Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00933E, Paper

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Huynh Quoc Nguyen, Van Dan Nguyen, Vu Minh Phan, Tae Seok Seo
The COVID-19 pandemic greatly impacted the in vitro diagnostic market, leading to the development of new technologies such as point-of-care testing (POCT), multiplex testing, and digital health platforms.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00118D, Paper

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Jiaheng Li, Lok Ting CHU, Hogi Hartanto, Guihuan Guo, Lu LIU, Jianpeng WU, Minghui Wu, Chenyu Cui, Gaobo Wang, Wengang LIU, Hoi Kwan Kwong, Siying WU, Ting-Hsuan Chen
Mucosal antibodies at the upper respiratory tract are the earliest and most critical responders to prevent respiratory infections, providing an indication to rapidly evaluate immune protection. Here, we report a...
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00131A, Paper

Fahima Akther, Hedieh Fallahi, Jun Zhang, Nam-Trung Nguyen, Hang Thu Ta
An atherothrombosis-on-chip model to evaluate thrombosis risk and patient-specific treatment strategy.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC01062G, Paper

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Steven A. Soper, Chathurika Rathnayaka, Indu Chandrasoma, Junseo Choi, Katie Childers, Maximillian Chibuike, Khurshed Akabirov, Farhad Shiri, Adam R Hall, Collin J McKinney, Matthew David Verber, Sunggook Park
We report the generation of ~8 nm dual in-plane pores fabricated in a thermoplastic via nanoimprint lithography (NIL). These pores were connected in series with nanochannels, one of which served...
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01061A, Paper

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Felix Reichel, Ruchi Goswami, Salvatore Girardo, Jochen Guck
We use hyperbolic microchannels to create a flow field with linearly increasing velocity, leading to a constant tensile stress to probe the viscoelastic properties of cells. We verify our approach on oil droplets and polyacrylamide beads.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01101A, Paper

Wei Wang, Jaime de la Fuente Diez, Nicolas Delsuc, Juan Peng, Riccardo Spezia, Rodolphe Vuilleumier, Yong Chen
A new method uses piezoelectric and microfluidic tuning to study vibrational polaritons in liquids under flow. This enables modifying cavity length adjustments and flexibility in experimental setups.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC00854A, Paper

Lu Xin, Xi Xiao, Wen Xiao, Ran Peng, Hao Wang, Feng Pan
The incidence of urothelial carcinoma continue to rise annually, particularly among the elderly. Prompt diagnosis and treatment can significantly enhance patient survival and quality of life. Urine cytology remains a...
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00165F, Paper

Xiaoming Chen, Shun Liu, Mo Shen, Jishun Shi, Chungang Wu, Zhipeng Song, Yong Zhao
We develop a microfluidic device with closed right-angle bipolar electrodes to realize dielectrophoretic characterization and selection of non-spherical flagellate algae.
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Lab Chip, 2024, 24,2237-2252
DOI: 10.1039/D3LC00694H, Paper

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Nilay Vora, Prashant Shekar, Taras Hanulia, Michael Esmail, Abani Patra, Irene Georgakoudi
We present a deep-learning enabled, label-free flow cytometry platform for identifying circulating tumor cell clusters in whole blood based on the endogenous scattering detected at three wavelengths. The method has potential for in vivo translation.
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Lab Chip, 2024, 24,2280-2286
DOI: 10.1039/D3LC00822C, Paper

Mingwei Zhao, Jing Yang, Zhenqing Li, Yuan Zeng, Chunxian Tao, Bo Dai, Dawei Zhang, Yoshinori Yamaguchi
Concentration gradient generation and mixed combinations of multiple solutions are of great value in the field of biomedical research.
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Lab Chip, 2024, 24,2262-2271
DOI: 10.1039/D4LC00055B, Paper

Kawin Khachornsakkul, Ruben Del-Rio-Ruiz, Lita Chheang, Wenxin Zeng, Sameer Sonkusale
A carbon dots and dopamine-imprinted polymer was immobilized onto a distance-based paper channel for simultaneous detection of three cytokine biomarkers without requiring expensive reagents and instruments.
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Lab Chip, 2024, 24,2202-2207
DOI: 10.1039/D4LC00014E, Paper

Matthew S. Viglione, Aubrianna Saxton, Dawson Downs, Adam T. Woolley, Kenneth A. Christensen, Pam M. Van Ry, Gregory P. Nordin
A new 3D printing method allows for fabrication of porous membranes with 7 μm pores. A device mimicking an organ-on-a-chip design is fabricated and seeded with living cells, demonstrating potential for diverse biological and mechanical applications.
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Lab Chip, 2024, 24,2146-2175
DOI: 10.1039/D3LC01086D, Critical Review

