an Demand flux: On growth dynamics By www.thehindu.com Published On :: Mon, 30 Sep 2024 00:20:00 +0530 Growth dynamics may falter with waning urban consumption Full Article Editorial
an Changes at the top: On the Tamil Nadu cabinet reshuffle By www.thehindu.com Published On :: Wed, 02 Oct 2024 00:10:00 +0530 Ministers must infuse confidence in the people they serve Full Article Editorial
an Heartland murmurs: On the Haryana Assembly elections By www.thehindu.com Published On :: Wed, 02 Oct 2024 00:20:00 +0530 Haryana may throw up surprises after the realignments Full Article Editorial
an Flipping scripts: On the Haryana and J&K election results By www.thehindu.com Published On :: Wed, 09 Oct 2024 00:20:00 +0530 BJP and INDIA bloc emerge clear winners in Haryana and Jammu & Kashmir Full Article Editorial
an Sweet and sour: On the laddu ‘adulteration’ case By www.thehindu.com Published On :: Thu, 10 Oct 2024 00:10:00 +0530 The inquiry into laddu adulteration must not be communalised Full Article Editorial
an Against the odds: On the 2024 Haryana Assembly elections By www.thehindu.com Published On :: Thu, 10 Oct 2024 00:20:00 +0530 The Congress could not counter the caste polarisation in Haryana Full Article Editorial
an Respect the mandate: On the 2024 Jammu and Kashmir elections By www.thehindu.com Published On :: Fri, 11 Oct 2024 00:20:00 +0530 With elections done and dusted, J&K now must return to statehood Full Article Editorial
an Biology transformed: On the Nobel Prize in chemistry By www.thehindu.com Published On :: Mon, 14 Oct 2024 00:28:00 +0530 Nobel for determining protein structure recognises a big advance Full Article Editorial
an Take the gauntlet: On safety and the Indian Railways By www.thehindu.com Published On :: Mon, 14 Oct 2024 00:38:00 +0530 ‘Kavach’ implementation is a priority but will not be a silver bullet Full Article Editorial
an A Korean win: On the 2024 Nobel Prize in Literature By www.thehindu.com Published On :: Tue, 15 Oct 2024 00:20:00 +0530 A Nobel raises Korean prose to success levels of its drama and music Full Article Editorial
an Taking guard: On the RBI and growth concerns By www.thehindu.com Published On :: Tue, 15 Oct 2024 00:26:00 +0530 The central bank’s price worries may be warranted but growth concerns are emerging Full Article Editorial
an Deeper role: On the U.S. and West Asia conflicts By www.thehindu.com Published On :: Wed, 16 Oct 2024 00:10:00 +0530 The escalating conflict cycle in West Asia could have disastrous consequences Full Article Editorial
an Abject failure: On India’s Global Hunger Index ranking By www.thehindu.com Published On :: Thu, 17 Oct 2024 00:10:00 +0530 India’s ranks 105 out of 127 countries in the Global Hunger Index, 2024 Full Article Editorial
an Canadian frostbite: On the India-Canada diplomatic war By www.thehindu.com Published On :: Thu, 17 Oct 2024 00:20:00 +0530 India must consider the impact of its next steps on its diplomacy and image Full Article Editorial
an Battle of wits: On the Maharashtra and Jharkhand elections By www.thehindu.com Published On :: Fri, 18 Oct 2024 00:20:00 +0530 The Maharashtra and Jharkhand polls will witness intense political battles Full Article Editorial
an Israel versus the UN: On Tel Aviv’s move and India’s response By www.thehindu.com Published On :: Sat, 19 Oct 2024 00:20:00 +0530 India’s stand must keep in mind the UN’s importance in the global order Full Article Editorial
an Complicit: On India and the U.S and Canada cases By www.thehindu.com Published On :: Mon, 21 Oct 2024 00:30:00 +0530 India must come clean on its stance on transnational killings Full Article Editorial
an Allow for deliberation: On the legitimate demands of Ladakh By www.thehindu.com Published On :: Tue, 22 Oct 2024 00:15:00 +0530 The lack of a legislature and regional autonomy in Ladakh has led to the current protests Full Article Editorial
an Culture and society: On upholding Section 6A of the Citizenship Act By www.thehindu.com Published On :: Tue, 22 Oct 2024 00:30:00 +0530 Supreme Court of India verdict on citizenship law for Assam helps avoid fresh problems Full Article Editorial
an West versus the rest: On western conduct and India By www.thehindu.com Published On :: Wed, 23 Oct 2024 00:10:00 +0530 The West must not tolerate terror threats in the name of free speech Full Article Editorial
