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Pentagonal-bipyramidal Dysprosium(III) complexes with two apical phosphine oxide ligands and equatorial pentadentate N3O2 Schiff-base ligands: Breakdown of the apical magnetic axiality by strong equatorial crystal field†

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Published On ::

Inorg. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QI02262A, Research Article
Tamara A. Bazhenova, Vyacheslav Kopotkov, Denis V. Korchagin, Elena Yureva, Michael V. Zhidkov, Alexey I Dmitriev, Ilya Yakushev, N. N. Efimov, Konstantin Andreevich Babeshkin, Vladimir Sergeevich Mironov, Eduard B. Yagubskii
A series of three new seven-coordinate pentagonal-bipyramidal (PBPY-7) Dy(III) complexes [Dy(LCH3)(Cy3PO)2]ClO4∙CH3CN (1), [Dy(L2(t-Bu))(Ph3PO)2]ClO4∙0.63C2H5OH (2), [Dy(LOCH3)(Ph3PO)2]ClO4∙2H2O (3) including various chelating pentadentate ligands with a [N3O2]2− binding node in the equatorial plane,...
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The use of single metal atoms-based photocatalysts for the production of ammonia through photocatalytic nitrogen fixation

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Inorg. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QI02449D, Review Article
Ping Zhang, Yongchong Yu, Reyila Tuerhong, Xinyu Du, Keyi Chai, Xiaoping Su, Qiong Su, Shujuan Meng, Lijuan Han
The conventional synthetic ammonia industry is characterized by its high energy consumption, necessitating the exploration of a new environmentally sustainable method for NH3 synthesis. A prospective alternative to the Haber-Bosch...
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Metal Node Exchange-Driven Ligand-Strain Modulation Strategy for One-Dimensional Crystalline Coordination Polymers

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Inorg. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QI02422B, Research Article
Gengxin Wu, Yong-Kang Zhu, Dongxia Li, Jia-Rui Wu, Yan Wang, Zhiquan Zhang, Ying-Wei Yang
Engineering ideal functional coordination polymers (CPs) via post-synthetic modification has emerged as a powerful synthetic strategy to achieve desirable functionalities and superior properties. In this work, we report a versatile...
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Dynamic behavior of floating magnetic liquid marbles under steady and pulse-width-modulated magnetic fields

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Lab Chip, 2024, 24,2005-2016
DOI: 10.1039/D3LC00578J, Paper
Hossein Dayyani, Alireza Mohseni, Mohamad Ali Bijarchi
The manipulation of biocompatible magnetic liquid marbles, formed by wrapping magnetic nanoparticles around water droplets, on the water surface under the steady and variable magnetic fields.
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Nanoscale sorting of extracellular vesicles via optically-induced dielectrophoresis on an integrated microfluidic system

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Lab Chip, 2024, 24,1965-1976
DOI: 10.1039/D3LC01007D, Paper
Wei-Jen Soong, Chih-Hung Wang, Chihchen Chen, Gwo-Bin Lee
We devised an innovative method for automated sorting of extracellular vesicles (EVs) employing optically-induced dielectrophoresis on an integrated microfluidic chip. EVs of three distinct size categories could be isolated in 1 h at a purity of 86%.
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Test strip coupled Cas12a-assisted signal amplification strategy for sensitive detection of uracil-DNA glycosylase

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Lab Chip, 2024, 24,1987-1995
DOI: 10.1039/D4LC00096J, Paper
Bin Guo, Chong Hu, Zeping Yang, Chu Tang, Chuanxian Zhang, Fu Wang
In this study, we employed Cas12a protein and enzyme-assisted cycle amplification technology with a test strip to establish a precise platform for the detection of UDG enzyme.
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A flexible electrode Array for genetic transfection of different layers of the retina by electroporation

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Lab Chip, 2024, 24,1957-1964
DOI: 10.1039/D3LC01014G, Paper
Yu Zhang, Tao Peng, Yu Ge, Mengda Li, Chendi Li, Jiyu Xi, Zixi Li, Zewen Wei, Yuntao Hu
Stratified delivery into specific retinal layers was realized by a flexible electrode array that exhibited high compatibility with surgical procedures.
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Confining calcium oxalate crystal growth in a carbonated apatite-coated microfluidic channel to better understand the role of Randall's plaque in kidney stone formation