Uditha Roshan, Amith Mudugamuwa, Haotian Cha, Samith Hettiarachchi, Jun Zhang, Nam-Trung Nguyen
This review paper provides a comprehensive overview of the state-of-the-art actuation mechanisms for flexible and stretchable microdevices.
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Lab Chip, 2024, 24,2317-2326
DOI: 10.1039/D4LC00151F, Paper

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Amirreza Gholivand, Olivera Korculanin, Knut Dahlhoff, Mehrnaz Babaki, Timo Dickscheid, Minne Paul Lettinga
Taking microfluidics to the third dimension causes scrambling of memory effects in blood flow due to out-of-plane vessel structures.
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Lab Chip, 2024, 24,2358-2359
DOI: 10.1039/D4LC90026J, Correction

Open Access

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Lei Mou, Kalpana Mandal, Marvin Magan Mecwan, Ana Lopez Hernandez, Surjendu Maity, Saurabh Sharma, Rondinelli Donizetti Herculano, Satoru Kawakita, Vadim Jucaud, Mehmet Remzi Dokmeci, Ali Khademhosseini
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Lab Chip, 2024, 24,2272-2279
DOI: 10.1039/D3LC01079A, Paper

Huilan Hu, Jiaqi Tian, Rui Shu, Huihui Liu, Shaochi Wang, Xuechi Yin, Jianlong Wang, Daohong Zhang
A lateral flow immunoassay (LFIA) is developed for enzyme-catalyzed double-reading determination of clenbuterol (CLE) through the direct electrostatic adsorption of ultra-small copper–gold bimetallic enzyme mimics (USCGs) and monoclonal antibodies.
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Lab Chip, 2024, 24,2287-2297
DOI: 10.1039/D3LC00866E, Paper

Arata Tsuchida, Taikopaul Kaneko, Kaori Nishikawa, Mayu Kawasaki, Ryuji Yokokawa, Hirofumi Shintaku
We introduce a simple integrated analysis method that links cellular phenotypic behaviour with single-cell RNA sequencing by utilizing a combination of optical indices from cells and hydrogel beads.
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Lab Chip, 2024, 24,2327-2334
DOI: 10.1039/D4LC00176A, Paper

Open Access

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Aravind M, Sajan D. George
Adhesive contrast contact lens fabricated by selective lubricant grafting splits tear film on specified zone by secretion and blinking. Integrating the contact lens with the spectroscopic technique offers an efficient platform for biomolecule sensing.
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Lab Chip, 2024, 24,2298-2305
DOI: 10.1039/D3LC00730H, Paper

Mahdi Samadi Khezri, Mohammad Reza Housaindokht, Mojtaba Firouzi
A volumetric bar-chart chip (V-chip) is a microfluidic device based on distance-based quantitative measurement that visualizes analyte concentration without the need for apparatus or data processing.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00931A, Perspective

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Fu Der Chen, Ankita Sharma, David A. Roszko, Tianyuan Xue, Xin Mu, Xianshu Luo, Hongyao Chua, Patrick Guo-Qiang Lo, Wesley D. Sacher, Joyce K. S. Poon
We explore the development of multifunctional nanophotonic neural probes, integrating microelectrodes, optical emitters, and microfluidic channels for multimodal brain mapping.
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Lab Chip, 2024, 24,2306-2316
DOI: 10.1039/D3LC01045G, Paper

Sabah H. Al-Jaf, Sameera Sh. Mohammed Ameen, Khalid M. Omer
On-site monitoring of ions in drinking water is essential for safeguarding public health, ensuring high water quality, and preserving the ecological balance of aquatic ecosystems.
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Lab Chip, 2024, 24,2335-2346
DOI: 10.1039/D4LC00032C, Paper

Rodin Chermat, Elena Refet-Mollof, Yuji Kamio, Jean-François Carrier, Philip Wong, Thomas Gervais
We introduce the first brachytherapy-on-chip device for in vitro testing of brachytherapy on naturally hypoxic tumor spheroids, for translational research and drug development.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00087K, Paper

Mohammad Mahdi Mardanpour, Ayyappasamy Sudalaiyadum Perumal, Zahra Mahmoodi, Karine Baassiri, Gala Montiel-Rubies, Kenneth M. LeDez, Dan V. Nicolau
This study conducted in vitro experimentation using microvascular tissue-like structures to examine the dynamics of interfacial forces leading to gas bubble cessation, with the objective of providing a medical guideline for preventing gas embolism.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01052J, Paper

Wenxin Wang, Yiyuan Liu, Zhikai Yao, Dengbo Chen, Yue Tang, Jingwei Cui, Jiangjiang Zhang, Hong Liu, Zikai Hao
A depression-on-gut-chip (DoGC) is prepared and enables extended co-culture of aerobic human intestinal epithelial cells and anaerobic gut microbiota, and allows direct study of interactions between human gut microbiota and depression.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00159A, Paper