an Celebration and vigil: On India, kala-azar and trachoma By www.thehindu.com Published On :: Thu, 24 Oct 2024 00:10:00 +0530 India must not let its guard down on kala-azar Full Article Editorial
an Building blocks: On the 16th BRICS Summit in Kazan By www.thehindu.com Published On :: Fri, 25 Oct 2024 00:24:00 +0530 The BRICS Summit showed that Russia was not without friends Full Article Editorial
an Neck and neck: On the U.S. presidential election By www.thehindu.com Published On :: Sat, 26 Oct 2024 00:10:00 +0530 Trump and Harris offer U.S. voters vastly different choices Full Article Editorial
an Fair trade: On the 29th COP and India’s carbon market By www.thehindu.com Published On :: Sat, 26 Oct 2024 00:20:00 +0530 India must develop a transparent carbon trade policy Full Article Editorial
an At a loss: On the New Zealand-India three-match series By www.thehindu.com Published On :: Mon, 28 Oct 2024 00:10:00 +0530 India batters frittered away the home advantage against New Zealand Full Article Editorial
an Escalation ladder: On conflict between Israel and Iran By www.thehindu.com Published On :: Tue, 29 Oct 2024 00:15:00 +0530 Iran should show strategic restraint; and the world should rein in Israel Full Article Editorial
an Western front: On the parties and their prospects in the Maharashtra polls By www.thehindu.com Published On :: Tue, 29 Oct 2024 00:30:00 +0530 Granular factors can determine the outcome in Maharashtra Full Article Editorial
an Tough task: On the battle lines in the Jharkhand Assembly election By www.thehindu.com Published On :: Wed, 30 Oct 2024 00:20:00 +0530 Coalitional incoherence could stymie the INDIA bloc’s effort to retain power in Jharkhand Full Article Editorial
an Sun signs: On extreme heat and Tamil Nadu’s policy decision By www.thehindu.com Published On :: Thu, 31 Oct 2024 00:10:00 +0530 States should prepare to assist the vulnerable during extreme heat events Full Article Editorial
an Towards Europe: On the India visits by the leaders of Germany, Spain By www.thehindu.com Published On :: Thu, 31 Oct 2024 00:20:00 +0530 India used visits by leaders of Germany and Spain to balance ties in Europe Full Article Editorial
an What Makes <I>Andaz Apna Apna</I> Such Fun Even Today By www.rediff.com Published On :: Andaz Apna Apna is practically the most quoted film since Sholay, observes Sukanya Verma, as she celebrates 30 years of this cult classic movie. Full Article
an Alia-Ranbir's Daughter Raha Turns 2 By www.rediff.com Published On :: Alia Bhatt and Ranbir Kapoor's little girl Raha turned two on November 6, and we were treated to the most adorable pictures on social media. Full Article
an The Raj & DK Line-Up You Cannot Miss By www.rediff.com Published On :: Sukanya Verma looks at their eclectic career of over two decades as their latest offering Citadel: Honey Bunny, the Indian leg of the Russo Brothers globetrotting spy universe series, drops on Amazon Prime Video on November 7. Full Article
an The Woman Who Lost Everything By www.rediff.com Published On :: When the landslide hit, Sruthi's house was washed away, along with its inhabitants. Full Article
an Ananya-Suhana Party Together By www.rediff.com Published On :: Ananya Panday celebrated her birthday with family and the media, but she really wasn't done yet. Full Article
an Pathogenesis of Alzheimer's disease and therapeutic strategies involving traditional Chinese medicine By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00660G, Review ArticleShutang Li, Jinfei YangAs research on AD has progressed, TCM and its active ingredients have increasingly played a crucial role in clinical treatment. This article summarizes extracts from TCM and briefly elucidates their pharmacological mechanisms against AD.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3395-3417DOI: 10.1039/D4MD00334A, Research ArticleVu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh ThanhD-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3495-3506DOI: 10.1039/D4MD00275J, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. RussellThe optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and in silico studies By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3507-3528DOI: 10.1039/D4MD00417E, Research ArticleYuying Liu, Zeyu Yang, Jie Zhang, Na Guo, Nanxin Liu, Qingqing Zhang, Xintao Dang, Yanchen Li, Jie Zhang, Xiaoyan PanIn continuation of our previous research, a series of novel Bcr-AblT315I inhibitors with tert-leucine or serine as a flexible linker were developed and biological evaluation was performed in vitro.