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Lab Chip, 2024, 24,2017-2024
DOI: 10.1039/D3LC01050C, Paper
Samantha Bourg, Karol Rakotozandriny, Ivan T. Lucas, Emmanuel Letavernier, Christian Bonhomme, Florence Babonneau, Ali Abou-Hassan
The successful formation of a carbonated apatite coating inside a micrometer channel is described, which was used to investigate its role on the formation of calcium oxalate crystals in the context of kidney stones.
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A microfluidic chip for sustained oxygen gradient formation in the intestine ex vivo

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Lab Chip, 2024, 24,1918-1929
DOI: 10.1039/D3LC00793F, Paper
Lauren M. Delong, Colby E. Witt, Madison Pennell, Ashley E. Ross
Here, we have developed a 3D printed microfluidic device capable of oxygen gradient formation within intestinal tissue slices ex vivo. The device is open-welled and compatible with external electrochemical recording during tissue analysis.
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AMF-SporeChip provides new insights into arbuscular mycorrhizal fungal asymbiotic hyphal growth dynamics at the cellular level

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Lab Chip, 2024, 24,1930-1946
DOI: 10.1039/D3LC00859B, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Felix Richter, Maryline Calonne-Salmon, Marcel G. A. van der Heijden, Stéphane Declerck, Claire E. Stanley
A new microfluidic platform – the AMF-SporeChip – enables immobilisation of arbuscular mycorrhizal fungal spores and confrontation of asymbiotic hyphae with physical obstacles, allowing the identification of various exploration strategies.
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Microfluidic impedance cytometry with flat-end cylindrical electrodes for accurate and fast analysis of marine microalgae

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Lab Chip, 2024, 24,2058-2068
DOI: 10.1039/D3LC00942D, Paper
Xiaoming Chen, Mo Shen, Shun Liu, Chungang Wu, Liangliang Sun, Zhipeng Song, Jishun Shi, Yulong Yuan, Yong Zhao
We develop a novel microfluidic impedance cytometer for analysis of marine microalgae by inserting ground flat-end cylindrical electrodes into microchannels.
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A system for fluid pumping by liquid metal multi-droplets

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Lab Chip, 2024, 24,1977-1986
DOI: 10.1039/D3LC01017A, Paper
Liyu Dai, Xiaomin Wu, Huimin Hou, Zhifeng Hu, Yukai Lin, Zhiping Yuan
Cuboid pump systems driven by liquid metal multi-droplets using pillars to restrain the motion of droplets are designed, which achieve a significant increase in the flow rate of the pump.
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Multifunctional cardiac microphysiological system based on transparent ITO electrodes for simultaneous optical measurement and electrical signal monitoring

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Lab Chip, 2024, 24,1903-1917
DOI: 10.1039/D3LC00908D, Paper
Zhangjie Li, Kai Niu, Chenyang Zhou, Feifan Wang, Kangyi Lu, Yijun Liu, Lian Xuan, Xiaolin Wang
We developed a multifunctional cardiac microphysiological system on transparent electrodes, enabling simultaneous electrical signal monitoring and optical observations of cardiac tissue, holding promise for applications in cardiac drug development.
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Comparison between dynamic versus static models and real-time monitoring of neuronal dysfunction in an amyloid-β induced neuronal toxic model on a chip platform

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Lab Chip, 2024, 24,1887-1902
DOI: 10.1039/D3LC00507K, Paper
Open Access
Chu-Chun Liang, Po-Yen Chen, Nien-Che Liu, I-Chi Lee
A 3D neural spheroid-based system with an interstitial level of flow for simulating the brain microenvironment toward a dynamic amyloid-β induced neuronal toxic model was established. A real-time impedance recording was used to monitor the neural network formation and disconnection.
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SeParate: multiway fluorescence-activated droplet sorting based on integration of serial and parallel triaging concepts

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Lab Chip, 2024, 24,2107-2121
DOI: 10.1039/D3LC01075A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Wannes Verbist, Jolien Breukers, Sapna Sharma, Iene Rutten, Hans Gerstmans, Lotte Coelmont, Francesco Dal Dosso, Kai Dallmeier, Jeroen Lammertyn
A novel platform, called SeParate, enabling accurate multiplex droplet sorting by integrating serial and parallel sorting principles for three model systems with increasing complexity and intra-subpopulation variation in fluorescence intensities.
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Lab on skin: real-time metabolite monitoring with polyphenol film based subdermal wearable patches

