:00 +1100 4 x 150 x g of pork loin steaks as your butcher to cut 3 x cup (210 g) Panko Breadcrumbs (Japanese bread crumb) 1/2 cup (80g) Plain flour Chopped flat leaf parsley, thyme, rosemary 2 Eggs, lightly beaten 1/2cup (80g) finely grated Parmesan CABBAGE SLAW 500 grams of Cabbage finely shredded Squeezed of Lemon juice 1/4 cup (60 ml) quality cider vinegar add to taste. May need less. 2 Tablespoon of Macadamia Oil 1 Tablespoon chop parsley Aioli just a little bit to bind Sea salt and cracked pepper 100 ml Macadamia oil for cooking 4 juicy lemon wedges to squeeze over Pork Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
me Autumn roasted vegetables with lemon thyme and a drizzle of macadamia honey By www.abc.net.au Published On :: Thu, 16 Mar 2017 13:45:00 +1100 Nothing beats beautifully roasted vegetables caramelized in their own sugar content to accompany a simple roast dinner or even on their own with a nice salad. The addition of perfumed lemon thyme and macadamia gives a nice touch. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
me Roast local pork belly with caramelised pear sauce By www.abc.net.au Published On :: Thu, 27 Apr 2017 06:20:00 +1000 Plenty of pears around at the moment. This sauce is a nice alternative to the traditional apple sauce with pork. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
me French salted caramel ganache tart By www.abc.net.au Published On :: Thu, 04 May 2017 13:39:00 +1000 An indulgent French chocolate and salted caramel tart. Decorate with fresh raspberries and pistachio nuts for great colour and a sweet zing. Full Article ABC Local widebay Lifestyle and Leisure:Food and Cooking:All Australia:QLD:Bundaberg 4670
me Japanese sweet ginger meatballs By www.abc.net.au Published On :: Thu, 15 Jun 2017 13:41:00 +1000 1 bunch of spring onions, finely chopped 250 g minced beef 250 g minced pork 20 g grated ginger 1 egg 2 tsps. roasted sesame oil 1 tbsp. cornflour, plus extra for dusting sunflower oil, for shallow frying 1 tbsp. white sesame seeds salt and ground white pepper For the sweet ginger sauce: 30 g grated ginger 3 tbsps. soy sauce 125 ml dashi stock or 1 tsp instant dashi powder mixed with water 2 tbsps. sugar 3 tbsps. mirin 3 tbsps. rice vinegar 1 tsp cornflour Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
me Mahatma Breakfast - Ayurvedic turmeric, rolled rice porridge By www.abc.net.au Published On :: Thu, 22 Jun 2017 13:51:00 +1000 This deliciously warming Ayurvedic gluten-free breakfast idea came from my good friend Brenda when she owned Mondo Organics in Brisbane. I've tweaked it a little to suit what was in my pantry today. The perfect brekky after Sunday morning yoga and a great way to start your surfing day. Rolled rice is available at most good food stores and organic outlets. Best to use fresh turmeric for its antioxidant properties and up to you whether you want yoghurt too. I prefer mine with a squeeze of lime. Om Shanti. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
me Spring cleansing beetroot and pomegranate salad By www.abc.net.au Published On :: Wed, 11 Oct 2017 13:10:00 +1100 Beets have strong detoxifying properties, as they are high in chlorine, which assists in the cleansing of the liver, kidneys and bloodstream. They are also rich in potassium, which balances the metabolism. The mighty beets nourish the blood, tonify the heart, calm the spirit and nervousness, and they lubricate the intestines and cleanse the liver! Oh my giddy Aunt! Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
me As More Migrants from Africa and Asia Arrive in Latin America, Governments Seek Orderly and Controlled Pathways By www.migrationpolicy.org Published On :: Mon, 21 Oct 2019 12:48:50 -0400 Growing numbers of African and Asian migrants are moving through Latin America, many hoping to reach the United States or Canada after expensive, arduous, and often dangerous journeys that can take months or even years. As more extracontinental migrants transit through South and Central America, Colombia, Panama, and Costa Rica have developed the most comprehensive policies to manage these flows, sometimes working in coordination with the U.S. government. Full Article