Lixue Liang, Xueying Wang, Dong Chen, Palaniappan Sethu, Guruprasad A. Giridharan, Yanxia Wang, Yu Wang, Kai-Rong Qin
The best pulsation frequency mode of the RBP would be one that changes every 2–3 times of the cardiac cycle. The proposed in vitro microfluidic model could provide an effective platform to select the best working mode of the RBP for heart failure.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00291A, Paper

Nana Jin, Fan Jiang, Fengzhen Yang, Ying Ding, Ming Liao, Yanbin Li, Jianhan Lin
A colorimetric biosensor was elaboratively designed for fast, sensitive and multiplex bacterial detection on a single microfluidic chip using immune magnetic nanobeads for specific bacterial separation, immune gold@platinum palladium nanoparticles...
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01116J, Paper

Duomei Tian, Zheng Mao, Li Wang, Xiaochen Huang, Wei Wang, Haoyue Luo, Juan Peng, Yong Chen
Tumor spheroids are cultured in hydrogel microwells with a gravity driven medium flow underneath the membrane on-a-chip. The rocking system is pumpless, powered with a rechargeable battery, and programmable with a built-in microprocess.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC00941F, Paper

Shizheng Zhou, Tianhui Chen, Edgar S. Fu, Liuyong Shi, Teng Zhou, Hong YAN
The composition of species and the physiological status of microalgal cells serve as significant indicators for monitoring marine environments. Symbiotic with corals, Symbiodiniacea are more sensitive to the environmental response....
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00105B, Critical Review

Shanqing Huang, Weixiong Shi, Shiyu Li, Qian Fan, Chaoyong Yang, Jiao Cao, Lingling Wu
Cells are the fundamental building blocks of living systems, exhibiting significant heterogeneity. The transcriptome connects the cellular genotype and phenotype, and profiling single-cell transcriptome is critical for uncovering distinct cell...
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00985H, Paper

Open Access

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Nan Jia, Tianyang Deng, Charles Larouche, Tigran Galstian, André Bégin-Drolet, Jesse Greener
We report a flow sensitive birefringent in-channel chitosan micromembrane. Using a simple cross-polarizer and a calibration curve, the membrane functions as a flow rate meter, which also works as a feedback element for a flow control system.
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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00149D, Paper

Sunil Shrestha, Vinod Kumar Reddy Lekkala, Prabha Acharya, Soo-Yeon Kang, Manav Goud Vanga, Moo-Yeal Lee
Human liver organoids (HLOs) hold significant potential for recapitulating the architecture and function of liver tissues in vivo. However, conventional culture methos of HLOs, forming Matrigel domes in 6-/24-well plates,...
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00163J, Paper

Open Access

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Yujia Li, Yingqi Kong, Yubing Hu, Yixuan Li, Rica Asrosa, Wenyu Zhang, Buddha Deka Boruah, Ali K. Yetisen, Andrew Davenport, Tung-Chun Lee, Bing Li
A safe, accurate, and reliable sensing platform for urinary biomarkers analysis of urinary biomarkers is clinically important for the early detection and monitoring of the progression of chronic kidney disease (CKD), as it has become one of the world's most prevalent non-communicable diseases.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00132J, Paper

Oriana G. Chavez-Pineda, Roberto Rodriguez-Moncayo, Alan M. Gonzalez-Suarez, Pablo E. Guevara-Pantoja, Jose L. Maravillas-Montero, Jose L. Garcia-Cordero
A microfluidic platform isolates leukocytes from blood efficiently, offering diagnostic and immunotherapeutic potential. Enhanced by a handheld pressure controller, it enables near-patient testing and integration with downstream assays.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC90040E, Correction

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Olivia M. Young, Xin Xu, Sunandita Sarker, Ryan D. Sochol
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00009A, Paper

Open Access

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Bastián Carnero, Yago Radziunas-Salinas, Bruno K. Rodiño-Janeiro, Sylvana Varela Ballesta, M. Teresa Flores-Arias
The proposed hybrid technique for passive straight micromixer manufacturing by combining pulsed laser ablation and stereolithographic 3D printing.
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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00193A, Paper

Marti Z. Hua, Shenmiao Li, M. S. Roopesh, Xiaonan Lu
A QD-MIP based microfluidic device to detect mycotoxin in food.
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React. Chem. Eng., 2024, Advance Article
DOI: 10.1039/D4RE00334A, Minireview

Chengxiong Dang, Hao Yu
A bifunctional catalyst for integrated CO₂ capture and utilization (ICCU).
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React. Chem. Eng., 2024, Accepted Manuscript
DOI: 10.1039/D4RE00400K, Paper