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Lab Chip, 2024, 24,2039-2048
DOI: 10.1039/D4LC00073K, Paper
Open Access
Georgeta Vulpe, Guoyi Liu, Sam Oakley, Guanghao Yang, Arjun Ajith Mohan, Mark Waldron, Sanjiv Sharma
Development of wearable sensing devices for minimally invasive and real time monitoring of physiological information in ambulatory conditions.
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Microphysiological pancreas-on-chip platform with integrated sensors to model endocrine function and metabolism

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Lab Chip, 2024, 24,2080-2093
DOI: 10.1039/D3LC00838J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katharina Schlünder, Madalena Cipriano, Aline Zbinden, Stefanie Fuchs, Torsten Mayr, Katja Schenke-Layland, Peter Loskill
Pancreatic in vitro models are crucial for research on diseases such as diabetes mellitus. A novel thermoplastic organ-on-chip with integrated real-time read-outs models the complex microphysiological structure and function of the endocrine pancreas.
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Tonicity-induced cargo loading into extracellular vesicles

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Lab Chip, 2024, 24,2069-2079
DOI: 10.1039/D3LC00830D, Paper
Open Access
Chaeeun Lee, Sumit Kumar, Juhee Park, Yongjun Choi, Elizabeth Maria Clarissa, Yoon-Kyoung Cho
Tonicity-induced cargo loading into extracellular vesicles (EVs) is achieved through controlled membrane permeability, ensuring cargo incorporation without causing damage to the EV membrane.
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Droplet microfluidic system for high throughput and passive selection of bacteria producing biosurfactants

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Published On ::

Lab Chip, 2024, 24,1947-1956
DOI: 10.1039/D3LC00656E, Paper
Open Access
Klaudia Staskiewicz, Maria Dabrowska-Zawada, Lukasz Kozon, Zofia Olszewska, Lukasz Drewniak, Tomasz S. Kaminski
Novel microfluidic technique for functional selection of biosurfactant-producing microorganisms. Single bacterial cells are encapsulated into picoliter droplets for clonal cultivation and passively sorted at high throughput by interfacial tension.
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Tuneable hydrogel patterns in pillarless microfluidic devices

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Lab Chip, 2024, 24,2094-2106
DOI: 10.1039/D3LC01082A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Claudia Olaizola-Rodrigo, Sujey Palma-Florez, Teodora Ranđelović, Clara Bayona, Mehran Ashrafi, Josep Samitier, Anna Lagunas, Mònica Mir, Manuel Doblaré, Ignacio Ochoa, Rosa Monge, Sara Oliván
A novel methodology utilizing plasma surface treatment enables the construction of cell culture chambers featuring abutment-free patterns, facilitating the precise distribution of shear stress.
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A self-assembly and cellular migration based fabrication of high-density 3D tubular constructs of barrier forming membranes

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00006D, Paper
Seyedaydin Jalali, Ponnambalam Ravi Selvaganapathy
A scalable method for creating perfusable 3D tissue constructs using self-assembly is introduced. Unlike conventional cell injection methods, here we leverage cell migration to form tissue barriers of low permeability, mimicking in vivo environments.
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Spatially controlled diffusion range of tumor-associated angiogenic factors to develop a tumor model using a microfluidic resistive circuit

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Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00891F, Paper
Yu-Hsiang Hsu, Wen-Chih Yang, Yi-Ting Chen, Che-Yu Lin, Chiou-Fong Yang, Wei-Wen Liu, Subhashree Shivani, Pai-Chi Li
The DC-MPS device uses a velocity V-clamp to create a partition with a steep concentration gradient for simultaneously developing vasculogenic vessels and a tumor. It enables vessel–tumor interaction to develop a tumor model with angiogenic vessels.
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Development of a self-contained microfluidic chip and an internet-of-things-based point-of-care device for automated identification of respiratory viruses

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Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00933E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Huynh Quoc Nguyen, Van Dan Nguyen, Vu Minh Phan, Tae Seok Seo
The COVID-19 pandemic greatly impacted the in vitro diagnostic market, leading to the development of new technologies such as point-of-care testing (POCT), multiplex testing, and digital health platforms.
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Microfluidic Particle Counter Visualizing Mucosal Antibody Levels against SARS-CoV-2 in the Upper Respiratory Tract for Rapid Evaluation of Immune Protection

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Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00118D, Paper
Open Access
Jiaheng Li, Lok Ting CHU, Hogi Hartanto, Guihuan Guo, Lu LIU, Jianpeng WU, Minghui Wu, Chenyu Cui, Gaobo Wang, Wengang LIU, Hoi Kwan Kwong, Siying WU, Ting-Hsuan Chen
Mucosal antibodies at the upper respiratory tract are the earliest and most critical responders to prevent respiratory infections, providing an indication to rapidly evaluate immune protection. Here, we report a...
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Evaluating thrombosis risk and patient-specific treatment strategy using an atherothrombosis-on-chip model