me Latin American Responses to the Venezuelan and Nicaraguan Migration Crises By www.migrationpolicy.org Published On :: Mon, 21 Oct 2019 12:56:39 -0400 Leading policymakers and key stakeholders from Latin America, as well as representatives of major international institutions, offer their views on the challenges ahead as Latin American governments seek to chart strategies for responding to large-scale forced migration flows, such as those from Venezuela and Nicaragua. Full Article
me Respuestas latinoamericanas a las crisis migratorias venezolanas y nicaragüenses By www.migrationpolicy.org Published On :: Fri, 01 Nov 2019 17:38:50 -0400 Responsables de políticos principales y partes interesadas de América Latina, así como representantes de instituciones internacionales claves, ofrecen sus puntos de vista sobre los desafíos futuros mientras gobiernos latinoamericanos buscan establecer las estrategias para responder a flujos migratorios forzados a gran escala, como los de Venezuela y Nicaragua. Full Article
me Refugee Sponsorship Programs: A Global State of Play and Opportunities for Investment By www.migrationpolicy.org Published On :: Wed, 11 Dec 2019 12:01:25 -0500 From Argentina to New Zealand and points beyond, a growing number of countries have begun exploring refugee sponsorship as a way to expand protection capacity at a time of rising need, involving individuals and communities more directly in resettlement. This brief takes stock of what both new and well-established programs need to succeed, and outlines opportunities for private philanthropic actors to support them. Full Article
me Welcome Wears Thin for Colombians in Ecuador as Venezuelans Become More Visible By www.migrationpolicy.org Published On :: Wed, 08 Jan 2020 19:31:49 -0500 Though Colombians displaced by a decades-long civil war found a welcome refuge in Ecuador, life has become more difficult for them in recent years, in part as a result of the influx of Venezuelans seeking safety. This article draws on surveys of migrants in Quito, comparing and contrasting the experiences of Colombians and Venezuelans, and assessing their perceptions of discrimination, victimization, trust in institutions, and hopes for the future. Full Article
me Is the Door Closing? Latin American and Caribbean Responses to Venezuelan Migration By www.migrationpolicy.org Published On :: Fri, 31 Jan 2020 16:30:49 -0500 This webinar marks the release of MPI's Latin American and Caribbean Migration Portal that offers up-to-date, authoritative research and data on migration trends and policies, and a report examining the policy responses of 11 countries in Latin America and the Caribbean to increased Venezuelan and Nicaraguan migration. Full Article
me An Uneven Welcome: Latin American and Caribbean Responses to Venezuelan and Nicaraguan Migration By www.migrationpolicy.org Published On :: Mon, 03 Feb 2020 17:19:48 -0500 Large-scale displacement from Venezuela and Nicaragua is reshaping the migration landscape in much of Latin America and the Caribbean. This report, accompanied by the launch of a new Migration Portal offering research and analysis on the region, examines the immigration and integration policy responses of 11 countries, including pathways to legal status and measures to integrate newcomers into schools, health-care systems, and labor markets. Full Article
me COVID-19 in Latin America: Tackling Health Care & Other Impacts for Vulnerable Migrant Populations By www.migrationpolicy.org Published On :: Fri, 27 Mar 2020 10:58:29 -0400 This MPI webinar brought together public health and migration experts to analyze the impact that COVID-19 preventative measures will have on vulnerable immigrants and refugees in Latin America, with a particular look at Colombia as a case study. Speakers also discussed how policymakers and international organizations can include migrant populations in their emergency response plans. Full Article
