Hyo Jung Kim
May 1, 2020; 61:722-733
Research Articles

Yipeng Sui
May 1, 2020; 61:696-706
Research Articles

Delphine Fontaine
Apr 7, 2020; 0:jlr.RA120000634v1-jlr.RA120000634
Research Articles

Sandi M. Azab
Mar 31, 2020; 0:jlr.D120000630v1-jlr.D120000630
Methods

Sookyoung Jeon
Apr 1, 2020; 61:470-479
Reviews

Kathrin B. Hasbargen
May 1, 2020; 61:734-745
Research Articles

Inês Magro dos Reis
Apr 14, 2020; 0:jlr.RA120000632v1-jlr.RA120000632
Research Articles

Inga Nilsson
Mar 10, 2020; 0:jlr.RA120000654v1-jlr.RA120000654
Research Articles

Jeroen van Smeden
Apr 7, 2020; 0:jlr.RA120000639v1-jlr.RA120000639
Research Articles

Henry J. Pownall
May 1, 2020; 61:595-597
Commentary

Chelsea DeLeon
May 1, 2020; 61:767-777
Research Articles

Björn Morén
Apr 15, 2020; 0:jlr.ILR120000808v1-jlr.ILR120000808
Images in Lipid Research

Xia Meng
May 1, 2020; 61:591-591
Images in Lipid Research

Zinc is a critical element for insulin storage in the secretory granules of pancreatic beta cells. The islet-specific zinc transporter ZnT8 mediates granular sequestration of zinc ions. A genetic variant of human ZnT8 arising from a single nonsynonymous nucleotide change contributes to increased susceptibility to type-2 diabetes (T2D), but it remains unclear how the high risk variant (Arg-325), which is also a higher frequency (>50%) allele, is correlated with zinc transport activity. Here, we compared the activity of Arg-325 with that of a low risk ZnT8 variant (Trp-325). The Arg-325 variant was found to be more active than the Trp-325 form following induced expression in HEK293 cells. We further examined the functional consequences of changing lipid conditions to mimic the impact of lipid remodeling on ZnT8 activity during insulin granule biogenesis. Purified ZnT8 variants in proteoliposomes exhibited more than 4-fold functional tunability by the anionic phospholipids, lysophosphatidylcholine and cholesterol. Over a broad range of permissive lipid compositions, the Arg-325 variant consistently exhibited accelerated zinc transport kinetics versus the Trp-form. In agreement with the human genetic finding that rare loss-of-function mutations in ZnT8 are associated with reduced T2D risk, our results suggested that the common high risk Arg-325 variant is hyperactive, and thus may be targeted for inhibition to reduce T2D risk in the general populations.

In the inaugural episode of the UK Tech Weekly Podcast host Matt Egan discusses Apple's disastrous Error 53 with David Price, acting editor of Macworld UK. Techworld.com editor Charlotte Jee discusses the London mayoral candidates views on the UK tech industry, including Zach Goldsmith's anti-Uber statement, and online editor Scott Carey jumps in with some inane ideas around fibre broadband. Finally the team talk about YouTube licensing rights, despite knowing absolutely nothing about the subject.  

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In the second episode of the UK Tech Weekly Podcast host Matt Egan discusses the Mobile World Congress (MWC) with producer Chris Martin before he jets off to Barcelona, including what device launches we are expecting from the likes of LG, Sony and Samsung. Acting editor at Macworld.co.uk David Price chats about the row between Apple and the FBI over encryption (14:50). Finally Scott Carey from Techworld.com discusses challenger banks (25:00) what they are, what the technology looks like and why you should care.  

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In this week's UK Tech Weekly Podcast host Matt Egan is joined by PC Advisor staff writer Chris Minasians chats about Facebook's new like buttons, the team has contracted smartphone fever from the Mobile World Conference in Barcelona and finally, acting editor of Macworld UK David Price, discusses Donald Trump boycotting Apple.  

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In this week's UK Tech Weekly Podcast host Matt Egan discusses VR with Lewis Painter, staff writer at PC Advisor and Chris Martin, consumer tech editor at PC advisor. Then Chris Minasians, staff writer at Macworld UK vents about how technology is destroying social interactions IRL (11:30), light stuff for your weekend listening pleasure! Finally (23:00) acting editor of Macworld UK David Price and the gang chat about paid-for-streaming advocate Kanye West doing a naughty and pirating music software.  

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This week host Matt Egan is joined by Ashleigh Allsopp, engagement editor of Macworld UK and physical bookshelf enthusiast to discuss eBooks and eReaders following the big Nook and Amazon Kindle news in the week (1:40). Producer Chris Martin chips in to talk about the death of the father of email, Ray Tomlinson, this week and the growth of workplace tools like Slack that are trying to reduce the amount we use email (12:30). Finally regular contributor and acting editor at Macworld UK David Price talks about Apple ransomware (24:00).  