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Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00131A, Paper
Fahima Akther, Hedieh Fallahi, Jun Zhang, Nam-Trung Nguyen, Hang Thu Ta
An atherothrombosis-on-chip model to evaluate thrombosis risk and patient-specific treatment strategy.
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High-throughput viscoelastic characterization of cells in hyperbolic microchannels

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01061A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Felix Reichel, Ruchi Goswami, Salvatore Girardo, Jochen Guck
We use hyperbolic microchannels to create a flow field with linearly increasing velocity, leading to a constant tensile stress to probe the viscoelastic properties of cells. We verify our approach on oil droplets and polyacrylamide beads.
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Piezoelectric and microfluidic tuning of an infrared cavity for vibrational polariton studies

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01101A, Paper
Wei Wang, Jaime de la Fuente Diez, Nicolas Delsuc, Juan Peng, Riccardo Spezia, Rodolphe Vuilleumier, Yong Chen
A new method uses piezoelectric and microfluidic tuning to study vibrational polaritons in liquids under flow. This enables modifying cavity length adjustments and flexibility in experimental setups.
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Operando scanning electron microscopy platform for in situ imaging of fluid evolution in nanoporous shale

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Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC01066J, Paper
Open Access
Artur Davletshin, Wen Song
Fluid-solid interactions in nanoporous materials underlie processes fundamental to nature and the engineered environment, including the thermochemical transformation of argillaceous materials during high-level nuclear waste disposal. Operando fluid-solid resolution at...
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Screening for Urothelial Carcinoma Cells in Urine Based on Digital Holographic Flow Cytometry through Machine Learning and Deep Learning Method

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Published On ::

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC00854A, Paper
Lu Xin, Xi Xiao, Wen Xiao, Ran Peng, Hao Wang, Feng Pan
The incidence of urothelial carcinoma continue to rise annually, particularly among the elderly. Prompt diagnosis and treatment can significantly enhance patient survival and quality of life. Urine cytology remains a...
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An economical in-class sticker microfluidic activity develops student expertise in microscale physics and device manufacturing

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Lab Chip, 2024, 24,2176-2192
DOI: 10.1039/D3LC00912B, Paper
Open Access
Priscilla Delgado, C. Alessandra Luna, Anjana Dissanayaka, Oluwamayokun Oshinowo, Jesse J. Waggoner, Sara Schley, Todd Fernandez, David R. Myers
This activity enables students to construct geometrically complex microfluidics at their desk with no specialized equipment. It can be easily transported, and helped students significantly improve their understanding of miniaturization science.
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Synthesis and photocatalytic property of Au–TiO2 nanocomposites with controlled morphologies in microfluidic chips

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Lab Chip, 2024, 24,2253-2261
DOI: 10.1039/D3LC01053H, Paper
Ziran Ye, Ping Lu, Yiben Chen, Zhixian Xu, Haixia Huang, Mingjia Zhi, Zi Ang Chen, Bo Yan
We present an efficient approach for the consecutive synthesis of Au–TiO2 nanocomposites with controlled morphologies in a microfluidic chip.
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Deep learning-enabled detection of rare circulating tumor cell clusters in whole blood using label-free, flow cytometry

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Lab Chip, 2024, 24,2237-2252
DOI: 10.1039/D3LC00694H, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nilay Vora, Prashant Shekar, Taras Hanulia, Michael Esmail, Abani Patra, Irene Georgakoudi
We present a deep-learning enabled, label-free flow cytometry platform for identifying circulating tumor cell clusters in whole blood based on the endogenous scattering detected at three wavelengths. The method has potential for in vivo translation.
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Distance-based paper analytical device for multiplexed quantification of cytokine biomarkers using carbon dots integrated with molecularly imprinted polymer

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Lab Chip, 2024, 24,2262-2271
DOI: 10.1039/D4LC00055B, Paper
Kawin Khachornsakkul, Ruben Del-Rio-Ruiz, Lita Chheang, Wenxin Zeng, Sameer Sonkusale
A carbon dots and dopamine-imprinted polymer was immobilized onto a distance-based paper channel for simultaneous detection of three cytokine biomarkers without requiring expensive reagents and instruments.
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Correction: Integrated biosensors for monitoring microphysiological systems