Open Access

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Sergio Carrillo De Hert, Rafael Lopez-Rodriguez, Michael Di Maso, Jonathan McMullen, Steven Ferguson
Continuous flow chemical photoreactors have emerged as a highly attractive platform, garnering considerable attention in both industry and academia. Utilizing thin channels, these reactors offer a promising solution for achieving...
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React. Chem. Eng., 2024, 9,2882-2891
DOI: 10.1039/D4RE00175C, Paper

Aravind Senthil Vel, Daniel Cortés-Borda, François-Xavier Felpin
This paper presents a chemist's guide for selecting multi-objective optimization algorithms for reaction optimization.
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React. Chem. Eng., 2024, 9,2868-2881
DOI: 10.1039/D4RE00168K, Paper

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Tim Delrieux, Shweta Sharma, Florian Maurer, Paolo Dolcet, Maximilian Lausch, Anna Zimina, Camilo Cárdenas, Patrick Lott, Maria Casapu, Thomas Lennon Sheppard, Jan-Dierk Grunwaldt
This work presents a fast and non-invasive photo-based channel analysis approach, which helps to screen and understand the effects of different coating parameters on the activity of noble metal-based oxidation catalyst coated on a ceramic cordierite.
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React. Chem. Eng., 2024, 9,2938-2953
DOI: 10.1039/D4RE00282B, Paper

Eyyup Yasar, Emine Aytar, Ahmet Kilic
The conversion of CO₂ into high value-added chemicals is receiving increasing attention from the scientific community, commercial enterprises, and policymakers due to environmental problems like global warming.
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React. Chem. Eng., 2024, 9,2925-2937
DOI: 10.1039/D4RE00271G, Paper

Nicolás Salas, Justin López, Carlos A. Arango
Effect of permutations σ_12,0 and σ₂₁ on graph G₂.
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React. Chem. Eng., 2024, 9,2892-2901
DOI: 10.1039/D4RE00269E, Paper

Yujue Du, Wende Hu, Yunlei Chen, Chuanming Wang, Weimin Yang
The Lewis acid sites in ZSM-5 zeolite involving Co, Ni, and Cu cations were computationally studied on the stability and the PDH catalytic activity.
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React. Chem. Eng., 2024, 9,2902-2914
DOI: 10.1039/D4RE00312H, Paper

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Manas Mokashi, Akash Bhimrao Shirsath, Sinan Demir, Ahmet Çelik, Patrick Lott, Steffen Tischer, Olaf Deutschmann
By combining numerical simulations and experiments, catalyst-free thermal dry reforming of biogas for sustainable syngas production and solid carbon capture is investigated under industrially viable conditions.
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React. Chem. Eng., 2024, 9,2954-2962
DOI: 10.1039/D4RE00226A, Paper

Hui Jin, Mengyu Cui, Peiwen Liu, Zhuo Wang, Tongxia Jin, Yonghui Yang, Weiping Zhu, Xuhong Qian
A novel magnetically recyclable heterogeneous palladium catalyst Fe₃O₄@FSM@Pd was constructed and characterized, which is highly efficient and reusable for the Suzuki–Miyaura cross-coupling reaction.
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React. Chem. Eng., 2024, 9,2975-2983
DOI: 10.1039/D4RE00301B, Paper

Yoshihiro Takebayashi, Kiwamu Sue, Sho Kataoka
An automated flow reactor with a rapid inline monitoring using a compact near-infrared spectrometer and a flow rate ramp control enabled high-density kinetic data acquisition.
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React. Chem. Eng., 2024, 9,2963-2974
DOI: 10.1039/D4RE00241E, Paper

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Esai Daniel Lopez, Patricia Zhang Musacchio, Andrew R. Teixeira
Wirelessly powering μLEDs within packed bed reactors enables scalable, continuous, green chemical manufacturing by overcoming classical light penetration limits.
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React. Chem. Eng., 2024, 9,2994-3002
DOI: 10.1039/D4RE00265B, Paper

Open Access

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Adrian Ioan Dudu, Csaba Paizs, Monica Ioana Toşa
In this study, the synthesis of aroma esters by the direct esterfication of carboxylic acids with aromatic alcohols mediated by lipase B from Candida antarctica encapsulated in a sol–gel matrix in a solvent-free system is presented.
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React. Chem. Eng., 2024, 9,2984-2993
DOI: 10.1039/D4RE00127C, Paper

Leon Hennecke, Lucas Schaare, Mirko Skiborowski, Andreas Liese
This study presents an automated reactor platform for the identification of enzyme kinetic models using model-based design of experiments on the example of the reduction of NAD⁺ by formate dehydrogenase from Candida boidinii.
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React. Chem. Eng., 2024, 9,3029-3037
DOI: 10.1039/D4RE00327F, Paper

Sanha Lim, Hwangho Lee, Hyun Sub Kim, Jun Seop Shin, Jong Min Lee, Do Heui Kim
Bayesian optimization approach facilitates an efficient optimization of multi-components catalyst for NH₃-SCR reaction.
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