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In this week's UK Tech Weekly Podcast host Matt Egan is joined by first time podder Tamlin Magee (1:50), online editor at ComputerworldUK.com, to discuss the UK tech implications of this year's Budget, including rural broadband and driverless cars. Then Christina Mercer, assistant online editor at Techworld.com, chats AlphaGo (10:00) and board games following the AI's historic win over world Go champion Lee Sedol. Later, resident Virtual Reality (VR) enthusiast and PCAdvisor.co.uk staff writer Lewis Painter discussed "the big three" VR headset release dates, pricing and features from HTC, Sony Playstation and Oculus Rift (19:00). Finally, UKTW Podcast regular David Price, acting editor at Macworld.co.uk chats about Apple's big upcoming event (28:45).  

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In this week's UK Tech Weekly Podcast host Matt Egan is joined by acting editor at Macworld.co.uk David Price to discuss this week's Apple event announcements, from the iPhone SE to the iPad Pro and iOS 9.3. Then first time podder and staff writer at Macworld.co.uk Henry Burrell wades in to discuss Facebook dropping its support for Blackberry and the future of the under-fire mobile phone maker (19:45). Finally, online editor at Techworld.com Scott Carey chats coding in schools following the BBC micro:bit news and how it differs from the Raspberry Pi (27:40).  

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In this week's UK Tech Weekly Podcast host Matt Egan is joined by online editor at Techworld.com Scott Carey to discuss all of the news coming out of Microsoft's Build 2016 developer conference, before being joined by producer Chris to talk about the company's genocidal AI chatbot Tay's public meltdown (13:00). Then, acting editor at Macworld.co.uk David Price jumps in to discuss the apparent resolution to the Apple vs FBI fight (29:00).  

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This week host Matt Egan kicks things off by chatting to staff writer Lewis Painter about the (genuinely) impressive Huawei P9 phone release. Then, acting editor at Macworld.co.uk David Price jumps in to discuss Whatsapp encryption (12:30) and the Panama Papers. Finally, Christina Mercer, online editor at Techworld.com, introduces you to the wonderful world of Li-Fi (24:30).  

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Producer Chris dives in this week to discuss the HTC 10 release, and why it's difficult to get excited about good mobile phones. Then Techworld.com editor Charlotte Jee chats Facebook chatbots and other F8 news (12:30). Finally, editor at Digitalartsonline.co.uk Neil Bennett jumps in to discuss the new Amazon e-reader (31:00) Kindle Oasis and why everyone is kicking off about the price.  

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This week host Matt Egan is rejoined by Macworld.co.uk acting editor David Price to chat about Apple's latest Macbook announcements. Then online editor at ComputerworldUK Christina Mercer jumps in to give a break down of Google's fight with the EU over antitrust infringements (13:00). Finally, ex-dating app user Scott Carey, online editor at Techworld.com gives a state of the union on dating apps, from Tinder to Bumble to Happn, if they are good for society and which one is set to corner the market (27:00).  

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This week host Matt Egan is joined by regular podder David Price, acting editor of Macworld.co.uk, to discuss Apple's not so awesome results and stalling iPhone sales. Then online editor Scott Carey jumps in to discuss Facebook's far better results and how it has come to dominate the mobile advertising market (15:00) Finally, producer Chris comes out from behind the glass to discuss Nintendo's secretive NX console and having to wait for the new Zelda game (28:00).  

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On this week's UK Tech Weekly podcast host Matt Egan is joined by Macworld UK and PC Advisor Staff Writer Lewis Painter, who has spent the past week in virtual reality, and is beyond excited to tell us all about the amazing HTC Vive. Then regular podder David Price, acting editor of Macworld UK, brings us tales from the murky world of Bitcoin, and explains how the crypto-currency is bringing about new tech that may revolutionise the finance industry (16:30) Finally, producer Chris throws aside his mic stand to discuss Sky Q and the current options in media streaming and TV. (25:30).  

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In this week's fiery episode host Matt Egan talks war and gaming with Macworld UK's David Price, the greatest graphics ever with Christopher Minasians of PC Advisor and Macworld UK (14:21), and the best networks in the UK with fellow PCA and MWUK stalwart Henry Burrell (25:23). Expect songs and laughter, and tech ever after.  

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Host Matt Egan is joined by producer Chris to talk about the raft of announcements coming out of the Google I/O developer conference this week, including Android N, Google assistant and Allo. Techworld.com editor Charlotte Jee joins in to discuss driverless cars (17:00) following the Queen's speech this week. Finally, acting editor at Macworld.co.uk David Price talks about terrible film adaptations of video games, from Angry Birds to World of Warcraft (29:00). Don't forget to like, share and tell your friends!  