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Published On ::

Lab Chip, 2024, 24,2358-2359
DOI: 10.1039/D4LC90026J, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Lei Mou, Kalpana Mandal, Marvin Magan Mecwan, Ana Lopez Hernandez, Surjendu Maity, Saurabh Sharma, Rondinelli Donizetti Herculano, Satoru Kawakita, Vadim Jucaud, Mehmet Remzi Dokmeci, Ali Khademhosseini
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A cheaper substitute for HRP: ultra-small Cu–Au bimetallic enzyme mimics with infinitesimal steric hindrance to promote catalytic lateral flow immunodetection of clenbuterol

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Published On ::

Lab Chip, 2024, 24,2272-2279
DOI: 10.1039/D3LC01079A, Paper
Huilan Hu, Jiaqi Tian, Rui Shu, Huihui Liu, Shaochi Wang, Xuechi Yin, Jianlong Wang, Daohong Zhang
A lateral flow immunoassay (LFIA) is developed for enzyme-catalyzed double-reading determination of clenbuterol (CLE) through the direct electrostatic adsorption of ultra-small copper–gold bimetallic enzyme mimics (USCGs) and monoclonal antibodies.
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Opto-combinatorial indexing enables high-content transcriptomics by linking cell images and transcriptomes

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Lab Chip, 2024, 24,2287-2297
DOI: 10.1039/D3LC00866E, Paper
Arata Tsuchida, Taikopaul Kaneko, Kaori Nishikawa, Mayu Kawasaki, Ryuji Yokokawa, Hirofumi Shintaku
We introduce a simple integrated analysis method that links cellular phenotypic behaviour with single-cell RNA sequencing by utilizing a combination of optical indices from cells and hydrogel beads.
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A microfluidic model to study the effects of arrhythmic flows on endothelial cells

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Lab Chip, 2024, 24,2347-2357
DOI: 10.1039/D3LC00834G, Paper
Austin Lai, Adam Hawke, Mokhaled Mohammed, Peter Thurgood, Gianmarco Concilia, Karlheinz Peter, Khashayar Khoshmanesh, Sara Baratchi
We created a versatile microfluidic system for studying the effect of arrhythmic flow patterns on endothelial cells in vitro. This system provides unique opportunities to identify the molecular machineries that control endothelial biology in response to arrhythmia.
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Designing and prototyping a novel biosensor based on a volumetric bar-chart chip for urea detection

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Lab Chip, 2024, 24,2298-2305
DOI: 10.1039/D3LC00730H, Paper
Mahdi Samadi Khezri, Mohammad Reza Housaindokht, Mojtaba Firouzi
A volumetric bar-chart chip (V-chip) is a microfluidic device based on distance-based quantitative measurement that visualizes analyte concentration without the need for apparatus or data processing.
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Development of wafer-scale multifunctional nanophotonic neural probes for brain activity mapping

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Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC00931A, Perspective
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Fu Der Chen, Ankita Sharma, David A. Roszko, Tianyuan Xue, Xin Mu, Xianshu Luo, Hongyao Chua, Patrick Guo-Qiang Lo, Wesley D. Sacher, Joyce K. S. Poon
We explore the development of multifunctional nanophotonic neural probes, integrating microelectrodes, optical emitters, and microfluidic channels for multimodal brain mapping.
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A novel ratiometric design of microfluidic paper-based analytical device for the simultaneous detection of Cu2+ and Fe3+ in drinking water using a fluorescent MOF@tetracycline nanocomposite

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Published On ::

Lab Chip, 2024, 24,2306-2316
DOI: 10.1039/D3LC01045G, Paper
Sabah H. Al-Jaf, Sameera Sh. Mohammed Ameen, Khalid M. Omer
On-site monitoring of ions in drinking water is essential for safeguarding public health, ensuring high water quality, and preserving the ecological balance of aquatic ecosystems.
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Vascularized tissue on mesh-assisted platform (VT-MAP): a novel approach for diverse organoid size culture and tailored cancer drug response analysis

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Lab Chip, 2024, 24,2208-2223
DOI: 10.1039/D3LC01055D, Paper
Open Access
Jungseub Lee, Sangmin Jung, Hye Kyoung Hong, Hyeonsu Jo, Stephen Rhee, Ye-Lin Jeong, Jihoon Ko, Yong Beom Cho, Noo Li Jeon
VT-MAP, a novel in vitro platform, offers better physiological reflection through the vascularized organoid. This advancement supports drug assessment with deeper insights into cancer biology through correlation between morphology and drug effects.
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Brachytherapy on-a-chip: a clinically-relevant approach for radiotherapy testing in 3d biology