me Microvascular and Cardiovascular Outcomes According to Renal Function in Patients Treated With Once-Weekly Exenatide: Insights From the EXSCEL Trial By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE To evaluate the impact of once-weekly exenatide (EQW) on microvascular and cardiovascular (CV) outcomes by baseline renal function in the Exenatide Study of Cardiovascular Event Lowering (EXSCEL). RESEARCH DESIGN AND METHODS Least squares mean difference (LSMD) in estimated glomerular filtration rate (eGFR) from baseline between the EQW and placebo groups was calculated for 13,844 participants. Cox regression models were used to estimate effects by group on incident macroalbuminuria, retinopathy, and major adverse CV events (MACE). Interval-censored time-to-event models estimated effects on renal composite 1 (40% eGFR decline, renal replacement, or renal death) and renal composite 2 (composite 1 variables plus macroalbuminuria). RESULTS EQW did not change eGFR significantly (LSMD 0.21 mL/min/1.73 m2 [95% CI –0.27 to 0.70]). Macroalbuminuria occurred in 2.2% of patients in the EQW group and in 2.5% of those in the placebo group (hazard ratio [HR] 0.87 [95% CI 0.70–1.07]). Neither renal composite was reduced with EQW in unadjusted analyses, but renal composite 2 was reduced after adjustment (HR 0.85 [95% CI 0.74–0.98]). Retinopathy rates did not differ by treatment group or in the HbA1c-lowering or prior retinopathy subgroups. CV outcomes in those with eGFR <60 mL/min/1.73 m2 did not differ by group. Those with eGFR ≥60 mL/min/1.73 m2 had nominal risk reductions for MACE, all-cause mortality, and CV death, but interactions by renal function group were significant for only stroke (HR 0.74 [95% CI 0.58–0.93]; P for interaction = 0.035) and CV death (HR 1.08 [95% CI 0.85–1.38]; P for interaction = 0.031). CONCLUSIONS EQW had no impact on unadjusted retinopathy or renal outcomes. CV risk was modestly reduced only in those with eGFR ≥60 mL/min/1.73 m2 in analyses unadjusted for multiplicity. Full Article
me Reduction in Global Myocardial Glucose Metabolism in Subjects With 1-Hour Postload Hyperglycemia and Impaired Glucose Tolerance By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Impaired insulin-stimulated myocardial glucose uptake has occurred in patients with type 2 diabetes with or without coronary artery disease. Whether cardiac insulin resistance is present remains uncertain in subjects at risk for type 2 diabetes, such as individuals with impaired glucose tolerance (IGT) or those with normal glucose tolerance (NGT) and 1-h postload glucose ≥155 mg/dL during an oral glucose tolerance test (NGT 1-h high). This issue was examined in this study. RESEARCH DESIGN AND METHODS The myocardial metabolic rate of glucose (MRGlu) was measured by using dynamic 18F-fluorodeoxyglucose positron emission tomography combined with a euglycemic-hyperinsulinemic clamp in 30 volunteers without coronary artery disease. Three groups were studied: 1) those with 1-h postload glucose <155 mg/dL (NGT 1-h low) (n = 10), 2) those with NGT 1-h high (n = 10), 3) and those with IGT (n = 10). RESULTS After adjusting for age, sex, and BMI, both subjects with NGT 1-h high (23.7 ± 6.4 mmol/min/100 mg; P = 0.024) and those with IGT (16.4 ± 6.0 mmol/min/100 mg; P < 0.0001) exhibited a significant reduction in global myocardial MRGlu; this value was 32.8 ± 9.7 mmol/min/100 mg in subjects with NGT 1-h low. Univariate correlations showed that MRGlu was positively correlated with insulin-stimulated whole-body glucose disposal (r = 0.441; P = 0.019) and negatively correlated with 1-h (r = –0.422; P = 0.025) and 2-h (r = –0.374; P = 0.05) postload glucose levels, but not with fasting glucose. CONCLUSIONS This study shows that myocardial insulin resistance is an early defect that is already detectable in individuals with dysglycemic conditions associated with an increased risk of type 2 diabetes, such as IGT and NGT 1-h high. Full Article