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This week host Matt Egan is joined by producer Chris to talk about the recent batch of new Pebble devices and the smartwatch market. Staff writer at PC Advisor Lewis Painter joins in to talk about the death of the hoverboard (13:00). Finally, regular podder David Price comes on to talk about Appl...oh Twitter, specifically changes to the character limit and the sad loss of the @ (24:00).  

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This week host Matt Egan is joined by PC Advisor staff writer Chris Minasians to chat about the AMD Radeon RX 480 graphics card and what this could mean for the future of virtual reality games. Fellow staff writer at PC Advisor Henry Burrell jumps in to talk about the "not terrible" Windows 10 phone as he starts using the Microsoft Lumia 950 and can't see what everyone's beef with it is (13:00). Finally Ashleigh Allsopp, engagement editor at Macworld UK chats about using your technology at concerts (24:30).  

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Host Matt Egan is joined this week by Henry Burrell, staff writer at Macworld UK to talk about the EU referendum website crashing Lewis Painter, staff writer at PC Advisor, jumps in to chat about Oculus Rift games and how immersive they are. Finally regular David Price comes on to talk about Apple's upcoming WWDC software developer conference and what we can (and cannot) expect.  

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Host Matt Egan is joined by Online Editor at Techworld.com Scott Carey to break down Microsoft's mega acquisition of LinkedIn. Staff Writer at PC Advisor Chris joins in to discuss all of the news coming out of E3 and how Xbox and Playstation are set to battle it out again this summer, or will Nintendo and Zelda steal the show? (13:00). Finally, David Price comes on to talk about all of the news coming out of Apple's WWDC developer conference this week, from Hair Force One to watchOS, tvOS, macOS and iOS (26:30) And please do share, rate and review the UK Tech Weekly Podcast.  

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Editor Matt Egan sits down with staff writer at PC Advisor Lewis Painter to chat about Samsung's S8 rumours. Editor of Techworld.com Charlotte Jee discusses all the goings on from London Tech Week and if London is as much of a tech city as it says it is (12:00). Finally, regular guest David Price, editor at Macworld UK, comes on to discuss Mark Zuckerberg's webcam paranoia and cyber security (22:00).  

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This week host Matt Egan is joined by first time podder and editor of PC Advisor Jim Martin to chat Microsoft Windows 10 anniversary updates and the impact on Microsoft Surface devices. Producer Chris then comes on to chat about Sky's two big NOW TV announcements, and the future of television and broadband (16:00). Finally, UKTW podcast regular David Price chats about the impact technology is having on our holidays (26:30).  

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In Matt Egan's absence first time host Henry Burrell heroically steps in to chat about Pokemon Go with producer Chris. Then fellow staff writer Chris Minasians discusses iOS 10 beta and all of the rumoured features for the latest Apple operating system, including dark mode (10:30). Finally, Lewis Painter, staff writer at PC Advisor, talks about Playstation VR being released for the PS4, pricing and games (23:30).  

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For the second week running hosting duties are taken by Henry Burrell, who is joined by Techworld.com editor Charlotte Jee to discuss the impact of Brexit on the UK's startups. Producer Chris then jumps in to discuss the Pokemon Go launch in the UK and a debate breaks out over whether it is for adults (13:00) Finally, online editor at Computerworld UK Scott Carey brings the latest news around driverless cars, from Tesla's recent struggles and how it may affect the industry in general (25:00)  

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Macworld UK’s Acting Editor David Price takes the reins for this edition, and is joined by Online Editor of Computerworld UK Scott Carey to chat about billions and billions of pounds and the acquisition of ARM by SoftBank. Second up, Staff Writer at PC Advisor and Macworld UK Christopher Minasians plugs in to the haunting world of graphics cards and makes sense of it all for the rest of us. Digital Arts Staff Writer Mimi Launder then explains why Twitter has slapped a troll right in the face in order to stand up to Internet bullying.  

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Hosting duties fall to Henry Burrell this week as he discusses the deadline for the free Microsoft Windows 10 update with Chris Minasians, staff writer at PC Advisor. Scott Carey, online editor at Techworld.com jumps in to talk about why the Verizon deal for Yahoo is ridiculous and charts the missteps that got the company to this point (15:00). Finally, regular guest David Price discusses Apple's less than stellar financial results and if the iPhone is plateauing (26:00).  

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Matt Egan is back in the hosting chair to chat with producer Chris about the Samsung Galaxy Note 7 and how we feel about phablets. Techworld.com editor Charlotte Jee comes in to explain what is going on at the GDS (government digital service) and why we should care (13:00). Then online editor at Techworld.com Scott Carey chats Instagram stories, why it is a blatant rip off of Snapchat stories and how the social media giant can get away with being so brazen (22:00).  