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Lab Chip, 2024, 24,2335-2346
DOI: 10.1039/D4LC00032C, Paper
Rodin Chermat, Elena Refet-Mollof, Yuji Kamio, Jean-François Carrier, Philip Wong, Thomas Gervais
We introduce the first brachytherapy-on-chip device for in vitro testing of brachytherapy on naturally hypoxic tumor spheroids, for translational research and drug development.
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Integrated high performance microfluidic organic analysis instrument for planetary and space exploration

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00012A, Paper
Anna L. Butterworth, Matin Golozar, Zachary Estlack, Jeremy McCauley, Richard A. Mathies, Jungkyu Kim
This work presents the design, fabrication, and automation of our space flight-format microfabricated sample processing and capillary electrophoresis analysis instrument.
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A microfluidic-based gut-on-a-chip model containing the gut microbiota of patients with depression reveals physiological characteristics similar to depression

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Published On ::

Lab Chip, 2024, Advance Article
DOI: 10.1039/D3LC01052J, Paper
Wenxin Wang, Yiyuan Liu, Zhikai Yao, Dengbo Chen, Yue Tang, Jingwei Cui, Jiangjiang Zhang, Hong Liu, Zikai Hao
A depression-on-gut-chip (DoGC) is prepared and enables extended co-culture of aerobic human intestinal epithelial cells and anaerobic gut microbiota, and allows direct study of interactions between human gut microbiota and depression.
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Study on the hemodynamic effects of different pulsatile working modes of a rotary blood pump using a microfluidic platform that realizes in vitro cell culture effectively

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00159A, Paper
Lixue Liang, Xueying Wang, Dong Chen, Palaniappan Sethu, Guruprasad A. Giridharan, Yanxia Wang, Yu Wang, Kai-Rong Qin
The best pulsation frequency mode of the RBP would be one that changes every 2–3 times of the cardiac cycle. The proposed in vitro microfluidic model could provide an effective platform to select the best working mode of the RBP for heart failure.
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Multiplex nanozymatic biosensing of Salmonella on a finger-actuated microfluidic chip

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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00291A, Paper
Nana Jin, Fan Jiang, Fengzhen Yang, Ying Ding, Ming Liao, Yanbin Li, Jianhan Lin
A colorimetric biosensor was elaboratively designed for fast, sensitive and multiplex bacterial detection on a single microfluidic chip using immune magnetic nanobeads for specific bacterial separation, immune gold@platinum palladium nanoparticles...
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A microfluidic microalgae detection system for cellular physiological response based on object detection algorithm

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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D3LC00941F, Paper
Shizheng Zhou, Tianhui Chen, Edgar S. Fu, Liuyong Shi, Teng Zhou, Hong YAN
The composition of species and the physiological status of microalgal cells serve as significant indicators for monitoring marine environments. Symbiotic with corals, Symbiodiniacea are more sensitive to the environmental response....
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Advanced sequencing-based high-throughput and long-read single-cell transcriptome analysis

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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00105B, Critical Review
Shanqing Huang, Weixiong Shi, Shiyu Li, Qian Fan, Chaoyong Yang, Jiao Cao, Lingling Wu
Cells are the fundamental building blocks of living systems, exhibiting significant heterogeneity. The transcriptome connects the cellular genotype and phenotype, and profiling single-cell transcriptome is critical for uncovering distinct cell...
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Reproducible generation of human liver organoids (HLOs) on a pillar plate platform via microarray 3D bioprinting

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Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00149D, Paper
Sunil Shrestha, Vinod Kumar Reddy Lekkala, Prabha Acharya, Soo-Yeon Kang, Manav Goud Vanga, Moo-Yeal Lee
Human liver organoids (HLOs) hold significant potential for recapitulating the architecture and function of liver tissues in vivo. However, conventional culture methos of HLOs, forming Matrigel domes in 6-/24-well plates,...
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A point-of-care testing platform for on-site identification of genetically modified crops

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Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00040D, Paper
Yangyang Wang, Furui Yang, Yingyi Fu, Xin He, Haowei Tian, Lili Yang, Mengxi Wu, Jijuan Cao, Junshan Liu
To fulfil the urgent needs of on-site testing, we develop a point-of-care testing platform that is able to identify 12 types of GM crops in less than 40 minutes without using laboratory settings.
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