me Plasma N-Glycans as Emerging Biomarkers of Cardiometabolic Risk: A Prospective Investigation in the EPIC-Potsdam Cohort Study By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Plasma protein N-glycan profiling integrates information on enzymatic protein glycosylation, which is a highly controlled ubiquitous posttranslational modification. Here we investigate the ability of the plasma N-glycome to predict incidence of type 2 diabetes and cardiovascular diseases (CVDs; i.e., myocardial infarction and stroke). RESEARCH DESIGN AND METHODS Based on the prospective European Prospective Investigation of Cancer (EPIC)-Potsdam cohort (n = 27,548), we constructed case-cohorts including a random subsample of 2,500 participants and all physician-verified incident cases of type 2 diabetes (n = 820; median follow-up time 6.5 years) and CVD (n = 508; median follow-up time 8.2 years). Information on the relative abundance of 39 N-glycan groups in baseline plasma samples was generated by chromatographic profiling. We selected predictive N-glycans for type 2 diabetes and CVD separately, based on cross-validated machine learning, nonlinear model building, and construction of weighted prediction scores. This workflow for CVD was applied separately in men and women. RESULTS The N-glycan–based type 2 diabetes score was strongly predictive for diabetes risk in an internal validation cohort (weighted C-index 0.83, 95% CI 0.78–0.88), and this finding was externally validated in the Finland Cardiovascular Risk Study (FINRISK) cohort. N-glycans were moderately predictive for CVD incidence (weighted C-indices 0.66, 95% CI 0.60–0.72, for men; 0.64, 95% CI 0.55–0.73, for women). Information on the selected N-glycans improved the accuracy of established and clinically applied risk prediction scores for type 2 diabetes and CVD. CONCLUSIONS Selected N-glycans improve type 2 diabetes and CVD prediction beyond established risk markers. Plasma protein N-glycan profiling may thus be useful for risk stratification in the context of precisely targeted primary prevention of cardiometabolic diseases. Full Article
me Impact of Glucose Level on Micro- and Macrovascular Disease in the General Population: A Mendelian Randomization Study By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To evaluate whether high glucose levels in the normoglycemic range and higher have a causal genetic effect on risk of retinopathy, neuropathy, nephropathy, chronic kidney disease (CKD), peripheral arterial disease (PAD), and myocardial infarction (MI; positive control) in the general population. RESEARCH DESIGN AND METHODS This study applied observational and one-sample Mendelian randomization (MR) analyses to individual-level data from 117,193 Danish individuals, and validation by two-sample MR analyses on summary-level data from 133,010 individuals from the Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC), 117,165 from the CKDGen Consortium, and 452,264 from the UK Biobank. RESULTS Observationally, glucose levels in the normoglycemic range and higher were associated with high risks of retinopathy, neuropathy, diabetic nephropathy, PAD, and MI (all P for trend <0.001). In genetic causal analyses, the risk ratio for a 1 mmol/L higher glucose level was 2.01 (95% CI 1.18–3.41) for retinopathy, 2.15 (1.38–3.35) for neuropathy, 1.58 (1.04–2.40) for diabetic nephropathy, 0.97 (0.84–1.12) for estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2, 1.19 (0.90–1.58) for PAD, and 1.49 (1.02–2.17) for MI. Summary-level data from the MAGIC, the CKDGen Consortium, and the UK Biobank gave a genetic risk ratio of 4.55 (95% CI 2.26–9.15) for retinopathy, 1.48 (0.83–2.66) for peripheral neuropathy, 0.98 (0.94–1.01) for eGFR <60 mL/min/1.73 m2, and 1.23 (0.57–2.67) for PAD per 1 mmol/L higher glucose level. CONCLUSIONS Glucose levels in the normoglycemic range and higher were prospectively associated with a high risk of retinopathy, neuropathy, diabetic nephropathy, eGFR <60 mL/min/1.73 m2, PAD, and MI. These associations were confirmed in genetic causal analyses for retinopathy, neuropathy, diabetic nephropathy, and MI, but they could not be confirmed for PAD and seemed to be refuted for eGFR <60 mL/min/1.73 m2. Full Article