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Host Matt Egan is joined by the world's number one authority on No Man's Sky, producer Chris, to discuss the hype around the vast Playstation and PC game, how it was made and parallel universes. Scott Carey, online editor at Techworld.com jumps in to speak about the government's Open Banking report and how technology could change the way we bank in the future (16:00). Finally, acting editor at Macworld UK David Price is talking water pistol emojis and the strange politics of Apple (27:00).  

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David Price is in the host chair this week and is joined by Lewis Painter, staff writer at PC Advisor and Macworld UK to discuss all the news coming out of Gamescom, including No Man's Sky, Metal Gear, Final Fantasy and Battlefield. Henry Burrell, staff writer at PC Advisor and Macworld UK jumps in to chat Blackberry and its trumped up security claims (15:00). Finally, Charlotte Jee, editor at Techworld.com talks about hacking planes, trains and automobiles (26:30).  

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Henry Burrell is the master of ceremonies this week, dropping beats on the hottest tech topics. First up, producer Chris joins to chat about the latest Android OS: Nougat. Then staff writer at Techworld.com Scott Carey jumps in to chat about the Deliveroo strikes this week and what this means for sharing economy companies like Uber and Airbnb in general (15:30). Finally, staff writer at Tech Advisor Lewis Painter has some Playstation console rumours to discuss (27:00).  

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This week Ashleigh Allsopp is simultaneously fascinated and worried by the UK launch of Amazon's Dash buttons, and discusses the many wonderful and not-so-wonderful things they enable you to buy on a drunken whim. Then David Price takes his turn to shine a spotlight on Apple's mysterious tax affairs (12:20) and tries to explain why the Irish government doesn't want to be given 13 billion euros. Finally a surprisingly riled-up Neil Bennett explains why women wearing headphones are not fair game for dimwitted pick-up artists (25:00), and ponders the social conventions surrounding the place of technology in each of our lives.  

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In this week's inexplicably klaxon-heavy and fish-themed APPLE SPECIAL episode, David Price praises Apple for rescuing us from the tyranny of wired headphones, and reveals a hitherto unsuspected penchant for former Everton strikers. Chris Martin (22:41) dazzles us with his knowledge of the Apple Watch Series Two, and display some unusual headphone usage, and Henry Burell (32:51) reveals that Berlin is big, and sheds some light on the tiny corner of tech that *isn't* Apple flavoured. Join us.  

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In episode 32, Techworld's Scott Carey looks at Amazon's Echo and finds a dystopian future world in which our household appliances listen to us and talk back. Digital Arts editor Neil Bennett (15:06) explains why Tesla now has to design products for stupid people, and Macworld's David Price explains why mums don't like Apple's iOS 10 (28:00). We also discuss the beauty and lyricism of the German language.  

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In episode 33 host David Price is joined by cool Christopher Minasians to shoot the breeze on the Galaxy Note 7 recall, remembering other devices that were literally on fire. Jumpin' Jim Martin (14 minutes) brings his sinister stylings to bear on the burgeoning GoPro market. And honey-voiced Henry Burrell (28 minutes) says hi to Google Allo. Listen very carefully, he will say this only once.  

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The team are back for the 34th episode of tech chat goodness as host ‘Mysterious’ David Price, acting Editor of Macworld UK invites Henry Burrell, Staff Writer at PC Advisor to talk about FIFA 17 and yearly game cycles. Next into the ring is Tamlin Magee (14 mins), Online Editor at ComputerWorld UK to discuss Oculus Rift’s Palmer Luckey and his odd meme-based support of Trump and the wider net of good-natured tech billionaires. Finally, Charlotte Jee (29 mins) Online Editor at Techworld lets us know why Elon Musk wants to sell you a ticket to space, and why it might actually be possible quite soon. Fill yer boots.  

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A premature mid-week Google-themed podcast from the team, who reflect on Google's big 4th October event where they launched the Pixel phone and much more. Acting editor of Macworld UK David Price takes the helm and asks Staff Writer at PC Advisor Henry Burrell to wade in and make sense of all the announcements. Expect AI and VR. Then Staff Writer Christopher Minasians (27:45) chats about the new Pokemon Go Plus wearable, and whether a £35 accessory can improve a free mobile game.  

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Matt Egan is back on hosting duties this week to break down the demise of the Samsung Galaxy Note 7 with producer Chris. Then staff writer at PC Advisor Lewis Painter comes on to talk about the Playstation VR release, games and pricing and compares it to the flagging Oculus Rift and HTC Vive (13:00). Finally, Scott Carey, online editor at Computerworld UK reports back from the biggest tech conference in the world, Dreamforce, chats about Salesforce's rumoured bid for Twitter and tries to make CRM interesting (25:00).  

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