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3576-3596DOI: 10.1039/D4MD00438H, Research ArticleRuolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang ChenRho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3469-3476DOI: 10.1039/D4MD00422A, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim NenckaSARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3418-3432DOI: 10.1039/D4MD00170B, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van TranMadecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an Semisynthetic phytochemicals in cancer treatment: a medicinal chemistry perspective By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3345-3370DOI: 10.1039/D4MD00317A, Review ArticleMeghna Arora, Ankit Kumar Singh, Adarsh Kumar, Harshwardhan Singh, Prateek Pathak, Maria Grishina, Jagat Pal Yadav, Amita Verma, Pradeep KumarSemisynthetic phytochemicals in cancer treatment.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3444-3459DOI: 10.1039/D4MD00318G, Research ArticleAnuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar MaitiNiloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an Synthesis of a celastrol derivative as a cancer stem cell inhibitor through regulation of the STAT3 pathway for treatment of ovarian cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3433-3443DOI: 10.1039/D4MD00468J, Research ArticleMeijuan Liu, Na Li, Zhaoxue Wang, Shuo Wang, Shaoda Ren, Xiaojing LiA synthetic celastrol derivative (Cel-N) attenuates cancer cell stemness, inhibits the STAT3 pathway, and exerts anti-ovarian cancer effects in cell and mouse models.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3529-3557DOI: 10.1039/D4MD00481G, Research ArticleMohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai AdelDiscovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an SLL-1A-16 suppresses proliferation and induces autophagy in non-small-cell lung cancer cells via the AKT/mTOR signaling pathway By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3460-3468DOI: 10.1039/D4MD00405A, Research ArticleXiaoqin Luo, Jin Wang, Ruichang Wang, Jiabing Lian, Mengnan Guo, Hongrui Zhou, Mengxue Zhang, Zhe Yang, Xiaolong Li, Xianran He, Xiuli BiSchematic of proposed mechanism for the treatment of the SLL-1A-16 inhibiting the proliferation in NSCLC.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an Design, synthesis and biological evaluation of a novel PSMA–PI3K small molecule drug conjugate By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3485-3494DOI: 10.1039/D4MD00246F, Research ArticleShouguo Peng, Haixia Li, Weilu Cui, Tianning Xiong, Jiaqi Hu, Haixiang Qi, Songwen Lin, Deyu Wu, Ming Ji, Heng XuA novel PSMA–PI3K small molecule drug conjugate has been prepared, highlighting its potential in targeted cancer therapy.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an Discovery and optimisation of pyrazolo[1,5-a]pyrimidines as aryl hydrocarbon receptor antagonists By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3477-3484DOI: 10.1039/D4MD00266K, Research ArticleRaitis Bobrovs, Svetlana Terentjeva, Ninni Elise Olafsen, Zilvinas Dambrauskas, Antanas Gulbinas, Toivo Maimets, Indrek Teino, Aigars Jirgensons, Jason Matthews, Kristaps JaudzemsThe aryl hydrocarbon receptor (AHR) is a versatile ligand-dependent transcription factor involved in diverse biological processes, from metabolic adaptations to immune system regulation.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
an Next-generation EGFR tyrosine kinase inhibitors to overcome C797S mutation in non-small cell lung cancer (2019–2024) By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3371-3394DOI: 10.1039/D4MD00384E, Review ArticleDebasis Das, Lingzhi Xie, Jian HongProspects of novel fourth-generation EGFR-TKIs overcoming C797S-mediated resistance in non-small cell lung cancer.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