me Predicting 10-Year Risk of End-Organ Complications of Type 2 Diabetes With and Without Metabolic Surgery: A Machine Learning Approach By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE To construct and internally validate prediction models to estimate the risk of long-term end-organ complications and mortality in patients with type 2 diabetes and obesity that can be used to inform treatment decisions for patients and practitioners who are considering metabolic surgery. RESEARCH DESIGN AND METHODS A total of 2,287 patients with type 2 diabetes who underwent metabolic surgery between 1998 and 2017 in the Cleveland Clinic Health System were propensity-matched 1:5 to 11,435 nonsurgical patients with BMI ≥30 kg/m2 and type 2 diabetes who received usual care with follow-up through December 2018. Multivariable time-to-event regression and random forest machine learning models were built and internally validated using fivefold cross-validation to predict the 10-year risk for four outcomes of interest. The prediction models were programmed to construct user-friendly web-based and smartphone applications of Individualized Diabetes Complications (IDC) Risk Scores for clinical use. RESULTS The prediction tools demonstrated the following discrimination ability based on the area under the receiver operating characteristic curve (1 = perfect discrimination and 0.5 = chance) at 10 years in the surgical and nonsurgical groups, respectively: all-cause mortality (0.79 and 0.81), coronary artery events (0.66 and 0.67), heart failure (0.73 and 0.75), and nephropathy (0.73 and 0.76). When a patient’s data are entered into the IDC application, it estimates the individualized 10-year morbidity and mortality risks with and without undergoing metabolic surgery. CONCLUSIONS The IDC Risk Scores can provide personalized evidence-based risk information for patients with type 2 diabetes and obesity about future cardiovascular outcomes and mortality with and without metabolic surgery based on their current status of obesity, diabetes, and related cardiometabolic conditions. Full Article
me Effectively Serving Immigrant and Dual Language Learner Families through Home Visiting Programs By www.migrationpolicy.org Published On :: Thu, 29 Aug 2019 12:01:27 -0400 Marking a policy brief's release, this webinar explores the promise of home visiting services that support new parents alongside their infants and toddlers, plus strategies for improving how these programs work with immigrant and linguistically diverse families. Full Article
me Latin American Responses to the Venezuelan and Nicaraguan Migration Crises By www.migrationpolicy.org Published On :: Thu, 31 Oct 2019 12:12:21 -0400 Leading policymakers and key stakeholders from Latin America, as well as representatives of major international institutions, offer their views on the challenges ahead as Latin American governments seek to chart strategies for responding to large-scale forced migration flows, such as those from Venezuela and Nicaragua. Spanish and English versions of the remarks are available. Full Article
me Respuestas latinoamericanas a las crisis migratorias venezolanas y nicaragüenses By www.migrationpolicy.org Published On :: Mon, 04 Nov 2019 08:58:25 -0500 Responsables de políticos principales y partes interesadas de América Latina, así como representantes de instituciones internacionales claves, ofrecen sus puntos de vista sobre los desafíos futuros mientras gobiernos latinoamericanos buscan establecer las estrategias para responder a flujos migratorios forzados a gran escala, como los de Venezuela y Nicaragua. Full Article
me Employment Services for Refugees: Leveraging Mainstream U.S. Systems and Funding By www.migrationpolicy.org Published On :: Mon, 27 Jan 2020 16:53:00 -0500 On this webinar, experts and state refugee resettlement program leaders discuss activities that can be key parts of a broader strategy for sustaining and improving employment services for refugees, including partnerships with experts in workforce development strategies, access to federal workforce development funding, and other policies and resources. Full Article
me Is the Door Closing? Latin American and Caribbean Responses to Venezuelan Migration By www.migrationpolicy.org Published On :: Thu, 13 Feb 2020 11:40:37 -0500 Fleeing crisis, nearly 4 million Venezuelans have moved to other Latin American and Caribbean countries over the past few years. This webinar marked the launch of a Latin American and Caribbean Migration Portal, and a report examining the migration and integration policy responses in the region. Full Article